ES2024357A6 - Procedimiento de obtencion de halohidrato de 2-halometil-3,5-dimetil-4-metoxipiri-dina. - Google Patents

Procedimiento de obtencion de halohidrato de 2-halometil-3,5-dimetil-4-metoxipiri-dina.

Info

Publication number
ES2024357A6
ES2024357A6 ES9003113A ES9003113A ES2024357A6 ES 2024357 A6 ES2024357 A6 ES 2024357A6 ES 9003113 A ES9003113 A ES 9003113A ES 9003113 A ES9003113 A ES 9003113A ES 2024357 A6 ES2024357 A6 ES 2024357A6
Authority
ES
Spain
Prior art keywords
methoxypyridine
halomethyl
halohydrate
dimethyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9003113A
Other languages
English (en)
Inventor
Coll Alberto Palomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Quimica SA
Original Assignee
Centro Genesis para la Investigacion SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centro Genesis para la Investigacion SL filed Critical Centro Genesis para la Investigacion SL
Priority to ES9003113A priority Critical patent/ES2024357A6/es
Priority to US07/796,070 priority patent/US5292886A/en
Publication of ES2024357A6 publication Critical patent/ES2024357A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE HALOHIDRATO DE 2-HALOMETIL-3,5-DIMETIL-4-METOXIPIRIDINA, DE FORMULA FIGURA 1 (X Y X'' SON HALOGENOS, IGUALES O NO), QUE COMPRENDE UNA PRIMERA ETAPA DE 0-ACILACION Y SUBSIGUIENTE ACILOXILACION DEL GRUPO METILO EN POSICION 2 DEL N-OXIDO DE 2,3,5-TRIMETIL-4-METOXIPIRIDINA, OBTENIENDO UN COMPUESTO DE FORMULA FIGURA 2 (R ES METILO, TRICLOROMETILO O TRIFLUOROMETILO Y N ES 0 O 1) Y UNA ULTIMA ETPA DE HALOGENACION, EN LA QUE EL SUSTITUYENTE EN POSICION 2 DEVIENE HALOMETIL. EL COMPUESTO ES UN ANTECEDENTE DE SINTESIS DEL OMEPRAZOL, QUE ES UN MEDICAMENTO MUY EFICAZ PARA EL TRATAMIENTO DE ULCERAS GASTRICAS.
ES9003113A 1990-12-05 1990-12-05 Procedimiento de obtencion de halohidrato de 2-halometil-3,5-dimetil-4-metoxipiri-dina. Expired - Lifetime ES2024357A6 (es)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES9003113A ES2024357A6 (es) 1990-12-05 1990-12-05 Procedimiento de obtencion de halohidrato de 2-halometil-3,5-dimetil-4-metoxipiri-dina.
US07/796,070 US5292886A (en) 1990-12-05 1991-11-20 Process for the preparation of 2-halomethyl-3,5-dimethyl-4-methoxypyridine halohydrate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9003113A ES2024357A6 (es) 1990-12-05 1990-12-05 Procedimiento de obtencion de halohidrato de 2-halometil-3,5-dimetil-4-metoxipiri-dina.

Publications (1)

Publication Number Publication Date
ES2024357A6 true ES2024357A6 (es) 1992-02-16

Family

ID=8269936

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9003113A Expired - Lifetime ES2024357A6 (es) 1990-12-05 1990-12-05 Procedimiento de obtencion de halohidrato de 2-halometil-3,5-dimetil-4-metoxipiri-dina.

Country Status (2)

Country Link
US (1) US5292886A (es)
ES (1) ES2024357A6 (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2066701A1 (es) * 1991-11-21 1995-03-01 Genesis Para La Investigacion Perfeccionamientos en el objeto de la patente 9102594 por procedimiento de obtencion de compuestos derivados de piridina.
WO2001079194A1 (es) * 2000-04-14 2001-10-25 Esteve Quimica, S.A. Procedimiento para la obtención de derivados de [[(piridil sustituido)metil]tio]bencimidazol

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103664750A (zh) * 2013-12-09 2014-03-26 惠州市莱佛士制药技术有限公司 一种拉唑氯代物的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0103353A3 (en) * 1982-09-13 1986-03-05 Genrad, Inc. Method of and apparatus for multiplexed automatic testing of electronic circuits and the like
SE8404065D0 (sv) * 1984-08-10 1984-08-10 Haessle Ab Novel biologically active compounds
FI90544C (fi) * 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
AT391693B (de) * 1988-11-15 1990-11-12 Cl Pharma Verfahren zur herstellung von 3-5-dimethyl-4methoxypyridinderivaten sowie neues zwischenprodukt hierfuer

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2066701A1 (es) * 1991-11-21 1995-03-01 Genesis Para La Investigacion Perfeccionamientos en el objeto de la patente 9102594 por procedimiento de obtencion de compuestos derivados de piridina.
ES2067407A1 (es) * 1991-11-21 1995-03-16 Genesis Para La Investigacion Perfeccionamientos en el objeto de la patente 9102594 por procedimiento de obtencion de derivados de piridina.
WO2001079194A1 (es) * 2000-04-14 2001-10-25 Esteve Quimica, S.A. Procedimiento para la obtención de derivados de [[(piridil sustituido)metil]tio]bencimidazol
ES2171116A1 (es) * 2000-04-14 2002-08-16 Esteve Quimica Sa Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol.
US6723852B2 (en) * 2000-04-14 2004-04-20 Esteve Quimica, S.A. Method for obtaining derivatives of [[(pyridil substituted)methyl]thio]benzomidazol

Also Published As

Publication number Publication date
US5292886A (en) 1994-03-08

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Legal Events

Date Code Title Description
PC1A Transfer granted

Owner name: ESTEVE QUIMICA, S.A.

FD2A Announcement of lapse in spain

Effective date: 20110214