ES2013391A6 - Procedimiento para la preparacion de derivados acetilenicos y alenicos de 2-aminometil -5-metoxiindoles. - Google Patents
Procedimiento para la preparacion de derivados acetilenicos y alenicos de 2-aminometil -5-metoxiindoles.Info
- Publication number
- ES2013391A6 ES2013391A6 ES8900452A ES8900452A ES2013391A6 ES 2013391 A6 ES2013391 A6 ES 2013391A6 ES 8900452 A ES8900452 A ES 8900452A ES 8900452 A ES8900452 A ES 8900452A ES 2013391 A6 ES2013391 A6 ES 2013391A6
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- 4alkyl
- compounds
- alkyne
- sec
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE DESCRIBE UN PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS ACETILENICOS Y ALENICOS DE 2-AMINOMETIL-5-METOXIINDOLES, DE INTERES FARMACOLOGICO COMO INHIBIDORES DE MONOAMINOOXIDASAS. EL PROCEDIMIENTO SE DESARROLLA EN TRES PASOS SUCESIVOS: A) SE PARTE DE LOS ACIDOS 1-H (ALQUIL O ARIL)-5-METOXIINDOL-2-CARBOXILICOS QUE TRATADOS CON HALUROS DE ACILO CONDUCEN A LOS CORRESPONDIENTES HALUROS DE ACIDO, LOS CUALES REACCIONAN CON AMINAS PARA DAR LAS RESPECTIVAS AMIDAS (2); B) LAS AMIDAS SE REDUCEN CON HIDRORURO DE LITIO Y ALUMINIO A LAS RESPECTIVAS AMINAS (3), QUE SE AISLAN Y CARACTERIZAN COMO BASES LIBRES O ALGUNAS DE SUS SALES; C) LAS AMINAS (3) OBTENIDAS SE SOMETEN A UNA REACCION DE N-ALQUILACION CON HALUROS ACETILENICOS O ALENICOS, EN PRESENCIA DE TERCBUTILAMINA PARA DAR LAS AMINAS ACETILENICAS O ALENICAS (4) DESEADAS, QUE SE AISLAN Y CARACTERIZAN POR LOS METODOS USUALES DE LA QUIMICA ORGANICA, YA COMO TALES O EN FORMA DE ALGUNA DE SUS SALES. LAS AMINAS (3) Y (4) SE ESTUDIARON COMO INHIBIDORES DE LAS MONOAMINOOXIDAS A Y B Y SE APORTAN DATOS SOBRE SUS ACTIVIDADES Y SELECTIVIDADES COMO INHIBIDORES DE ESTAS ENZIMAS.
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES8900452A ES2013391A6 (es) | 1989-02-08 | 1989-02-08 | Procedimiento para la preparacion de derivados acetilenicos y alenicos de 2-aminometil -5-metoxiindoles. |
IE43890A IE64235B1 (en) | 1989-02-08 | 1990-02-07 | Indole derivatives |
CA002025663A CA2025663C (en) | 1989-02-08 | 1990-02-08 | Indole derivatives |
AU50299/90A AU626640B2 (en) | 1989-02-08 | 1990-02-08 | Indole derivatives |
DE9090301346T DE69000806T2 (de) | 1989-02-08 | 1990-02-08 | Indol-derivate. |
ES90301346T ES2054234T3 (es) | 1989-02-08 | 1990-02-08 | Un procedimiento para la preparacion de derivados indol. |
AT90301346T ATE85047T1 (de) | 1989-02-08 | 1990-02-08 | Indol-derivate. |
EP90301346A EP0382533B1 (en) | 1989-02-08 | 1990-02-08 | Indole derivates |
ZA90936A ZA90936B (en) | 1989-02-08 | 1990-02-08 | Indole derivatives |
PCT/EP1990/000221 WO1990009375A1 (en) | 1989-02-08 | 1990-02-08 | Indole derivatives |
JP2502961A JP2994457B2 (ja) | 1989-02-08 | 1990-02-08 | インドール誘導体 |
DK90301346.4T DK0382533T3 (da) | 1989-02-08 | 1990-02-08 | Indolderivater |
US07/585,137 US5130327A (en) | 1989-02-08 | 1990-02-08 | Indole derivatives |
KR1019900702206A KR0171579B1 (ko) | 1989-02-08 | 1990-02-08 | 인돌유도체, 이의 제조방법 및 그를 함유한 약제학적 조성물 |
NZ232426A NZ232426A (en) | 1989-02-08 | 1990-02-08 | 5-methoxyindol-2-yl methylamine derivatives and pharmaceutical compositions |
HK98100639A HK1002410A1 (en) | 1989-02-08 | 1998-01-23 | Indole derivates |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES8900452A ES2013391A6 (es) | 1989-02-08 | 1989-02-08 | Procedimiento para la preparacion de derivados acetilenicos y alenicos de 2-aminometil -5-metoxiindoles. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2013391A6 true ES2013391A6 (es) | 1990-05-01 |
Family
ID=8260310
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8900452A Expired - Fee Related ES2013391A6 (es) | 1989-02-08 | 1989-02-08 | Procedimiento para la preparacion de derivados acetilenicos y alenicos de 2-aminometil -5-metoxiindoles. |
ES90301346T Expired - Lifetime ES2054234T3 (es) | 1989-02-08 | 1990-02-08 | Un procedimiento para la preparacion de derivados indol. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90301346T Expired - Lifetime ES2054234T3 (es) | 1989-02-08 | 1990-02-08 | Un procedimiento para la preparacion de derivados indol. |
Country Status (15)
Country | Link |
---|---|
US (1) | US5130327A (es) |
EP (1) | EP0382533B1 (es) |
JP (1) | JP2994457B2 (es) |
KR (1) | KR0171579B1 (es) |
AT (1) | ATE85047T1 (es) |
AU (1) | AU626640B2 (es) |
CA (1) | CA2025663C (es) |
DE (1) | DE69000806T2 (es) |
DK (1) | DK0382533T3 (es) |
ES (2) | ES2013391A6 (es) |
HK (1) | HK1002410A1 (es) |
IE (1) | IE64235B1 (es) |
NZ (1) | NZ232426A (es) |
WO (1) | WO1990009375A1 (es) |
ZA (1) | ZA90936B (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2137104A1 (es) * | 1997-03-10 | 1999-12-01 | Consejo Superior Investigacion | Procedimiento para la preparacion de n-propargil-2-(5-benciloxi-indolil)-metilamina |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2724171B1 (fr) * | 1994-09-05 | 1997-01-03 | Synthelabo | Derives de 3,3a,4,5-tetrahydro-1h-oxazolo(3,4-a)quinolein-1-one, leur preparation et leur application en therapeutique |
WO2021118318A2 (ko) * | 2019-12-13 | 2021-06-17 | 주식회사 메타센테라퓨틱스 | 신규한 인돌 유도체 및 이의 용도 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB846560A (en) * | 1957-02-06 | 1960-08-31 | Smith & Nephew | Improvements in indole derivatives |
-
1989
- 1989-02-08 ES ES8900452A patent/ES2013391A6/es not_active Expired - Fee Related
-
1990
- 1990-02-07 IE IE43890A patent/IE64235B1/en not_active IP Right Cessation
- 1990-02-08 NZ NZ232426A patent/NZ232426A/en unknown
- 1990-02-08 AU AU50299/90A patent/AU626640B2/en not_active Expired
- 1990-02-08 JP JP2502961A patent/JP2994457B2/ja not_active Expired - Fee Related
- 1990-02-08 EP EP90301346A patent/EP0382533B1/en not_active Expired - Lifetime
- 1990-02-08 US US07/585,137 patent/US5130327A/en not_active Expired - Lifetime
- 1990-02-08 DE DE9090301346T patent/DE69000806T2/de not_active Expired - Lifetime
- 1990-02-08 WO PCT/EP1990/000221 patent/WO1990009375A1/en active Application Filing
- 1990-02-08 KR KR1019900702206A patent/KR0171579B1/ko not_active IP Right Cessation
- 1990-02-08 AT AT90301346T patent/ATE85047T1/de not_active IP Right Cessation
- 1990-02-08 CA CA002025663A patent/CA2025663C/en not_active Expired - Lifetime
- 1990-02-08 DK DK90301346.4T patent/DK0382533T3/da active
- 1990-02-08 ES ES90301346T patent/ES2054234T3/es not_active Expired - Lifetime
- 1990-02-08 ZA ZA90936A patent/ZA90936B/xx unknown
-
1998
- 1998-01-23 HK HK98100639A patent/HK1002410A1/xx not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2137104A1 (es) * | 1997-03-10 | 1999-12-01 | Consejo Superior Investigacion | Procedimiento para la preparacion de n-propargil-2-(5-benciloxi-indolil)-metilamina |
Also Published As
Publication number | Publication date |
---|---|
CA2025663C (en) | 1999-07-27 |
EP0382533A1 (en) | 1990-08-16 |
AU5029990A (en) | 1990-09-05 |
DE69000806T2 (de) | 1993-05-19 |
HK1002410A1 (en) | 1998-08-21 |
WO1990009375A1 (en) | 1990-08-23 |
AU626640B2 (en) | 1992-08-06 |
ATE85047T1 (de) | 1993-02-15 |
NZ232426A (en) | 1992-05-26 |
DK0382533T3 (da) | 1993-03-01 |
IE900438L (en) | 1990-08-08 |
JPH03504979A (ja) | 1991-10-31 |
CA2025663A1 (en) | 1990-08-09 |
US5130327A (en) | 1992-07-14 |
JP2994457B2 (ja) | 1999-12-27 |
KR0171579B1 (ko) | 1999-02-01 |
IE64235B1 (en) | 1995-07-26 |
ZA90936B (en) | 1990-12-28 |
EP0382533B1 (en) | 1993-01-27 |
KR910700233A (ko) | 1991-03-14 |
ES2054234T3 (es) | 1994-08-01 |
DE69000806D1 (de) | 1993-03-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20041102 |