ES2011653A6 - Metodo y aparato para amezclar rapidamente pequenos volumenes con el fin de mejorar reacciones biologicas. - Google Patents
Metodo y aparato para amezclar rapidamente pequenos volumenes con el fin de mejorar reacciones biologicas.Info
- Publication number
- ES2011653A6 ES2011653A6 ES8800747A ES8800747A ES2011653A6 ES 2011653 A6 ES2011653 A6 ES 2011653A6 ES 8800747 A ES8800747 A ES 8800747A ES 8800747 A ES8800747 A ES 8800747A ES 2011653 A6 ES2011653 A6 ES 2011653A6
- Authority
- ES
- Spain
- Prior art keywords
- microspheres
- cells
- small volumes
- rapid mixing
- biological reactions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/20—Mixing the contents of independent containers, e.g. test tubes
- B01F31/201—Holders therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/20—Mixing the contents of independent containers, e.g. test tubes
- B01F31/22—Mixing the contents of independent containers, e.g. test tubes with supporting means moving in a horizontal plane, e.g. describing an orbital path for moving the containers about an axis which intersects the receptacle axis at an angle
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Zoology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Sampling And Sample Adjustment (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
METODO Y APARATO PARA MEZCLAR RAPIDAMENTE PEQUEÑOS VOLUMENES CON EL FIN DE MEJORAR REACCIONES BIOLOGICAS. METODO Y APARATO PARA MEZCLAR RAPIDAMENTE PEQUEÑOS VOLUMENES CON EL FIN DE MEJORAR REACCIONES BIOLOGICAS. SE DESCRIBE UN METODO Y APARATO (10), PARA ACELERAR POR LO MENOS UNA REACCION BIOLOGICA DEFINITIVA Y PARA AUMENTAR LA PRECISION DE LAS DETERMINACIONES HECHAS A PARTIR DE LA MISMA. LA REACCION IMPLICA CELULAS BIOLOGICAS VIABLES ESCOGIDAS QUE SE PREPARAN EN UN PEQUEÑO VOLUMEN DE MUESTRA (12) Y SE MEZCLAN (16) RAPIDAMENTE CON MICROESFERAS (14) QUE TIENEN UNIDO A ELLAS UN ANTICUERPO ESPECIFICO POR LO MENOS PARA CELULAS ESPECIFICAS. LAS MICROESFERAS PUEDEN SER MAGNETICAS Y LAS CELULAS UNIDAS A ELLAS PUEDEN SER RETIRADAS MAGNETICAMENTE PARA ANALIZAR LAS RESTANTES POBLACIONES DE CELULAS DE LA SANGRE. LAS MICROESFERAS PUEDEN SER INTRODUCIDAS SECUENCIAL O SIMULTANEAMENTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2533787A | 1987-03-13 | 1987-03-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2011653A6 true ES2011653A6 (es) | 1990-02-01 |
Family
ID=21825432
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8800747A Expired - Lifetime ES2011653A6 (es) | 1987-03-13 | 1988-03-11 | Metodo y aparato para amezclar rapidamente pequenos volumenes con el fin de mejorar reacciones biologicas. |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0349591B1 (es) |
KR (1) | KR890700397A (es) |
CN (1) | CN1018673B (es) |
AT (1) | ATE108279T1 (es) |
AU (1) | AU610581B2 (es) |
CA (1) | CA1326435C (es) |
DE (1) | DE3850573T2 (es) |
ES (1) | ES2011653A6 (es) |
NO (1) | NO177809C (es) |
WO (1) | WO1988006918A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2644893B1 (fr) * | 1989-03-24 | 1991-07-12 | Sanofi Sa | Trousse et methode de dosage applicables a des cellules entieres |
FR2644894B1 (fr) * | 1989-03-24 | 1994-05-13 | Sanofi | Trousse et methode de dosage enzymatique applicables a des cellules entieres |
US5348859A (en) * | 1990-11-23 | 1994-09-20 | Coulter Corporation | Method and apparatus for obtaining an absolute white blood cell subset count and white blood cell multipart differential |
EP0558639A1 (en) * | 1990-11-23 | 1993-09-08 | Coulter Corporation | Method and apparatus for optically screening microscopic cells |
US5340719A (en) * | 1990-11-23 | 1994-08-23 | Corporation Coulter | Method and apparatus for optically screening microscopic cells |
CN101149371B (zh) * | 2007-10-26 | 2011-03-09 | 南方医科大学珠江医院 | 一种鼠免疫状态监测试剂及其制备方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3985649A (en) * | 1974-11-25 | 1976-10-12 | Eddelman Roy T | Ferromagnetic separation process and material |
US3970518A (en) * | 1975-07-01 | 1976-07-20 | General Electric Company | Magnetic separation of biological particles |
US4267234A (en) * | 1978-03-17 | 1981-05-12 | California Institute Of Technology | Polyglutaraldehyde synthesis and protein bonding substrates |
US4230685A (en) * | 1979-02-28 | 1980-10-28 | Northwestern University | Method of magnetic separation of cells and the like, and microspheres for use therein |
US4325910A (en) * | 1979-07-11 | 1982-04-20 | Technicraft, Inc. | Automated multiple-purpose chemical-analysis apparatus |
US4276260A (en) * | 1980-01-28 | 1981-06-30 | Coulter Electronics, Inc. | Fluid transfer mechanism |
EP0051496B1 (en) * | 1980-11-04 | 1986-02-05 | Olympus Optical Co., Ltd. | Analyzing method and apparatus for immunological agglutinating reaction |
WO1982003462A1 (en) * | 1981-03-27 | 1982-10-14 | Ltd Biospecia | Immunological analysis and a biochemical agent therefore |
US4511662A (en) * | 1982-06-18 | 1985-04-16 | Bio-Rad Laboratories, Inc. | Simultaneous assay for T and B lymphocyte populations and subpopulations |
US4550017A (en) * | 1982-10-15 | 1985-10-29 | Syntex (U.S.A.) Inc. | Fluorescence screening for blood typing |
US4485175A (en) * | 1983-01-03 | 1984-11-27 | Coulter Electronics, Inc. | Method for three-volume differential determination of lymphocyte, monocyte and granulocyte populations of leukocytes |
US4584277A (en) * | 1983-04-05 | 1986-04-22 | Syntex (U.S.A.) Inc. | Fluorescent multiparameter particle analysis |
US4672040A (en) * | 1983-05-12 | 1987-06-09 | Advanced Magnetics, Inc. | Magnetic particles for use in separations |
US4628026A (en) * | 1983-11-15 | 1986-12-09 | Dietlind Gardell | Method and apparatus for automated double fluorochromization analysis in lymphocytotoxicity testing |
JPS61225656A (ja) * | 1985-03-29 | 1986-10-07 | Toshiba Corp | 検体検査装置 |
-
1988
- 1988-03-10 CA CA000561092A patent/CA1326435C/en not_active Expired - Fee Related
- 1988-03-11 WO PCT/US1988/000969 patent/WO1988006918A1/en active IP Right Grant
- 1988-03-11 DE DE3850573T patent/DE3850573T2/de not_active Expired - Lifetime
- 1988-03-11 EP EP88903636A patent/EP0349591B1/en not_active Expired - Lifetime
- 1988-03-11 AU AU15700/88A patent/AU610581B2/en not_active Ceased
- 1988-03-11 ES ES8800747A patent/ES2011653A6/es not_active Expired - Lifetime
- 1988-03-11 AT AT88903636T patent/ATE108279T1/de active
- 1988-03-12 CN CN88101256A patent/CN1018673B/zh not_active Expired
- 1988-11-11 NO NO885042A patent/NO177809C/no unknown
- 1988-11-12 KR KR1019880701454A patent/KR890700397A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1988006918A1 (en) | 1988-09-22 |
ATE108279T1 (de) | 1994-07-15 |
NO885042D0 (no) | 1988-11-11 |
EP0349591A4 (en) | 1991-01-16 |
AU610581B2 (en) | 1991-05-23 |
CA1326435C (en) | 1994-01-25 |
DE3850573D1 (de) | 1994-08-11 |
NO885042L (no) | 1989-01-09 |
EP0349591A1 (en) | 1990-01-10 |
KR890700397A (ko) | 1989-04-24 |
DE3850573T2 (de) | 1994-10-27 |
AU1570088A (en) | 1988-10-10 |
EP0349591B1 (en) | 1994-07-06 |
CN88101256A (zh) | 1988-09-21 |
NO177809C (no) | 1995-11-22 |
NO177809B (no) | 1995-08-14 |
CN1018673B (zh) | 1992-10-14 |
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