ES2007064A6 - Un procedimiento para la obtencion de 4(3h)-oxo-5,6,8-tetrahidropirido (2,3-d)pirimidinas - Google Patents
Un procedimiento para la obtencion de 4(3h)-oxo-5,6,8-tetrahidropirido (2,3-d)pirimidinasInfo
- Publication number
- ES2007064A6 ES2007064A6 ES8701888A ES8701888A ES2007064A6 ES 2007064 A6 ES2007064 A6 ES 2007064A6 ES 8701888 A ES8701888 A ES 8701888A ES 8701888 A ES8701888 A ES 8701888A ES 2007064 A6 ES2007064 A6 ES 2007064A6
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- tetrahydropyrido
- oxo
- derivatives
- pyrimidine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
UN PROCEDIMIENTO PARA LA OBTENCION DE 4(3H)-OXO-5,6,7,8-TETRAHIDROPIRIDO (2,3-D) PIRIMIDINAS DE FORMULA (I) DONDE R1 ES H O R5CO-; R5 ES H O ALQUILO DE 1 A 6 ATOMOS DE CARBONO, Y LA CONFIGURACION ALREDEDOR DEL CARBONO QUIRAL ES L, SUS FORMAS TAUTOMERICAS Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. EL PROCEDIMIENTO CONSISTE EN HIDROLIZAR UN COMPUESTO DE FORMULA (II) DONDE R2 Y R3 SON GRUPOS PROTECTORES DEL CARBOXILO Y R4 ES UN GRUPO PROTECTOR DEL AMINO. ALTERNATIVAMENTE LOS COMPUESTOS DE FORMULA (I) O (II) PUEDEN OBTENERSE POR HIDROGENACION DE UN COMPUESTO DE FORMULA (III). LOS COMPUESTOS DE FORMULA (III) DONDE R1 ES R5CO- SE OBTIENEN POR ACILACION DE UN COMPUESTO DE FORMULA (III) DONDE R1 ES H. LOS COMPUESTOS DE FORMULA (I) ASI OBTENIDOS SON AGENTES ANTINEOPLASICOS ADECUADOS PARA COMBATIR EL CRECIMIENTO NEOPLASICO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87993586A | 1986-06-30 | 1986-06-30 | |
US07/040,330 US4831037A (en) | 1987-04-20 | 1987-04-20 | 4 (3H)-oxo-5,6,7,8-tetrahydropyrido-(2,3-d)pyrimidine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2007064A6 true ES2007064A6 (es) | 1989-06-01 |
Family
ID=26716970
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES198787305636T Expired - Lifetime ES2031894T3 (es) | 1986-06-30 | 1987-06-24 | Procedimiento para preparar derivados de 4(3h)-oxo-5,6,7,8-tetrahidropirido-(2,3-d)-pirimidina. |
ES8701888A Expired ES2007064A6 (es) | 1986-06-30 | 1987-06-29 | Un procedimiento para la obtencion de 4(3h)-oxo-5,6,8-tetrahidropirido (2,3-d)pirimidinas |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES198787305636T Expired - Lifetime ES2031894T3 (es) | 1986-06-30 | 1987-06-24 | Procedimiento para preparar derivados de 4(3h)-oxo-5,6,7,8-tetrahidropirido-(2,3-d)-pirimidina. |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0255228B1 (es) |
JP (1) | JPH07116189B2 (es) |
KR (1) | KR950001017B1 (es) |
CN (1) | CN1014895B (es) |
AU (1) | AU594163B2 (es) |
CA (1) | CA1301156C (es) |
DE (1) | DE3769721D1 (es) |
DK (1) | DK172896B1 (es) |
EG (1) | EG18301A (es) |
ES (2) | ES2031894T3 (es) |
GR (1) | GR870943B (es) |
HU (1) | HU198482B (es) |
IE (1) | IE60038B1 (es) |
IL (1) | IL82896A (es) |
NZ (1) | NZ220871A (es) |
PT (1) | PT85090B (es) |
SU (1) | SU1581222A3 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8625019D0 (en) * | 1986-10-18 | 1986-11-19 | Wellcome Found | Compounds |
JP2830008B2 (ja) * | 1988-04-01 | 1998-12-02 | 武田薬品工業株式会社 | 縮合ピリミジン誘導体 |
US5223620A (en) * | 1988-04-01 | 1993-06-29 | Takeda Chemical Industries, Ltd. | Pyrido[2,3-d]pyrimidine compounds useful as intermediates |
DK172753B1 (da) * | 1988-05-25 | 1999-06-28 | Lilly Co Eli | N-(5,6,7,8-tetrahydropyrido[2,3--d]pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater, deres anvendelse, farmaceutiske præparat |
US4871746A (en) * | 1988-05-31 | 1989-10-03 | The Trustees Of Princeton University | N-[N-(tetrahydropyrido[2,3-D]pyrimidinylmethyl)-aminomethylbenzoyl]glutamic acid derivatives as neoplastic growth inhibitors |
JP3015957B2 (ja) * | 1989-05-29 | 2000-03-06 | 武田薬品工業株式会社 | ピロロ[2,3―d]ピリミジン誘導体およびその製造法 |
US5159079A (en) * | 1991-12-20 | 1992-10-27 | Eli Lilly And Company | 2-piperidones as intermediates for 5-deaza-10-oxo- and 5-deaza-10-thio-5,6,7,8-tetrahydrofolic acids |
WO1993020075A1 (en) * | 1992-04-01 | 1993-10-14 | The University Of Sydney | 8-substituted-n5-deazapterins as antifolates |
CN1962658B (zh) * | 2005-11-10 | 2010-05-12 | 北京大学 | 一种四氢吡啶并[3,2-d]嘧啶类化合物及制备抗肿瘤药物的用途 |
WO2017079533A1 (en) | 2015-11-06 | 2017-05-11 | Avent, Inc. | Ostomy device, apparatus, and system |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3276808D1 (de) * | 1981-09-25 | 1987-08-27 | Southern Res Inst | Pyrido (2,3-d) pyrimidines |
ZA861235B (en) * | 1985-03-08 | 1986-10-29 | Univ Princeton | Pyrido(2,3-d)pyrimidine derivatives |
NZ219971A (en) * | 1986-06-06 | 1989-08-29 | Univ Princeton | Tetrahydropyrido (2,3-d pyrimidine derivatives and pharmaceutical compositions |
-
1987
- 1987-06-15 IE IE158687A patent/IE60038B1/en not_active IP Right Cessation
- 1987-06-16 CA CA000539751A patent/CA1301156C/en not_active Expired - Lifetime
- 1987-06-16 PT PT85090A patent/PT85090B/pt unknown
- 1987-06-16 AU AU74262/87A patent/AU594163B2/en not_active Ceased
- 1987-06-16 IL IL82896A patent/IL82896A/xx not_active IP Right Cessation
- 1987-06-16 GR GR870943A patent/GR870943B/el unknown
- 1987-06-17 DK DK198703073A patent/DK172896B1/da not_active IP Right Cessation
- 1987-06-23 JP JP62156387A patent/JPH07116189B2/ja not_active Expired - Lifetime
- 1987-06-24 EG EG367/87A patent/EG18301A/xx active
- 1987-06-24 ES ES198787305636T patent/ES2031894T3/es not_active Expired - Lifetime
- 1987-06-24 EP EP87305636A patent/EP0255228B1/en not_active Expired - Lifetime
- 1987-06-24 DE DE8787305636T patent/DE3769721D1/de not_active Expired - Lifetime
- 1987-06-25 KR KR1019870006506A patent/KR950001017B1/ko not_active IP Right Cessation
- 1987-06-26 SU SU874202827A patent/SU1581222A3/ru active
- 1987-06-29 NZ NZ220871A patent/NZ220871A/xx unknown
- 1987-06-29 ES ES8701888A patent/ES2007064A6/es not_active Expired
- 1987-06-29 HU HU872927A patent/HU198482B/hu not_active IP Right Cessation
- 1987-06-30 CN CN87104596A patent/CN1014895B/zh not_active Expired
Also Published As
Publication number | Publication date |
---|---|
GR870943B (en) | 1987-10-19 |
AU7426287A (en) | 1988-01-07 |
ES2031894T3 (es) | 1993-01-01 |
IE60038B1 (en) | 1994-05-18 |
KR950001017B1 (ko) | 1995-02-07 |
DK307387A (da) | 1987-12-31 |
DE3769721D1 (de) | 1991-06-06 |
HU198482B (en) | 1989-10-30 |
JPH07116189B2 (ja) | 1995-12-13 |
KR880000432A (ko) | 1988-03-25 |
CN1014895B (zh) | 1991-11-27 |
HUT44548A (en) | 1988-03-28 |
PT85090A (en) | 1987-07-01 |
PT85090B (pt) | 1990-03-08 |
DK172896B1 (da) | 1999-09-20 |
IL82896A0 (en) | 1987-12-20 |
EG18301A (en) | 1993-02-28 |
SU1581222A3 (ru) | 1990-07-23 |
NZ220871A (en) | 1989-07-27 |
EP0255228B1 (en) | 1991-05-02 |
EP0255228A1 (en) | 1988-02-03 |
CN87104596A (zh) | 1988-01-20 |
IE871586L (en) | 1987-12-30 |
CA1301156C (en) | 1992-05-19 |
IL82896A (en) | 1991-06-10 |
AU594163B2 (en) | 1990-03-01 |
DK307387D0 (da) | 1987-06-17 |
JPS6333379A (ja) | 1988-02-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
SA6 | Expiration date (snapshot 920101) |
Free format text: 2007-06-29 |
|
FD1A | Patent lapsed |
Effective date: 20000601 |