EP4251239A1 - Seringue préremplie (pfs) à embout sécable par rotation, garantissant à la fois l'inviolabilité et une ouverture fiable de la seringue - Google Patents
Seringue préremplie (pfs) à embout sécable par rotation, garantissant à la fois l'inviolabilité et une ouverture fiable de la seringueInfo
- Publication number
- EP4251239A1 EP4251239A1 EP21819116.1A EP21819116A EP4251239A1 EP 4251239 A1 EP4251239 A1 EP 4251239A1 EP 21819116 A EP21819116 A EP 21819116A EP 4251239 A1 EP4251239 A1 EP 4251239A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- cap
- syringe
- opening
- lug
- prefilled syringe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229940071643 prefilled syringe Drugs 0.000 title claims abstract description 46
- 230000008878 coupling Effects 0.000 claims description 15
- 238000010168 coupling process Methods 0.000 claims description 15
- 238000005859 coupling reaction Methods 0.000 claims description 15
- 230000001954 sterilising effect Effects 0.000 claims description 10
- 238000004659 sterilization and disinfection Methods 0.000 claims description 10
- 238000001802 infusion Methods 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- 230000000295 complement effect Effects 0.000 claims description 6
- 238000000465 moulding Methods 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 5
- 238000000926 separation method Methods 0.000 claims description 5
- 229920002994 synthetic fiber Polymers 0.000 claims description 3
- 230000035764 nutrition Effects 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 229940079593 drug Drugs 0.000 description 11
- 239000003814 drug Substances 0.000 description 11
- 239000012528 membrane Substances 0.000 description 7
- 239000004775 Tyvek Substances 0.000 description 4
- 229920000690 Tyvek Polymers 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 238000004806 packaging method and process Methods 0.000 description 4
- 239000004743 Polypropylene Substances 0.000 description 3
- 229920001971 elastomer Polymers 0.000 description 3
- 239000000806 elastomer Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920001155 polypropylene Polymers 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 210000003811 finger Anatomy 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 208000036647 Medication errors Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 235000016236 parenteral nutrition Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
- A61M5/288—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened by piercing without internal pressure increase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M5/3134—Syringe barrels characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
- A61M5/5086—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile for indicating if defective, used, tampered with or unsterile
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
- A61M2005/3118—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula
- A61M2005/312—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula comprising sealing means, e.g. severable caps, to be removed prior to injection by, e.g. tearing or twisting
Definitions
- the present invention relates to the field of packaging injectable drugs for parenteral administration in liquid form.
- the invention relates to pre-filled syringes (PFS) in which drugs are packaged and which require aseptic presentation, that is to say that the drug transfer interface to its place of administration (site of injection into a patient) must be sterile at the time of use.
- PFS pre-filled syringes
- the aim of the invention is to propose a tip that can be cut by rotation which guarantees both inviolability and reliable opening of the syringe.
- a pre-filled syringe is a syringe in which a drug in liquid form has been packaged and sterilized, before or after filling the syringe, with a view to its storage, which may be long term. This avoids a sampling step in a vial or in an ampoule at the time of use, for the purpose of immediate administration. This ready-to-use packaging avoids the preparation of the drug before its injection and the associated risks of error.
- the syringe is plugged at one end of the volume containing the drug by a seal mounted on the plunger of the syringe, and at the other end by a tip with a removable cap.
- Syringe 1 comprises a tubular body 2 of generally cylindrical shape with two open longitudinal ends 3, 4.
- a pusher 5 passes through the opening of the first end 3 of the tubular body 2.
- the end of the pusher 5 mounted in the tubular body 2 is surmounted by a seal 6.
- the pusher 5 and the seal 6 form a piston which is adapted to slide inside the tubular body 2 along the longitudinal axis X.
- the seal 6 is preferably provided with peripheral ribs directly in surface contact with deformation elastic against the inside of the body 2 to guarantee sealing.
- the pusher 5 allows a user to actuate the translational movement of the piston to release the packaged liquid, once the syringe is open.
- the tubular body 2 has, at the first end 3, a support flange 7 which projects outwards.
- a user's fingers come to rest under the collar 7, while another finger, generally the thumb, moves the pusher 5 and therefore the piston with its seal 6 by pressing on the end 50 of the pusher 5 opposite to that forming the piston.
- the second end 4 of the tubular body comprises a substantially transverse wall 8 open at its center and which is extended by a connection piece 9 of the Luer-lock or Luer or NR Fit or EN Fit type (or other specific connectors developed for applications allowing keying with other existing connectors).
- the tip 9 comprises a tubular inner part 10 and an outer part 11, coaxial with the inner part, which forms a neck and whose internal surface is threaded to allow the screwing of a tip of complementary shape for connection to a needle or an infusion line or a catheter or a device known by the Anglo-Saxon designation "luer activated device" (LAD) or any other connector on the market, once the syringe 1 has been opened.
- LAD luer activated device
- the tubular inner part 10 is of substantially frustoconical shape and opens, on the side of its largest diameter which coincides with the opening of the transverse wall 8, on the inside of the tubular body 2.
- a cap 12 is screwed into the threaded part 11 of the end piece 9, thereby closing the tubular inner part 10 of the end piece 9.
- the tubular body 2, the piston with its seal 6, the endpiece 9 and the stopper 12 delimit a sealed space serving as a reservoir for a liquid to be administered to a patient.
- the cap 12 is unscrewed which opens the syringe, then a needle or an infusion line or a catheter or an LAD device or any other connector on the market, is connected to the tip 9.
- a user can actuate the pusher 5 which administers the liquid contained in the reservoir to the patient.
- a pre-filled syringe limits preparation, confusion, and the risk of contamination at the time of injection, because all of the contact zones are sterile, insofar as the pre-filled syringe is in a sterile container (blister).
- a pre-filled syringe allows rapid and safe administration of the drug.
- Such a syringe generally comprises a scale allowing the desired dosage.
- the stopper can be made of polypropylene, directly screwed onto an endpiece of the one-piece Luer-Lock type or attached to the tubular body of the syringe.
- Stoppers/caps have therefore been developed which incorporate a tamper-evident function in order to guarantee the sterility of the parts of the syringe with a plastic or glass body, protected by a stopper/cap.
- Some of the stoppers/caps are configured so that the user has visual proof of tampering (“tamper evidence”) when the syringe has been undesirably opened prior to its intended end use.
- a potential drawback of this solution is that in certain circumstances, particularly in the event of an emergency, and even if this may occur rarely, there are still risks of poor opening if the cap is not operated with the correct rotation gesture by the user, which would prevent proper opening and therefore use of the syringe.
- the object of the invention is to meet this need at least in part.
- the invention relates, in one of its aspects, to a prefilled syringe comprising:
- tubular body extending along a longitudinal axis, comprising two open ends and containing a liquid to be administered to a patient
- a pusher one of its ends of which forms a piston mounted to slide in the tubular body, the pusher passing through the opening of one of the ends of the tubular body,
- connection endpiece comprising a tubular part communicating with the opening of the other end of the tubular body to achieve the passage of the fluid to be administered;
- a sealed shutter comprising a breakable zone connected to the free end of the tubular part of the end piece
- a cap comprising: a portion for fixing or coupling to the obturator, a portion forming an integral skirt or molded with the fixing or coupling portion, and which extends as far as the tubular body;
- the means comprising at least one snap-fastening lug and at least one opening or snap-fastening groove cooperating with snap-fastening with the latching lug, and being configured to allow rotation of at least part of the cap around its longitudinal axis to cause the breakable zone to break and thereby allow the physical separation of the cap from the obturator of the tip.
- connection end piece comprises an outer part, at the outer periphery of the tubular part, comprising the at least one lug projecting outwards;
- the skirt comprises the at least one through opening or groove cooperating by snap-fastening with the at least one lug.
- the lug(s) can be made inside the cap and an additional snap groove in the connection endpiece or the tubular body of the syringe.
- the skirt comprises an inner part comprising the at least one lug projecting inwards
- connection end piece comprises an outer part, at the outer periphery of the tubular part, the at least one emerging opening or groove cooperating by snap-fastening with the at least one lug.
- the cap comprises:
- the cap is made in a single one-piece piece comprising:
- the at least one opening or latching groove delimited by at least two zones, including a first zone in which the latching of the lug is carried out and at least a second zone in the continuity of the first zone, in which the lug is lodged during the rotation of the cap;
- the groove or through-opening for clearance being configured to allow the physical separation of the cap with the obturator.
- the at least one opening or latching groove comprises a single second zone allowing the rotation of the cap in a single direction of rotation.
- the at least one opening or latching groove comprises a constriction between the two zones, configured so that during rotation of the cap, the passage of the lug in the constriction generates an auditory click indicating to a user that the manipulation is carried out correctly.
- the auditory click guarantees the user that the obturator has indeed broken simultaneously with the rotation of the cap according to a given angle which corresponds to the stroke of the lug between the first zone and the second zone.
- the outer part of the end piece comprises two diametrically opposed latching lugs and the skirt comprising two through-openings or two diametrically opposite latching grooves, each cooperating with one of the two latching lugs.
- the tubular body, the end piece for connection with the shutter and the snap-fastening lug(s) are molded in a single, one-piece piece.
- the one-piece part is made of synthetic material and obtained by molding.
- the material may be a plastic material, advantageously polypropylene (PP).
- the cap has at least one open orifice intended for the passage of a sterilization fluid.
- the orifice(s) allow steam in particular to easily access the parts to be sterilized, covered in part or in whole by the cap.
- the steam coming from an autoclave passes through the orifice(s) of the cap and goes in particular towards the surfaces of the connection piece which are at the inside the volume bounded by the cap.
- the cap may include a closure membrane sealing off the orifice, as described and claimed in patent FR3084263B1.
- This closure membrane is advantageously made of Tyvek® and makes it possible to dispense with the use of a usual outer container (blister) which is equipped with a Tyvek®.
- This membrane allows the passage of water vapor but guarantees sterility during storage by preventing bacteria from passing through. In other words, the membrane avoids any recontamination inside the cap, once sterilization has been carried out.
- This membrane can make it possible to dispense with the currently existing packaging blisters.
- the pre-filled syringe can be packaged in an outer container (blister) fitted with a Tyvek® which guarantees that sterilization is maintained in the blister.
- the cap comprises an upper end wall from which protrudes the coupling portion in tubular form which is coupled with the shutter by complementarity of shapes.
- the sterilization orifice(s) is (are) preferably made opening out through this upper wall.
- the shutter and/or the tubular coupling portion has (have) complementary polygonal cross-sections, and preferably a generally frustoconical shape. These shapes allow optimal coupling and therefore an increased guarantee that the obturator, once broken, is actually removed by the part of the cap removed from the rest of the syringe.
- connection tip can be in the shape of a cone of the Luer or Luer-Lock or NR Fit or EN Fit type, or any other connection integrating a keying device with the other existing connections which makes it possible to avoid medication errors, to be connected in particular to a needle or to an infusion or infusion line or a catheter or an LAD device or other connector on the market, such as for example enteral/parenteral nutrition lines.
- the invention essentially consists of a cap attached and fixed by snapping/clipping onto the connection endpiece or the tubular body of a prefilled syringe, and inside which is fixed or coupled a breakable obturator whose rupture is guaranteed by rotation of at least part of the cap around the longitudinal axis of the syringe.
- Maintaining the whole cap or part of it by the snap-in lug(s) during rotation ensures that the breakable zone of the obturator is guaranteed to break with the correct spinning gesture.
- a breakage which a user can visually observe, of breakable bridges linking a part of the snap-on cap and another to be removed with the obturator, or an auditory click following the rotation correctly carried out by the user, indicates to him the aforementioned breakage .
- Figure 1 is a longitudinal sectional view of a prefilled syringe according to the state of the prior art in the configuration filled before use.
- Figure 2 is a longitudinal sectional view of part of a prefilled syringe according to a first embodiment in the closed configuration with the cap attached by snapping before use.
- Figure 3 is a perspective view of part of a pre-filled syringe according to Figure 2 prior to attachment of the snap-on cap.
- Figure 4A is a perspective view of part of a prefilled syringe according to Figures 2 and 3 illustrating the step of opening the syringe by rotating part of the cap.
- Figure 4B is a perspective view of part of a prefilled syringe according to Figures 2 and 3 illustrating the opening of the syringe once made.
- Figure 5 is a longitudinal sectional view of part of a prefilled syringe according to a second embodiment in the closed configuration with the cap attached by snap-fastening before use.
- Figure 6 is a perspective view of the syringe part according to Figure 5.
- Figure 7 is a perspective view of part of a prefilled syringe according to Figures 5 and 6 prior to attachment of the snap-on cap.
- Figure 8A is a perspective view of part of a prefilled syringe according to Figures 5 to 7 illustrating the step of opening the syringe by rotating the cap.
- Figure 8B is a perspective view of part of a prefilled syringe according to Figures 5 to 7 illustrating the step of opening the syringe by rotating the cap.
- Figure 8C is a perspective view of part of a prefilled syringe according to Figures 5 to 7 illustrating the opening of the syringe by rotation of the cap, once made.
- a prefilled syringe comprises a pusher, one of its ends of which forms a piston mounted to slide in the tubular body of the syringe, the pusher passing through the opening of one of the ends of the tubular body.
- FIGS 2 and 3 show a prefilled syringe 1 according to a first embodiment of the invention.
- Syringe 1 with longitudinal axis X comprises a tubular body 2, one open end 4 of which incorporates a Luer-Lock or Luer or NR Fit or EN Fit type connection endpiece 9 (or other specific connector developed for specific applications allowing keying with the other existing connectors).
- the end piece 9 comprises a tubular inner part 10 communicating with the opening of the transverse wall 8 of the tubular body 2 and an outer part 11 which is internally threaded.
- At least one snap-in lug 90 protrudes outward from the outer part 11 of the end piece 9.
- a sealed shutter 13 is connected by a breakable zone 130 to the free end of the tubular part 10 of the endpiece 9.
- the breakable zone 130 is produced by an annular thinning of the material along the line of connection between the free end of the tubular part 10 and the shutter 13. This makes it possible to be able to separate these two parts, the thinning zone having a low resistance to tearing or breaking, under the effect of a torsion.
- a cap 14 is mounted on the connection end piece 9.
- the cap 14 comprises an inner portion 15 which is coupled to the sealed shutter 13 by complements of shapes, for example frustoconical general shapes with hexagonal cross sections.
- the portion 15 of the cap 14 and the sealed shutter 13 have shapes which ensure a force fitting of the shutter 13 in said portion 15.
- the cap 14 also comprises a portion forming a skirt in two parts 16, 17, the lower part of which comprises at least one through opening 160, two diametrically opposed in the example illustrated, which are each snapped/clipped onto one of the lugs 90 of the tip 9. This snapping/clipping thus achieves the fixing of the cap 14 on the tip 9 of the syringe.
- the two parts 16, 17 of the cap 14 are interconnected, before opening of the syringe, by a plurality of breakable bridges 18, equally distributed angularly around the longitudinal axis X.
- the cap 14 further comprises at least one orifice 19, four evenly distributed angularly in the example shown, intended for the passage of a sterilization fluid. During moist heat sterilization, the steam can thus reach from the outside of the cap 14 towards the areas to be sterilized of the tip 9.
- the cap can comprise a closure membrane sealingly sealing all the orifices, as described and claimed in the patent FR3084263B1 which makes it possible to dispense with the use of a blister provided with a Tyvek®.
- an operator or an assembly machine brings the cap 14 into the longitudinal axis X of the end piece. 9 and brings these two elements together by translation, as shown in FIG. 3 according to arrow E, until the studs 90 snap into the complementary openings 160 provided for this purpose.
- the latching lugs 90 and the complementary through openings 160 are configured to allow rotation of at least a part of the cap 14 around the longitudinal axis X to cause the breakage of the breakable zone 130 and thereby allow the physical separation of the cap with the obturator, from the tip.
- any other unwanted manual effort exerted on the part of the cap does not allow the opening of the cap. Indeed, the lugs 90 snapped into the openings 90 mechanically prevent inadvertent removal of the cap 14, which would be tempted in particular by pulling on the latter.
- the lower part 16 of the cap 14 remains for its part always snapped onto the end piece 9.
- Figures 5 to 7 show a prefilled syringe 1 according to a second embodiment of the invention.
- cap 14 consists of a single piece.
- Each snap opening 160 is delimited by two zones 161, 162 interconnected by a constriction 163.
- a clearance groove 164 is provided in the continuity of zone 162 to the lower edge of the skirt of the cap.
- One of the two zones 161 is the one in which the latching of a lug 90 is made.
- the other of the two zones 162 is the one in which the lug 90 is housed during the rotation of the cap 14.
- an operator or an assembly machine brings the cap 14 into the longitudinal axis X of the end piece. 9 and brings these two elements together by translation, as shown in FIG. 7 along arrow E, until the lugs 90 snap into the zones 161 of the complementary openings 160 provided for this purpose (FIG. 8A).
- a user performs a manual rotation of the cap 14 (FIG. 8B, arrow R) until obtaining the abutment of the lugs 90 in the zone 162.
- the positioning of the lugs 90 visually indicates to the user that the rupture of the shutter 13 has indeed taken place
- the constriction 163 between the two zones 161, 162 is configured so that when the cap is rotated, the passage of the lug in the constriction 163 generates an auditory click indicating to a user that the manipulation has been carried out correctly.
- the tubular body 2, the connecting piece 9, the shutter 13 and the latching lugs 90 are made of synthetic material and in one piece by molding.
- the lugs are made on the periphery of the syringe connection endpiece and the through openings in which the lugs are individually snapped are made on the periphery of the cap, it is possible to consider the reverse, that is to say with lugs on the periphery of the cap and corresponding latching grooves on the periphery of the connecting piece.
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR2012159A FR3116442A1 (fr) | 2020-11-26 | 2020-11-26 | Seringue préremplie (PFS) à embout sécable par rotation, garantissant à la fois l’inviolabilité et une ouverture fiable de la seringue. |
PCT/EP2021/083144 WO2022112492A1 (fr) | 2020-11-26 | 2021-11-26 | Seringue préremplie (pfs) à embout sécable par rotation, garantissant à la fois l'inviolabilité et une ouverture fiable de la seringue. |
Publications (1)
Publication Number | Publication Date |
---|---|
EP4251239A1 true EP4251239A1 (fr) | 2023-10-04 |
Family
ID=75108423
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP21819116.1A Withdrawn EP4251239A1 (fr) | 2020-11-26 | 2021-11-26 | Seringue préremplie (pfs) à embout sécable par rotation, garantissant à la fois l'inviolabilité et une ouverture fiable de la seringue |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP4251239A1 (fr) |
JP (1) | JP2023550841A (fr) |
CA (1) | CA3198768A1 (fr) |
FR (1) | FR3116442A1 (fr) |
WO (1) | WO2022112492A1 (fr) |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040225258A1 (en) * | 2002-03-30 | 2004-11-11 | Ernest Balestracci | Tamper evident overcap for a container |
FR2896168B1 (fr) * | 2006-01-19 | 2008-10-17 | Aguettant Soc Par Actions Simp | Seringue hypodermique preremplie equipee d'un dispositif de bouchage |
US8752722B2 (en) * | 2008-09-29 | 2014-06-17 | Vifor (International) Ag | Cap assembly and production method |
WO2013047042A1 (fr) * | 2011-09-26 | 2013-04-04 | テルモ株式会社 | Seringue |
JPWO2018164250A1 (ja) * | 2017-03-10 | 2020-01-09 | テルモ株式会社 | シリンジ組立体及びプレフィルドシリンジ |
KR102631243B1 (ko) * | 2017-06-26 | 2024-01-29 | 타이세이카코 카부시키가이샤 | 시린지의 개봉 확인 구조 |
FR3084263B1 (fr) * | 2018-07-27 | 2020-07-10 | Laboratoire Aguettant | Systeme d’administration comportant un dispositif d’administration et un dispositif de protection pourvu d’une membrane de fermeture |
US11844937B2 (en) * | 2019-03-19 | 2023-12-19 | Credence Medsystems, Inc. | System and method for adjustable length needle |
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2020
- 2020-11-26 FR FR2012159A patent/FR3116442A1/fr active Pending
-
2021
- 2021-11-26 WO PCT/EP2021/083144 patent/WO2022112492A1/fr active Application Filing
- 2021-11-26 EP EP21819116.1A patent/EP4251239A1/fr not_active Withdrawn
- 2021-11-26 JP JP2023532333A patent/JP2023550841A/ja active Pending
- 2021-11-26 CA CA3198768A patent/CA3198768A1/fr active Pending
Also Published As
Publication number | Publication date |
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JP2023550841A (ja) | 2023-12-05 |
CA3198768A1 (fr) | 2022-06-02 |
WO2022112492A1 (fr) | 2022-06-02 |
FR3116442A1 (fr) | 2022-05-27 |
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