EP4117430A1 - Reinigungszusammensetzung - Google Patents
ReinigungszusammensetzungInfo
- Publication number
- EP4117430A1 EP4117430A1 EP21710325.8A EP21710325A EP4117430A1 EP 4117430 A1 EP4117430 A1 EP 4117430A1 EP 21710325 A EP21710325 A EP 21710325A EP 4117430 A1 EP4117430 A1 EP 4117430A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- composition
- mixtures
- composition according
- thymol
- unsaturated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 200
- 238000004140 cleaning Methods 0.000 title claims abstract description 38
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims abstract description 62
- 230000000845 anti-microbial effect Effects 0.000 claims abstract description 61
- 235000007586 terpenes Nutrition 0.000 claims abstract description 46
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 43
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims abstract description 42
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 40
- 239000005844 Thymol Substances 0.000 claims abstract description 31
- 150000003505 terpenes Chemical class 0.000 claims abstract description 31
- 229960000790 thymol Drugs 0.000 claims abstract description 31
- 150000002989 phenols Chemical class 0.000 claims abstract description 30
- -1 aliphatic terpene alcohols Chemical class 0.000 claims abstract description 27
- MOYAFQVGZZPNRA-UHFFFAOYSA-N Terpinolene Chemical compound CC(C)=C1CCC(C)=CC1 MOYAFQVGZZPNRA-UHFFFAOYSA-N 0.000 claims abstract description 26
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims abstract description 26
- 235000001510 limonene Nutrition 0.000 claims abstract description 22
- 229940087305 limonene Drugs 0.000 claims abstract description 22
- 239000004599 antimicrobial Substances 0.000 claims abstract description 21
- 229940041616 menthol Drugs 0.000 claims abstract description 21
- 239000003093 cationic surfactant Substances 0.000 claims abstract description 20
- YHQGMYUVUMAZJR-UHFFFAOYSA-N α-terpinene Chemical compound CC(C)C1=CC=C(C)CC1 YHQGMYUVUMAZJR-UHFFFAOYSA-N 0.000 claims abstract description 20
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000005770 Eugenol Substances 0.000 claims abstract description 13
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229960002217 eugenol Drugs 0.000 claims abstract description 13
- NGFPWHGISWUQOI-UHFFFAOYSA-N 2-sec-butylphenol Chemical compound CCC(C)C1=CC=CC=C1O NGFPWHGISWUQOI-UHFFFAOYSA-N 0.000 claims abstract description 11
- LCHYEKKJCUJAKN-UHFFFAOYSA-N 2-propylphenol Chemical compound CCCC1=CC=CC=C1O LCHYEKKJCUJAKN-UHFFFAOYSA-N 0.000 claims abstract description 10
- WSTYNZDAOAEEKG-UHFFFAOYSA-N Mayol Natural products CC1=C(O)C(=O)C=C2C(CCC3(C4CC(C(CC4(CCC33C)C)=O)C)C)(C)C3=CC=C21 WSTYNZDAOAEEKG-UHFFFAOYSA-N 0.000 claims abstract description 10
- HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 claims abstract description 10
- RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 claims abstract description 10
- 235000007746 carvacrol Nutrition 0.000 claims abstract description 10
- WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000001169 1-methyl-4-propan-2-ylcyclohexa-1,4-diene Substances 0.000 claims abstract description 9
- 229930007927 cymene Natural products 0.000 claims abstract description 9
- HFPZCAJZSCWRBC-UHFFFAOYSA-N p-cymene Chemical compound CC(C)C1=CC=C(C)C=C1 HFPZCAJZSCWRBC-UHFFFAOYSA-N 0.000 claims abstract description 9
- 150000007875 phellandrene derivatives Chemical class 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims description 27
- WUOACPNHFRMFPN-UHFFFAOYSA-N alpha-terpineol Chemical compound CC1=CCC(C(C)(C)O)CC1 WUOACPNHFRMFPN-UHFFFAOYSA-N 0.000 claims description 16
- 125000001931 aliphatic group Chemical group 0.000 claims description 13
- NOOLISFMXDJSKH-OPRDCNLKSA-N Isomenthol Chemical compound CC(C)[C@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-OPRDCNLKSA-N 0.000 claims description 10
- NOOLISFMXDJSKH-LPEHRKFASA-N Isomenthol Natural products CC(C)[C@@H]1CC[C@H](C)C[C@H]1O NOOLISFMXDJSKH-LPEHRKFASA-N 0.000 claims description 9
- 210000000214 mouth Anatomy 0.000 claims description 9
- 229930007461 neoisomenthol Natural products 0.000 claims description 8
- 230000000249 desinfective effect Effects 0.000 claims description 7
- 239000004094 surface-active agent Substances 0.000 claims description 6
- 239000002736 nonionic surfactant Substances 0.000 claims description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 4
- 239000003945 anionic surfactant Substances 0.000 claims description 4
- 125000001453 quaternary ammonium group Chemical group 0.000 claims description 3
- 125000000396 limonene group Chemical group 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 27
- 238000004659 sterilization and disinfection Methods 0.000 description 19
- 150000001875 compounds Chemical class 0.000 description 16
- 239000007787 solid Substances 0.000 description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 239000002904 solvent Substances 0.000 description 12
- 239000003921 oil Substances 0.000 description 10
- 235000019198 oils Nutrition 0.000 description 10
- 239000000344 soap Substances 0.000 description 10
- 229960000686 benzalkonium chloride Drugs 0.000 description 9
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 9
- 239000007788 liquid Substances 0.000 description 9
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 8
- 230000001580 bacterial effect Effects 0.000 description 7
- 239000002585 base Substances 0.000 description 7
- 230000002401 inhibitory effect Effects 0.000 description 7
- 239000002304 perfume Substances 0.000 description 7
- 238000005406 washing Methods 0.000 description 7
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- WOWHHFRSBJGXCM-UHFFFAOYSA-M cetyltrimethylammonium chloride Chemical group [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C WOWHHFRSBJGXCM-UHFFFAOYSA-M 0.000 description 6
- 229960004670 didecyldimethylammonium chloride Drugs 0.000 description 6
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000011236 particulate material Substances 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 238000010790 dilution Methods 0.000 description 5
- 239000012895 dilution Substances 0.000 description 5
- 230000000670 limiting effect Effects 0.000 description 5
- 230000002195 synergetic effect Effects 0.000 description 5
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 4
- GJYCVCVHRSWLNY-UHFFFAOYSA-N 2-butylphenol Chemical compound CCCCC1=CC=CC=C1O GJYCVCVHRSWLNY-UHFFFAOYSA-N 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 150000001298 alcohols Chemical class 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000010348 incorporation Methods 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 230000000813 microbial effect Effects 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- PLXBWHJQWKZRKG-UHFFFAOYSA-N Resazurin Chemical compound C1=CC(=O)C=C2OC3=CC(O)=CC=C3[N+]([O-])=C21 PLXBWHJQWKZRKG-UHFFFAOYSA-N 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- 239000003570 air Substances 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 230000003750 conditioning effect Effects 0.000 description 3
- 238000007865 diluting Methods 0.000 description 3
- 229960001760 dimethyl sulfoxide Drugs 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 239000008247 solid mixture Substances 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000000454 talc Substances 0.000 description 3
- 229910052623 talc Inorganic materials 0.000 description 3
- 235000012222 talc Nutrition 0.000 description 3
- 239000001974 tryptic soy broth Substances 0.000 description 3
- XMGQYMWWDOXHJM-JTQLQIEISA-N (+)-α-limonene Chemical compound CC(=C)[C@@H]1CCC(C)=CC1 XMGQYMWWDOXHJM-JTQLQIEISA-N 0.000 description 2
- NOOLISFMXDJSKH-BBBLOLIVSA-N (1s,2r,5r)-5-methyl-2-propan-2-ylcyclohexan-1-ol Chemical compound CC(C)[C@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-BBBLOLIVSA-N 0.000 description 2
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 229920003171 Poly (ethylene oxide) Chemical class 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 description 2
- 150000008052 alkyl sulfonates Chemical class 0.000 description 2
- 239000002199 base oil Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical group C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 description 2
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 150000002191 fatty alcohols Chemical class 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 150000002334 glycols Chemical class 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 230000002779 inactivation Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 229960004873 levomenthol Drugs 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000003641 microbiacidal effect Effects 0.000 description 2
- 229940124561 microbicide Drugs 0.000 description 2
- 239000006072 paste Substances 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000003380 propellant Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- 108010050327 trypticase-soy broth Proteins 0.000 description 2
- 239000001993 wax Substances 0.000 description 2
- 229940075966 (+)- menthol Drugs 0.000 description 1
- NOOLISFMXDJSKH-AEJSXWLSSA-N (+)-menthol Chemical compound CC(C)[C@H]1CC[C@H](C)C[C@@H]1O NOOLISFMXDJSKH-AEJSXWLSSA-N 0.000 description 1
- NOOLISFMXDJSKH-GUBZILKMSA-N (-)-neoisomenthol Chemical compound CC(C)[C@@H]1CC[C@H](C)C[C@@H]1O NOOLISFMXDJSKH-GUBZILKMSA-N 0.000 description 1
- OAAZUWWNSYWWHG-UHFFFAOYSA-N 1-phenoxypropan-1-ol Chemical compound CCC(O)OC1=CC=CC=C1 OAAZUWWNSYWWHG-UHFFFAOYSA-N 0.000 description 1
- WCGCDDRTGKUVKC-UHFFFAOYSA-N 2-methyl-5-propan-2-ylphenol;5-methyl-2-propan-2-ylphenol Chemical compound CC(C)C1=CC=C(C)C(O)=C1.CC(C)C1=CC=C(C)C=C1O WCGCDDRTGKUVKC-UHFFFAOYSA-N 0.000 description 1
- ZUTYZAFDFLLILI-UHFFFAOYSA-N 4-sec-Butylphenol Chemical compound CCC(C)C1=CC=C(O)C=C1 ZUTYZAFDFLLILI-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 1
- 229910021532 Calcite Inorganic materials 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
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- 241000195493 Cryptophyta Species 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 239000005909 Kieselgur Substances 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
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- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
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- IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
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- 239000000975 dye Substances 0.000 description 1
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- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
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- 150000002576 ketones Chemical class 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- ZADYMNAVLSWLEQ-UHFFFAOYSA-N magnesium;oxygen(2-);silicon(4+) Chemical compound [O-2].[O-2].[O-2].[Mg+2].[Si+4] ZADYMNAVLSWLEQ-UHFFFAOYSA-N 0.000 description 1
- 239000004579 marble Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000002855 microbicide agent Substances 0.000 description 1
- 238000009629 microbiological culture Methods 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920001296 polysiloxane Chemical class 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 231100000121 skin sensitizing Toxicity 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000011885 synergistic combination Substances 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- QCRXMFTZTSTGJM-UHFFFAOYSA-N triacetyl 2-hydroxypropane-1,2,3-tricarboxylate Chemical compound CC(=O)OC(=O)CC(O)(C(=O)OC(C)=O)CC(=O)OC(C)=O QCRXMFTZTSTGJM-UHFFFAOYSA-N 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N27/00—Biocides, pest repellants or attractants, or plant growth regulators containing hydrocarbons
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/06—Oxygen or sulfur directly attached to a cycloaliphatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/38—Cationic compounds
- C11D1/62—Quaternary ammonium compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/18—Hydrocarbons
- C11D3/188—Terpenes
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2006—Monohydric alcohols
- C11D3/2034—Monohydric alcohols aromatic
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2006—Monohydric alcohols
- C11D3/2037—Terpenes
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
- C11D2111/10—Objects to be cleaned
- C11D2111/14—Hard surfaces
Definitions
- the present invention relates to an antimicrobial composition and a method for disinfection involving the antimicrobial composition. It particularly relates to an antimicrobial composition for personal cleaning, oral care or hard surface cleaning applications.
- Sanitising and disinfecting soap or cleaning compositions are of great benefit to individuals, since proper use generally may reduce the number of germs and pathogens the individual is exposed to. Thus, such compositions may for instance play an important role in reducing the occurrence and spread of infectious diseases.
- Sanitising and disinfecting soap compositions comprising chlorine-based antimicrobial agents such as triclosan are known. Such compositions require a rather long contact time to provide efficacious antimicrobial action.
- users, in particular children do not spend a long time on cleaning and as a result cleaning with such compositions does not provide adequate prevention from surface or topical infection or adequate protection against diseases. The user, in spite of cleaning his hands, is generally likely to end up with relatively inadequate bacterial removal from his skin.
- the antimicrobial actives in the compositions are in contact with the substrate for less than a few minutes, after which the surface is either wiped off or rinsed with water.
- These short time scales of cleaning action are ineffective in providing the desired benefit since most known antimicrobials commonly used in such products take many minutes to hours to provide the desired kill of microbes. Therefore, there is a need for providing a composition that -upon application- provides relatively more efficacious antimicrobial action during a relatively short cleaning period, preferably about 30 seconds or less, more preferably 15 seconds or less.
- a well-established class of antimicrobially active compounds are phenolic compounds [P. A.
- surfactants although anti-microbially active may exhibit undesirable side effects, such as corrosion, malodour and skin irritation or skin-sensitising effects when applied on human or animal skin.
- a particular problem of thymol is that it has a potent odour which is odour typically held to be too intense by consumers at concentrations at which thymol is efficacious as a disinfectant.
- a lower concentration of odoriferous compounds including thymol or the availability of antimicrobial compounds that are less or not odoriferous allows greater flexibility to the manufacturer in providing alternative scents to his composition at lower doses.
- antimicrobial compositions and methods that require lower concentrations of thymol and/or have a more acceptable sensory profile.
- an object of the present invention to provide an antimicrobial composition in which the olfactory contribution of the antimicrobially active compounds is reduced or in which the active compound contributes to providing a consumer-acceptable or even consumer-appreciated scent.
- compositions have been found that provide efficacious antimicrobial action at lower concentrations when compared to cationic surfactant alone.
- complete microbial inactivation could be effected with compositions as defined herein after a contact time of less than 5 minutes, preferably 2 minutes, more preferably less than 1 minute and most preferably less than 30 seconds.
- the composition contributes to a reduction in olfactory disadvantages associated with the presence of large amounts of thymol.
- an antimicrobial composition comprising: a) a cationic surfactant, b) one or more substituted phenols selected from the group comprising thymol, sec- butylphenol, carvacrol, eugenol, propylphenol and mixtures thereof, c) one or more aliphatic terpene alcohols selected from menthol, isomenthol, neomenthol, neoisomenthol and mixtures thereof; and d) one or more unsaturated terpenes selected from the group comprising limonene, alpha-terpinene, terpinolene, cymene, phellandrene or mixtures thereof, preferably limonene, wherein the substituted phenol, the aliphatic terpene alcohol and the unsaturated terpene are present in the ratio 1:0.5:0.5.
- any feature of one aspect of the present invention may be utilised in any other aspect of the invention.
- the word “comprising” is intended to mean “including” but not necessarily “consisting of” or “composed of”.
- the term “comprising” is meant not to be limiting to any subsequently stated elements, but rather to optionally also encompass non-specified elements of major or minor functional importance. In other words, the listed steps or options need not be exhaustive.
- the words “including” or “having” are used, these terms are meant to be equivalent to “comprising” as defined above. It is noted that the examples given in the description below are intended to clarify the invention and are not intended to limit the invention to those examples per se.
- disinfection refers to reduction of the number of viable microorganisms in a given medium or on a given surface by physical or chemical means. Typically, disinfection involves the destruction or inactivation of said microorganisms. Both animate and inanimate media and surfaces are contemplated.
- microbicide refers to a compound capable of killing, inhibiting the growth of or controlling the growth of microorganisms at a locus; microbicides include bactericides, fungicides and algaecides.
- microorganism includes, for example, fungi (such as yeast and mould), bacteria and algae.
- compositions of the present invention are preferred for non-therapeutic use, and more particularly preferred for use in cleaning surfaces, preferably wherein the surface is a hard surface and more preferably for use in cleaning applications such as cleaning kitchen, bathroom and floor surfaces.
- the composition comprises a cationic surfactant.
- the cationic surfactant is a quaternary ammonium surfactant, preferably the quaternary ammonium surfactant is selected from cetyl trimethyl ammonium chloride (CTAC), didecyl dimethyl ammonium chloride (DDAC), alkyl dimethyl benzyl ammonium chloride (ADBAC) and mixtures thereof. More preferably the cationic surfactant is alkyl dimethyl benzylammonium chloride e.g. benzalkonium chloride (BKC).
- CTAC cetyl trimethyl ammonium chloride
- DDAC didecyl dimethyl ammonium chloride
- ADBAC alkyl dimethyl benzyl ammonium chloride
- BKC benzalkonium chloride
- the composition comprises 0.01 to 20 wt%, more preferably 0.05 to 15 wt%, most preferably 0.1 to 10 wt% cationic surfactant.
- the composition comprises one or more substituted phenols selected from thymol, sec- butylphenol, carvacrol, eugenol, propylphenol and mixtures thereof.
- the amount of the one or more substituted phenols selected from thymol, sec-butylphenol, carvacrol, eugenol, propylphenol and mixtures thereof is preferably in the range of 0.01 to 5 wt%, more preferably 0.02 to 2.5 wt%, even more preferably 0.05 to 2 wt%, further more preferably 0.075 to 1.5 %, yet more preferably 0.1 to 1.0 % and most preferably 0.5 to 1.0%.
- the substituted phenol is butyl phenol or thymol, more preferably thymol.
- the structural isomer of thymol (carvacrol) may also preferably be used.
- the composition preferably comprises 0.01 to 5 wt%, more preferably 0.02 to 2.5 wt%, even more preferably 0.05 to 2 wt%, further more preferably 0.075 to 1.5 wt%, yet more preferably 0.1 to 1.0 wt% and most preferably 0.5 to 1.0 wt% of thymol.
- the composition comprises one or more aliphatic terpene alcohols.
- the terpene alcohol is preferably present in the composition in the range 0.01 to 5 wt%, more preferably 0.02 to 2.5 wt%, even more preferably 0.025 to 1.0 wt%, yet more preferably 0.05 to 0.75 wt% and even more preferably 0.1 to 0.5 wt% of terpene alcohol.
- the aliphatic terpene alcohol is preferably selected from menthol, isomenthol, neomenthol, neoisomenthol and mixtures thereof.
- the terpene alcohol may be the (+) or (-) stereoisomers, for example (+)-menthol, (+)-isomenthol, (+)-neomenthol, (+)-neoisomenthol, (-)-menthol, (-)-isomenthol, (-)-neomenthol, (-)-neoisomenthol.
- aliphatic terpene preferably means that the terpene does not contain unsaturated (carbon-carbon) bonds.
- the aliphatic terpene is a saturated aliphatic terpene.
- the composition of the present invention also comprises one or more unsaturated terpenes.
- the amount of one or more unsaturated terpenes preferably is in the range 0.01 to 5 wt%, more preferably 0.02 to 2.5 wt%, even more preferably 0.025 to 1.0 wt%, yet more preferably 0.05 to 0.75 wt% and even more preferably 0.1 to 0.5 wt%.
- the one or more unsaturated terpenes comprises limonene, alpha-terpinene, terpinolene, cymene, phellandrene or mixtures thereof, preferably limonene.
- unsaturated terpene preferably means that the terpene contains at least one unsaturated (carbon-carbon) bond and does not contain a hydroxyl moiety.
- the unsaturated terpene is limonene.
- the structure of limonene is given below:
- the substituted phenol, the aliphatic terpene alcohol and the unsaturated terpene are present in the ratio 1:0.5:0.5.
- the substituted phenol is present in 1 part, then the aliphatic terpene alcohol is present in 0.5 part; and the unsaturated terpene is present in 0.5 parts.
- a substituted phenol e. g. thymol or eugenol or butyl phenol
- an aliphatic terpene alcohol e. g. menthol
- an unsaturated terpene e. g. limonene or terpinolene or alpha-terpinene
- the composition comprises thymol, menthol, and limonene.
- the composition comprises 0.05 to 2 wt% thymol, 0.025 to 1 wt% menthol, 0.25 to 2 wt% limonene.
- the composition preferably comprises 0.1 to 10 wt%, more preferably 1 to 9 wt%, even more preferably 2 to 8 wt% and most preferably 3 to 7 wt%, of the substituted phenols, aliphatic terpene alcohols, unsaturated terpenes and mixtures thereof.
- the minimum preferred concentrations of the one or more substituted phenol, aliphatic terpene alcohol and unsaturated terpene can be higher.
- the lather produced is typically a 50 wt% dilution of the original composition.
- soap bars or soap liquids are typically diluted until about 8 wt% soap in water, corresponding to an approximately tenfold dilution of the product.
- compositions according to the invention intended for dilution upon use preferably comprise 0.05 to 4.5 wt%, more preferably 0.1 to 4 wt% even more preferably 0.2 to 3 wt% still more preferably 0.4 to 1 wt% and still more preferably 0.5 to 1 wt% of the components.
- concentration of the one or more components in the antimicrobial composition is preferably such that, when the composition is diluted or dissolved with a suitable medium during use, the concentration in the diluted or dissolved mixture is still sufficient to be anti-microbially efficacious.
- the antimicrobial composition according to the invention preferably comprise: b) 0.05 to 2 wt% thymol, c) 0.025 to 1 wt%, one or more aliphatic terpene alcohols; and d) 0.025 to 1 wt% one or more unsaturated terpenes.
- the composition comprises 0.1 to 80 wt %, more preferably 0.5 to 50 wt%, even more preferably 1 to 20 wt % cationic surfactant.
- the composition preferably comprises one or more anionic surfactants, preferably less than 5 wt%, more preferably less than 2.5 wt%, most preferably less than 1 wt%, based on the weight of the total composition, of one or more anionic surfactants.
- the anionic surfactant is selected from alkylbenzene sulfonates, alkyl sulfonates, alkyl sulfonates, alkyl sulfates, salts of fluorinated fatty acids, silicones, fatty alcohol sulfates, polyoxyethylene fatty alcohol ether sulfates, a-olefin sulfonate, polyoxyethylene fatty alcohol phosphates ether and alkyl alcohol.
- the composition comprises less than 2 wt%, preferably less than 1 wt% of the composition of non-ionic surfactants, most preferably the composition is free of non-ionic surfactants.
- the non-ionic surfactant is selected from aminopolyglucoside (APG), fatty alcohol ethoxylate, alkyl phenol ethoxylate and fatty acid alkoxylate and tergitol (ethoxylated alcohol).
- the antimicrobial composition preferably comprises a carrier.
- the carrier is selected from water, oil, solvent, inorganic particulate material, starch, air and mixtures thereof.
- the carrier of the composition according to the first aspect of the invention comprises water, ethanol, propanol, isopropanol, ethylene glycol, propylene glycol, diethylene glycol, or a mixture thereof.
- the carrier is preferably from 0.1 to 99% based on the weight of the total composition.
- the antimicrobial composition may be in form of a solid, liquid, gel, paste or soft solid and the carrier may be selected by a person skilled in the art depending on the format of the antimicrobial composition.
- oils examples include mineral oils, oils of biological origin (e.g. vegetable oils), and petroleum-derived oils and waxes.
- the oils of biological origin are preferably triglyceride-based.
- the carrier oil is not a perfume oil.
- the carrier oil preferably does not substantially contribute to the odour of the composition, more preferably it does not contribute to that odour.
- solvents include alcohols, ethers and acetone.
- the starch may be natural starch obtained from food grains or may be a modified starch.
- suitable solvents include, for example, water; glycols, including ethylene glycol, propylene glycol, diethylene glycol, dipropylene glycol, polyethylene glycol, and polypropylene glycol; glycol ethers; alcohols, such as methanol, ethanol, propanol, phenethyl alcohol and phenoxypropanol; ketones, including acetone and methyl ethyl ketone; esters, including ethyl acetate, butyl acetate, triacetyl citrate, and glycerol triacetate; carbonates, including propylene carbonate and dimethyl carbonate; and mixtures thereof.
- glycols including ethylene glycol, propylene glycol, diethylene glycol, dipropylene glycol, polyethylene glycol, and polypropylene glycol
- glycol ethers such as methanol, ethanol, propanol, phenethyl alcohol and phenoxypropanol
- ketones including acetone and
- the solvent is selected from water, glycols, glycol ethers, esters and mixtures thereof.
- suitable solid carriers include, for example, cyclodextrin, silicas, diatomaceous earth, waxes, cellulosic materials, alkali and alkaline earth (e.g., sodium, magnesium, potassium) metal salts (e.g., chloride, nitrate, bromide, sulfate) and charcoal.
- the antimicrobial composition may be formulated with either an aqueous base or a oil/solvent base.
- Compositions with an aqueous base (water being the carrier), may also for instance be products in gel format.
- Compositions with a purely oil/solvent base may for instance be products in anhydrous stick form or propellant- containing products.
- the antimicrobial composition may for instance, preferably be an antimicrobial anhydrous stick personal care composition on a purely oil/solvent base wherein the composition has a water content of less than 0.01 wt%, and wherein the composition is preferably free of water.
- the antimicrobial composition may for instance, preferably be an antimicrobial propellant-drivable personal care composition, also comprising a propellant. Air can also be used as propellant, for instance in the form of compressed or liquefied air.
- the most preferred product format has an emulsion base (water and/or oil being the carrier) or is capable of forming an emulsion upon dilution, e.g.
- soap products in liquid, solid, lotion or semi-solid form for hand washing, face washing, body washing, or shaving applications; toothpaste/ dentifrices for oral care applications or products for hard surface cleaning in bar or liquid form.
- the product comprises an emulsion base, it preferably also comprises one or more surfactants as described herein.
- the antimicrobial composition may be in form of a solid, a liquid, a gel or a paste.
- a person skilled in the art can prepare compositions in various formats by choosing one or more carrier materials and/or surfactant.
- the antimicrobial compositions of the present invention are useful for cleaning and care, in particular for skin cleaning and skin care. It is envisaged that the antimicrobial composition can be used as either a leave-on product or a wash-off product, preferably a wash-off product.
- the antimicrobial composition of the present invention can also be used for cleaning and care of hard surfaces such as glass, metal, plastic and the like.
- a particularly preferred carrier is water.
- water When water is present, it is preferably present in at least 1 wt%, more preferably at least 2 wt%, furthermore preferably at least 5 wt%.
- the composition comprises water from 0.1 to 99%, more preferably from 0.5 to 95%, even more preferably from 1 to 90%, further more preferably from 3 to 85%, still more preferably from 5 to 80%, yet more preferably from 10 to 75%, still further more preferably from 20 to 65% and yet further more preferably from 30 to 50% based on the weight of the total composition.
- water When water is the carrier, both liquid and solid compositions are possible. Different amounts of water may be preferred depending on the product format.
- a preferred liquid antimicrobial composition comprises: a) a cationic surfactant; b) one or more substituted phenols selected from the group comprising thymol, sec- butylphenol, carvacrol, eugenol, propylphenol and mixtures thereof, c) one or more aliphatic terpene alcohol selected from menthol, isomenthol, neomenthol, neoisomenthol and mixtures thereof, d) one or more unsaturated terpenes selected from the group comprising limonene, alpha-terpene, terpinolene, cymene, phellandrene or mixtures thereof; and e) water, wherein the substituted phenol, the aliphatic terpene alcohol and the unsaturated terpene are present in the ratio from 1:0.5:0.5.
- the solid antimicrobial composition is preferably in form of a shaped solid, more preferably a bar.
- the solid antimicrobial composition is particularly useful for skin cleaning, in particular for hand washing or a face washing.
- Such a bar-shaped solid antimicrobial composition may be a soap bar.
- Soap bar compositions are well-known and may be similar to the following non-limiting example composition, comprising 75.6 wt% of anhydrous sodium soap, 1.0 wt% of glycerine, 0.5 wt% of sodium carbonate, 0.2 wt% of EHDP (ethane- 1 -hydroxy- 1,1- disphosphonate) acid, 0.04 wt% of EDTA (ethylenediaminetetraacetic acid) tetrasodium salt, 8.5 wt % of hydrated magnesium silicate (Talc), 0.7 wt% of sodium chloride, 0.05 wt% of dyes, 0.75 wt% perfume and water up to 100 wt
- inorganic particulate material is also a suitable carrier.
- the antimicrobial composition is in a solid form.
- the inorganic particulate material is talc.
- the solid antimicrobial composition is particularly useful as a talcum powder for application on face or body.
- a solvent different from water is a preferred carrier.
- Alcohol is a preferred solvent.
- Short chain alcohols in particular ethanol, propanol, and isopropanol, are particularly preferred as carrier for an antimicrobial wipe or an antimicrobial hand sanitiser composition.
- Solvents such as ethanol and isopropanol typically demonstrate antimicrobial efficacy themselves. However, they are also volatile and may readily evaporate during application of the composition. Thus, their levels on the surface that is treated might even reduce until below the minimum level required for antimicrobial action, before the minimum period needed for disinfection has passed. In contrast, the thymol is much less volatile and may therefore yield prolonged antimicrobial action after applying them to the skin.
- composition may further comprise various additional ingredients known to a person skilled in the art.
- additional ingredients include, but are not limited to: perfumes, pigments, preservative, emollients, sunscreens, emulsifiers, gelling agents, thickening agents, humectants (e.g. glycerine, sorbitol), sequestrants (e.g. EDTA) or polymers (e.g. cellulose derivatives for structuring such as methyl cellulose).
- the substituted phenols according to the invention may contribute to the olfactory properties of the composition. Although some of these compounds might be applied for instance in perfume compositions, the present invention is directed towards antimicrobial compositions. Therefore, the composition is preferably not a perfume composition, although other perfume components can be present.
- a perfume composition is defined as a composition comprising a plurality of olfactory components, wherein the composition is solely intended to provide a harmonious scent.
- the antimicrobial action of two or more active compounds is considered additive if the combined action merely results from the addition of the effects the individual components would have in isolation.
- the antimicrobial action of two or more active compounds is considered to be synergistic if the combined effect of the two or more compounds is stronger than expected based on the assumption of additivity.
- the antimicrobial action of the one compound may be enhanced by the action of the other compound and vice versa.
- Such enhancement may for instance originate from cooperative interplay between the mechanisms of antimicrobial action at the molecular level.
- Such enhanced antimicrobial action may manifest itself for instance by the fact that lower concentrations of active compounds are required to obtain complete microbial kill, or alternatively, that the same extent of microbial kill is arrived at in a shorter time.
- an antimicrobial composition comprising two or more active compounds is capable of synergistic antimicrobial action may for instance be determined following the procedures and using the criteria as outlined in the examples hereafter.
- evidence of synergistic antimicrobial action may be provided at concentrations below the minimum biocidal concentrations of each of the components when taken individually.
- synergistic action can still occur when the concentration of one or more of the active compounds is raised above its minimum biocidal concentration (when taken individually).
- an antimicrobial composition comprising: a) 0.01 to 20 wt% cationic surfactant, wherein the cationic surfactant is benzalkylammonium chloride, b) 0.05 to 2 wt% substituted phenols selected from thymol, sec-butylphenol, carvacrol, eugenol, propylphenol and mixtures thereof, c) 0.025 to 1 wt% aliphatic terpene alcohols selected from menthol, isomenthol, neomenthol, neoisomenthol and mixtures thereof; and d) 0.025 to 1 wt% unsaturated terpenes selected from limonene, alpha-terpinene, terpinolene, cymene, phellandrene and mixtures thereof.
- a method of disinfecting a surface comprising the steps of: i. applying a composition comprising: a) a cationic surfactant, b) one or more substituted phenols selected from thymol, sec-butylphenol, carvacrol, eugenol, propylphenol and mixtures thereof, c) one or more aliphatic terpene alcohols selected from menthol, isomenthol, neomenthol, neoisomenthol and mixtures thereof; and d) one or more unsaturated terpenes selected from limonene, alpha-terpinene, terpinolene, cymene, phellandrene and mixtures thereof, to a surface, and ii. removing the composition from the surface, wherein the substituted phenol, the aliphatic terpene alcohol and the unsaturated terpene are present in the ratio 1:0.5:0.5.
- the surface is a hard surface, more preferably wherein the hard surface is a kitchen, bathroom or floor surface.
- hard surfaces are surfaces that require frequent cleaning and preferably also sanitisation and/or disinfection.
- Such surfaces may be found in many household or industrial environments, and may include kitchen and bathroom surfaces, tabletops, floors, walls, windows, utensils, cutlery, and crockery.
- Such surfaces may be made from many different materials, including for instance plastics, wood, metal, ceramics, glass, concrete, marble, and painted surfaces.
- the composition may be applied to the surface by any suitable means known to the skilled person. For instance, a suitable means may be pouring, dropping, spraying or wiping in case of liquid compositions.
- the method includes diluting or dissolving the composition with a suitable solvent, preferably water, before or whilst applying the composition to the surface.
- a suitable solvent preferably water
- Such dissolving is particularly preferred when the composition is a solid.
- solid compositions may also be directly spread, rubbed, or sprayed, e.g. in the form of a powder.
- a suitable medium for rinsing the surface is water.
- Another suitable medium for rinsing the surface is a mixture of water and alcohol.
- the surface is then rinsed, preferably with sufficient amounts of water after a pre-determined period of time to remove any visible or sensory residue of the composition.
- an alcohol wipe or a water/alcohol impregnated wipe may be used to wipe the surface to be visibly free of the anti-microbial composition.
- the step of removing the composition is preferably started less than 5 minutes, more preferably less than 2 minutes, even more preferably less than 1 minute, still more preferably less than 30 seconds and yet more preferably less than 20 seconds after commencement of the step of applying the composition on the surface, because of the surprisingly fast antimicrobial action of the compositions according to the present invention.
- the step of removing the composition from the surface is started after at least 5 seconds, preferably at least 10 seconds, more preferably at least 20 seconds after commencement of the step of applying the composition on the surface, in order to effect optimal antimicrobial action. Therefore, it is particularly preferred that the step of removing the composition from the surface (i.e. step ii) is started between 5 minutes and 5 seconds, more preferably between 1 minute and 10 seconds, even more preferably between 30 and 20 seconds and still more preferably between 20 and 15 seconds after commencement of the step of applying the composition on the surface (i.e. step i).
- the disinfecting action of the method (as may be expressed in terms of the disinfection time T D ) is preferably determined according to the protocol of the examples as described hereinafter.
- This test relates to a standardised test environment in which the microbial culture is kept in suspension.
- a similarly suitable test is the standard suspension method described in European Standard EN 1276, with the proviso that the disinfection time is adapted to suit the above criteria as will be clear to a person skilled in the art.
- one of the test methods as described in WO 2010/046238 may for instance be applied to establish the disinfecting action.
- the invention preferably relates to a method according to the present invention, wherein the surface disinfection time T2 of said method is less than 60 seconds, preferably less than 15 seconds, wherein T2 is defined as the time starting from the moment of applying the composition to the surface to be disinfected after which the number of microbes per unit area is reduced by a factor of 10000 (i.e. a 4 log reduction), wherein the initial number of microbes preferably exceeds 103, more preferably 105, and even more preferably 107 microbes per square centimeter.
- Such tests may for instance be performed as described in WO 2010/046238, or as described in European Standards EN 13697:2001 and EN 1500:1997.
- compositions as defined herein for cleaning a hard surface preferably wherein the hard surface is a kitchen, bathroom or floor surface.
- composition and surface on which the composition is used is as defined above.
- non-therapeutic use of a composition as defined herein cleaning skin and/or oral cavity there is provided a non-therapeutic use of a composition according to the invention for improved hygiene of surfaces of the human body.
- Such surfaces include for example the skin, hands and the oral cavity.
- non-therapeutic use means that the subject, whose skin, hand or oral cavity is contact with the composition defined herein, is not in need of medical treatment, e.g. the skin, hands and oral cavity are not infected in a way that requires medical attention.
- the skin, hands and oral cavity of the subject are contacted with the composition as defined herein in order to maintain a normal hygiene level associated with day-to-day cleanliness.
- the invention relates to use of a composition according to the invention for improved hand hygiene. According to another preferred embodiment, the invention relates to use of a composition according to the invention for improved oral hygiene.
- the invention relates to compositions according to the invention for use as or incorporation in home care products and personal care products. More preferably, this embodiment of the invention relates to a composition according to the invention which is a home care product or a personal care product.
- a "home care product” is a product for the treatment, cleaning, caring or conditioning of the home or any of its contents. The foregoing includes, but is not limited to, compositions, products, or combinations thereof relating to or having use or application in the treatment, cleaning, cleansing, caring or conditioning of surfaces, furniture and atmosphere of the home and household contents, such as clothes, fabrics and/or cloth fibres and the manufacture of all of the foregoing products.
- a "personal care product” is a product for cleaning of the person.
- the foregoing includes, but is not limited to, chemicals, compositions, products, or combinations thereof relating to or having use or application in the treatment, cleaning, cleaning or conditioning of the person (including in particular the skin, hair and oral cavity), and the manufacture of all the foregoing.
- Home care products and personal care products are for example products marketed under mass market brands, non-limiting examples being soap bars, deodorants, shampoos, and home surface sanitisers/disinfectants.
- compositions according to the invention for use as or incorporation in industrial and/or institutional products. More preferably, this embodiment of the invention relates to a composition according to the invention which is an industrial and/or an institutional product.
- Industrial and institutional products are for example products being marketed under professional brands, with non limiting examples being products for industrial, institutional, janitorial, and medical cleaning, cleaning-in-place, food services, veterinary, and agricultural products.
- Industrial and/or institutional products also include products for cleaning of the person (such as hand sanitisers) for medical offices, hospitals and/or other institutions.
- the invention also relates to a method or use according to the invention involving home care products or personal care products.
- the method according to the invention which comprises application of a composition according to the invention in step i, can be a method wherein that composition is a composition for use as or incorporation in home care products and personal care products as described hereinabove.
- the invention also relates to a method or use according to the invention involving industrial and/or institutional products.
- the method according to the invention which comprises application of a composition according to the invention in step i, can be a method wherein that composition is a composition for use as or incorporation in industrial and/or institutional products as described hereinabove.
- Products and/or methods for use in the home care or personal care field are generally distinct from products and/or methods for use in the industrial and/or institutional field.
- a product that is marketed as a home or personal care product will generally not be marketed as a product for industrial and/or institutional use and vice versa. Therefore, certain embodiments of the present invention, when carried forth into practice, will relate to the one field, but not the other.
- BKC Benzalkonium chloride
- CAC Cetyltrimethylammonium chloride
- MIC Minimum inhibitory concentration
- FIC (component A) [MIC (component A tested in the mixture)] / [MIC (component A tested as a single active)]
- FIC (component B) [MIC (component B tested in the mixture)] / [MIC (component B tested as a single active)]
- FIC (component A) + FIC (component B) ⁇ FIC 0.5 strong synergy / 0.75 synergy / 1 additive effect
- Antimicrobial efficacy is tested against a representative pathogenic bacterial organism, Gram negative Escherichia coli. Concentrations of actives are expressed in terms of the percentage weight/volume (w/v.%) throughout Example 1.
- E. coli Escherichia coli (10536 strain) was prepared in 50 ml total volume of tryptic soy broth, grown for ca. 18 hrs at 37°C and shaken at 150 rpm. 1 ml of this E. coli culture was transferred to 50 ml of fresh TSB broth and incubated at 37 °C at 150 rpm for ca. 4 hours. This culture was separated into equal volumes and centrifuged at 4000 rpm for 15 minutes, washed with sterile saline (0.85% NaCI), centrifuged once more and re-suspended in saline to give a final concentration of 0.8 OD620, equivalent to about 10 cells per millilitre for this particular organism.
- OD620 indicates the absorbance of a sample in a cuvette of 1.0 cm path length at a wavelength of 620 nm. This bacterial stock was used for assaying against antimicrobial actives (in triplicate).
- test compositions 20% w/w solutions of the test compositions were prepared in dimethylsulphoxide (DMSO)/ distilled water as appropriate. Stock solutions of the actives at 1:1 ratio concentration prepared by serially diluting in DMSO or water in 96 micro titre plate.
- DMSO dimethylsulphoxide
- Fractional inhibitory concentration is the estimate the interaction (additive effect, synergy or antagonism) between two or more actives intended to be used in combination.
- FIC is calculated using the formula given above.
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EP20162999 | 2020-03-13 | ||
PCT/EP2021/056302 WO2021180909A1 (en) | 2020-03-13 | 2021-03-12 | A cleaning composition |
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CN (1) | CN115209731B (de) |
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WO2023180179A1 (en) | 2022-03-25 | 2023-09-28 | Unilever Ip Holdings B.V. | An antimalodour composition |
CN115737611B (zh) * | 2022-12-01 | 2024-05-14 | 成都科宏达科技有限公司 | 一种低温稳定的动物药浴液 |
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EP0791362A3 (de) * | 1996-02-23 | 1998-03-04 | The Procter & Gamble Company | Desinfizierende Zusammensetzungen und Verfahren zum Entkeimen von Oberflächen |
JP4153485B2 (ja) | 2002-07-15 | 2008-09-24 | ユニリーバー・ナームローゼ・ベンノートシヤープ | 毛髪および/または頭皮トリートメント用組成物 |
CN102186341B (zh) | 2008-10-20 | 2013-12-25 | 荷兰联合利华有限公司 | 抗菌组合物 |
US9132103B2 (en) * | 2009-09-24 | 2015-09-15 | Conopco, Inc. | Disinfecting agent comprising eugenol, terpineol and thymol |
AR079508A1 (es) * | 2009-12-17 | 2012-02-01 | Colgate Palmolive Co | Formulacion dentifrica |
WO2012076309A1 (en) * | 2010-12-07 | 2012-06-14 | Unilever Nv | An antimicrobial composition capable of forming a turbid suspension upon dilution with water |
US20130280180A1 (en) * | 2010-12-07 | 2013-10-24 | Deeleep Kumar Rout | Antimicrobial microemulsion mouthwash composition |
EP2782550A2 (de) * | 2011-11-25 | 2014-10-01 | Unilever N.V. | Mundpflegezusammensetzung mit polyphenol |
BR112014013614B1 (pt) * | 2011-12-06 | 2020-04-14 | Unilever Nv | composição antimicrobiana de fenóis monossubstituídos e terpineol, método não-terapêutico de desinfecção de uma superfície e uso não-terapêutico de uma composição de fenóis monossubstituídos e terpineol |
JP2015505834A (ja) * | 2011-12-06 | 2015-02-26 | ユニリーバー・ナームローゼ・ベンノートシヤープ | 殺微生物性組成物 |
WO2014001059A1 (en) * | 2012-06-27 | 2014-01-03 | Unilever N.V. | Antimicrobial composition |
WO2014001056A1 (en) * | 2012-06-27 | 2014-01-03 | Unilever N.V. | Antimicrobial composition |
WO2015138479A1 (en) * | 2014-03-10 | 2015-09-17 | The Trustees Of Columbia University In The City Of New York | Botanical antimicrobial compositions |
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