EP4116294A4 - Benzo 2-azaspiro[4.4]nonane compound and use thereof - Google Patents
Benzo 2-azaspiro[4.4]nonane compound and use thereof Download PDFInfo
- Publication number
- EP4116294A4 EP4116294A4 EP21764222.2A EP21764222A EP4116294A4 EP 4116294 A4 EP4116294 A4 EP 4116294A4 EP 21764222 A EP21764222 A EP 21764222A EP 4116294 A4 EP4116294 A4 EP 4116294A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- azaspiro
- benzo
- nonane compound
- nonane
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 Benzo 2-azaspiro[4.4]nonane compound Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010144397 | 2020-03-04 | ||
| CN202010144413 | 2020-03-04 | ||
| CN202010464155 | 2020-05-27 | ||
| CN202010464132 | 2020-05-27 | ||
| CN202010902712 | 2020-09-01 | ||
| PCT/CN2021/078742 WO2021175223A1 (en) | 2020-03-04 | 2021-03-02 | Benzo 2-azaspiro[4.4]nonane compound and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP4116294A1 EP4116294A1 (en) | 2023-01-11 |
| EP4116294A4 true EP4116294A4 (en) | 2024-06-19 |
Family
ID=77614388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP21764222.2A Pending EP4116294A4 (en) | 2020-03-04 | 2021-03-02 | Benzo 2-azaspiro[4.4]nonane compound and use thereof |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11760751B2 (en) |
| EP (1) | EP4116294A4 (en) |
| JP (1) | JP7307282B2 (en) |
| CN (1) | CN115279740A (en) |
| WO (1) | WO2021175223A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022213935A1 (en) * | 2021-04-09 | 2022-10-13 | 南昌弘益药业有限公司 | Oxadiazole-substituted spirocyclic compound and application thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2740783A1 (en) | 2008-10-17 | 2010-04-22 | Exelixis, Inc. | Sphingosine-1-phosphate receptor antagonists |
| WO2011007324A1 (en) | 2009-07-16 | 2011-01-20 | Actelion Pharmaceuticals Ltd | Pyridin-4-yl derivatives |
| CA2986521C (en) | 2009-11-13 | 2020-06-30 | Celgene International Ii Sarl | Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis |
| TWI522361B (en) | 2010-07-09 | 2016-02-21 | 艾伯維公司 | Fused heterocyclic derivatives as s1p modulators |
| WO2012158550A2 (en) * | 2011-05-13 | 2012-11-22 | Receptos, Inc. | Selective heterocyclic sphingosine 1 phosphate receptor modulators |
| TW201720822A (en) | 2015-08-28 | 2017-06-16 | 艾伯維股份有限公司 | Fused heterocyclic compounds as S1P modulators |
| EP3535244A1 (en) | 2016-11-02 | 2019-09-11 | Abbvie Deutschland GmbH & Co. KG | Spiro-compounds as s1p modulators |
| US10981900B2 (en) * | 2017-02-28 | 2021-04-20 | Medshine Discovery Inc. | Spiro compound and use thereof |
| GB201710851D0 (en) | 2017-07-06 | 2017-08-23 | Galápagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of fibrosis |
| US20210147381A1 (en) | 2017-07-17 | 2021-05-20 | AbbVie Deutschland GmbH & Co. KG | 1,2,3,4-substituted quinoline compounds as sip modulators |
-
2021
- 2021-03-02 WO PCT/CN2021/078742 patent/WO2021175223A1/en unknown
- 2021-03-02 CN CN202180018856.XA patent/CN115279740A/en active Pending
- 2021-03-02 EP EP21764222.2A patent/EP4116294A4/en active Pending
- 2021-03-02 US US17/905,531 patent/US11760751B2/en active Active
- 2021-03-02 JP JP2022553172A patent/JP7307282B2/en active Active
Non-Patent Citations (1)
| Title |
|---|
| No further relevant documents disclosed * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4116294A1 (en) | 2023-01-11 |
| WO2021175223A1 (en) | 2021-09-10 |
| US11760751B2 (en) | 2023-09-19 |
| CN115279740A (en) | 2022-11-01 |
| JP7307282B2 (en) | 2023-07-11 |
| JP2023506599A (en) | 2023-02-16 |
| US20230126480A1 (en) | 2023-04-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
| 17P | Request for examination filed |
Effective date: 20220930 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
| DAV | Request for validation of the european patent (deleted) | ||
| DAX | Request for extension of the european patent (deleted) | ||
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R079 Free format text: PREVIOUS MAIN CLASS: C07D0273020000 Ipc: C07D0403040000 |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 31/433 20060101ALI20240209BHEP Ipc: A61P 37/00 20060101ALI20240209BHEP Ipc: A61K 31/41 20060101ALI20240209BHEP Ipc: A61K 31/395 20060101ALI20240209BHEP Ipc: C07D 417/04 20060101ALI20240209BHEP Ipc: C07D 413/04 20060101ALI20240209BHEP Ipc: C07D 403/04 20060101AFI20240209BHEP |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20240517 |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 31/433 20060101ALI20240513BHEP Ipc: A61P 37/00 20060101ALI20240513BHEP Ipc: A61K 31/41 20060101ALI20240513BHEP Ipc: A61K 31/395 20060101ALI20240513BHEP Ipc: C07D 417/04 20060101ALI20240513BHEP Ipc: C07D 413/04 20060101ALI20240513BHEP Ipc: C07D 403/04 20060101AFI20240513BHEP |