EP4111189A4 - Mass spectrometry of samples including coaxial desorption/ablation and image capture - Google Patents

Mass spectrometry of samples including coaxial desorption/ablation and image capture Download PDF

Info

Publication number
EP4111189A4
EP4111189A4 EP21761749.7A EP21761749A EP4111189A4 EP 4111189 A4 EP4111189 A4 EP 4111189A4 EP 21761749 A EP21761749 A EP 21761749A EP 4111189 A4 EP4111189 A4 EP 4111189A4
Authority
EP
European Patent Office
Prior art keywords
ablation
desorption
image capture
mass spectrometry
samples including
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21761749.7A
Other languages
German (de)
French (fr)
Other versions
EP4111189A1 (en
Inventor
Jeffrey T. Williams
Oleg V. Maltsev
Gurpreet Singh
Stephen C. Strickland
Cole D. Naymark
Jonathan Putman
Jens COLE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Exum Instruments
Original Assignee
Exum Instruments
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exum Instruments filed Critical Exum Instruments
Publication of EP4111189A1 publication Critical patent/EP4111189A1/en
Publication of EP4111189A4 publication Critical patent/EP4111189A4/en
Pending legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0004—Imaging particle spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0459—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
    • H01J49/0463—Desorption by laser or particle beam, followed by ionisation as a separate step
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/162—Direct photo-ionisation, e.g. single photon or multi-photon ionisation

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Electron Tubes For Measurement (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
EP21761749.7A 2020-02-27 2021-02-26 Mass spectrometry of samples including coaxial desorption/ablation and image capture Pending EP4111189A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062982473P 2020-02-27 2020-02-27
PCT/US2021/019823 WO2021173934A1 (en) 2020-02-27 2021-02-26 Mass spectrometry of samples including coaxial desorption/ablation and image capture

Publications (2)

Publication Number Publication Date
EP4111189A1 EP4111189A1 (en) 2023-01-04
EP4111189A4 true EP4111189A4 (en) 2024-06-19

Family

ID=77490517

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21761749.7A Pending EP4111189A4 (en) 2020-02-27 2021-02-26 Mass spectrometry of samples including coaxial desorption/ablation and image capture

Country Status (2)

Country Link
EP (1) EP4111189A4 (en)
WO (1) WO2021173934A1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060097143A1 (en) * 2004-10-25 2006-05-11 Bruker Daltonik Gmbh Protein profiles with atmospheric pressure ionization
US20100213367A1 (en) * 2009-02-02 2010-08-26 Miller R J Dwayne Soft ablative desorption method and system
US20180190478A1 (en) * 2016-12-19 2018-07-05 Perkinelmer Health Sciences Canada, Inc. Inorganic and organic mass spectrometry systems and methods of using them
WO2020210688A1 (en) * 2019-04-11 2020-10-15 Exum Instruments Laser desorption, ablation, and ionization system for mass spectrometry analysis of samples including organic and inorganic materials

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8207494B2 (en) * 2008-05-01 2012-06-26 Indiana University Research And Technology Corporation Laser ablation flowing atmospheric-pressure afterglow for ambient mass spectrometry
CA2798182A1 (en) * 2010-05-05 2011-11-10 George Washington University Methods for detecting metabolic states by laser ablation electrospray ionization mass spectrometry
EP3548854A4 (en) * 2016-11-29 2020-10-14 Photothermal Spectroscopy Corp. Method and apparatus for enhanced photo-thermal imaging and spectroscopy
DE102016124889B4 (en) * 2016-12-20 2019-06-06 Bruker Daltonik Gmbh Mass spectrometer with laser system for generating photons of different energy

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060097143A1 (en) * 2004-10-25 2006-05-11 Bruker Daltonik Gmbh Protein profiles with atmospheric pressure ionization
US20100213367A1 (en) * 2009-02-02 2010-08-26 Miller R J Dwayne Soft ablative desorption method and system
US20180190478A1 (en) * 2016-12-19 2018-07-05 Perkinelmer Health Sciences Canada, Inc. Inorganic and organic mass spectrometry systems and methods of using them
WO2020210688A1 (en) * 2019-04-11 2020-10-15 Exum Instruments Laser desorption, ablation, and ionization system for mass spectrometry analysis of samples including organic and inorganic materials

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SAVINA M R ET AL: "Chemical imaging of surfaces with laser desorption mass spectrometry", TRAC TRENDS IN ANALYTICAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 16, no. 5, 1 May 1997 (1997-05-01), pages 242 - 252, XP004097039, ISSN: 0165-9936, DOI: 10.1016/S0165-9936(97)00028-9 *
See also references of WO2021173934A1 *

Also Published As

Publication number Publication date
WO2021173934A1 (en) 2021-09-02
EP4111189A1 (en) 2023-01-04

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