EP4076240A4 - Treatment of cardiac tissue with pulsed electric fields - Google Patents

Treatment of cardiac tissue with pulsed electric fields Download PDF

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Publication number
EP4076240A4
EP4076240A4 EP20903305.9A EP20903305A EP4076240A4 EP 4076240 A4 EP4076240 A4 EP 4076240A4 EP 20903305 A EP20903305 A EP 20903305A EP 4076240 A4 EP4076240 A4 EP 4076240A4
Authority
EP
European Patent Office
Prior art keywords
treatment
electric fields
cardiac tissue
pulsed electric
pulsed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20903305.9A
Other languages
German (de)
French (fr)
Other versions
EP4076240A1 (en
Inventor
Quim CASTELLVI
Timothy James GUNDERT
Robert E. Ii Neal
Jonathan R. WALDSTREICHER
Isidro Gandionco
Steven D. Girouard
Vikramaditya MEDIRATTA
Kevin James TAYLOR
Armaan G. VACHANI
William S. Krimsky
Rajesh Pendekanti
Curt Robert EYSTER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cardiofocus Inc
Original Assignee
Galvanize Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galvanize Therapeutics Inc filed Critical Galvanize Therapeutics Inc
Publication of EP4076240A1 publication Critical patent/EP4076240A1/en
Publication of EP4076240A4 publication Critical patent/EP4076240A4/en
Pending legal-status Critical Current

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    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14Probes or electrodes therefor
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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
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  • Otolaryngology (AREA)
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  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Plasma & Fusion (AREA)
  • Cardiology (AREA)
  • Electromagnetism (AREA)
  • Surgical Instruments (AREA)
  • Electrotherapy Devices (AREA)
EP20903305.9A 2019-12-18 2020-12-18 Treatment of cardiac tissue with pulsed electric fields Pending EP4076240A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962949633P 2019-12-18 2019-12-18
US202063000275P 2020-03-26 2020-03-26
US202063083644P 2020-09-25 2020-09-25
PCT/US2020/066205 WO2021127558A1 (en) 2019-12-18 2020-12-18 Treatment of cardiac tissue with pulsed electric fields

Publications (2)

Publication Number Publication Date
EP4076240A1 EP4076240A1 (en) 2022-10-26
EP4076240A4 true EP4076240A4 (en) 2024-01-17

Family

ID=76478829

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20903305.9A Pending EP4076240A4 (en) 2019-12-18 2020-12-18 Treatment of cardiac tissue with pulsed electric fields

Country Status (7)

Country Link
US (1) US20210393327A1 (en)
EP (1) EP4076240A4 (en)
JP (1) JP2023509387A (en)
CN (1) CN115315222A (en)
AU (1) AU2020405195A1 (en)
CA (1) CA3165729A1 (en)
WO (1) WO2021127558A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018092070A1 (en) * 2016-11-16 2018-05-24 Navix International Limited Esophagus position detection by electrical mapping
WO2019133608A1 (en) 2017-12-26 2019-07-04 Gala Therapeutics, Inc. Optimization of energy delivery for various applications
CN113365566A (en) * 2019-12-03 2021-09-07 圣犹达医疗用品心脏病学部门有限公司 Electroporation system and method
US11796671B2 (en) * 2021-03-08 2023-10-24 GM Global Technology Operations LLC Transmission scheme for implementing code division multiple access in a radar system
US20230009191A1 (en) * 2021-07-09 2023-01-12 Biosense Webster (Israel) Ltd. Irreversible electroporation and thermal ablation by focal catheter
US20230009573A1 (en) * 2021-07-09 2023-01-12 Biosense Webster (Israel) Ltd. Ablation and mapping with a singular multi-electrode catheter
US20230240746A1 (en) * 2022-01-28 2023-08-03 Galary, Inc. Tissue modification systems and methods and signal generators for use therewith
US20230285074A1 (en) * 2022-03-11 2023-09-14 Boston Scientific Medical Device Limited Medical devices and methods for carrying out a medical procedure
WO2023192054A1 (en) * 2022-04-01 2023-10-05 Medtronic, Inc. Dual focal and linear pulse field ablation (pfa) catheter
WO2023192056A1 (en) * 2022-04-01 2023-10-05 Medtronic, Inc. Dual focal and linear pulse field ablation (pfa) catheter
WO2023212250A1 (en) * 2022-04-28 2023-11-02 Galvanize Therapeutics, Inc. Lesion optimization in the use of pulsed electric fields
WO2023244854A1 (en) * 2022-06-18 2023-12-21 The Board Of Trustees Of The Leland Stanford Junior University Pulsed field atrial fibrillation systems and methods for use
WO2024013601A1 (en) * 2022-07-12 2024-01-18 Medtronic, Inc. Timing of pulsed field ablation energy deliveries
WO2024075034A1 (en) * 2022-10-05 2024-04-11 Btl Medical Technologies S.R.O. Pulsed field ablation device and method
IL308363A (en) 2022-11-23 2024-06-01 Biosense Webster Israel Ltd Combined electrodes for tissue Penetrative irreversible Electroporation (IRE)
WO2024129731A1 (en) * 2022-12-13 2024-06-20 St. Jude Medical, Cardiology Division, Inc. Apparatus for transseptal catheterization

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018208795A1 (en) * 2017-05-12 2018-11-15 St. Jude Medical, Cardiology Division, Inc. Electroporation systems and catheters for electroporation systems
WO2019217317A1 (en) * 2018-05-07 2019-11-14 Farapulse, Inc. Systems, apparatuses, and methods for filtering high voltage noise induced by pulsed electric field ablation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6749604B1 (en) * 1993-05-10 2004-06-15 Arthrocare Corporation Electrosurgical instrument with axially-spaced electrodes
US6012457A (en) * 1997-07-08 2000-01-11 The Regents Of The University Of California Device and method for forming a circumferential conduction block in a pulmonary vein
US10493259B2 (en) * 2003-01-21 2019-12-03 Baylis Medical Company Inc. Medical apparatus for fluid communication
US7736360B2 (en) * 2006-03-17 2010-06-15 Microcube, Llc Devices and methods for creating continuous lesions
US8641704B2 (en) * 2007-05-11 2014-02-04 Medtronic Ablation Frontiers Llc Ablation therapy system and method for treating continuous atrial fibrillation
US9387032B2 (en) * 2012-06-18 2016-07-12 Medtronic Ablation Frontiers Llc Systems and methods for detecting channel faults in energy delivery systems
US10849677B2 (en) * 2017-01-27 2020-12-01 Medtronic, Inc. Methods of ensuring pulsed field ablation generator system electrical safety
CN111065327B (en) * 2017-09-12 2023-01-06 波士顿科学医学有限公司 Systems, devices, and methods for ventricular focal ablation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018208795A1 (en) * 2017-05-12 2018-11-15 St. Jude Medical, Cardiology Division, Inc. Electroporation systems and catheters for electroporation systems
WO2019217317A1 (en) * 2018-05-07 2019-11-14 Farapulse, Inc. Systems, apparatuses, and methods for filtering high voltage noise induced by pulsed electric field ablation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2021127558A1 *

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JP2023509387A (en) 2023-03-08
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