EP4059572A4 - Cell reprogramming method - Google Patents
Cell reprogramming method Download PDFInfo
- Publication number
- EP4059572A4 EP4059572A4 EP20888103.7A EP20888103A EP4059572A4 EP 4059572 A4 EP4059572 A4 EP 4059572A4 EP 20888103 A EP20888103 A EP 20888103A EP 4059572 A4 EP4059572 A4 EP 4059572A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- cell reprogramming
- reprogramming method
- cell
- reprogramming
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000008672 reprogramming Effects 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0656—Adult fibroblasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0653—Adipocytes; Adipose tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/44—Thiols, e.g. mercaptoethanol
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/235—Leukemia inhibitory factor [LIF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/603—Oct-3/4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases (EC 2.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/85—Hormones derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C12N2501/855—Corticotropin [ACTH]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1307—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from adult fibroblasts
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2019206270 | 2019-11-14 | ||
PCT/JP2020/043095 WO2021095887A1 (en) | 2019-11-14 | 2020-11-12 | Cell reprogramming method |
Publications (2)
Publication Number | Publication Date |
---|---|
EP4059572A1 EP4059572A1 (en) | 2022-09-21 |
EP4059572A4 true EP4059572A4 (en) | 2024-01-17 |
Family
ID=75912431
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP20888103.7A Pending EP4059572A4 (en) | 2019-11-14 | 2020-11-12 | Cell reprogramming method |
Country Status (5)
Country | Link |
---|---|
US (1) | US20220403337A1 (en) |
EP (1) | EP4059572A4 (en) |
JP (2) | JP7448243B2 (en) |
CN (1) | CN115003795A (en) |
WO (1) | WO2021095887A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023176931A1 (en) * | 2022-03-16 | 2023-09-21 | 公益財団法人京都大学iPS細胞研究財団 | Method for producing pluripotent stem cell from somatic cell, differentiated cell produced employing same, and suspension culture device for producing these cells |
WO2024078119A1 (en) * | 2022-10-12 | 2024-04-18 | Peking University | Methods for chemical reprogramming and pluripotent stem cells |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070087437A1 (en) * | 2005-10-14 | 2007-04-19 | Jifan Hu | Methods for rejuvenating cells in vitro and in vivo |
CN101580816B (en) * | 2009-04-23 | 2012-02-29 | 中国科学院广州生物医药与健康研究院 | Novel serum-free culture medium for inducing fast and efficient production of pluripotent stem cells and use method thereof |
JP2014133703A (en) | 2011-03-30 | 2014-07-24 | Clio Inc | Composition for cell therapy for allotransplant including ssea-3 positive pluripotent stem cell that can be isolated from biological tissue |
JP2011135864A (en) * | 2009-12-30 | 2011-07-14 | Korea Univ Research & Business Foundation | Composition for retrodifferentiating somatic cell to embryonic stem cell-like cell, by using oct4 in combination with bmi1 or upstream regulator thereof, and method for generating embryonic stem cell-like cell using the same |
CN102093981B (en) * | 2010-12-17 | 2012-12-19 | 深圳市北科生物科技有限公司 | Method for efficiently inducing reprogramming of human body cells into pluripotent stem cells |
US10920192B2 (en) * | 2013-04-23 | 2021-02-16 | Yeda Research And Development Co. Ltd. | Isolated naive pluripotent stem cells and methods of generating same |
JP7122160B2 (en) | 2018-05-29 | 2022-08-19 | 株式会社ジェイテクト | steering controller |
-
2020
- 2020-11-12 EP EP20888103.7A patent/EP4059572A4/en active Pending
- 2020-11-12 CN CN202080093262.0A patent/CN115003795A/en active Pending
- 2020-11-12 US US17/776,605 patent/US20220403337A1/en active Pending
- 2020-11-12 JP JP2021556199A patent/JP7448243B2/en active Active
- 2020-11-12 WO PCT/JP2020/043095 patent/WO2021095887A1/en unknown
-
2024
- 2024-02-21 JP JP2024024228A patent/JP2024059771A/en active Pending
Non-Patent Citations (4)
Title |
---|
HE SONGWEI ET AL: "Reprogramming somatic cells to cells with neuronal characteristics by defined medium both in vitro and in vivo", CELL REGENERATION, vol. 4, no. 1, 1 January 2015 (2015-01-01), London, UK, pages 4:12, XP093108690, ISSN: 2045-9769, DOI: 10.1186/s13619-015-0027-6 * |
MIN XIE ET AL: "Pharmacological Reprogramming of Somatic Cells for Regenerative Medicine", ACCOUNTS OF CHEMICAL RESEARCH, vol. 50, no. 5, 16 May 2017 (2017-05-16), US, pages 1202 - 1211, XP055652043, ISSN: 0001-4842, DOI: 10.1021/acs.accounts.7b00020 * |
SAMOILOVA E M ET AL: "Chemical Reprogramming of Somatic Cells in Neural Direction: Myth or Reality?", BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, SPRINGER NEW YORK LLC, US, vol. 167, no. 4, 1 August 2019 (2019-08-01), pages 546 - 555, XP037095913, ISSN: 0007-4888, [retrieved on 20190909], DOI: 10.1007/S10517-019-04570-5 * |
See also references of WO2021095887A1 * |
Also Published As
Publication number | Publication date |
---|---|
JP7448243B2 (en) | 2024-03-12 |
WO2021095887A1 (en) | 2021-05-20 |
JPWO2021095887A1 (en) | 2021-05-20 |
EP4059572A1 (en) | 2022-09-21 |
JP2024059771A (en) | 2024-05-01 |
CN115003795A (en) | 2022-09-02 |
US20220403337A1 (en) | 2022-12-22 |
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Legal Events
Date | Code | Title | Description |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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STAA | Information on the status of an ep patent application or granted ep patent |
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17P | Request for examination filed |
Effective date: 20220613 |
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AK | Designated contracting states |
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DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20231214 |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 35/12 20150101ALI20231208BHEP Ipc: C12N 5/071 20100101ALI20231208BHEP Ipc: A61P 43/00 20060101AFI20231208BHEP |