EP4031867B1 - Device for taking a sample of biological liquid - Google Patents
Device for taking a sample of biological liquid Download PDFInfo
- Publication number
- EP4031867B1 EP4031867B1 EP20771859.4A EP20771859A EP4031867B1 EP 4031867 B1 EP4031867 B1 EP 4031867B1 EP 20771859 A EP20771859 A EP 20771859A EP 4031867 B1 EP4031867 B1 EP 4031867B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- housing
- strip
- diffusion
- band
- absorbent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000007788 liquid Substances 0.000 title claims description 87
- 239000002250 absorbent Substances 0.000 claims description 111
- 230000002745 absorbent Effects 0.000 claims description 111
- 238000009792 diffusion process Methods 0.000 claims description 92
- 238000005070 sampling Methods 0.000 claims description 59
- 230000008021 deposition Effects 0.000 claims description 19
- 238000013519 translation Methods 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 9
- 238000010521 absorption reaction Methods 0.000 claims description 6
- 239000000523 sample Substances 0.000 description 35
- 238000004458 analytical method Methods 0.000 description 30
- 238000000151 deposition Methods 0.000 description 18
- 230000008859 change Effects 0.000 description 15
- 238000003780 insertion Methods 0.000 description 9
- 230000037431 insertion Effects 0.000 description 9
- 239000013060 biological fluid Substances 0.000 description 8
- 210000002105 tongue Anatomy 0.000 description 7
- 230000007704 transition Effects 0.000 description 6
- 210000002700 urine Anatomy 0.000 description 6
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 239000003086 colorant Substances 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000003100 immobilizing effect Effects 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 238000002791 soaking Methods 0.000 description 2
- 230000002485 urinary effect Effects 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 150000002826 nitrites Chemical class 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0825—Test strips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
- B01L2300/126—Paper
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
Definitions
- the present invention relates to a device for collecting a biological liquid sample. It applies, in particular, to a cartridge for collecting a urine sample for the purpose of analyzing urinary marker values.
- This home solution does not always provide reliable information to the user, the user may have difficulty discerning a change in color from the instructions, the soaking time of the strip in the biological liquid is not necessarily controlled by the user, time latency between the end of soaking and the interpretation of the colors of the reagents is also not always controlled by the user.
- WO 00/42430 A1 describes a biological sample collection device according to the state of the art.
- the present invention aims to remedy these drawbacks with a completely innovative approach.
- the present invention relates to. a biological liquid sample collection device intended to be able to be inserted into a portable biological liquid analysis reader, the collection device comprising a transparent or translucent strip extending along a longitudinal axis and comprising on its upper face a plurality reactive color-changing elements arranged one after the other along the longitudinal axis; an absorbent assembly extending along the longitudinal axis and comprising a biological liquid deposition portion; a biological liquid diffusion band arranged over the plurality of reactive elements; a housing extending along the longitudinal axis between two lateral ends, the housing comprising: a housing bottom, the strip being arranged at the bottom of the housing, the lower face of the strip being arranged facing the housing bottom, each element reagent being arranged transparently through the strip facing an opening in the bottom of the housing; an upper cover arranged over the diffusion strip, and comprising at least one protruding pattern forming a first bearing surface configured to press the diffusion strip into contact with the plurality of reactive elements; an access opening configured
- the biological liquid deposit portion can be arranged through the access opening.
- the absorbent set can be a single blotting paper.
- the biological liquid deposition portion may include an absorbent reservoir band distinct from the diffusion band;
- the box which may include a second support surface configured to press at least one contact portion of the absorbent reservoir strip) into contact with a contact pad of the diffusion strip.
- the absorbent reservoir strip and the diffusion strip can be arranged generally longitudinally one after the other, the reservoir strip can be configured to move in translation along the longitudinal axis; the contact portion can be arranged at the end of the absorbent tank strip; the contact portion can be configured to strike the second support surface by pushing along the longitudinal axis of the absorbent reservoir strip so as to be brought into contact with the contact pad of the diffusion strip.
- the diffusion strip and the absorbent reservoir strip may respectively comprise a diffusion blotting paper and a reservoir blotting paper distinct from the diffusion blotting paper, the reservoir blotting paper comprising a liquid absorption characteristic greater than that of the blotting paper of diffusion.
- the diffusion strip may comprise a plurality of reception areas arranged successively along the longitudinal axis, each reactive element being arranged under a single reception area, the diffusion strip may include a recess of material between each reception beaches.
- the access opening can be arranged on one of the side ends of the housing.
- the housing may comprise two opposite longitudinal walls internal to the housing forming a slide cooperating with a removable support of the absorbent assembly, the removable support being configured to be inserted into the housing through the access opening.
- the access opening can be arranged on the cover of the housing or on the bottom of the housing.
- a system 10 for analyzing a biological liquid sample comprises a device 12, or cartridge, for collecting a biological liquid sample and a portable reader 14 for analyzing a biological liquid sample.
- a device 12 or cartridge for collecting a biological liquid sample
- a portable reader 14 for analyzing a biological liquid sample.
- left and right orientations are defined along a longitudinal axis L and orientations above and below, or upper and lower, are defined along a vertical axis V.
- the device 12 for taking a biological liquid sample is intended to be inserted into the portable reader 14 for analyzing biological liquid.
- the sampling device 12 comprises a housing 16 extending generally along the longitudinal axis L between two left and right lateral ends 18, 20, the housing 16 being configured to be inserted in translation, in a longitudinal direction D, in an opening 22 of the reader 14.
- a sampling device 12 of approximately 10 centimeters in length along the longitudinal axis L, with a thickness of less than one centimeter along the vertical axis V and a width along an axis transverse to the longitudinal axis L of the order of a centimeter could correspond to the need.
- the device 12 for sampling the figure 1 comprises the housing 16 comprising a lower element or housing base 24 and an upper element or cover 26 making it possible to close the top of the housing 16.
- the sampling device 12 comprises an absorbent assembly 28, extending along the longitudinal axis L, configured to be arranged in the housing 16.
- the sampling device 12 also comprises a strip 30 extending longitudinally and comprising on its upper face a plurality of reactive elements 32, 34 with color change arranged one after the other along the longitudinal axis L.
- a reactive element 32, 34 when brought into contact with a biological liquid, for example and without limitation, a change from orange color to blue for an indication of acidity (or also denoted 'pH') of the biological liquid, but still an appearance of color, that is to say from the white appearance of the reactive element 32, 34 to a pink color during the detection of nitrites in the biological liquid in contact with the adequate reactive element 32, 34.
- a strip 30 which can comprise ten reactive elements 32, 34 is compatible with the housing 16 and is suitable for a sufficiently exhaustive analysis of biological liquid.
- the absorbent assembly 28 like an absorbent paper capable of absorbing a liquid, has the role of receiving the biological liquid and diffusing it in contact with the reactive elements 32, 34.
- the The absorbent assembly 28 comprises an absorbent reservoir strip 36 intended for the deposition of biological liquid, and a diffusion strip 38 configured to diffuse by capillary action the biological liquid previously deposited on the absorbent reservoir strip 36 on the reactive elements 32, 34 of the strip 30.
- the absorbent reservoir strip 36 therefore comprises at least one portion configured to be in contact with the diffusion strip 38.
- the diffusion strip 38 and the absorbent reservoir strip 36 respectively comprise a diffusion blotting paper and a reservoir blotting paper distinct from the diffusion blotting paper, the reservoir blotting paper comprising a superior liquid absorption characteristic to that of diffusion blotting paper.
- the reservoir blotting paper must allow absorption of a quantity of biological liquid necessary for the analysis, and also allow rapid transfer of the biological liquid to the diffusion blotting paper.
- a reservoir blotting paper with a thickness between 2 and 3 millimeters, and with a liquid absorption characteristic of between 200 and 300 milligrams of liquid per square centimeter could be suitable for sampling device 12, this type of reservoir blotting paper comprising a liquid advancement speed of between 3 and 5 cm for a time of ten seconds.
- a diffusion blotting paper comprising a thickness less than a millimeter, preferably between 0.2 and 0.6 millimeter, and an absorption capacity of between 20 and 40 milligrams of liquid per square centimeter could be suitable for the device 12 sampling, this type of diffusion blotting paper comprising a liquid advancement speed of between 0.5 and 1.5 cm for a time of 10 seconds.
- the absorbent reservoir strip 36 and the diffusion strip 38 are arranged generally longitudinally one after the other.
- the absorbent reservoir strip 36 extending from the right lateral end 20 of the housing 16 to its second end forming a contact portion 40
- the diffusion strip 38 extending from the left lateral end 18 of the housing 16 to 'at its second end forming a contact pad 42.
- the contact portion 40 is configured to be in contact with the diffusion strip 38.
- the contact portion 40 is arranged over the contact pad 42 of the end of the broadcast band 38.
- the strip 30 is arranged below the diffusion strip 38. More particularly, the upper face of the strip 30, equipped with the plurality of reactive elements 32, 34 faces the lower face of the diffusion strip 38 so that the diffusion band 38 can come to bear on the reactive elements 32, 34, allowing a reaction of the reactive elements 32, 34 in contact with the biological liquid diffused by capillarity through the diffusion band 38.
- the diffusion of the biological liquid through the diffusion strip takes place from the contact portion 40 of the absorbent reservoir strip 36 in contact with the contact pad 42 of the end of the diffusion strip 38, up to the end opposite the contact area 40 of the diffusion band 38.
- the reactive elements 32, 34 are in contact with the diffusion band 38, they are in turn in contact with the biological liquid diffusing in the longitudinal direction D.
- the diffusion strip 38 comprises a plurality of reception areas 44, 46 arranged successively along the longitudinal axis L and separated from each other along the longitudinal axis L by a material recess 48, 50 of the strip diffusion strip 38.
- Each reactive element 32 is configured to be arranged in contact with a single reception area 44, the diffusion strip 38 comprising a material recess between each of the reception areas 44, 46.
- the reception areas 44, 46 are arranged along a longitudinal edge of the diffusion band 38, thus forming a series of reception areas 44, 46 in the form of successive slots.
- This embodiment allows the biological liquid to diffuse along the other longitudinal edge of the diffusion band 38, this other edge being opposite the edge forming the slots.
- the biological liquid can impregnate the reception areas 44, 46 successively and progressively one after the other.
- the strip 30 is configured to be arranged in the bottom of the housing 24 along the longitudinal axis L.
- the lower face of the strip 30, that is to say the face of the strip 30 opposite the face of the strip 30 on which the reactive elements 32, 34 are arranged, is arranged facing the bottom of the housing 24.
- the strip 30 is preferably a transparent strip 30, each reactive element 32, 34 of the strip being arranged, by transparency through the strip 30, facing an opening 52 in the bottom of the housing 24.
- the opening 52 of the housing bottom 24 is an opening 52 extending longitudinally, of a length along the longitudinal axis L slightly less than that of the strip 30 and of a width, in a direction transverse to the longitudinal axis L, slightly less than that of the strip 30, so that the strip 30 can come to rest on the periphery of the opening 52 of the housing base 24.
- the strip 30 is configured to be arranged between a first side wall 51 of a first edge of the housing bottom 24 extending longitudinally, and lateral stop pins 53 of the strip 30 arranged on the bottom of the housing 24.
- the strip 30 is configured to be arranged between a transverse wall 55 of the left end of the housing base 24 and another transverse wall 57, opposite the transverse wall 55 of the left end of the housing base 24, arranged on the housing base 24. It should be noted that the strip 30 makes it possible in particular to hold the elements reagents 32, 34 fixed in the housing 16, and to protect the reactive elements 32, 34 against impurities outside the housing 16
- the case back 24 is configured to be able to keep the diffusion band 38 fixed both against longitudinal movements and against lateral movements.
- the lateral stop pins 53 of the strip 30 are configured to be arranged between slots or material recesses 48, 50 of the diffusion strip 38.
- the edge of the diffusion strip 38 not having slots is configured to be arranged abutting against a second side wall 59 of the second edge of the housing base 24 extending longitudinally.
- the absorbent reservoir strip 36 is of generally parallelepiped shape.
- the housing base 24 comprises a plurality of transverse support tabs 64 extending between each longitudinal edge of the housing base 24 and projecting towards the interior of the housing 16.
- the transverse support tabs 64 of the plurality of transverse tabs 64 support are spaced regularly from the right lateral end 20 of the bottom of the housing 24 so as to be able to maintain the absorbent reservoir strip 36 in a balanced manner when closing the housing 16.
- the cover 26 of the housing 16 comprises a housing 54 configured to receive the absorbent tank strip 36.
- the housing 54 is formed by a reduction of material from the internal face of the cover 26.
- the housing 54 extends longitudinally from the end right side 20 of the cover 26 and is generally rectangular in shape making it possible to maintain fixed both against translational movements along the longitudinal axis L, and against lateral movements, the absorbent tank strip 36.
- the housing 54 of the absorbent tank strip 36 has an access opening 56 allowing direct access to a portion of the absorbent reservoir strip 36 from outside the housing 16 of the sampling device 12.
- the portion of the absorbent reservoir strip 36 arranged opposite the access opening 56 forms a portion 37 for depositing the biological liquid.
- the internal face of the cover 26 comprises support tabs 60 projecting from the internal face of the cover 26, the support tabs 60 extending longitudinally from the left lateral end 18 of the cover 26 to the housing 54 of the absorbent reservoir strip 36.
- the support tabs 60 form protruding patterns towards the inside of the housing 16, the tabs 60 being configured to rest on the diffusion strip 38.
- the internal face of the cover 26 comprises support pads 62 configured to bear against the reception areas 44, 46 of the diffusion strip 38.
- the absorbent reservoir strip 36 when the housing 16 is closed, that is to say when the periphery of the cover 26 is fixed with the periphery of the bottom of the housing 24, for example non-limiting, by clipping, the absorbent reservoir strip 36 is in contact with the diffusion strip 38, the diffusion strip 38 is in contact with the reactive elements 32, 34. More particularly, when the housing 16 is closed, the internal surface of the housing 54 rests on the absorbent reservoir strip 36. The absorbent reservoir strip 36 is therefore compressed between the internal surface of the housing 54 and the transverse tongues 64 so that the contact portion 40 of the absorbent reservoir strip 36 is in contact with support against the contact pad 42 of the diffusion strip 38. For this purpose , in the event of deposit of biological liquid on the deposit portion 37 of the sampling device 12, the biological liquid can diffuse from the absorbent reservoir strip 36 to the diffusion strip 38.
- the longitudinal support tabs 60 exert pressure on the diffusion strip 38 towards the bottom of the housing 24.
- the support pads 62 exert a force d support on the diffusion strip 38, allowing contact in support of the reception areas 44, 46 against the reactive elements 32, 34.
- the support force exerted by the longitudinal support tabs 60 associated with the force of The support exerted by the support pads 62 on the diffusion strip 38 allows reliable and durable support contact of the reception pads 44, 46 against the reactive elements 32, 34, thus allowing, in the event of the presence of liquid biological on the diffusion band 38, a reliable reaction of the reactive elements 32, 34 with the biological liquid which can result in a change of color of the reactive elements 32, 34.
- the strip 30, preferably transparent can be flexible in order to be able to withstand the assembly constraints of the sampling device 12.
- the strip 30 it is advantageous for the strip 30 to be a strip 30 of plastic material.
- Other material solutions such as for example, and not limited to, glass or even polymethyl methacrylate, could have been possible.
- the strip 30 may not necessarily be transparent, but only allow the passage of light, like a translucent material.
- the access opening 56 could also have been arranged on the bottom of the housing 24. Also, it could have been possible to provide a first access opening on the bottom of the housing 24 and a second access opening on the cover 26.
- a second embodiment of a sampling device 112 is shown.
- This second embodiment differs from the first embodiment in that the absorbent reservoir strip 136 is no longer arranged in a housing of the cover 126 fixed against translational movements.
- the absorbent element 128 includes an absorbent reservoir strip 136 arranged through a lateral access opening 156 arranged on the right lateral face of the right lateral end 120 of the housing 116 so that the biological liquid deposit portion 137 of the absorbent reservoir strip 136 is configured to be arranged outside the housing 116.
- the deposit portion 137 is advantageously configured to be covered by a cap 166 allowing the sampling device 112 to be handled manually without having to grasp the device 112 directly by touching the portion 137 deposit during its insertion into the reader 14.
- the absorbent reservoir strip 136 is arranged so as to be movable in translation along the longitudinal axis L.
- the absorbent reservoir strip 136 comprises from its left end to its right end, successively, a contact portion 140 configured to be in contact with the diffusion strip 138, a guide portion 168 in translation configured to be arranged in a guide ring 170, and the portion 137 for depositing biological liquid.
- the absorbent reservoir strip 136 and the diffusion strip 138 are arranged generally longitudinally one after the other in a manner generally similar to the first embodiment.
- the guide ring 170 is arranged integrally with the guide portion 168 of the absorbent tank strip 136.
- the guide ring 170 cooperates with guide rails extending inside the housing 116 from the side access opening 156.
- the guide ring 170 is configured to extend simultaneously inside the housing 116 so as to be partially arranged on its guide rails and also partially outside the housing 116 so as to form a first stop stop for the cap 166 when the latter is arranged in translation on the deposition portion 137.
- the guide ring 170 comprises an upper element and a lower element respectively comprising a male element such as a tenon and a female element, the guide portion 168 in translation of the absorbent reservoir strip 136 comprising a fixing opening 171 allowing the passage of the female element of the lower element through the absorbent tank band 136 in order to allow the coupling of the two elements of the guide ring 170.
- the guide ring 170 is configured to maintain the portion of guidance 168 during translation of the absorbent tank strip 136.
- the cover 126 of the housing comprises a support section 127 arranged over the reception areas 144, 146 of the diffusion band 138 and configured to come to bear on the reception areas 144, 146 of the diffusion band 138 when closing the housing 116 to bring the receiving areas 144, 146 into contact with the reactive elements 132, 134.
- the cover 126 of the housing includes a sliding section 129 arranged raised in relation to the support section 127 and configured for sliding in translation of the guide ring 170, the guide rails being arranged in this sliding section 129.
- the cover 126 comprises a sloping transition section 131 connecting the support section 127 and the sliding section 129.
- the contact pad 142 of the end of the diffusion strip 138 is arranged at least partially under the transition section of the cover 126.
- the contact portion 140 of the absorbent reservoir strip 136 is configured to be arranged out of contact with the contact pad 142 of the diffusion strip 138 according to an initial position of the guide ring 170. According to this initial position, the guide ring 170 forms a first stop for the cap 166 during its arrangement in translation on the deposition portion 137.
- the guide ring 170 is configured to be slid in translation towards the inside of the sliding section 129 by pushing action P on the cap 166 until the cap 166 abuts on the outer periphery of the opening d lateral access 156 of the housing 116, the periphery of the lateral access opening 156 forming a second stop for the cap 166.
- the contact portion 140 of the absorbent reservoir strip 136 hits the internal surface of the section transition 131 of the cover 126 so as to be folded in the direction of the contact area 142 of the diffusion strip 138.
- the internal surface of the transition section 131 is a bearing surface of the cover 126 for the contact portion 140 of the absorbent tank strip 136.
- the sliding section 129 may comprise a means for immobilizing the guide ring 170 of the notch type, the immobilizing means being configured to immobilize the guide ring 170 when it is pressed by the cap 166 in the stop position against the second stop stop.
- the immobilization means can advantageously only be operational up to a certain extraction force exerted on the cap 166 or directly on the deposit portion 137.
- the immobilization means may comprise at least one boss on a guide rail so that the guide ring 170 must be inserted with adequate force to override this boss. This boss can generate a tactile rendering of confirmation of effective insertion of the absorbent reservoir strip 136 into the sampling device 112 so as to ensure the contact portion 140 of the absorbent reservoir strip 136 with the beach contact 142 of the diffusion band 138.
- the second embodiment also differs from the first embodiment in that the housing bottom 124 comprises a plurality of housing bottom openings 152, 153 arranged one after the other along the longitudinal axis L.
- each reactive element 132, 134 of the strip 130 is arranged, by transparency through the strip 130, in with respect to a single opening 152 of the housing bottom 124 different from another opening 154 of the housing bottom 124 associated with another element reagent 134.
- a single housing bottom opening 124 extending longitudinally could be suitable, the solution consisting of a plurality of housing bottom openings 152, 154 124 makes it possible to robusten the overall structure of the case back 124.
- the second embodiment also differs from the first embodiment in that the upper surface of the cover 126 comprises a first boss 172 and a second boss 174, each boss 172, 174 projecting towards the outside of the housing 116.
- the first boss 172 is arranged in the vicinity of the free end of the support section 127 of the cover 126 so as to be aligned vertically with the left end of the diffusion strip 138, the second boss 174 being arranged astride the transition section 131 of the cover 126 and the support section 127 of the cover 126.
- the first boss 172 and the second boss 174 make it possible to guarantee flat maintenance along the longitudinal axis L of the diffusion strip 138 during its insertion in the portable reader 14 for analyzing a biological liquid sample, the first boss 172 and the second boss 174 being inserted in friction with a wall of the reader 14 so as to exert pressure on the diffusion strip 138.
- the first boss 172 and the second boss 174 also contribute to reinforcing the contact between the reception areas 144, 146 of the diffusion strip 138 on the reactive elements 132, 134. It will be appropriate, that depending on the length along the longitudinal axis L of the strip diffusion 138, a single boss or a plurality of bosses distributed on the upper surface of the cover 126 can also be suitable according to the invention.
- the first boss 172 and the second boss 174 make it possible to press the sampling device 112 on the base of the reader at the end of the stroke, the approach being done with play.
- a third embodiment of a sampling device 212 is shown.
- This third embodiment differs in particular from the first embodiment in that the housing 216 comprises a lateral access opening 256 arranged on the right side face of the right end 220 of the housing 216, in a manner similar to the second embodiment .
- the sampling device 212 comprises a handle 266 for handling the sampling device 212 configured to be arranged abutting against the periphery of the lateral access opening 256.
- the third embodiment differs from the second embodiment in that the handling handle 266 allows the complete insertion and extraction of the absorbent assembly 228 from the housing 216.
- the sampling device 212 comprises a removable support 276 of the absorbent assembly 228 configured to be inserted or extracted from the housing 216, the removable support 276 extending longitudinally from a first end comprising the handling handle 266 to its second end configured to be inserted into the housing 216 through the side access opening 256.
- the bottom of the housing 224 of the sampling device 212 has two opposite longitudinal walls sufficiently spaced from one another so as to form a slide 278 configured to guide the removable support 276 of the absorbent assembly 228 during its insertion in the housing 216.
- the strip 230 comprising the reactive elements 232, 234 is configured to be arranged longitudinally in the bottom of the housing 224, each of the ends of the strip 230 being configured to be held in a notch 280, 282 in the bottom of the housing 224 .
- the slide 278 and the removable support 276 of the absorbent assembly 228 may include immobilization means of the type of stop of the removable support 276, so as to keep the absorbent assembly 228 stationary when the handle 266 handling of the removable support 276 abuts against the periphery of the side access opening 256 of the housing 216.
- the face of the strip 230 not comprising any reactive elements 232, 234 is configured to be arranged to rest against the bottom of the housing 224 facing an opening 252 extending longitudinally, of a length along the longitudinal axis L slightly less than that of the strip 30 and of a width, in a direction transverse to the longitudinal axis L, slightly less than that of the strip 230, so that the strip 230 can come to rest on the periphery of the opening 252 of the housing base 224.
- the absorbent assembly 228 comprises a single absorbent element extending longitudinally and generally forming a parallelepiped element.
- the single absorbent element may be, for example non-limiting, of the reservoir blotting paper type.
- the single absorbent element acts as a diffusion band 238 and also allows the deposition of the biological liquid.
- the single absorbent element comprises a biological liquid deposition portion 237 and a diffusion band 238, the deposition portion 237 also being able to serve as a diffusion band 238.
- the removable support 276 is configured to hold the absorbent assembly 228 on its periphery so that its upper surface and its lower surface are directly accessible from above or below the support removable 276.
- the removable support 276 comprises retaining side walls 284 of the absorbent assembly 228, each retaining side wall 284 comprising edges 286 bearing on the upper surface and on the lower surface of the assembly absorbent 228.
- the portion 237 for depositing biological liquid can be as well defined on the upper or lower surface of the absorbent assembly 228 forming a single absorbent element, the diffusion band 238 being able to be identified as also being the upper surface or the lower surface of the absorbent assembly 228.
- slot-type patterns on one of the faces of the absorbent assembly 228 as illustrated on the diffusion band 38 of the first and second embodiment.
- a succession of zones reduced in thickness arranged successively along the longitudinal axis L on one face of the absorbent assembly 228 and each being separated by zones not reduced in thickness can form a diffusion band 238 in the shape of a crenel .
- the surface of the absorbent assembly 228 opposite the diffusion band 238 can therefore be defined as a deposition portion 237, the biological liquid being able to diffuse from the surface acting as a portion 237 deposited up to the surface acting as a diffusion band 238.
- the absorbent assembly 228 when the housing 216 is closed and the removable support 276 comprising the absorbent assembly 228 is entirely arranged in the housing 216, that is to say when the handle 266 abuts against the periphery of the lateral access opening 256, the absorbent assembly 228 is not in contact with the reactive elements 232, 234 of the strip 230.
- the distance d along the vertical axis V between the reactive elements 232, 324 and the surface of the absorbent assembly 228 forming the single absorbent element serving as a diffusion strip 238 may be less than a millimeter, this distance d being able to correspond to the thickness along the vertical axis V of the edges 286 of the side walls of maintaining 284 of the absorbent assembly 228.
- the sampling device 212 does not by itself allow the biological liquid to be brought into contact with the reactive elements 232, 234.
- the sampling device 212 of the third embodiment is configured so that the biological liquid only comes into contact with the reactive elements 232, 234 when this sampling device 212 is inserted into the reader 14 for analyzing a biological liquid sample.
- the cover 226 of the housing 216 comprises at its right end, in the vicinity of the lateral access opening 256, an oblique sloping portion 288 of the bevel type extending upwards from the surface of the cover 226 towards the opening of 256 side access.
- This oblique sloping portion is configured to abut against a wall of the reader 14 so as to progressively slide downwards the sampling device 212 in vertical thrust into contact with an internal stop of the analysis reader 14.
- the internal stop of the analysis reader 14 is then configured to crush the strip 230 towards the absorbent assembly 228 during the vertical downward thrust of the sampling device 12, the reactive elements 232, 234 of the strip 230 then being in compressed contact between the absorbent assembly 228 and the strip 230 arranged in direct support against an excrescence of the base of the analysis reader 14.
- the strip 230 is crushed, the two ends of the strip 230 are each ejected from their notch 280, 282 of the bottom of the housing 224 of the sampling device 212.
- a fourth embodiment of a sampling device 312 is shown.
- This fourth embodiment is a variant of the third embodiment.
- the housing 316 includes a side access opening 356 arranged on the right side face of the right end of the housing 316, similarly to the third embodiment.
- the sampling device 312 comprises a handling handle 366 allowing insertion in a longitudinal direction D1 and extraction in a direction opposite to D1 complete of the absorbent assembly 328 of the housing 316.
- the sampling device 312 comprises a removable support 376 of the absorbent assembly 328 configured to be inserted or extracted from the housing 316, the removable support 376 extending longitudinally from a first end comprising the handling handle 366 up to its second end configured to be inserted into the housing 316 through the side access opening 356.
- the housing 316 of the sampling device 312 comprises a top of the housing 324 and two longitudinal walls 323 opposite and sufficiently spaced from one another so as to form a slide 378 configured to guide the removable support 376 of the absorbent assembly 328 when it is inserted into the housing 316.
- the strip 330 comprising the reactive elements 332, 334 is configured to be arranged longitudinally at the top of the housing 324 between the two longitudinal walls 323 forming the slide 378 of the removable support 376 of the absorbent assembly 328, each of the ends of the strip 330 being configured to be held in a notch 380, 382 of the top of the housing 324.
- top of the housing or bottom of the housing of the housing of the device sampling of biological fluid can be considered equivalent, the overall orientation of the sampling device and the reader of the device being indications.
- the names simply allow an intuitive and clear description of the figures illustrating the invention. More generally, none of the overall orientations described of the sampling device is a limiting constraint on the invention.
- the slide 378 and the removable support 376 of the absorbent assembly 328 may include locking means of the removable support 376 type, so as to keep the absorbent assembly 328 stationary when the removable support 376 abuts against the periphery of the side access opening 356 of the housing 316.
- the removable support 376 comprises respectively from its first end to its second end, the handling handle 366 delimited by a guard element 377 preferably of trapezoidal shape and configured to close the opening of the reader case in which it is provided to introduce the biological sampling device 312, then a reception area 379 configured to arrange an electronic identification label 381 and forming a stop 383 of the removable support 376 against the housing 316 of the sampling device 312, and finally a support portion 385 of the absorbent assembly 328.
- the support portion 385 comprises a support tongue 329 of the absorbent assembly 328, that is to say a tongue 329 on which the absorbent assembly 328 rests, the tongue 329 of support which may include side walls 384 allowing the absorbent assembly 328 to be maintained on the tongue 329.
- the housing 316 of the sampling device 312 does not include a housing base, when the removable support 376 is inserted into the housing 316 of the device 312 of sampling, the tab 329 supporting the absorbent assembly 328 acts as the bottom of the housing of the sampling device 312.
- the face of the strip 330 not comprising any reactive elements 332, 334 is configured to be arranged to rest against the top of the housing 324 facing a plurality of openings 352, 354 high of housing 324. More particularly, in order to be able to read the change in color of the reactive elements 332, 334 arranged on the strip 330, each reactive element 332, 334 of the strip 330 is arranged, by transparency through the strip 330, facing a single opening 352 of the plurality of openings at the top of the housing 324, this single opening 352 being different from another opening 354 at the top of the housing 324 associated with another reactive element 334.
- the absorbent assembly 328 comprises a single absorbent element extending longitudinally and generally forming a parallelepiped element.
- the single absorbent element 328 can be, for example non-limiting, of the reservoir blotting paper type.
- the single absorbent element 328 acts as a diffusion band 338 and also allows the deposition of the biological liquid.
- the single absorbent element 328 comprises a biological liquid deposition portion 337 and a diffusion band 338, the deposition portion 337 serving as diffusion band 338.
- a transparent longitudinal section of the sampling device 312 and a reader 314 for analyzing a biological fluid sample according to the fourth embodiment is shown.
- the housing 316 is closed, that is to say when the removable support 376 comprising the absorbent assembly 328 is arranged abutting in the housing 316, the absorbent assembly 328 is not in contact with the reactive elements 332 , 334 of the strip 330.
- the distance d1 along the vertical axis V between the reactive elements 332, 324 and the surface of the absorbent assembly 328 serving as diffusion strip 338 can be less than a millimeter.
- the sampling device 312 does not by itself allow the biological liquid to be brought into contact with the reactive elements 332, 334.
- the sampling device 312 of the fourth embodiment is configured so that the biological liquid only comes into contact with the reactive elements 332, 334 when this sampling device 312 is inserted into the reader 314 for analyzing a biological liquid sample.
- the right end of the support tongue 329 of the absorbent assembly 328 comprises a beveled portion 357 of thickness, along the vertical axis, greater than the rest of the support tongue 329, the beveled portion comprising a downward slope towards the reception area 379 of the identification label 381.
- the beveled portion 357 is configured to abut on a first boss 315 of the sample analysis reader 314 before its complete insertion into the analysis reader 314 of sample, that is to say before the guard element 377 closes the opening of the reader box 314 for sample analysis.
- the absorbent assembly 328 is not in contact with the reactive elements 332, 334 of the strip 330.
- the opposite longitudinal walls 323 forming the slide 378 of the removable support 376 move away from each other so as to bring out the removable support 376 of the slide 378, the removable support 376 being pushed by the first boss 315 towards the reactive elements 332, 334 of the strip 330.
- sample analysis reader 314 may include a second embossment 317 configured to also raise the free end of the support tab 329 of the absorbent assembly 328 towards the reactive elements 332, 334 of the strip 330 and therefore improve the contact between the absorbent assembly 328 towards the reactive elements 332, 334 of the strip 330.
- each housing 16, 116, 216, 316 of each sampling device 12, 112, 212, 312 can also include a lug arranged on a wall of the housing 16, 116, 216, 316 of so as to form a detection stop cooperating with a position sensor of the analysis reader 14, 314, thus allowing the reader 14, 314 analysis to check the presence or non-presence of the sampling device 12, 112, 212, 312 correctly arranged in the analysis reader 14, 314.
- each housing 16, 116, 216, 316 of each sampling device 12, 112, 212, 312 can include an electronic identification label arranged for example stuck on the cover 26, 126 , 226, or according to the fourth embodiment, glued to the removable support 376, so as to guarantee traceability of each sampling device 12, 112, 212.
- the housing 216 more particularly the upper cover 226 of the housing may also include lateral guide fins 227 making it possible to facilitate the insertion of the sampling cartridge into the analysis reader 14, 314.
- the guide fins 227 are configured to be able to cooperate with guide means specific to the analysis reader 14, 314.
- the reader 14, 314 for analyzing the figure 1 may include several variants so as to be compatible with each of the embodiments.
- a non-limiting example is illustrated in figures 21, 22 and 23 .
- each reactive element 32, 132, 232, 332 is particularly suitable for optical reading by reflection of light on each reactive element 32, 132, 232, 332 through the openings 52, 152, 252, 352 of the bottom of the housing 24, 124 , 224, or the top of the housing 324 and the strip 30, 130, 230, 330 allowing detection by the reader 14, 314 for analyzing a change in color of the reactive elements 32, 132, 232, 332 and therefore allowing automatic analysis by the reader 14 of the properties of the sample of the biological liquid to be analyzed.
- the reactive elements 32, 132, 232, 332 change color on contact with urine, can for example and in a non-limiting manner, provide information relating to the monitoring of the acidity of urine via its hydrogen potential, noted pH, or the urinary density and its creatinine concentration. Uric acid concentration is also a possible monitoring factor.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
Description
La présente invention concerne un dispositif de prélèvement d'échantillon liquide biologique. Elle s'applique, en particulier, à une cartouche de prélèvement d'échantillon d'urine à des fins d'analyse de valeur de marqueur urinaire.The present invention relates to a device for collecting a biological liquid sample. It applies, in particular, to a cartridge for collecting a urine sample for the purpose of analyzing urinary marker values.
Il est courant, chez les professionnels de la santé, de pouvoir faire analyser un échantillon de liquide biologique tel que de l'urine ou encore de la salive. Il est connu d'utiliser des bandelettes équipées de quelques éléments réactifs dont la couleur peut varier au contact du liquide biologique. Après un trempage de la bandelette dans le liquide biologique, les éléments réactifs peuvent changer de couleur. Une première manière connue de lecture des couleurs et son interprétation est de détecter à l'oeil nu le changement de couleur et d'interpréter ce changement selon un tableau de correspondance des couleurs à une concentration de composée dans le liquide biologique. Une autre manière consiste à utiliser chez un professionnel de la santé, un appareillage encombrant et coûteux permettant l'analyse de la bandelette comprenant les éléments réactifs.It is common among health professionals to be able to have a sample of biological fluid such as urine or saliva analyzed. It is known to use strips equipped with a few reactive elements whose color can vary upon contact with the biological liquid. After dipping the strip in the biological fluid, the reactive elements may change color. A first known way of reading colors and its interpretation is to detect the change in color with the naked eye and to interpret this change according to a color correspondence table at a concentration of compound in the biological liquid. Another way consists of using bulky and expensive equipment for a health professional to analyze the strip comprising the reactive elements.
Il a déjà été tenté de résoudre ce problème en proposant au grand public de tremper lui-même des bandelettes équipées d'éléments réactifs dans un bocal comprenant par exemple de l'urine, et d'analyser lui-même à l'oeil nu, le changement de couleur des réactifs et d'interpréter les couleurs selon une notice fournie avec la bandelette.It has already been attempted to resolve this problem by offering the general public the opportunity to dip strips equipped with reactive elements into a jar containing, for example, urine, and to analyze it themselves with the naked eye, the change in color of the reagents and interpret the colors according to instructions provided with the strip.
Cette solution à domicile ne renseigne pas toujours de manière fiable l'utilisateur, l'utilisateur pouvant avoir du mal à discerner un changement de couleur au regard de la notice, le temps de trempage de la bandelette dans le liquide biologue n'étant pas forcément maitrisé par l'utilisateur, le temps de latence entre la fin de trempage et l'interprétation des couleurs des réactifs n'étant également pas toujours maitrisé par l'utilisateur.This home solution does not always provide reliable information to the user, the user may have difficulty discerning a change in color from the instructions, the soaking time of the strip in the biological liquid is not necessarily controlled by the user, time latency between the end of soaking and the interpretation of the colors of the reagents is also not always controlled by the user.
La présente invention vise à remédier à ces inconvénients avec une approche totalement novatrice.The present invention aims to remedy these drawbacks with a completely innovative approach.
A cet effet, selon un premier aspect, la présente invention se rapporte à. un dispositif de prélèvement d'échantillon liquide biologique destiné à pouvoir être inséré dans un lecteur portable d'analyse du liquide biologique, le dispositif de prélèvement comprenant une bandelette transparente ou translucide s'étendant selon un axe longitudinal et comportant sur sa face supérieure une pluralité d'éléments réactifs à changement de couleur agencés les uns à la suite des autres selon l'axe longitudinal ; un ensemble absorbant s'étendant selon l'axe longitudinal et comportant une portion de dépôt de liquide biologique ; une bande de diffusion du liquide biologique agencée par-dessus la pluralité d'éléments réactifs; un boîtier s'étendant selon l'axe longitudinal entre deux extrémités latérales, le boîtier comportant : un fond de boîtier, la bandelette étant agencée en fond de boîtier, la face inférieure de la bandelette étant agencée en regard du fond de boîtier, chaque élément réactif étant agencée par transparence au travers de la bandelette en vis-à-vis d'une ouverture du fond de boîtier; un couvercle supérieur agencé par-dessus la bande de diffusion, et comportant au moins un motif protubérant formant une première surface d'appui configurée pour presser la bande de diffusion au contact de la pluralité d'éléments réactifs ; une ouverture d'accès configurée pour accéder à la portion de dépôt de liquide biologiqueTo this end, according to a first aspect, the present invention relates to. a biological liquid sample collection device intended to be able to be inserted into a portable biological liquid analysis reader, the collection device comprising a transparent or translucent strip extending along a longitudinal axis and comprising on its upper face a plurality reactive color-changing elements arranged one after the other along the longitudinal axis; an absorbent assembly extending along the longitudinal axis and comprising a biological liquid deposition portion; a biological liquid diffusion band arranged over the plurality of reactive elements; a housing extending along the longitudinal axis between two lateral ends, the housing comprising: a housing bottom, the strip being arranged at the bottom of the housing, the lower face of the strip being arranged facing the housing bottom, each element reagent being arranged transparently through the strip facing an opening in the bottom of the housing; an upper cover arranged over the diffusion strip, and comprising at least one protruding pattern forming a first bearing surface configured to press the diffusion strip into contact with the plurality of reactive elements; an access opening configured to access the biological liquid deposition portion
L'invention est mise en oeuvre selon les modes de réalisation et les variantes exposées ci-après, lesquelles sont à considérer individuellement ou selon toute combinaison techniquement opérante.The invention is implemented according to the embodiments and the variants set out below, which are to be considered individually or according to any technically effective combination.
Avantageusement, la portion de dépôt de liquide biologique peut être agencée au travers de l'ouverture d'accès. L'ensemble absorbant peut-être un unique papier buvard.Advantageously, the biological liquid deposit portion can be arranged through the access opening. The absorbent set can be a single blotting paper.
Avantageusement, la portion de dépôt de liquide biologique peut comporter une bande absorbante réservoir distincte de la bande de diffusion ; le boîtier pouvant comporter une seconde surface d'appui configurée pour presser au moins une portion de contact de la bande absorbante réservoir) au contact d'une plage de contact de la bande de diffusion.Advantageously, the biological liquid deposition portion may include an absorbent reservoir band distinct from the diffusion band; The box which may include a second support surface configured to press at least one contact portion of the absorbent reservoir strip) into contact with a contact pad of the diffusion strip.
Avantageusement, la bande absorbante réservoir et la bande de diffusion peuvent être agencées globalement longitudinalement l'une à la suite de l'autre, la bande réservoir pouvant être configurée mobile en translation selon l'axe longitudinal ; la portion de contact peut être agencée en extrémité de la bande absorbante réservoir; la portion de contact pouvant être configurée pour heurter la seconde surface d'appui par poussée selon l'axe longitudinal de la bande absorbante réservoir de sorte à être mise en contact avec la plage de contact de la bande de diffusion.Advantageously, the absorbent reservoir strip and the diffusion strip can be arranged generally longitudinally one after the other, the reservoir strip can be configured to move in translation along the longitudinal axis; the contact portion can be arranged at the end of the absorbent tank strip; the contact portion can be configured to strike the second support surface by pushing along the longitudinal axis of the absorbent reservoir strip so as to be brought into contact with the contact pad of the diffusion strip.
Avantageusement, la bande de diffusion et la bande absorbante réservoir peuvent comprendre respectivement un papier buvard de diffusion et un papier buvard réservoir distinct du papier buvard de diffusion, le papier buvard réservoir comprenant une caractéristique d'absorption de liquide supérieure à celle du papier buvard de diffusion.Advantageously, the diffusion strip and the absorbent reservoir strip may respectively comprise a diffusion blotting paper and a reservoir blotting paper distinct from the diffusion blotting paper, the reservoir blotting paper comprising a liquid absorption characteristic greater than that of the blotting paper of diffusion.
Avantageusement, la bande de diffusion peut comporter une pluralité de plages d'accueil agencées de manière successive selon l'axe longitudinal, chaque élément réactif étant agencé sous une seule plage d'accueil, la bande de diffusion pouvant comporter un évidement de matière entre chacune des plages d'accueil.Advantageously, the diffusion strip may comprise a plurality of reception areas arranged successively along the longitudinal axis, each reactive element being arranged under a single reception area, the diffusion strip may include a recess of material between each reception beaches.
Avantageusement, l'ouverture d'accès peut être agencée sur une des extrémités latérales du boîtier. Le boîtier peut comporter deux parois longitudinales opposées interne au boîtier formant une glissière coopérant avec un support amovible de l'ensemble absorbant, le support amovible étant configuré pour être inséré dans le boîtier à travers l'ouverture d'accès.Advantageously, the access opening can be arranged on one of the side ends of the housing. The housing may comprise two opposite longitudinal walls internal to the housing forming a slide cooperating with a removable support of the absorbent assembly, the removable support being configured to be inserted into the housing through the access opening.
Alternativement, l'ouverture d'accès peut être agencée sur le couvercle du boîtier ou sur le fond de boîtier.Alternatively, the access opening can be arranged on the cover of the housing or on the bottom of the housing.
D'autres avantages, buts et caractéristiques de la présente invention ressortent de la description qui suit faite, dans un but explicatif et nullement limitatif, en regard des dessins annexés, dans lesquels :
- [
Fig. 1 ] lafigure 1 est une vue schématique en perspective d'un système d'analyse d'échantillon liquide biologique comportant un dispositif de prélèvement d'échantillon liquide biologique selon un premier mode de réalisation de l'invention, et un lecteur d'analyse de l'échantillon du liquide biologique prélevé par le dispositif. - [
Fig. 2 ] lafigure 2 est une vue schématique éclatée en perspective de dessus du dispositif de prélèvement d'échantillon liquide biologique selon le premier mode de réalisation de l'invention. - [
Fig. 3 ] lafigure 3 est une vue schématique éclatée en perspective de dessous du dispositif de prélèvement d'échantillon liquide biologique selon le premier mode de réalisation de l'invention. - [
Fig. 4 ] lafigure 4 est une vue schématique en perspective de dessus d'un dispositif de prélèvement d'échantillon liquide biologique selon un second mode de réalisation de l'invention et selon un premier positionnement de la portion de dépôt de liquide biologique. - [
Fig. 5 ] lafigure 5 est une vue schématique éclatée en perspective du dispositif de lafigure 4 . - [
Fig. 6 ] lafigure 6 est une vue schématique éclatée en perspective de dessous du dispositif de lafigure 4 . - [
Fig. 7 ] lafigure 7 est une vue schématique en perspective de dessus par transparence du dispositif de lafigure 4 . - [
Fig. 8 ] lafigure 8 est une vue schématique en coupe longitudinale du dispositif de lafigure 4 . - [
Fig. 9 ] lafigure 9 est une vue schématique en perspective de dessus du dispositif de prélèvement d'échantillon liquide biologique selon le second mode de réalisation de l'invention et selon un second positionnement de la portion de dépôt de liquide biologique. - [
Fig. 10 ] lafigure 10 est une vue schématique en perspective de dessus par transparence du dispositif de lafigure 9 . - [
Fig. 11 ] lafigure 11 est une vue schématique en coupe longitudinale du dispositif de lafigure 9 . - [
Fig. 12 ] lafigure 12 est une vue schématique en perspective de dessus d'un dispositif de prélèvement d'échantillon liquide biologique selon un troisième mode de réalisation de l'invention. - [
Fig. 13 ] lafigure 13 est une vue schématique en perspective de dessus d'un dispositif de prélèvement de lafigure 12 selon laquelle la portion de dépôt de liquide biologique est extraite du boîtier du dispositif. - [
Fig. 14 ] lafigure 14 est une vue schématique éclatée en perspective de dessus du dispositif de prélèvement de lafigure 13 . - [
Fig. 15 ] lafigure 15 est une vue schématique éclatée en perspective de dessus du fond de boîtier et d'une bandelette comportant les éléments réactifs de lafigure 14 . - [
Fig. 16 ] lafigure 16 est une vue schématique en coupe longitudinale du dispositif de lafigure 12 . - [
Fig. 17 ] lafigure 17 est un agrandissement d'une portion de lafigure 16 . - [
Fig. 18 ] lafigure 18 est une vue schématique en perspective de dessus d'un dispositif de prélèvement d'échantillon liquide biologique selon un quatrième mode de réalisation de l'invention. - [
Fig. 19 ] lafigure 19 est une vue schématique en perspective de dessus d'un dispositif de prélèvement de lafigure 18 selon laquelle la portion de dépôt de liquide biologique est extraite du boîtier du dispositif. - [
Fig. 20 ] lafigure 20 est une vue schématique éclatée en perspective de dessus du dispositif de prélèvement de lafigure 19 . - [
Fig. 21 ] lafigure 21 est une vue schématique en perspective d'un système d'analyse d'échantillon liquide biologique selon le quatrième mode de réalisation comportant un lecteur d'analyse de l'échantillon du liquide biologique et le dispositif de prélèvement d'échantillon liquide biologique non inséré dans le lecteur d'analyse. - [
Fig. 22 ] lafigure 22 est une vue schématique en perspective du système de lafigure 21 selon laquelle le dispositif de prélèvement d'échantillon liquide biologique est inséré selon une première poussée dans le lecteur d'analyse de l'échantillon du liquide biologique. - [
Fig. 23 ] lafigure 23 est une vue schématique en perspective du système de lafigure 21 selon laquelle le dispositif de prélèvement d'échantillon liquide biologique est inséré selon une seconde poussée dans le lecteur d'analyse de l'échantillon du liquide biologique.
- [
Fig. 1 ] therefigure 1 is a schematic perspective view of a biological liquid sample analysis system comprising a biological liquid sample collection device according to a first embodiment of the invention, and a reader for analyzing the sample of the biological fluid collected by the device. - [
Fig. 2 ] therefigure 2 is a schematic exploded perspective view from above of the biological liquid sample collection device according to the first embodiment of the invention. - [
Fig. 3 ] thereFigure 3 is a schematic exploded perspective view from below of the biological liquid sample collection device according to the first embodiment of the invention. - [
Fig. 4 ] therefigure 4 is a schematic perspective view from above of a biological liquid sample collection device according to a second embodiment of the invention and according to a first positioning of the biological liquid deposition portion. - [
Fig. 5 ] therefigure 5 is an exploded schematic perspective view of the device of thefigure 4 . - [
Fig. 6 ] thereFigure 6 is a schematic exploded perspective view from below of the device of thefigure 4 . - [
Fig. 7 ] thereFigure 7 is a schematic perspective view from above through transparency of the device of theFigure 4 . - [
Fig. 8 ] therefigure 8 is a schematic view in longitudinal section of the device of theFigure 4 . - [
Fig. 9 ] thereFigure 9 is a schematic perspective view from above of the biological liquid sample collection device according to the second embodiment of the invention and according to a second positioning of the biological liquid deposition portion. - [
Fig. 10 ] thereFigure 10 is a schematic perspective view from above through transparency of the device of theFigure 9 . - [
Fig. 11 ] thereFigure 11 is a schematic view in longitudinal section of the device of theFigure 9 . - [
Fig. 12 ] thereFigure 12 is a schematic perspective view from above of a biological liquid sample collection device according to a third embodiment of the invention. - [
Fig. 13 ] thereFigure 13 is a schematic perspective view from above of a device for sampling theFigure 12 according to which the biological liquid deposit portion is extracted from the housing of the device. - [
Fig. 14 ] thereFigure 14 is a schematic exploded perspective view from above of the device for sampling theFigure 13 . - [
Fig. 15 ] thereFigure 15 is a schematic exploded perspective view from above of the housing base and a strip comprising the reactive elements of theFigure 14 . - [
Fig. 16 ] thereFigure 16 is a schematic view in longitudinal section of the device of theFigure 12 . - [
Fig. 17 ] thereFigure 17 is an enlargement of a portion of theFigure 16 . - [
Fig. 18 ] thereFigure 18 is a schematic top perspective view of a biological liquid sample collection device according to a fourth embodiment of the invention. - [
Fig. 19 ] thereFigure 19 is a schematic perspective view from above of a device for sampling theFigure 18 according to which the biological liquid deposit portion is extracted from the housing of the device. - [
Fig. 20 ] thereFigure 20 is a schematic exploded perspective view from above of the device for sampling theFigure 19 . - [
Fig. 21 ] thereFigure 21 is a schematic perspective view of a biological liquid sample analysis system according to the fourth embodiment comprising a biological liquid sample analysis reader and the biological liquid sample collection device not inserted in the analysis reader. - [
Fig. 22 ] thereFigure 22 is a schematic perspective view of the system of theFigure 21 according to which the biological liquid sample collection device is inserted with a first push into the reader for analyzing the biological liquid sample. - [
Fig. 23 ] thereFigure 23 is a schematic perspective view of the system of theFigure 21 according to which the liquid sample collection device biological fluid is inserted with a second push into the reader for analyzing the biological fluid sample.
Selon la
Selon la
L'ensemble absorbant 28, tel un papier absorbant capable d'absorber un liquide, a pour rôle de recevoir le liquide biologique et de le diffuser au contact des éléments réactifs 32, 34. A cet effet, selon ce premier mode de réalisation, l'ensemble absorbant 28 comporte une bande absorbante réservoir 36 prévue pour le dépôt de liquide biologique, et une bande de diffusion 38 configurée pour diffuser par capillarité le liquide biologique préalablement déposé sur la bande absorbante réservoir 36 sur le éléments réactifs 32, 34 de la bandelette 30. La bande absorbante réservoir 36 comprend donc au moins une portion configurée pour être en contact avec la bande de diffusion 38.The
À cet effet, de préférence, la bande de diffusion 38 et la bande absorbante réservoir 36 comprennent respectivement un papier buvard de diffusion et un papier buvard réservoir distinct du papier buvard de diffusion, le papier buvard réservoir comprenant une caractéristique d'absorption de liquide supérieure à celle du papier buvard de diffusion. Le papier buvard réservoir doit permettre une absorption d'une quantité de liquide biologique nécessaire pour l'analyse, et également permettre un transfert rapide du liquide biologique vers le papier buvard de diffusion. À titre d'exemple non limitatif, il a été constaté qu'un papier buvard réservoir d'une épaisseur entre 2 et 3 millimètres, et de caractéristique d'absorption de liquide comprise entre 200 et 300 milligrammes de liquide par centimètre carré pouvait convenir au dispositif 12 de prélèvement, ce type de papier buvard réservoir comprenant une vitesse d'avancée du liquide comprise entre 3 et 5 cm pour un temps de dix secondes. Il a également été constaté qu'un papier buvard de diffusion comprenant une épaisseur inférieure au millimètre, de préférence comprise entre 0.2 et 0.6 millimètre, et une capacité d'absorption comprise entre 20 et 40 milligrammes de liquide par centimètre carré pouvait convenir au dispositif 12 de prélèvement, ce type de papier buvard de diffusion comprenant une vitesse d'avancée du liquide comprise entre 0.5 et 1.5 cm pour un temps de 10 secondes.For this purpose, preferably, the
Selon le premier mode de réalisation de la
La bandelette 30 est agencée en dessous de la bande de diffusion 38. Plus particulièrement, la face supérieure de la bandelette 30, équipée de la pluralité d'éléments réactifs 32, 34 fait face à la face inférieure de la bande diffusion 38 de sorte que la bande de diffusion 38 puisse venir en appui sur les éléments réactifs 32, 34, permettant une réaction des éléments réactifs 32, 34 au contact du liquide biologique diffusé par capillarité au travers de la bande de diffusion 38.The
Selon le premier mode de réalisation représenté à la
De préférence et telle que représenté à la
Ce mode de réalisation permet au liquide biologique de diffuser le long de l'autre bordure longitudinale de la bande de diffusion 38, cette autre bordure étant opposée à la bordure formant les créneaux. À cet effet, le liquide biologique peut venir imprégner les plages d'accueils 44, 46 de manière successive et progressive les unes après les autres.This embodiment allows the biological liquid to diffuse along the other longitudinal edge of the
Selon la
Selon le premier mode de réalisation de la
Afin de pouvoir maintenir la bandelette 30 fixe contre des mouvements latéraux, la bandelette 30 est configurée pour être agencée entre une première paroi latérale 51 d'une première bordure du fond de boîtier 24 s'étendant longitudinalement, et des pions de butée 53 latérale de la bandelette 30 agencés sur le fond de boîtier 24. Afin de pouvoir maintenir la bandelette 30 fixe contre des mouvements de translation selon l'axe longitudinal L, la bandelette 30 est configurée pour être agencée entre une paroi transversale 55 de l'extrémité gauche du fond de boîtier 24 et une autre paroi transversale 57, opposée à la paroi transversale 55 de l'extrémité gauche du fond de boîtier 24, agencée sur le fond de boîtier 24. Il est à noter que la bandelette 30 permet notamment de maintenir les éléments réactifs 32, 34 fixe dans le boîtier 16, et de protéger les éléments réactifs 32, 34 contre des impuretés hors du boîtier 16In order to be able to keep the
Selon la
Selon la
Selon la
Selon la
Selon le premier mode de réalisation de la
Lorsque le boîtier 16 est fermé, les languettes 60 d'appuis longitudinales exercent une pression sur la bande de diffusion 38 vers le fond de boîtier 24. De plus, lorsque le boîtier 16 est fermé, les plots d'appuis 62 exercent une force d'appui sur de la bande de diffusion 38, permettant un contact en appui des plages d'accueil 44, 46 contre les éléments réactifs 32, 34. La force d'appui exercée par les languettes 60 d'appuis longitudinales associée à la force d'appui exercée par les plots d'appuis 62 sur la bande de diffusion 38, permet un contact en appui fiable et durable des plages d'accueil 44, 46 contre les éléments réactifs 32, 34, permettant ainsi, en cas de présence de liquide biologique sur la bande de diffusion 38, une réaction fiable des éléments réactifs 32, 34 avec le liquide biologique pouvant se traduire par un changement de couleur des éléments réactifs 32, 34.When the
Selon le premier mode de réalisation du dispositif 12 de prélèvement de la
Selon la
Plus particulièrement et selon la
La bague 170 de guidage est agencée solidaire avec la portion de guidage 168 de la bande absorbante réservoir 136. La bague 170 de guidage coopère avec des rails de guidage s'étendant à l'intérieur du boîtier 116 depuis l'ouverture d'accès latérale 156. La bague 170 de guidage est configurée pour s'étendre simultanément à l'intérieur du boîtier 116 de sorte à être partiellement agencée sur ses rails de guidage et également partiellement à l'extérieur du boîtier 116 de sorte à former une première butée d'arrêt pour le capuchon 166 lorsque ce dernier est agencé en translation sur la portion 137 de dépôt.The
Plus particulièrement, la bague de guidage 170 comporte un élément supérieur et un élément inférieur comprenant respectivement un élément male tel un tenon et un élément femelle, la portion de guidage 168 en translation de la bande absorbante réservoir 136 comportant une ouverture de fixation 171 permettant le passage de l'élément femelle de l'élément inférieur au travers de la bande absorbante réservoir 136 afin de permettre l'accouplement des deux éléments de la bague de guidage 170. La bague de guidage 170 est configurée pour maintenir la portion de guidage 168 lors d'une translation de la bande absorbante réservoir 136.More particularly, the
Le couvercle 126 du boîtier comporte une section d'appui 127 agencée par-dessus les plages d'accueil 144, 146 de la bande de diffusion 138 et configurée pour venir en appui sur les plages d'accueil 144, 146 de la bande de diffusion 138 lors de la fermeture du boîtier 116 pour une mise en contact des plages d'accueil 144, 146 avec les éléments réactifs 132, 134. Le couvercle 126 du boîtier comporte une section de coulissement 129 agencée surélevée au regard de la section d'appui 127 et configurée pour le coulissement en translation de la bague 170 de guidage, les rails de guidages étant agencés dans cette section de coulissement 129. Le couvercle 126 comprend une section de transition 131 pentue reliant la section d'appui 127 et la section de coulissement 129. La plage de contact 142 de l'extrémité de la bande de diffusion 138 est agencée au moins partiellement sous la section de transition du couvercle 126.The
Selon la
Selon la
De façon optionnelle, la section de coulissement 129 peut comprendre un moyen d'immobilisation de type cran d'arrêt de la bague 170 de guidage, le moyen d'immobilisation étant configuré pour immobiliser la bague 170 de guidage lorsqu'elle est enfoncée par le capuchon 166 en position d'arrêt contre la seconde butée d'arrêt. Le moyen d'immobilisation peut avantageusement n'être qu'opérationnel que jusqu'à une certaine force d'extraction exercée sur le capuchon 166 ou directement sur la portion 137 de dépôt. À titre d'exemple non limitatif, le moyen d'immobilisation peut comprendre au moins un bossage sur un rail de guidage de sorte que la bague 170 de guidage doit être insérée avec une force adéquate pour passer outre ce bossage. Ce bossage peut générer un rendu tactile de confirmation d'insertion effective de la bande absorbante réservoir 136 dans le dispositif 112de prélèvement de sorte à s'assurer de la mise en contact de la portion de contact 140 de la bande absorbante réservoir 136 avec la plage de contact 142 de la bande de diffusion 138.Optionally, the sliding
Selon la
Selon la
Selon la
Selon la
Selon la
De façon optionnelle, la glissière 278 et le support amovible 276 de l'ensemble absorbant 228 peuvent comprendre des moyens d'immobilisations de type cran d'arrêt du support amovible 276, de sorte à maintenir immobile l'ensemble absorbant 228 lorsque la poignée 266 de manipulation du support amovible 276 est en butée contre le pourtour de l'ouverture 256 d'accès latérale du boîtier 216.Optionally, the
La face de la bandelette 230 ne comprenant aucun éléments réactifs 232, 234 est configurée pour être agencée en appui contre le fond de boîtier 224 en regard d'une ouverture 252 s'étendant longitudinalement, d'une longueur selon l'axe longitudinal L légèrement inférieure à celle de la bandelette 30 et d'une largeur, selon une direction transversale à l'axe longitudinal L, légèrement inférieure à celle de la bandelette 230, de sorte que la bandelette 230 puisse venir en appui sur le pourtour de l'ouverture 252 du fond de boîtier 224.The face of the
Selon la
Selon la
De façon optionnelle, il est possible de former sur une des faces de l'ensemble absorbant 228 des motifs de type créneaux tel qu'illustrés sur la bande de diffusion 38 du premier et du second mode de réalisation. À cet effet, une succession de zones réduites en épaisseur agencées successivement selon l'axe longitudinal L sur une face de l'ensemble absorbant 228 et étant chacune séparée par des zones non réduites en épaisseur peuvent former une bande de diffusion 238 en forme de créneau. La surface de l'ensemble absorbant 228 opposée à la bande de diffusion 238 pouvant donc être défini comme portion 237 de dépôt, le liquide biologique pouvant diffuser depuis la surface faisant office de portion 237 dépôt jusqu'à la surface faisant office de bande de diffusion 238.Optionally, it is possible to form slot-type patterns on one of the faces of the
Selon la
A cet effet, par conséquent, le dispositif 212 de prélèvement ne permet pas à lui seul une mise en contact du liquide biologique avec les éléments réactifs 232, 234. Le dispositif 212 de prélèvement du troisième mode de réalisation est configuré pour que le liquide biologique n'arrive au contact des éléments réactifs 232, 234 que lorsque ce dispositif 212 de prélèvement est inséré dans le lecteur 14 d'analyse d'échantillon de liquide biologique.For this purpose, consequently, the
A cet effet, selon la
Selon les
Selon la
De façon optionnelle, la glissière 378 et le support amovible 376 de l'ensemble absorbant 328 peuvent comprendre des moyens d'immobilisations de type cran d'arrêt du support amovible 376, de sorte à maintenir immobile l'ensemble absorbant 328 lorsque le support amovible 376 est en butée contre le pourtour de l'ouverture 356 d'accès latérale du boîtier 316.Optionally, the
Le support amovible 376 comprend respectivement depuis sa première extrémité jusqu'à sa seconde extrémité, la poignée 366 de manipulation délimitée par un élément de garde 377 de préférence de forme trapézoïdale et configuré pour obturer l'ouverture du boitier de lecteur dans laquelle il est prévu d'introduire le dispositif 312 de prélèvement biologique, puis une plage d'accueil 379 configurée pour y agencer une étiquette électronique d'identification 381 et formant une butée 383 du support amovible 376 contre le boîtier 316 du dispositif 312 de prélèvement, et finalement une portion 385 de support de l'ensemble absorbant 328. La portion 385 de support comporte une languette 329 de support de l'ensemble absorbant 328, c'est à dire une languette 329 sur laquelle repose l'ensemble absorbant 328, la languette 329 de support pouvant comprendre des parois latérales 384 permettant le maintien de l'ensemble absorbant 328 sur la languette 329. Le boîtier 316 du dispositif 312 de prélèvement ne comprenant pas de fond de boîtier, lorsque le support amovible 376 est inséré dans le boîtier 316 du dispositif 312 de prélèvement, la languette 329 de support de l'ensemble absorbant 328 fait office de fond de boîtier du dispositif 312 de prélèvement.The
De manière comparable au troisième mode de réalisation, la face de la bandelette 330 ne comprenant aucun éléments réactifs 332, 334 est configurée pour être agencée en appui contre le haut de boîtier 324 en regard d'une pluralité d'ouvertures 352, 354 de haut de boîtier 324. Plus particulièrement, afin de pouvoir effectuer une lecture du changement de couleur des éléments réactifs 332, 334 agencés sur la bandelette 330, chaque élément réactif 332, 334 de la bandelette 330 est agencé, par transparence au travers de la bandelette 330, en vis-à-vis d'une seule ouverture 352 de la pluralité d'ouvertures de haut de boîtier 324, cette seule ouverture 352 étant différente d'une autre ouverture 354 de haut de boîtier 324 associée à un autre élément réactif 334.Comparably to the third embodiment, the face of the
Selon la
Selon la
A cet effet, par conséquent, le dispositif 312 de prélèvement ne permet pas à lui seul une mise en contact du liquide biologique avec les éléments réactifs 332, 334. Le dispositif 312 de prélèvement du quatrième mode de réalisation est configuré pour que le liquide biologique n'arrive au contact des éléments réactifs 332, 334 que lorsque ce dispositif 312 de prélèvement est inséré dans le lecteur 314 d'analyse d'échantillon de liquide biologique.For this purpose, consequently, the
A cet effet, selon la
Selon la
Selon la
Il est à noter que le lecteur 314 d'analyse d'échantillon peut comporter un second bosselage 317 configuré pour surélever également l'extrémité libre de la languette 329 de support de l'ensemble absorbant 328 vers les éléments réactifs 332, 334 de la bandelette 330 et donc améliorer le contact entre l'ensemble absorbant 328 vers les éléments réactifs 332, 334 de la bandelette 330.It should be noted that the
De manière commune aux quatre modes de réalisation décrits, chaque boîtier 16, 116, 216, 316 de chaque dispositif 12, 112, 212, 312 de prélèvement peut comprendre également un ergot agencé sur une paroi du boîtier 16, 116, 216, 316 de sorte à former une butée de détection coopérant avec un capteur de position du lecteur 14, 314 d'analyse, permettant ainsi au lecteur 14, 314 d'analyse de contrôler la présence ou la non présence du dispositif 12, 112, 212, 312 de prélèvement correctement agencé dans le lecteur 14, 314 d'analyse.In a manner common to the four embodiments described, each
Également de manière commune aux quatre modes de réalisation décrits, chaque boîtier 16, 116, 216, 316 de chaque dispositif 12, 112, 212, 312 de prélèvement peut comprendre une étiquette électronique d'identification agencée par exemple collée sur le couvercle 26, 126, 226, ou encore selon la quatrième mode de réalisation, collée sur le support amovible 376, de sorte à garantir une traçabilité de chaque dispositif 12, 112, 212 de prélèvement.Also common to the four embodiments described, each
Également de manière commune aux quatre modes de réalisation décrits, tel qu'illustré aux
Il est à noter que selon les quatre modes de réalisations décrits des dispositifs 12, 112, 212, 312 de prélèvement, le lecteur 14, 314 d'analyse de la
Il est à noter que les quatre modes de réalisation décrits conviennent particulièrement à une lecture optique par réflexion de lumière sur chaque élément réactif 32, 132, 232, 332 au travers des ouvertures 52, 152, 252, 352 de fond de boîtier 24, 124, 224, ou de haut de boîtier 324 et de la bandelette 30, 130, 230, 330 permettant la détection par le lecteur 14, 314 d'analyse d'un changement de couleur des éléments réactifs 32, 132, 232, 332 et donc permettant l'analyse automatique par le lecteur 14 des propriétés de l'échantillon du liquide biologique à analyser.It should be noted that the four embodiments described are particularly suitable for optical reading by reflection of light on each
Il est à noter que l'invention est particulièrement avantageuse pour l'analyse de liquide biologique de type urine. Les éléments réactifs 32, 132, 232, 332 à changement de couleur au contact de l'urine, peuvent par exemple et de manière non limitative, donner une information relative à la surveillance de l'acidité de l'urine via son potentiel hydrogène, noté pH, ou encore la densité urinaire et sa concentration en créatinine. La concentration en acide urique est également un facteur de surveillance possible.It should be noted that the invention is particularly advantageous for the analysis of biological fluid such as urine. The
Claims (10)
- Device (12, 112, 212, 312) for taking a biological liquid sample intended to be able to be inserted into a portable reader (14, 314) for analysing the biological liquid, the sampling device (12, 112, 212, 312) comprising:- a transparent or translucent strip (30, 130, 230, 330) extending along a longitudinal axis (L) and comprising, on its upper face thereof, a plurality of colour-changing reactive elements (32, 132, 232, 332) which are arranged one after the other along the longitudinal axis (L);- an absorbent assembly (28; 128, 228, 328) extending along the longitudinal axis (L) and comprisingo a biological liquid deposition portion (37, 137, 237, 337);o a biological liquid diffusion band (38, 138, 238, 338) arranged over the plurality of reactive elements (32, 132, 232, 332);- a housing (16, 116, 216, 316) extending along the longitudinal axis (L) between two lateral ends, the housing (16, 116, 216) comprising:o a housing bottom (24, 124, 224, 324), the strip (30, 130, 230, 330) being arranged in the housing bottom (24, 124, 224, 324), the lower face of the strip (30, 130, 230, 330) being arranged opposite the housing bottom (24, 124, 224, 324), each reactive element (32, 132, 232, 332) being arranged by transparency through the strip (30, 130, 230, 330) facing an opening (52, 152, 252, 352) of the housing bottom (24, 124, 224, 324);o an upper cover (26, 126, 226, 326) arranged over the diffusion band (38, 138, 238), and comprising at least one protruding pattern (60, 172, 288) forming a first bearing surface configured to press the diffusion band (38, 138, 238, 338) into contact with the plurality of reactive elements (32, 132, 232, 332);o an access opening (56, 156, 256, 356) configured to provide access the biological liquid deposition portion (37, 137, 237, 337).
- Device (12, 112, 212, 312) according to claim 1, characterised in that the biological liquid deposition portion (37, 137, 237, 337) is arranged through the access opening (56, 156, 256, 356).
- Device (212, 312) according to any one of the preceding claims, characterised in that the absorbent assembly (228) is a single blotting paper.
- Device (12, 112) according to any one of claims 1 or 2, characterised in that- the biological liquid deposition portion (37, 137) comprises an absorbent reservoir band (36, 136) which is distinct from the diffusion band (38, 138);- the housing (16, 216) comprises a second bearing surface (64, 131) configured to press at least one contact portion (40, 140) of the absorbent reservoir band (36, 136) into contact with a contact pad (42, 142) of the diffusion band (38, 138).
- Device (112) according to claim 4, characterised in that- the absorbent reservoir band (136) and the diffusion band (138) are arranged generally longitudinally one after the other, the reservoir band (136) being configured to be movable in translation along the longitudinal axis (L),- the contact portion (140) is arranged at the end of the absorbent reservoir band (136); the contact portion (140) being configured to hit the second bearing surface (131) by pushing, along the longitudinal axis (L), of the absorbent reservoir band (136) so as to be brought into contact with the contact pad (142) of the diffusion band (138).
- Device (12, 112) according to any one of claims 4 or 5, characterised in that- the diffusion band (38, 138) and the absorbent reservoir band (36, 136) respectively comprise a diffusion blotting paper and a reservoir blotting paper which is distinct from the diffusion blotting paper, the reservoir blotting paper comprising a liquid absorption feature greater than that of the diffusion blotting paper.
- Device (12, 112, 212) according to any one of the preceding claims, characterised in that- the diffusion band (38, 138, 238) comprises a plurality of receiving pads (44, 144) arranged successively along the longitudinal axis (L), each reactive element (32, 132, 232) being arranged under a single receiving pad (44, 144), the diffusion band (38, 138, 238) comprising a material recess between each of the receiving pads (44, 144).
- Device (112, 212) according to any one of the preceding claims, characterised in that- the access opening (156, 256) is arranged on one of the lateral ends (220) of the housing (116, 216).
- Device (212) according to claim 8, characterised in that the housing (216) comprises two opposite longitudinal walls inside the housing (216) forming a guideway (278) cooperating with a removable support (276) of the absorbent assembly (228), the removable support (276) being configured to be inserted into the housing (224) through the access opening (256).
- Device (12) according to any one of the preceding claims 1 to 7, characterised in that- the access opening (56) is arranged on the cover (26) of the housing or on the housing bottom (24).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1910242A FR3100889B1 (en) | 2019-09-17 | 2019-09-17 | Biological fluid sample collection device |
PCT/EP2020/075812 WO2021052984A1 (en) | 2019-09-17 | 2020-09-16 | Device for taking a sample of biological liquid |
Publications (4)
Publication Number | Publication Date |
---|---|
EP4031867A1 EP4031867A1 (en) | 2022-07-27 |
EP4031867C0 EP4031867C0 (en) | 2023-11-08 |
EP4031867B1 true EP4031867B1 (en) | 2023-11-08 |
EP4031867B8 EP4031867B8 (en) | 2023-12-13 |
Family
ID=68425143
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP20771859.4A Active EP4031867B8 (en) | 2019-09-17 | 2020-09-16 | Device for taking a sample of biological liquid |
Country Status (5)
Country | Link |
---|---|
US (1) | US20220280934A1 (en) |
EP (1) | EP4031867B8 (en) |
JP (1) | JP7514915B2 (en) |
FR (1) | FR3100889B1 (en) |
WO (1) | WO2021052984A1 (en) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6566051B1 (en) * | 1999-01-15 | 2003-05-20 | Medtox Scientific, Inc. | Lateral flow test strip |
US6844149B2 (en) | 2001-06-29 | 2005-01-18 | International Business Machines Corporation | Method, system, and apparatus for measurement and recording of blood chemistry and other physiological measurements |
WO2005031351A1 (en) * | 2003-09-23 | 2005-04-07 | Oakville Hong Kong Co., Limited | Lateral flow assay devices and methods of use |
KR101816520B1 (en) | 2015-12-29 | 2018-01-10 | 광주과학기술원 | Chip structure for multiple molecular diagonosis |
-
2019
- 2019-09-17 FR FR1910242A patent/FR3100889B1/en active Active
-
2020
- 2020-09-16 EP EP20771859.4A patent/EP4031867B8/en active Active
- 2020-09-16 US US17/637,062 patent/US20220280934A1/en active Pending
- 2020-09-16 JP JP2022516401A patent/JP7514915B2/en active Active
- 2020-09-16 WO PCT/EP2020/075812 patent/WO2021052984A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2022548097A (en) | 2022-11-16 |
EP4031867B8 (en) | 2023-12-13 |
US20220280934A1 (en) | 2022-09-08 |
FR3100889A1 (en) | 2021-03-19 |
EP4031867C0 (en) | 2023-11-08 |
EP4031867A1 (en) | 2022-07-27 |
FR3100889B1 (en) | 2021-09-10 |
WO2021052984A1 (en) | 2021-03-25 |
JP7514915B2 (en) | 2024-07-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1954159B1 (en) | Protective case for credit card or the like | |
FR2778080A1 (en) | METHOD, DEVICE AND KIT FOR MONITORING THE MAXIMUM FERTILITY MOMENT IN THE MAMMAL'S OVULATION CYCLE | |
EP0959343A1 (en) | Optical sensor utilizing an immunological reaction and a fluorescence marker | |
AU2002253388A1 (en) | Assay system | |
US20120037521A1 (en) | Easy strip access primary container and methods of manufacturing and utilization thereof | |
CH632915A5 (en) | CONSERVATION AND SERVICE CONTAINER. | |
EP0557403B1 (en) | Reaction segment for an automatic sample analyzer | |
EP2764363B1 (en) | Assembly for determining the presence or absence of an analyte in a blood sample and analysis unit comprising such an assembly | |
EP3372313A2 (en) | Tray for storing sample plates, cabinet for storing same and device for identifying said plates | |
EP4031867B1 (en) | Device for taking a sample of biological liquid | |
FR3100890A1 (en) | Portable body fluid sample analysis method and reader | |
EP1253978A2 (en) | Cuvettes, automated biological analysis apparatus using such cuvettes, means for transferring said cuvettes in such an apparatus and transfer method | |
EP3264984B1 (en) | Device for collecting a liquid sample by capillary action | |
EP1870160A1 (en) | Package for body secretion collecting tool | |
CA2162486A1 (en) | Applicator device for a flat microorganism collecting element such as a petri dish | |
EP3423840B1 (en) | Automatic analysing system for in vitro diagnostics | |
WO2017006037A1 (en) | Apparatus for analysing a liquid sample including a locking and withdrawal device | |
EP3314263B1 (en) | Lateral flow device comprising sampling | |
FR2934506A1 (en) | Liquid reagent product containing container for cartridge of analyzing assembly in analyzing apparatus, has closure plug whose bottom wall closes end of skirt, where wall has slot permitting passage of probe or needle of analyzing apparatus | |
FR2929407A1 (en) | Body fluid e.g. blood, biological analysis device for in vitro diagnosing of e.g. dengue, has notch arranged for cooperating with body part of human or animal subject such that body fluid of subject is deposited on analysis band | |
EP4077161B1 (en) | Device for storing and dispensing strips | |
FR3091184A1 (en) | Plate for biological samples | |
EP1126433A1 (en) | Device to display information for bottles | |
EP0442232A1 (en) | Apparatus for the analysis of liquid samples | |
FR2883375A1 (en) | Body secretion e.g. saliva, analyzing package for detecting consumption of e.g. marihuana, has swab including padded end introduced in input end of channel and sliding along length of channel to make contact with strip of cassette |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: UNKNOWN |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
17P | Request for examination filed |
Effective date: 20220329 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: GRANT OF PATENT IS INTENDED |
|
INTG | Intention to grant announced |
Effective date: 20230426 |
|
GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE PATENT HAS BEEN GRANTED |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: FG4D Free format text: NOT ENGLISH |
|
RAP4 | Party data changed (patent owner data changed or rights of a patent transferred) |
Owner name: IKI |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PK Free format text: RECTIFICATION B8 Ref country code: CH Ref legal event code: EP |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R096 Ref document number: 602020020770 Country of ref document: DE |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D Free format text: LANGUAGE OF EP DOCUMENT: FRENCH |
|
U01 | Request for unitary effect filed |
Effective date: 20231110 |
|
U07 | Unitary effect registered |
Designated state(s): AT BE BG DE DK EE FI FR IT LT LU LV MT NL PT SE SI Effective date: 20231116 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20240209 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20240308 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: ES Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20231108 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20240308 Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20240209 Ref country code: ES Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20231108 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: RS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20231108 Ref country code: PL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20231108 Ref country code: NO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20240208 Ref country code: HR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20231108 |