EP4022072A4 - Compositions et méthodes pour le traitement d'infections virales - Google Patents

Compositions et méthodes pour le traitement d'infections virales Download PDF

Info

Publication number: EP4022072A4
Authority: EP; European Patent Office
Prior art keywords: compositions; methods; viral infections; treating viral; treating
Prior art date: 2019-08-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

EP20858496.1A

Other languages

German (de)

English (en)

Other versions

EP4022072A1 (fr

Inventor

Serhat GUMRUKCU

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

G Tech Bio LLC

Original Assignee

G Tech Bio LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2019-08-29

Filing date

2020-08-28

Publication date

2023-09-06

2020-08-28 Application filed by G Tech Bio LLC filed Critical G Tech Bio LLC

2022-07-06 Publication of EP4022072A1 publication Critical patent/EP4022072A1/fr

2023-09-06 Publication of EP4022072A4 publication Critical patent/EP4022072A4/fr

Status Pending legal-status Critical Current

Links

208000036142 Viral infection Diseases 0.000 title 1
239000000203 mixture Substances 0.000 title 1
230000009385 viral infection Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/02—Pentosyltransferases (2.4.2)
- C12Y204/02036—NAD(+)--diphthamide ADP-ribosyltransferase (2.4.2.36)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/22—Cysteine endopeptidases (3.4.22)
- C12Y304/22062—Caspase-9 (3.4.22.62)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Biophysics (AREA)
General Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Toxicology (AREA)
Virology (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

EP20858496.1A 2019-08-29 2020-08-28 Compositions et méthodes pour le traitement d'infections virales Pending EP4022072A4 (fr)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US201962893460P	2019-08-29	2019-08-29
US202062968387P	2020-01-31	2020-01-31
US202062976491P	2020-02-14	2020-02-14
US202062985597P	2020-03-05	2020-03-05
PCT/US2020/048370 WO2021041787A1 (fr)	2019-08-29	2020-08-28	Compositions et méthodes pour le traitement d'infections virales

Publications (2)

Publication Number	Publication Date
EP4022072A1 EP4022072A1 (fr)	2022-07-06
EP4022072A4 true EP4022072A4 (fr)	2023-09-06

Family

ID=74686046

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP20858496.1A Pending EP4022072A4 (fr)	2019-08-29	2020-08-28	Compositions et méthodes pour le traitement d'infections virales

Country Status (11)

Country	Link
EP (1)	EP4022072A4 (fr)
JP (1)	JP2022546402A (fr)
KR (1)	KR20220095183A (fr)
CN (1)	CN114761566A (fr)
AU (1)	AU2020335886A1 (fr)
BR (1)	BR112022003814A2 (fr)
CA (1)	CA3149041A1 (fr)
IL (1)	IL290826A (fr)
MX (1)	MX2022002211A (fr)
WO (1)	WO2021041787A1 (fr)
ZA (1)	ZA202202370B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20220282279A1 (en) *	2021-03-06	2022-09-08	Serhat Gumrukcu	Compositions and methods for treating and preventing coronavirus infections
WO2023220086A1 (fr) *	2022-05-13	2023-11-16	Suntec Medical, Inc.	Méthode de traitement d'une maladie infectieuse

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7001760B2 (en) *	2000-04-20	2006-02-21	Wang-Schick Ryu	Hepatitis B virus vectors for gene therapy
WO2012170431A2 (fr) *	2011-06-06	2012-12-13	Bluebird Bio, Inc.	Systèmes perfectionnés de commutation génique
EP3521303A1 (fr) *	2014-06-20	2019-08-07	Drexel University	Antigène e d'hepadnavirus marqué et son utilisation pour le criblage de substances antivirales

2020
- 2020-08-28 CN CN202080069618.7A patent/CN114761566A/zh active Pending
- 2020-08-28 CA CA3149041A patent/CA3149041A1/fr active Pending
- 2020-08-28 MX MX2022002211A patent/MX2022002211A/es unknown
- 2020-08-28 KR KR1020227010035A patent/KR20220095183A/ko unknown
- 2020-08-28 EP EP20858496.1A patent/EP4022072A4/fr active Pending
- 2020-08-28 JP JP2022513124A patent/JP2022546402A/ja active Pending
- 2020-08-28 AU AU2020335886A patent/AU2020335886A1/en active Pending
- 2020-08-28 BR BR112022003814A patent/BR112022003814A2/pt unknown
- 2020-08-28 WO PCT/US2020/048370 patent/WO2021041787A1/fr active Application Filing
2022
- 2022-02-23 IL IL290826A patent/IL290826A/en unknown
- 2022-02-24 ZA ZA2022/02370A patent/ZA202202370B/en unknown

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PROTZER U ET AL: "INTERFERON GENE TRANSFER BY A HEPATITIS B VIRUS VECTOR EFFICIENTLY SUPPRESSES WILD-TYPE VIRUS INFECTION", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 96, no. 19, 14 September 1999 (1999-09-14), pages 10818 - 10823, XP002129421, ISSN: 0027-8424, DOI: 10.1073/PNAS.96.19.10818 *

Also Published As

Publication number	Publication date
WO2021041787A1 (fr)	2021-03-04
IL290826A (en)	2022-04-01
BR112022003814A2 (pt)	2022-05-24
JP2022546402A (ja)	2022-11-04
AU2020335886A1 (en)	2022-03-17
ZA202202370B (en)	2022-11-30
CN114761566A (zh)	2022-07-15
MX2022002211A (es)	2022-05-24
KR20220095183A (ko)	2022-07-06
EP4022072A1 (fr)	2022-07-06
CA3149041A1 (fr)	2021-03-04

Legal Events

Date	Code	Title	Description
2021-03-05	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2022-06-03	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2022-06-03	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2022-07-06	17P	Request for examination filed	Effective date: 20220310
2022-07-06	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2023-02-17	REG	Reference to a national code	Ref country code: HK Ref legal event code: DE Ref document number: 40076807 Country of ref document: HK
2023-06-21	P01	Opt-out of the competence of the unified patent court (upc) registered	Effective date: 20230516
2023-09-06	A4	Supplementary search report drawn up and despatched	Effective date: 20230807
2023-09-06	RIC1	Information provided on ipc code assigned before grant	Ipc: C12N 7/01 20060101ALI20230801BHEP Ipc: C12N 15/86 20060101AFI20230801BHEP

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