EP3906947A4 - Targeted radiopharmaceuticals for tumors, and combination therapy of targeted radiotherapy thereof and immunotherapy under guidance of images - Google Patents

Targeted radiopharmaceuticals for tumors, and combination therapy of targeted radiotherapy thereof and immunotherapy under guidance of images Download PDF

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Publication number
EP3906947A4
EP3906947A4 EP20815331.2A EP20815331A EP3906947A4 EP 3906947 A4 EP3906947 A4 EP 3906947A4 EP 20815331 A EP20815331 A EP 20815331A EP 3906947 A4 EP3906947 A4 EP 3906947A4
Authority
EP
European Patent Office
Prior art keywords
targeted
tumors
images
combination therapy
radiopharmaceuticals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20815331.2A
Other languages
German (de)
French (fr)
Other versions
EP3906947A1 (en
Inventor
Fan Wang
Jiyun SHI
Hannan GAO
Bing JIA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Peking University
Original Assignee
Peking University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201910441556.7A external-priority patent/CN110227169B/en
Priority claimed from CN202010373843.1A external-priority patent/CN113616818B/en
Application filed by Peking University filed Critical Peking University
Publication of EP3906947A1 publication Critical patent/EP3906947A1/en
Publication of EP3906947A4 publication Critical patent/EP3906947A4/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP20815331.2A 2019-05-24 2020-05-22 Targeted radiopharmaceuticals for tumors, and combination therapy of targeted radiotherapy thereof and immunotherapy under guidance of images Pending EP3906947A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910441556.7A CN110227169B (en) 2019-05-24 2019-05-24 Nuclear medicine of RGD polypeptide with modified structure
CN202010373843.1A CN113616818B (en) 2020-05-06 2020-05-06 Pharmaceutical composition for targeted radiation and immunity combined treatment of tumor
PCT/CN2020/091861 WO2020238800A1 (en) 2019-05-24 2020-05-22 Targeted radiopharmaceuticals for tumors, and combination therapy of targeted radiotherapy thereof and immunotherapy under guidance of images

Publications (2)

Publication Number Publication Date
EP3906947A1 EP3906947A1 (en) 2021-11-10
EP3906947A4 true EP3906947A4 (en) 2022-07-13

Family

ID=73553832

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20815331.2A Pending EP3906947A4 (en) 2019-05-24 2020-05-22 Targeted radiopharmaceuticals for tumors, and combination therapy of targeted radiotherapy thereof and immunotherapy under guidance of images

Country Status (3)

Country Link
US (1) US20230117927A1 (en)
EP (1) EP3906947A4 (en)
WO (1) WO2020238800A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114853851B (en) * 2021-02-04 2023-08-15 南方医科大学南方医院 Targeting PD-L1 polypeptide probe and application thereof in preparation of PET imaging agent

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008053360A2 (en) * 2006-11-03 2008-05-08 Philochem Ag Albumin binding molecules and uses thereof
WO2017196806A1 (en) * 2016-05-09 2017-11-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chemical conjugates of evans blue derivatives and their use as radiotherapy and imaging agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101485891A (en) * 2009-02-13 2009-07-22 北京大学 Radioactive nuclide marked RGD polypeptide medicament and preparation method thereof
CN104844806B (en) * 2015-05-11 2017-10-17 厦门大学 It is a kind of for target compound of isotope labeling and its preparation method and application
WO2018045376A2 (en) * 2016-09-02 2018-03-08 Ikaria Inc. Functionally modified polypeptides and radiobiosynthesis
CN117563022A (en) * 2017-04-05 2024-02-20 康奈尔大学 Trifunctional constructs with tunable pharmacokinetics for imaging and anti-tumor therapy
CN110227169B (en) * 2019-05-24 2020-07-07 北京大学 Nuclear medicine of RGD polypeptide with modified structure

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008053360A2 (en) * 2006-11-03 2008-05-08 Philochem Ag Albumin binding molecules and uses thereof
WO2017196806A1 (en) * 2016-05-09 2017-11-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chemical conjugates of evans blue derivatives and their use as radiotherapy and imaging agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2020238800A1 *

Also Published As

Publication number Publication date
EP3906947A1 (en) 2021-11-10
WO2020238800A1 (en) 2020-12-03
US20230117927A1 (en) 2023-04-20

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Effective date: 20220615

RIC1 Information provided on ipc code assigned before grant

Ipc: C07K 7/64 20060101ALI20220610BHEP

Ipc: A61P 35/00 20060101ALI20220610BHEP

Ipc: A61K 51/08 20060101AFI20220610BHEP

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