EP3820487A4 - Gene editing for autoimmune disorders - Google Patents
Gene editing for autoimmune disorders Download PDFInfo
- Publication number
- EP3820487A4 EP3820487A4 EP19803321.9A EP19803321A EP3820487A4 EP 3820487 A4 EP3820487 A4 EP 3820487A4 EP 19803321 A EP19803321 A EP 19803321A EP 3820487 A4 EP3820487 A4 EP 3820487A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- autoimmune disorders
- gene editing
- editing
- gene
- autoimmune
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862762708P | 2018-05-14 | 2018-05-14 | |
PCT/US2019/032214 WO2019222212A1 (en) | 2018-05-14 | 2019-05-14 | Gene editing for autoimmune disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3820487A1 EP3820487A1 (en) | 2021-05-19 |
EP3820487A4 true EP3820487A4 (en) | 2022-03-09 |
Family
ID=68540991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19803321.9A Pending EP3820487A4 (en) | 2018-05-14 | 2019-05-14 | Gene editing for autoimmune disorders |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP3820487A4 (en) |
JP (1) | JP2021523943A (en) |
CN (1) | CN112384230A (en) |
WO (1) | WO2019222212A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20220339192A1 (en) * | 2019-09-07 | 2022-10-27 | Themba Inc. | Gene editing for viral infections |
US20230223102A1 (en) * | 2020-03-31 | 2023-07-13 | Themba Inc. | Genetic model validation methods |
WO2022175674A1 (en) * | 2021-02-19 | 2022-08-25 | Oxford University Innovation Limited | Modified human cells and uses thereof in the treatment of immune-mediated diseases |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018035388A1 (en) * | 2016-08-17 | 2018-02-22 | The Broad Institute, Inc. | Novel crispr enzymes and systems |
WO2018064208A1 (en) * | 2016-09-28 | 2018-04-05 | The Broad Institute, Inc. | Systematic screening and mapping of regulatory elements in non-coding genomic regions, methods, compositions, and applications thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016049251A1 (en) * | 2014-09-24 | 2016-03-31 | The Broad Institute Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling mutations in leukocytes |
WO2017066561A2 (en) * | 2015-10-16 | 2017-04-20 | President And Fellows Of Harvard College | Regulatory t cell pd-1 modulation for regulating t cell effector immune responses |
AU2017230011A1 (en) * | 2016-03-11 | 2018-09-27 | 2Seventy Bio, Inc. | Genome edited immune effector cells |
WO2018022473A1 (en) * | 2016-07-25 | 2018-02-01 | Wave Life Sciences Ltd. | Phasing |
CA3034094A1 (en) * | 2016-08-16 | 2018-02-22 | Bluebird Bio, Inc. | Il-10 receptor alpha homing endonuclease variants, compositions, and methods of use |
US20190291916A1 (en) * | 2016-08-16 | 2019-09-26 | Mars, Incorporated | Open-walled pack |
EP3510157B1 (en) * | 2016-09-08 | 2023-05-31 | 2seventy bio, Inc. | Pd-1 homing endonuclease variants, compositions, and methods of use |
-
2019
- 2019-05-14 JP JP2021514296A patent/JP2021523943A/en active Pending
- 2019-05-14 CN CN201980045883.9A patent/CN112384230A/en active Pending
- 2019-05-14 EP EP19803321.9A patent/EP3820487A4/en active Pending
- 2019-05-14 WO PCT/US2019/032214 patent/WO2019222212A1/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018035388A1 (en) * | 2016-08-17 | 2018-02-22 | The Broad Institute, Inc. | Novel crispr enzymes and systems |
WO2018064208A1 (en) * | 2016-09-28 | 2018-04-05 | The Broad Institute, Inc. | Systematic screening and mapping of regulatory elements in non-coding genomic regions, methods, compositions, and applications thereof |
Non-Patent Citations (4)
Title |
---|
GLOCKER ERIK-OLIVER ET AL: "IL-10 and IL-10 receptor defects in humans : IL-10/IL-10R deficiency", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 1246, no. 1, 1 December 2011 (2011-12-01), US, pages 102 - 107, XP055883124, ISSN: 0077-8923, DOI: 10.1111/j.1749-6632.2011.06339.x * |
HUANG HAILIANG ET AL: "Fine-mapping inflammatory bowel disease loci to single-variant resolution", NATURE, vol. 547, no. 7662, 1 July 2017 (2017-07-01), London, pages 173 - 178, XP055882978, ISSN: 0028-0836, Retrieved from the Internet <URL:https://www.nature.com/articles/nature22969.pdf> DOI: 10.1038/nature22969 * |
See also references of WO2019222212A1 * |
SIVANESAN DURGA ET AL: "IL23R (Interleukin 23 Receptor) Variants Protective against Inflammatory Bowel Diseases (IBD) Display Loss of Function due to Impaired Protein Stability and Intracellular Trafficking", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 291, no. 16, 1 April 2016 (2016-04-01), US, pages 8673 - 8685, XP055883125, ISSN: 0021-9258, DOI: 10.1074/jbc.M116.715870 * |
Also Published As
Publication number | Publication date |
---|---|
CN112384230A (en) | 2021-02-19 |
EP3820487A1 (en) | 2021-05-19 |
WO2019222212A1 (en) | 2019-11-21 |
JP2021523943A (en) | 2021-09-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
17P | Request for examination filed |
Effective date: 20201113 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20220204 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12N 5/0781 20100101ALI20220131BHEP Ipc: C07K 16/28 20060101ALI20220131BHEP Ipc: A61K 35/28 20150101ALI20220131BHEP Ipc: A61K 35/17 20150101AFI20220131BHEP |