EP3810110A4 - A combination comprising fingolimod and amantadine - Google Patents

A combination comprising fingolimod and amantadine Download PDF

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Publication number
EP3810110A4
EP3810110A4 EP19823241.5A EP19823241A EP3810110A4 EP 3810110 A4 EP3810110 A4 EP 3810110A4 EP 19823241 A EP19823241 A EP 19823241A EP 3810110 A4 EP3810110 A4 EP 3810110A4
Authority
EP
European Patent Office
Prior art keywords
fingolimod
amantadine
combination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19823241.5A
Other languages
German (de)
French (fr)
Other versions
EP3810110A2 (en
Inventor
Ali Turkyilmaz
Merve PEKER
Emine TUNCAY
Erkin Ozturk
Muge ULUSOY BOZYEL
Yavuz Dedeoglu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanovel Ilac Sanayi ve Ticaret AS
Original Assignee
Sanovel Ilac Sanayi ve Ticaret AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanovel Ilac Sanayi ve Ticaret AS filed Critical Sanovel Ilac Sanayi ve Ticaret AS
Publication of EP3810110A2 publication Critical patent/EP3810110A2/en
Publication of EP3810110A4 publication Critical patent/EP3810110A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP19823241.5A 2018-06-21 2019-06-20 A combination comprising fingolimod and amantadine Withdrawn EP3810110A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR201808819 2018-06-21
PCT/TR2019/050477 WO2019245513A2 (en) 2018-06-21 2019-06-20 A combination comprising fingolimod and amantadine

Publications (2)

Publication Number Publication Date
EP3810110A2 EP3810110A2 (en) 2021-04-28
EP3810110A4 true EP3810110A4 (en) 2022-03-16

Family

ID=68983747

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19823241.5A Withdrawn EP3810110A4 (en) 2018-06-21 2019-06-20 A combination comprising fingolimod and amantadine

Country Status (2)

Country Link
EP (1) EP3810110A4 (en)
WO (1) WO2019245513A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013055907A1 (en) * 2011-10-12 2013-04-18 Teva Pharmaceutical Industries Ltd. Treatment of multiple sclerosis with combination of laquinimod and fingolimod

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016064997A1 (en) * 2014-10-22 2016-04-28 The Regents Of The University Of California Compositions and methods for treating fatigue and depression
EP3215132B1 (en) * 2014-11-04 2021-01-27 Adamas Pharmaceuticals, Inc. Amantadine for improving gait in multiple sclerosis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013055907A1 (en) * 2011-10-12 2013-04-18 Teva Pharmaceutical Industries Ltd. Treatment of multiple sclerosis with combination of laquinimod and fingolimod

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ALICE LARONI ET AL: "Safety of the first dose of fingolimod for multiple sclerosis: results of an open-label clinical trial", BMC NEUROLOGY, BIOMED CENTRAL LTD., LONDON, GB, vol. 14, no. 1, 1 April 2014 (2014-04-01), pages 65, XP021184467, ISSN: 1471-2377, DOI: 10.1186/1471-2377-14-65 *
JEFFREY A COHEN ET AL: "MULTIPLE SCLEROSIS MSJ JOURNAL Safety and efficacy of ADS-5102 (amantadine) extended release capsules to improve walking in multiple sclerosis: A randomized, placebo- controlled, phase 2 trial", 1 January 2018 (2018-01-01), XP055472325, Retrieved from the Internet <URL:http://journals.sagepub.com/doi/pdf/10.1177/1352458518754716> [retrieved on 20180503] *
LIMMROTH V ET AL: "Electrocardiographic assessments and cardiac events after fingolimod first dose - a comprehensive monitoring study", BMC NEUROLOGY 20170118 BIOMED CENTRAL LTD. GBR, vol. 17, no. 1, 18 January 2017 (2017-01-18), XP009533336, ISSN: 1471-2377 *
See also references of WO2019245513A2 *

Also Published As

Publication number Publication date
EP3810110A2 (en) 2021-04-28
WO2019245513A2 (en) 2019-12-26
WO2019245513A3 (en) 2020-03-19

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