EP3807282A4 - Dérivés hétérocycliques et leur utilisation - Google Patents

Dérivés hétérocycliques et leur utilisation Download PDF

Info

Publication number: EP3807282A4
Authority: EP; European Patent Office
Prior art keywords: heterocyclic derivatives; heterocyclic; derivatives
Prior art date: 2018-05-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP19810281.6A

Other languages

German (de)

English (en)

Other versions

EP3807282A1 (fr

Inventor

Kwang Seok Ko

Soon Ok Lee

Young Jin Kwon

Jee Hun YUN

Nam Chul Cho

Ji Eun Lee

Jung Sook Kim

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

C&C Research Laboratories

Original Assignee

C&C Research Laboratories

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2018-05-31

Filing date

2019-05-31

Publication date

2022-03-02

2019-05-31 Application filed by C&C Research Laboratories filed Critical C&C Research Laboratories

2021-04-21 Publication of EP3807282A1 publication Critical patent/EP3807282A1/fr

2022-03-02 Publication of EP3807282A4 publication Critical patent/EP3807282A4/fr

Status Withdrawn legal-status Critical Current

Links

125000000623 heterocyclic group Chemical group 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

EP19810281.6A 2018-05-31 2019-05-31 Dérivés hétérocycliques et leur utilisation Withdrawn EP3807282A4 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
KR20180062254		2018-05-31
PCT/KR2019/006553 WO2019231270A1 (fr)	2018-05-31	2019-05-31	Dérivés hétérocycliques et leur utilisation

Publications (2)

Publication Number	Publication Date
EP3807282A1 EP3807282A1 (fr)	2021-04-21
EP3807282A4 true EP3807282A4 (fr)	2022-03-02

Family

ID=68698381

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19810281.6A Withdrawn EP3807282A4 (fr)	2018-05-31	2019-05-31	Dérivés hétérocycliques et leur utilisation

Country Status (12)

Country	Link
US (1)	US20210198259A1 (fr)
EP (1)	EP3807282A4 (fr)
JP (1)	JP2021525738A (fr)
KR (1)	KR102344295B1 (fr)
CN (1)	CN112204032A (fr)
AU (1)	AU2019279421A1 (fr)
BR (1)	BR112020023946A2 (fr)
CA (1)	CA3098825A1 (fr)
MX (1)	MX2020011955A (fr)
SG (1)	SG11202010985TA (fr)
TW (1)	TW202021969A (fr)
WO (1)	WO2019231270A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2021174024A1 (fr)	2020-02-28	2021-09-02	First Wave Bio, Inc.	Méthodes de traitement de la colite auto-immune iatrogène
KR20230035031A (ko)	2020-06-05	2023-03-10	킨네이트 바이오파마 인크.	섬유아세포 성장 인자 수용체 키나아제의 억제제
EP4067357A1 (fr) *	2021-03-30	2022-10-05	JW Pharmaceutical Corporation	Nouvelle forme cristalline de 1-(8-bromopyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-4-yl)-n-méthylazetidin-3-amine monohydrate de sulfate d'hydrogène
CN113929634A (zh) *	2021-11-22	2022-01-14	山西永津集团有限公司	一种2,3-二溴喹喔啉的合成方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1205519A (en) *	1967-09-27	1970-09-16	Siegfried Ag	Novel 1,2-dihydro-benztriazine derivatives and process for preparing the same
WO2010030785A2 (fr) *	2008-09-10	2010-03-18	Kalypsys Inc.	Inhibiteurs hétérocyliques des récepteurs de l'histamine destinés au traitement d'une maladie
WO2011112731A2 (fr) *	2010-03-10	2011-09-15	Kalypsys, Inc.	Inhibiteurs hétérocycliques de récepteurs de l'histamine destinés au traitement de maladie
WO2012012264A1 (fr) *	2010-07-19	2012-01-26	Alcon Research, Ltd.	Méthodes et compositions utilisées pour le traitement de l'allergie
WO2013048214A2 (fr) *	2011-09-30	2013-04-04	C&C Research Laboratories	Nouveaux dérivés hétérocycliques et leurs utilisations
WO2014152029A2 (fr) *	2013-03-15	2014-09-25	Epigenetix, Inc.	Composés d'oxazolo[5,4-c] quinolin-2-one en tant qu'inhibiteurs de bromodomaines
WO2017085053A1 (fr) *	2015-11-16	2017-05-26	Fundación Para La Investigación Médica Aplicada	Utilisation de nouveaux composés comme inhibiteurs d'adn méthyltransférases
WO2018022865A1 (fr) *	2016-07-28	2018-02-01	Promega Corporation	Analogues de coelentérazine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2006521343A (ja) *	2003-03-27	2006-09-21	ファイザー・プロダクツ・インク	置換４−アミノ［１，２，４］トリアゾロ［４，３−ａ］キノキサリン

2019
- 2019-05-30 TW TW108118749A patent/TW202021969A/zh unknown
- 2019-05-31 SG SG11202010985TA patent/SG11202010985TA/en unknown
- 2019-05-31 CN CN201980035540.4A patent/CN112204032A/zh active Pending
- 2019-05-31 US US17/057,753 patent/US20210198259A1/en not_active Abandoned
- 2019-05-31 AU AU2019279421A patent/AU2019279421A1/en not_active Abandoned
- 2019-05-31 CA CA3098825A patent/CA3098825A1/fr active Pending
- 2019-05-31 KR KR1020190064284A patent/KR102344295B1/ko active IP Right Grant
- 2019-05-31 MX MX2020011955A patent/MX2020011955A/es unknown
- 2019-05-31 EP EP19810281.6A patent/EP3807282A4/fr not_active Withdrawn
- 2019-05-31 WO PCT/KR2019/006553 patent/WO2019231270A1/fr unknown
- 2019-05-31 JP JP2020566706A patent/JP2021525738A/ja not_active Withdrawn
- 2019-05-31 BR BR112020023946-1A patent/BR112020023946A2/pt not_active Application Discontinuation

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1205519A (en) *	1967-09-27	1970-09-16	Siegfried Ag	Novel 1,2-dihydro-benztriazine derivatives and process for preparing the same
WO2010030785A2 (fr) *	2008-09-10	2010-03-18	Kalypsys Inc.	Inhibiteurs hétérocyliques des récepteurs de l'histamine destinés au traitement d'une maladie
WO2011112731A2 (fr) *	2010-03-10	2011-09-15	Kalypsys, Inc.	Inhibiteurs hétérocycliques de récepteurs de l'histamine destinés au traitement de maladie
WO2012012264A1 (fr) *	2010-07-19	2012-01-26	Alcon Research, Ltd.	Méthodes et compositions utilisées pour le traitement de l'allergie
WO2013048214A2 (fr) *	2011-09-30	2013-04-04	C&C Research Laboratories	Nouveaux dérivés hétérocycliques et leurs utilisations
WO2014152029A2 (fr) *	2013-03-15	2014-09-25	Epigenetix, Inc.	Composés d'oxazolo[5,4-c] quinolin-2-one en tant qu'inhibiteurs de bromodomaines
WO2017085053A1 (fr) *	2015-11-16	2017-05-26	Fundación Para La Investigación Médica Aplicada	Utilisation de nouveaux composés comme inhibiteurs d'adn méthyltransférases
WO2018022865A1 (fr) *	2016-07-28	2018-02-01	Promega Corporation	Analogues de coelentérazine

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BASHANDY HASSAN ET AL: "Synthesis and biological evaluation studies of some novel quinazoline and quinazolinone derivatives as anti-liver cancer agents", EGYPTIAN JOURNAL OF CHEMISTRY, NATIONAL INFORMATION AND DOCUMENTATION CENTRE, CAIRO, vol. 55, no. 6, 1 January 2012 (2012-01-01), pages 659 - 676, XP009532864, ISSN: 0449-2285 *
BURBIEL JOACHIM C. ET AL: "2-Amino[1,2,4]triazolo[1,5 -c ]quinazolines and Derived Novel Heterocycles: Syntheses and Structure-Activity Relationships of Potent Adenosine Receptor Antagonists", CHEMMEDCHEM COMMUNICATIONS, vol. 11, no. 20, 19 October 2016 (2016-10-19), DE, pages 2272 - 2286, XP055881576, ISSN: 1860-7179, DOI: 10.1002/cmdc.201600255 *
MORKOS A HENEN ET AL: "[1,2,4]Triazolo[4,3-]quinoxaline: synthesis, antiviral, and antimicrobial activities", MEDICINAL CHEMISTRY RESEARCH, BIRKHÄUSER-VERLAG, BOSTON, vol. 21, no. 9, 6 August 2011 (2011-08-06), pages 2368 - 2378, XP035092232, ISSN: 1554-8120, DOI: 10.1007/S00044-011-9753-7 *
SAUNDANE ANAND R ET AL: "Synthesis, antimicrobial and antioxidant activities of some indole analogues containing naphthyridine and pyrimidonaphthyridine systems", vol. 51, no. 11, 1 November 2012 (2012-11-01), pages 1593 - 1606, XP009532865, ISSN: 0376-4699, Retrieved from the Internet <URL:http://hdl.handle.net/123456789/14982> *
See also references of WO2019231270A1 *
VICENTE-GARCÍA ESTHER ET AL: "New Heterocyclic Inputs for the Povarov Multicomponent Reaction", SYNTHESIS, vol. 2011, no. 14, 1 July 2011 (2011-07-01), STUTTGART, DE., pages 2237 - 2246, XP055881552, ISSN: 0039-7881, Retrieved from the Internet <URL:https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0030-1260062.pdf> DOI: 10.1055/s-0030-1260062 *

Also Published As

Publication number	Publication date
US20210198259A1 (en)	2021-07-01
KR20190137013A (ko)	2019-12-10
CA3098825A1 (fr)	2019-12-05
SG11202010985TA (en)	2020-12-30
AU2019279421A1 (en)	2020-12-03
TW202021969A (zh)	2020-06-16
BR112020023946A2 (pt)	2021-02-23
WO2019231270A1 (fr)	2019-12-05
KR102344295B1 (ko)	2021-12-29
EP3807282A1 (fr)	2021-04-21
JP2021525738A (ja)	2021-09-27
MX2020011955A (es)	2021-01-15
CN112204032A (zh)	2021-01-08

Legal Events

Date	Code	Title	Description
2019-12-07	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2021-01-13	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2021-03-19	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2021-03-19	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2021-04-21	17P	Request for examination filed	Effective date: 20210111
2021-04-21	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2021-04-21	AX	Request for extension of the european patent	Extension state: BA ME
2021-09-08	DAV	Request for validation of the european patent (deleted)
2021-09-08	DAX	Request for extension of the european patent (deleted)
2022-01-27	REG	Reference to a national code	Ref country code: DE Ref legal event code: R079 Free format text: PREVIOUS MAIN CLASS: C07D0487140000 Ipc: C07D0471140000
2022-03-02	A4	Supplementary search report drawn up and despatched	Effective date: 20220202
2022-03-02	RIC1	Information provided on ipc code assigned before grant	Ipc: A61P 11/00 20060101ALI20220127BHEP Ipc: A61P 37/00 20060101ALI20220127BHEP Ipc: A61P 29/00 20060101ALI20220127BHEP Ipc: A61K 31/53 20060101ALI20220127BHEP Ipc: A61K 31/4985 20060101ALI20220127BHEP Ipc: C07D 471/04 20060101ALI20220127BHEP Ipc: C07D 487/14 20060101ALI20220127BHEP Ipc: C07D 471/14 20060101AFI20220127BHEP
2023-02-24	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: EXAMINATION IS IN PROGRESS
2023-03-29	17Q	First examination report despatched	Effective date: 20230224
2023-11-03	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2023-12-06	18D	Application deemed to be withdrawn	Effective date: 20230707

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