EP3777939B1 - Administration nasale - Google Patents
Administration nasale Download PDFInfo
- Publication number
- EP3777939B1 EP3777939B1 EP20193142.5A EP20193142A EP3777939B1 EP 3777939 B1 EP3777939 B1 EP 3777939B1 EP 20193142 A EP20193142 A EP 20193142A EP 3777939 B1 EP3777939 B1 EP 3777939B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- subject
- nasal
- nosepiece
- tip element
- delivery device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
- A61M15/085—Fixing means therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0091—Inhalators mechanically breath-triggered
- A61M15/0098—Activated by exhalation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0625—Mouth
Definitions
- the present invention relates to a nasal delivery device for delivering a substance, in particular one of a liquid, as a suspension or solution, or a powder containing a medicament, especially systemic or topical pharmaceuticals, or a vaccine to the nasal airway of a subject.
- the nasal airway 1 comprises the two nasal cavities separated by the nasal septum, which airway 1 includes numerous ostia, such as the paranasal sinus ostia 3 and the tubal ostia 5, and olfactory cells, and is lined by the nasal mucosa.
- the nasal airway 1 can communicate with the nasopharynx 7, the oral cavity 9 and the lower airway 11, with the nasal airway 1 being in selective communication with the anterior region of the nasopharynx 7 and the oral cavity 9 by opening and closing of the oropharyngeal velum 13.
- the velum 13, which is often referred to as the soft palate, is illustrated in solid line in the closed position, as achieved by providing a certain positive pressure in the oral cavity 9, such as achieved on exhalation through the oral cavity 9, and in dashed line in the open position.
- nasal inflammation specifically rhinitis
- allergic and non-allergic inflammation of the nasal airway can typically effect between 10 and 20 % of the population, with nasal congestion of the erectile tissues of the nasal concha, lacrimation, secretion of watery mucus, sneezing and itching being the most common symptoms.
- nasal congestion impedes nasal breathing and promotes oral breathing, leading to snoring and sleep disturbance.
- Other nasal conditions include nasal polyps which arise from the paranasal sinuses, hypertrophic adenoids, secretory otitis media, sinus disease and reduced olfaction.
- the topical administration of medicaments is preferable, particularly where the nasal mucosa is the prime pathological pathway, such as in treating or relieving nasal congestion.
- Medicaments that are commonly topically delivered include decongestants, anti-histamines, cromoglycates, steroids and antibiotics.
- topical steroids have been shown to have an effect on nasal congestion.
- Topical decongestants have also been suggested for use in relieving nasal congestion.
- the treatment of hypertrophic adenoids and chronic secretory otitis media using topical decongestants, steroids and anti-microbial agents, although somewhat controversial, has also been proposed.
- the topical administration of pharmaceuticals has been used to treat or at least relieve symptoms of inflammation in the anterior region of the nasopharynx, the paranasal sinuses and the auditory tubes.
- Medicaments can also be systemically delivered through the nasal pathway, the nasal pathway offering a good administration route for the systemic delivery of pharmaceuticals, such as hormones, for example, oxytocin and calcitonin, and analgetics, such as anti-migraine compositions, as the high blood flow and large surface area of the nasal mucosa advantageously provides for rapid systemic uptake.
- pharmaceuticals such as hormones, for example, oxytocin and calcitonin, and analgetics, such as anti-migraine compositions, as the high blood flow and large surface area of the nasal mucosa advantageously provides for rapid systemic uptake.
- Nasal delivery is also expected to be advantageous for the administration of medicaments requiring a rapid onset of action, for example, analgetics, anti-emetics, insulin, anti-epileptics, sedatives and hypnotica, and also other pharmaceuticals, for example, cardio-vascular drugs. It is envisaged that nasal administration will provide for a fast onset of action, at a rate similar to that of injection and at a rate much faster than that of oral administration. Indeed, for the treatment of many acute conditions, nasal administration is advantageous over oral administration, since gastric stasis can further slow the onset of action following oral administration.
- nasal delivery could provide an effective delivery route for the administration of proteins and peptides as produced by modern biotechnological techniques.
- the metabolism in the intestines and the first-pass-effect in the liver represent significant obstacles for reliable and cost-efficient delivery.
- nasal delivery using the nasal delivery technique of the present invention will prove effective in the treatment of many common neurological diseases, such as Alzheimer's, Parkinson's, psychiatric diseases and intracerebral infections, where not possible using existing techniques.
- the nasal delivery technique of the present invention allows for delivery to the olfactory region, which region is located in the superior region of the nasal cavities and represents the only region where it is possible to circumvent the blood-to-brain barrier (BBB) and enable communication with the cerebrospinal fluid (CSF) and the brain.
- BBB blood-to-brain barrier
- CSF cerebrospinal fluid
- nasal delivery technique of the present invention will allow for the effective delivery of vaccines.
- liquids in particular saline solutions
- saline solutions are commonly practised to remove particles and secretions, as well as to improve the mucociliary activity of the nasal mucosa.
- WO-A-00/51672 discloses a delivery device for delivering a substance, in particular a medicament, in a bi-directional flow through the nasal cavities, that is, an air flow which passes into one nostril, around the posterior margin of the nasal septum and in the opposite direction out of the other nostril.
- This bi-directional air flow advantageously acts to stimulate the sensory nerves in the nasal mucosa, thereby conditioning the subject for the delivery and providing a more comfortable delivery situation.
- US-A-5797390 discloses a nasal inhaler which includes an attachment which is sized and shaped to fit within a nostril.
- WO-A-1994/017753 discloses a conduit for use with an aerosol generating device, in administering an aerosol to a large animal, such as a horse.
- WO-A-2007/102089 discloses a nasal delivery device which includes a nosepiece having a tip element with an elongate lateral section which has a longer dimension in a first, sagittal direction than a second direction orthogonal to the sagittal direction.
- One particular aim of the present invention is to optimize the shape, direction and particle distribution of the plume of a delivered dose, in order to reach targeted regions and reduce deposition outside these regions.
- Another particular aim of the present invention is to provide for improved targeting of specific regions of the nasal airway and improved reproducibility and consistency of dosing.
- the present inventors have recognized that an increased delivery of substance to the posterior region of the nasal airway, and in particular the upper posterior region of the nasal airway, as illustrated in Figure 1(b) , relative to the anterior region of the nasal airway, surprisingly provides for a disproportionately greater effect, in particular a CNS effect, which is suggestive of a greater uptake of substance into the CNS than would be predicted from the blood plasma concentration of the substance, but also systemic absorption and local action.
- the posterior region of the nasal airway is that region which is posterior of the nasal valve NV, as illustrated in Figure 1(b) .
- the nasal valve NV comprises the anterior bony cavum which contains inferior turbinate erectile tissue and septal erectile tissue, which are supported respectively by compliant ala tissue and the rigid cartilaginous septum (Cole). These elements combine to form a dynamic valve, which extends over several millimetres, that adjusts nasal airflow, and is stabilized by cartilage and bone, modulated by voluntary muscle and regulated by erectile tissue.
- the lumen of the nasal valve NV is the section of narrowest cross-sectional area between the posterior and anterior regions of the nasal airway, and is much longer and narrower dorsally than ventrally, and this lumen defines a triangular entrance which extends to the piriform region of the bony cavum.
- the nasal valve NV is lined in its anterior part with transitional epithelium, with a gradual transition posterior to respiratory epithelium.
- the nasal valve NV and anterior vestibule define roughly the anterior one-third of the nose.
- the upper lateral wall of the nasal valve NV collapses to form a collapsed region, as illustrated in Figure 1(b) , which significantly narrows the upper part of the nasal valve NV and obstructs access to the upper posterior region of the nasal cavity, and in particular the olfactory region.
- This collapsed region in combination with the upper lateral wall of the nasal valve NV having a curved shape, makes the insertion of a rigid structure into the lumen of the nasal valve NV particularly difficult and uncomfortable.
- the posterior region of the nasal airway is that region which is lined with respiratory epithelium, which is ciliated, and olfactory epithelium, which comprises nerves which extend downwards through the cribiform plate CP from the olfactory bulb, whereas the anterior region of the nasal airway is that region which is lined with squamous epithelium, which is not ciliated, and transitional epithelium which has no or few cilia.
- the olfactory epithelium extends on both the lateral and medial sides of the nasal airway, and typically extends downwards about 1.5 to 2.5 cm.
- the upper posterior region is the region above the inferior meatus IM, as illustrated in Figure 1(b) , and encompasses the middle turbinate, the sinus ostia in infundibulum (ostia to maxillary, frontal and ethmoidal sinuses), the olfactory region, and the upper branches of the trigeminal nerve, and is that region which includes veins which drain to the venous sinuses that surround the brain.
- the posterior region of the nasal airway is the nasal region posterior of an imaginary vertical plane VERT1 which is located at a position corresponding to one-quarter of the distance between the anterior nasal spine AnS, which is a pointed projection at the anterior extremity of the intermaxillary suture, and the posterior nasal spine PnS, which is the sharp posterior extremity of the nasal crest of the hard palate and represents the transition between the nose and the nasopharynx, which corresponds to a distance posterior of the anterior nasal spine AnS of between about 13 mm and about 14 mm (Rosenberger defines the distance between the anterior nasal spine AnS and the posterior nasal spine PnS as being 56 mm in eighteen year old boys and 53.3 mm in eighteen year old girls).
- the posterior nasal region is bounded posteriorly by an imaginary vertical plane VERT2 which extends through the posterior nasal spine PnS.
- the upper region of the nasal airway is an upper segment of the nasal airway which is bounded by the cribiform plate CP and a horizontal plane HORIZ which is located at a position corresponding to one-third of the distance between the nasal floor NF of the nasal airway and the cribiform plate CP, which corresponds to a height of typically between about 13 and about 19 mm above the nasal floor NF (Zacharek et al define the distance from the nasal floor NF to the cribiform plate CP as 46 +/- 4 mm).
- the upper posterior region is thus that upper posterior region which is bounded by the above-defined vertical and horizontal planes VERT1, HORIZ.
- the present inventors have postulated that this increased concentration within the CNS arises as a result of the veins in the upper posterior region of the nasal airway draining backwards to the venous sinuses that surround the brain, which leads to a higher local concentration in the cerebrovasculature.
- the sinus cavernous is outside the blood-to-brain barrier
- animal models have shown that substances can be transported by a counter-current mechanism from the veins therein to the carotid artery which passes through the sinus cavernous.
- Other mechanisms have been proposed which include extra axonal transport along the surface of the olfactory and trigeminal nerves. This mode of transport is apparently quite rapid as compared to intra axonal transport.
- nasal spray administration systems have been determined initially to deliver largely to the anterior one-third of the nasal airway, that is, the nasal region anterior of the nasal valve, from which region drainage is mainly along the floor of the nose and in which region the veins drain to the external facial vein, which in turn drains to the external carotid and in turn to the peripheral circulation.
- the present invention provides a nasal delivery device according to claim 1.
- the present invention provides a nosepiece which provides for expansion in the sagittal plane, opening the connection of the mucosal surfaces of the nasal valve and isthmus, in particular by expansion of the collapsed region at the upper lateral wall of the nasal valve.
- the present invention is particularly advantageous when used in combination with bi-directional nasal delivery, but is not restricted to such delivery.
- the present invention can be combined with delivery concepts which generate a mist, an aerosol, an aerosol spray of particles, either liquid or powder, drops, droplets, or liquid jet of liquid.
- An entraining flow can be provided by the exhalation breath of the subject or from an external flow source, such as from an air chamber or a compressed air supply.
- the delivery device can be triggered, such that one or both of the dose and gas flow are triggered by an intraoral pressure which is such as to close the oropharyngeal velum or by another event, which may or may not secure velum closure.
- the present invention also finds application in delivery systems which do not utilize an auxiliary gas flow and even with inhalation environments which provide for nasal inhalation or a sniffing manoeuvre through one or both of the nostrils.
- the devices can be a multi-dose or single-dose.
- US-A-6647980 discloses a device which utilizes a modified plume in order to attempt to decrease lateral deposition, and thereby increase the amount of the dose which reaches the upper region of the nasal airway.
- this device may provide for reduced deposition in the anterior part of the nasal cavity which is lined by squamous epithelium, owing to the narrower cone angle, only a moderate increase in deposition in the upper region of the nose is expected to be achieved, owing to the difficult and protected access to this region.
- narrowing of the nose during inhalation as caused by the Bernoulli effect, will further narrow the nasal cavity to increase the fraction deposited in valve region.
- the present invention provides for a bi-directional air flow in the nasal passages in which optimally-sized particles are entrained and subsequently delivered to appropriate target sites in the nasal airway.
- the present invention aims further to improve upon the devices as disclosed in the applicant's earlier WO-A-03/000310 .
- the present invention provides for optimisation of the delivery to upper parts of the nasal airway, including the olfactory region, by configuring the nosepiece, in particular the shape and position thereof, and the emitted plume of particles or liquid jet in conjunction.
- the present invention provides for significantly enhanced access and deposition in the upper region of the nasal airway, and thereby improved dose-to-dose consistency and repeatability of drug delivery to this region of the nasal airway.
- the delivery device of the present invention provides both for positioning of the outlet nozzle and the expansion of the upper lateral and medial surfaces of the valve region of a nasal cavity.
- the nosepiece By configuring the external and internal shape of the nosepiece, the nosepiece both ensures the correct positioning of the outlet nozzle and optimizes the vertical expansion of the nasal cavity.
- the operative function of the nosepiece of the present invention in vertically expanding the nasal cavity, can be contrasted to that of a conventional, frusto-conical nosepiece, which, during insertion into a nasal cavity, has been found by the present inventor to push the soft, nasal tissue rearwardly, which is particularly disadvantageous where attempting delivery to posterior regions of the nasal airway.
- the present invention extends to devices which are adapted to bi-directional delivery where driven by the exhalation breath of the subject or an auxiliary gas source, and conventional nasal delivery devices which do not utilize an auxiliary gas flow.
- the present invention can be adapted to any traditional delivery modality, including but not restricted to a spray pump, a pMDI, a nebulizer or any other means of delivering liquid jets, particles or drops, either in powder or liquid form, and is not restricted to bi-directional devices.
- the delivery device comprises a housing 15, a nosepiece 17 for fitting in a nasal cavity of a subject, and a mouthpiece 19 through which the subject exhales to actuate the delivery device.
- the nosepiece 17 is attached to the housing 15 and defines a delivery channel 23 which is in fluid communication with the mouthpiece 19 such that an air flow is delivered into and through the nasal airway of the subject on exhalation by the subject through the mouthpiece 19.
- the nosepiece 17 comprises a tip element 25 for insertion into the nasal cavity of the subject, which includes a delivery aperture 26 from which substance is delivered into the nasal cavity of the subject, and a base section 27 from which the tip element 25 extends, in this embodiment substantially axially to the longitudinal axis of the nosepiece 17.
- the tip element 25 is of asymmetric, elongate section, in having a dimension d1 in a first, sagittal direction which is greater than a dimension d2 in a second, lateral direction orthogonal to the first, sagittal direction.
- the longer, sagittal section of the tip element 25 of the nosepiece 17 becomes aligned in the sagittal plane and acts to engage upper and lower walls of the nasal cavity of the subject and cause the expansion of the nasal cavity in the vertical, sagittal plane, in particular the upper wall of the nasal cavity of the subject, which is a fleshy structure, as compared to the lower wall of the nasal cavity of the subject, which is a relatively-hard structure, and also position the nosepiece 17 in the nasal cavity of the subject, with the lower wall of the nasal cavity of the subject, in being a relatively-hard structure, acting as a reference for the expansion.
- This expansion further acts to tension the lateral walls of the nasal cavity of the subject which defines the nasal valve, which causes the lateral walls of the nasal cavity to be urged into sealing contact with the nosepiece 17.
- the distal end of the tip element 25 is, at least in part, tapered, such as to be inclined, here in the sagittal plane, to the longitudinal axis of the nosepiece 17.
- the delivery aperture 26 extends both laterally across the tip element 25 and along a longitudinal extent of the tip element 25. The present inventors have recognized that this configuration is particularly advantageous in ensuring the delivery of substance from the nosepiece 17 when inserted substantially in any orient into the nasal cavity of a subject.
- the present inventors have found that the provision of the delivery aperture 26 in a conventional sense, that is, in an orthogonal relation to the longitudinal axis of the nosepiece 17, can lead to obstruction of the delivery aperture 26 by soft tissue within the nasal cavity, and that this problem is remarkably overcome by providing that the delivery aperture 26 is inclined to the longitudinal axis of the nosepiece 17, thereby in effect extending along a length of the longitudinal extent of the tip element 25.
- the delivery aperture 26 has an asymmetric shape in plan view, as illustrated in Figure 3(c) , with the delivery aperture 26 having a sharper, narrower section 26' adjacent one, the forwardmost, end of the tip element 25 and a wider, flatter section 26" adjacent the other, rearwardmost, end of the tip element 25.
- This configuration acts to provide for greater air flow through the delivery aperture 26 at a location spaced rearwardly of the forwardmost section of the tip element 25, which represents that section which is most likely to abut soft tissue in the nasal cavity of the subject.
- the base section 27 defines a shoulder 29, which provides both a seal with the nares of the nostril of the subject and determines the extent of the insertion of the nosepiece 17 into the nasal cavity of the subject.
- the shoulder 29 allows for the nare of the nostril of the subject to be gripped thereagainst by a finger of the subject, in fixing the position of the delivery device.
- the skin of the nose can be particularly slippery due to excreted oils, and the provision of a gripping surface at the shoulder 29 is particularly beneficial.
- This grip can also be improved by the use of a wipe, such as a tissue, particularly where impregnated with an agent which removes the excreted oils, such as to promote the grip with the skin, or alternatively with a grip enhancer, such as a sticky material, for example, a wax, resin, gel or liquid, which promotes the adhesion with the skin.
- a wipe such as a tissue
- an agent which removes the excreted oils such as to promote the grip with the skin
- a grip enhancer such as a sticky material, for example, a wax, resin, gel or liquid, which promotes the adhesion with the skin.
- the nosepiece 17 is formed as a substantially rigid structure, here formed of a plastics material.
- the delivery device further comprises an outlet unit 33 which comprises a nozzle 35 at the distal end thereof, in this embodiment disposed in the nosepiece 17, for delivering substance to the nasal airway of the subject.
- the nozzle 35 is configured to extend at least about 2 cm, preferably at least about 3 cm, more preferably at least about 4 cm, and preferably from about 2 cm to about 4 cm, into the nasal cavity of the subject on insertion of the nosepiece 17 into the nasal cavity of the subject.
- the nozzle 35 is configured to provide an aerosol spray, either as a liquid or powder aerosol.
- the nozzle 35 could be configured to deliver a jet as a column of substance, either as a liquid or powder jet.
- the nozzle 35 is configured to deliver a symmetric aerosol spray.
- the nozzle 35 is configured to deliver an aerosol spray with a spray angle of not more than about 30°, preferably not more than about 25°, and more preferably not more than about 30°.
- the nozzle 35 could be configured to deliver an asymmetric aerosol spray, with the aerosol spray having a significantly greater spray angle in the vertical, sagittal plane than in the horizontal plane.
- Such an aerosol spray has been found to be particularly advantageous in the delivery of substance to posterior regions of the nasal cavities, in particular the olfactory region.
- the spray angle in the vertical, sagittal plane is greater than about 35°, more preferably greater than about 40°, still more preferably greater than about 45° and yet more preferably greater than about 50°.
- the spray angle in the horizontal plane is not more than about 35°, more preferably not more than about 30°, still more preferably not more than about 25°, yet more preferably not more than about 20°, and still yet more preferably not more than about 15°.
- the aerosol spray could present an elliptical spray zone.
- the aerosol spray could present a substantially rectangular spray zone.
- the delivery device further comprises a substance supply unit 37 for delivering metered doses of a substance, which is fluidly connected to the nozzle 35 of the outlet unit 33 to deliver substance from the nosepiece 17, in this embodiment as an aerosol spray.
- the substance supply unit 37 is a multi-dose unit for delivering a plurality of metered doses of substance.
- the substance supply unit 37 could be a single-dose unit for delivering a single metered dose of substance.
- the substance supply unit 37 is pre-primeable, in this embodiment by loading a resilient element, and includes a breath-actuated release mechanism 39 which, when triggered, releases the resilient element and actuates the substance supply unit 37 to deliver a metered dose of substance through the nozzle 35 of the outlet unit 33.
- the release mechanism 39 is configured to cause actuation of the substance supply unit 37 on generation of a predetermined flow rate through the delivery channel 23 of the nosepiece 17.
- the release mechanism 39 could be configured to cause actuation of the substance supply unit 37 on generation of a predetermined pressure within the delivery channel 23 of the nosepiece 17.
- the release mechanism 39 could be configured to cause actuation of the substance supply unit 37 on generation of either one of a predetermined flow rate through the delivery channel 23 of the nosepiece 17 or a predetermined pressure within the delivery channel 23 of the nosepiece 17.
- the substance supply unit 37 comprises a mechanical delivery pump, in particular a liquid delivery pump or a powder delivery pump, which delivers metered doses of a substance on actuation thereof.
- the substance supply unit 37 could comprise an aerosol canister for delivering metered volumes of a propellant, preferably a hydrofluoroalkane (HFA) propellant or the like, containing medicament, either as a suspension or solution.
- a propellant preferably a hydrofluoroalkane (HFA) propellant or the like
- the substance supply unit 37 could comprise a dry powder delivery unit which delivers metered doses of a substance, as a dry powder, on actuation thereof.
- the substance supply unit 37 could comprise a nebulizer which delivers metered doses of a substance, as an aerosol spray, on actuation thereof.
- the subject first primes the delivery unit 37, in this embodiment by loading a biasing element, wipes the nares of his/her nostril with a tissue or the like, and grips the delivery device between the thumb and the second, third and fourth fingers, keeping the first, index finger free, as illustrated in Figure 4(a) .
- the nosepiece 17 is then inserted into one of the nostrils, in this embodiment the left nostril, with a twisting movement, such as to align the mouthpiece 19 with the mouth of the subject, and then the mouthpiece 19 is gripped in the lips of the subject, as illustrated in Figure 4(b) .
- the longer, sagittal section of the tip element 25 is aligned in the sagittal plane and engages upper and lower walls of the nasal cavity of the subject, which engagement causes the expansion of the nasal cavity in the vertical, sagittal plane, in particular the upper wall of the nasal cavity of the subject, which is a fleshy structure, as compared to the lower wall of the nasal cavity of the subject, which is a relatively-hard structure, and also positions the nosepiece 17 in the nasal cavity of the subject, with the lower wall of the nasal cavity of the subject, in being a relatively-hard structure, acting as a reference for the expansion.
- This expansion acts to prevent the bulging of the fleshy structure which can cause partial or full obstruction of the nasal valve and further acts to tension the lateral walls of the nasal cavity of the subject which defines the nasal valve, which causes the lateral walls of the nasal cavity to be urged into sealing contact with the nosepiece 17.
- the subject then extends his/her index finger adjacent the nare of the nostril, such that the index finger is directed to a point between the eyes and the tip of the finger is broadly aligned with the distal end of the nosepiece 17 which is located within the nasal cavity, as illustrated in Figure 4(b) .
- the free finger could be another finger other than the index finger.
- the index finger is then pressed against the skin of the nose, such as to press the nare of the nostril against the nosepiece 17, and gently retracted, such as to pull the nare of the nostril onto the shoulder 29 of the nosepiece 17, as illustrated in Figure 4(c) .
- This action acts to straighten the flow path and improve access beyond the nasal valve.
- the skin of the nose can be cleaned by the use of a wipe, which can be impregnated with a cleaning agent to promote the removal of the secreted oils, or alternatively a grip-enhancing agent can be applied to the skin of the nose to promote the grip therewith.
- the subject then begins to exhale through the mouthpiece 19, which exhalation acts to close the oropharyngeal velum of the subject and drive an air flow through the delivery channel 23 of the nosepiece 17, with the air flow passing into the one nasal cavity, around the posterior margin of the nasal septum and out of the other nasal cavity, thereby achieving a bi-directional air flow through the nasal airway of the subject.
- the release mechanism 39 when the flow rate developed through the delivery channel 23 of the nosepiece 17 reaches a predetermined value, the release mechanism 39 is triggered to actuate the substance supply unit 37 to deliver a metered dose of a substance to the nozzle 35 of the outlet unit 33 and into the nasal cavity of the subject, in this embodiment as an aerosol spray. In an alternative embodiment the release mechanism 39 could be triggered on the generation of a predetermined pressure in the delivery channel 23 of the nosepiece 17.
- the subject then releases the mouthpiece 19 and the nosepiece 17 is withdrawn from the nasal cavity of the subject.
- the device can be discarded.
- the device is ready for further use following priming of the substance supply unit 37.
- a second dose of substance is delivered into the other nostril, here the right nostril, in the same manner as described hereinabove and illustrated in Figures 4(d) to (f) .
- Figures 5(a) to (c) illustrate a modified nosepiece 17 for the delivery device of the above-described embodiment.
- the tip element 25 has a greater length than the tip element 25 of the above-described embodiment.
- FIGS 6(a) to (c) illustrate another modified nosepiece 17 for the delivery device of the above-described embodiment.
- the ratio of the lengths of the sagittal sections 26', 26" of the tip element 25 is greater than that of the above-described embodiment, such as to provide a more elongate delivery aperture 26.
- the length l1 of the forwardmost sagittal section 26' is greater than twice the length l2 of the rearwardmost sagittal section 26".
- the tip element 25 is shaped such that the delivery aperture 26 comprises an orthogonal section adjacent the forwardmost sagittal section 26'.
- Figures 7(a) to (c) illustrate a further modified nosepiece 17 for the delivery device of the above-described embodiment.
- the tip element 25 has a greater length than the tip element 25 of the embodiment of Figures 6(a) to (c) .
- Figures 8(a) to (c) illustrate a yet further modified nosepiece 17 for the delivery device of the above-described embodiment.
- the tip element 25 has a greater width at the proximal end thereof than the tip element 25 of the embodiment of Figures 6(a) to (c) .
- the shoulder 29 acts to promote sealing with the nares of the nostril of the subject.
- the length l1 of the forwardmost sagittal section 26' is about twice the length l2 of the rearwardmost sagittal section 26".
- Figures 9(a) to (c) illustrate a still further modified nosepiece 17 for the delivery device of the above-described embodiment.
- the tip element 25 has a wider, frusto-conical section than the tip element 25 of the above-described embodiment.
- the shoulder 29 acts to promote sealing with the nares of the nostril of the subject deeper in the nasal cavity.
- the length l1 of the forwardmost sagittal section 26' is less than twice the length l2 of the rearwardmost sagittal section 26".
- Figures 10(a) to (c) illustrate a yet still further modified nosepiece 17 for the delivery device of the above-described embodiment.
- the proximal section of the tip element 25 has a wider lateral section than the tip element 25 of the above-described embodiment.
- the shoulder 29 acts further to promote sealing with the nares of the nostril of the subject.
- FIGS 11(a) to (c) illustrate yet another modified nosepiece 17 for the delivery device of the above-described embodiment.
- the nosepiece 17 is formed of two body parts 41, 43, a first, inner body part 41, here formed of a rigid material, such as a rigid plastics material, and a second, outer body part 43 which is disposed about the distal end of the inner body part 41 and defines the tip element 25.
- the outer body part 43 is formed of a soft, resilient material, such as a rubber or plastics material, which confers sufficient flexibility as to facilitate insertion of the tip element 25 into the nasal valve of the subject, and yet the inner body part 41 confers rigidity in the sagittal plane as to promote expansion of the fleshy tissues at the nasal valve.
- the tip element 25 is configured such that the delivery aperture 26 has a symmetric shape, here of circular shape, in a plane orthogonal to the longitudinal axis of the nosepiece 17.
- FIGS 12(a) to (c) illustrate still another modified nosepiece 17 for the delivery device of the above-described embodiment.
- the tip element 25 has a greater length than the tip element 25 of the embodiment of Figures 11(a) to (c) .
- the length l1 of the forwardmost sagittal section 26' is less than twice the length l2 of the rearwardmost sagittal section 26".
- FIGS 13(a) to (d) illustrate still another modified nosepiece 17 for the delivery device of the above-described embodiment.
- This embodiment is a modification of the embodiment of Figures 11(a) to (c) .
- the nozzle 25 is integrally formed with the tip element 25, here the inner body part 41 of the tip element 25.
- Figures 14 illustrates yet still another modified nosepiece 17 for the delivery device of the above-described embodiment.
- This embodiment is a modification of the embodiment of Figures 13(a) to (d) .
- the nozzle 25 is integrally formed with the tip element 25, but here the inner body part 43 of the tip element 25.
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Claims (12)
- - Dispositif d'administration par voie nasale pour administrer une substance à une cavité nasale d'un sujet, à l'arrière d'une valve nasale du sujet, le dispositif d'administration comprenant :un embout nasal (17) ayant un axe longitudinal et comprenant un élément pointe (25) qui s'étend axialement par rapport à l'axe longitudinal de l'embout nasal (17) et qui comprend une ouverture d'administration (26) par laquelle, lors de l'utilisation, une substance est administrée à la cavité nasale du sujet, une extrémité distale de l'élément pointe (25) étant effilée et inclinée par rapport à l'axe longitudinal de l'embout nasal (17), d'une section sagittale la plus en avant de l'élément pointe (25) à une section sagittale la plus en arrière de l'élément pointe (25), ce par quoi l'ouverture d'administration (26) s'étend à la fois latéralement en travers de l'élément pointe (25) et le long d'une étendue longitudinale de l'élément pointe (25), et l'élément pointe (25) a une section latérale allongée qui a une dimension (d 1) dans une première direction, sagittale, plus longue que dans une seconde direction orthogonale à la direction sagittale, de telle sorte que, lorsque l'embout nasal (17) est introduit dans la cavité nasale du sujet, la plus longue dimension (d 1) de l'élément pointe (25) agit pour s'engager avec des surfaces inférieure et supérieure de la cavité nasale du sujet ;une buse (35) à travers laquelle, lors de l'utilisation, une substance est administrée à la cavité nasale du sujet ; etune unité d'administration (37) pour administrer une substance à travers la buse (35).
- - Dispositif d'administration selon la revendication 1, dans lequel la plus longue dimension (d 1) de l'élément pointe (25) agit pour étendre la cavité nasale du sujet dans le plan sagittal.
- - Dispositif d'administration selon la revendication 1 ou 2, dans lequel la section latérale allongée de l'élément pointe (25) est sensiblement elliptique ou sensiblement rectangulaire.
- - Dispositif d'administration selon l'une quelconque des revendications 1 à 3, dans lequel l'ouverture d'administration (26) présente une section plus étroite adjacente à la section sagittale la plus en avant de l'élément pointe (25) et une section plus large adjacente à la section sagittale la plus en arrière de l'élément pointe (25).
- - Dispositif d'administration selon la revendication 4, dans lequel l'ouverture d'administration (26) a une forme de larme ou une forme triangulaire lorsqu'elle est observée le long de l'axe longitudinal de l'embout nasal (17).
- - Dispositif d'administration selon l'une quelconque des revendications 1 à 5, dans lequel l'embout nasal (17) comprend en outre une section de base (27) à partir de laquelle s'étend l'élément pointe (25).
- - Dispositif d'administration selon la revendication 6, dans lequel la section de base (27) définit un épaulement (29) qui définit un joint avec une narine d'un trou de nez du sujet et fournit des moyens auxquels la narine du trou de nez peut être tenue par le sujet.
- - Dispositif d'administration selon l'une quelconque des revendications 1 à 7, dans lequel la section sagittale la plus en avant de l'élément pointe (25) est supérieure à deux fois la longueur de la section sagittale la plus en arrière de l'élément pointe (25).
- - Dispositif d'administration selon l'une quelconque des revendications 1 à 8, dans lequel l'embout nasal (17) est configuré, une fois introduit dans la cavité nasale du sujet, pour s'étendre dans la valve nasale du sujet.
- - Dispositif d'administration selon l'une quelconque des revendications 1 à 9, comprenant en outre : un embout buccal (19) à travers lequel, lors de l'utilisation, le sujet expire pour entraîner la fermeture du voile oropharyngé du sujet.
- - Dispositif d'administration selon la revendication 10, comprenant en outre :
un canal d'écoulement reliant fluidiquement l'embout nasal (17) et l'embout buccal (19), ce par quoi de l'air expiré lors d'une respiration d'expiration est administré à travers l'embout nasal (17). - - Dispositif d'administration selon la revendication 10, comprenant en outre :un canal d'écoulement relié fluidiquement à l'embout nasal (17), à travers lequel, lors de l'utilisation, un écoulement de gaz, séparé d'un écoulement d'air expiré provenant d'une respiration d'expiration du sujet, est administré à l'embout nasal (17) ; etune unité d'alimentation en gaz pour fournir un écoulement de gaz au canal d'écoulement.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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GB0706863A GB2448193A (en) | 2007-04-05 | 2007-04-05 | Nasal delivery device |
EP08736896.5A EP2136865B2 (fr) | 2007-04-05 | 2008-04-07 | Administration nasale |
PCT/GB2008/001217 WO2008122791A2 (fr) | 2007-04-05 | 2008-04-07 | Administration nasale |
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EP08736896.5A Division EP2136865B2 (fr) | 2007-04-05 | 2008-04-07 | Administration nasale |
EP08736896.5A Division-Into EP2136865B2 (fr) | 2007-04-05 | 2008-04-07 | Administration nasale |
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EP3777939A2 EP3777939A2 (fr) | 2021-02-17 |
EP3777939A3 EP3777939A3 (fr) | 2021-05-12 |
EP3777939C0 EP3777939C0 (fr) | 2023-06-07 |
EP3777939B1 true EP3777939B1 (fr) | 2023-06-07 |
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EP20193142.5A Active EP3777939B1 (fr) | 2007-04-05 | 2008-04-07 | Administration nasale |
EP08736896.5A Active EP2136865B2 (fr) | 2007-04-05 | 2008-04-07 | Administration nasale |
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EP08736896.5A Active EP2136865B2 (fr) | 2007-04-05 | 2008-04-07 | Administration nasale |
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EP (2) | EP3777939B1 (fr) |
DK (1) | DK2136865T3 (fr) |
ES (2) | ES2947933T3 (fr) |
GB (1) | GB2448193A (fr) |
PL (1) | PL2136865T3 (fr) |
WO (1) | WO2008122791A2 (fr) |
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GB0114272D0 (en) | 2001-06-12 | 2001-08-01 | Optinose As | Nasal delivery device |
ZA200306564B (en) | 2001-02-26 | 2004-10-15 | Optinose As | Nasal devices. |
GB0215270D0 (en) | 2002-07-02 | 2002-08-14 | Optinose As | Nasal devices |
GB0311570D0 (en) | 2003-05-20 | 2003-06-25 | Optinose As | Delivery device and method |
GB0319119D0 (en) | 2003-08-14 | 2003-09-17 | Optinose As | Delivery devices |
GB0320171D0 (en) | 2003-08-28 | 2003-10-01 | Optinose As | Delivery devices |
GB0420513D0 (en) * | 2004-09-15 | 2004-10-20 | Optinose As | Powder delivery devices |
GB0503738D0 (en) * | 2005-02-23 | 2005-03-30 | Optinose As | Powder delivery devices |
WO2007083073A1 (fr) | 2006-01-19 | 2007-07-26 | Optinose As | Administration nasale |
GB0604444D0 (en) * | 2006-03-06 | 2006-04-12 | Optinose As | Nasal devices |
GB0605799D0 (en) | 2006-03-23 | 2006-05-03 | Optinose As | Nasal delivery devices |
GB2438834A (en) | 2006-06-08 | 2007-12-12 | Optinose As | Intranasal protein administration |
GB2440316A (en) * | 2006-07-25 | 2008-01-30 | Optinose As | Nasal inhaler with scrubber |
GB0623731D0 (en) | 2006-11-28 | 2007-01-10 | Optinose As | Delivery device |
GB0623728D0 (en) | 2006-11-28 | 2007-01-10 | Optinose As | Delivery devices |
GB0623732D0 (en) | 2006-11-28 | 2007-01-10 | Optinose As | Powder delivery devices |
GB2448183A (en) | 2007-04-05 | 2008-10-08 | Optinose As | Nasal powder delivery device |
GB2448193A (en) | 2007-04-05 | 2008-10-08 | Optinose As | Nasal delivery device |
US9248076B2 (en) * | 2007-05-16 | 2016-02-02 | Mystic Pharmaceuticals, Inc. | Dose dispensing containers |
GB0719299D0 (en) | 2007-10-03 | 2007-11-14 | Optinose As | Nasal delivery devices |
CN101459908B (zh) * | 2007-12-13 | 2012-04-25 | 华为技术有限公司 | 一种业务订阅方法、***、服务器 |
CA2713762C (fr) | 2008-02-07 | 2016-10-18 | University Of Washington | Dispositif aerosol peripherique |
US8231588B2 (en) * | 2008-08-01 | 2012-07-31 | Tian Xia | Methods for ameliorating pain and devices for delivering a medicament |
US8905980B2 (en) | 2008-08-01 | 2014-12-09 | Tian Xia | Devices for delivering a medicament and methods for ameliorating pain |
US8690839B2 (en) | 2008-08-01 | 2014-04-08 | Tian Xia | Devices for delivering a medicament and connector for same |
AU2009298395B2 (en) | 2008-10-02 | 2014-11-20 | Lumen Devices Llc | A palate retainer with attached nasopharyngeal airway extender for use in the treatment of obstructive sleep apnea |
CA2744704C (fr) | 2008-11-25 | 2016-01-26 | Lumen Devices Llc | Dispositifs, systemes et methodes de traitement de l'apnee du sommeil |
WO2010070083A1 (fr) | 2008-12-19 | 2010-06-24 | Novartis Ag | Embout buccal pour un inhalateur |
ES2728423T3 (es) * | 2009-01-27 | 2019-10-24 | De La Mer Laboratoire | Cánula para la administración de una solución fluida en una ventana de la nariz |
GB201015371D0 (en) | 2010-09-14 | 2010-10-27 | Optinose As | Nasal delivery |
WO2012112783A1 (fr) * | 2011-02-17 | 2012-08-23 | Lumen Devices Llc | Appareil et procédés de traitement de l'apnée du sommeil |
WO2012119153A2 (fr) | 2011-03-03 | 2012-09-07 | Impel Neuropharma Inc. | Dispositif d'administration de médicament par voie nasale |
WO2012123819A1 (fr) | 2011-03-15 | 2012-09-20 | Optinose As Et Al | Administration nasale |
RU2618084C2 (ru) | 2011-05-09 | 2017-05-02 | Импел Ньюрофарма Инк. | Наконечники для назальной доставки лекарственных средств |
CN107510872A (zh) * | 2011-07-13 | 2017-12-26 | 铸造有限责任公司 | 用于鼻咽粘膜靶的递送装置 |
SG11201405179VA (en) | 2012-02-24 | 2014-10-30 | Optinose As | Nasal delivery devices |
RU2644293C2 (ru) * | 2012-02-24 | 2018-02-08 | Оптиноуз Ас | Устройство для назального введения |
DK2817052T3 (da) | 2012-02-24 | 2017-11-27 | Optinose As | Nasale indgivelsesindretninger |
US11554229B2 (en) | 2013-03-26 | 2023-01-17 | OptiNose Inc. | Nasal administration |
EP2991713B1 (fr) | 2013-04-28 | 2019-06-19 | Impel Neuropharma Inc. | Récipient à dose unitaire médical |
USD761951S1 (en) | 2013-05-23 | 2016-07-19 | Optinose As | Nosepiece unit |
US11116914B2 (en) | 2014-11-09 | 2021-09-14 | Sipnose Ltd. | Device and method for aerosolized delivering of substance to a natural orifice of the body |
US11278682B2 (en) | 2014-11-09 | 2022-03-22 | Sipnose Ltd. | Device and method for aerosolized delivery of substance to a natural orifice of the body |
DE202013105715U1 (de) * | 2013-08-22 | 2014-02-19 | Sipnose Ltd. | Vorrichtung zur Abgabe einer vorbestimmten Menge einer Substanz an eine natürliche Öffnung des Körpers |
US11471618B2 (en) | 2014-11-09 | 2022-10-18 | Sipnose Ltd. | Adjustable dosing delivery and multi sectioned drug compartment |
US11992604B2 (en) | 2014-11-09 | 2024-05-28 | Sipnose Ltd. | Devices and methods for delivering a substance to a body cavity |
EP2868334B1 (fr) | 2013-11-05 | 2017-01-11 | Benedict Gerber | Douche nasale |
US10016580B2 (en) | 2013-12-17 | 2018-07-10 | Biovision Technologies, Llc | Methods for treating sinus diseases |
US9694163B2 (en) | 2013-12-17 | 2017-07-04 | Biovision Technologies, Llc | Surgical device for performing a sphenopalatine ganglion block procedure |
US9516995B2 (en) | 2013-12-17 | 2016-12-13 | Biovision Technologies, Llc | Surgical device for performing a sphenopalatine ganglion block procedure |
US9510743B2 (en) | 2013-12-17 | 2016-12-06 | Biovision Technologies, Llc | Stabilized surgical device for performing a sphenopalatine ganglion block procedure |
US9884148B2 (en) * | 2014-05-30 | 2018-02-06 | Neilmed Pharmaceuticals, Inc. | Angular cap for dispensing liquids |
WO2015197798A1 (fr) * | 2014-06-25 | 2015-12-30 | Optinose As | Administration par voie nasale |
WO2016049082A1 (fr) * | 2014-09-22 | 2016-03-31 | Mehta Ketan C | Bouchon angulaire pour distribuer des liquides |
EP3220988B1 (fr) * | 2014-11-19 | 2022-01-12 | Optinose AS | Administration intranasale |
US20160199599A1 (en) * | 2015-01-13 | 2016-07-14 | Bhl Patent Holdings Llc | Nasal Delivery Device and Methods of Use |
DE102015201826A1 (de) * | 2015-02-03 | 2016-08-04 | Robert Bosch Gmbh | Mundstück für eine Vorrichtung zur Messung eines Parameters von Atemluft und Atemluftmessgerät |
NZ741171A (en) | 2015-09-10 | 2022-01-28 | Impel Neuropharma Inc | In-line nasal delivery device |
EP3713626A4 (fr) | 2017-11-21 | 2021-08-18 | Impel Neuropharma Inc. | Dispositif intra-nasale avec interface d'entrée |
JP7191099B2 (ja) | 2017-11-21 | 2022-12-16 | インペル ファーマシューティカルズ インコーポレイテッド | 浸漬管を備えた鼻腔内装置 |
US10391269B2 (en) * | 2017-11-29 | 2019-08-27 | Meshil A. M. O. H. Al-Jarba | Nasal sprayer with multiple applicators |
EP3735244B1 (fr) | 2018-01-05 | 2022-11-23 | Impel Pharmaceuticals Inc. | Administration intranasale de dihydroergotamine par un dispositif olfactif de précision |
EP3735223A4 (fr) | 2018-01-05 | 2021-10-13 | Impel Neuropharma Inc. | Administration intranasale d'olanzapine par un dispositif olfactif de précision |
US10525240B1 (en) | 2018-06-28 | 2020-01-07 | Sandler Scientific LLC | Sino-nasal rinse delivery device with agitation, flow-control and integrated medication management system |
KR20210034047A (ko) | 2018-07-19 | 2021-03-29 | 임펠 뉴로파마 인코포레이티드 | 파킨슨 병 치료를 위한 레보도파 및 도파 데카르복실라아제 저해제의 기도 전달 |
EA202191856A1 (ru) | 2019-01-03 | 2021-09-02 | Импел Ньюрофарма, Инк. | Устройство для назальной доставки лекарственных средств |
CN109621172A (zh) * | 2019-02-15 | 2019-04-16 | 云南中医学院 | 一种鼻腔缓释给药装置 |
BR112021023049A8 (pt) | 2019-05-17 | 2022-10-18 | Impel Neuropharma Inc | Dispositivo de dispensação nasal de uso único |
CA3142934A1 (fr) | 2019-06-09 | 2020-12-17 | Kblv Medical, Llc | Dispositif et systeme de regulation et de surveillance a distance d'administration de medicament et procede associe |
EP4013369A1 (fr) * | 2019-08-14 | 2022-06-22 | GSK Consumer Healthcare SARL | Buse de récipient pour administration intranasale |
US20230064327A1 (en) | 2020-01-22 | 2023-03-02 | Seelos Therapeutics, Inc. | Reducing side effects of nmda antagonists |
WO2021158736A1 (fr) * | 2020-02-06 | 2021-08-12 | Corbett Lair, Inc. | Méthode, appareil et kit de traitement de congestion nasale chronique et à long terme |
WO2022241214A1 (fr) | 2021-05-14 | 2022-11-17 | Seelos Therapeutics, Inc. | Procédés d'utilisation d'antagonistes du récepteur nmda |
TW202310825A (zh) | 2021-05-14 | 2023-03-16 | 美商西羅斯醫療公司 | 減少nmda受體拮抗劑之副作用 |
US11984211B2 (en) | 2021-08-30 | 2024-05-14 | Isaac Abadi | System and method for utilization of data from remote regulation and monitoring of drug delivery |
Family Cites Families (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US605436A (en) | 1898-06-07 | Inhaler | ||
US642748A (en) | 1899-02-23 | 1900-02-06 | Arthur Manners | Inhaler. |
US658436A (en) | 1900-05-28 | 1900-09-25 | Hans Hennerich Groth | Insufflator. |
US746749A (en) | 1903-03-18 | 1903-12-15 | George E Seidel | Nasal medicator. |
US794641A (en) | 1905-03-06 | 1905-07-11 | Alfred H Ramey | Inhaler. |
US902832A (en) | 1907-09-20 | 1908-11-03 | Edward F Philbrook | Inhaler. |
US888869A (en) | 1908-01-04 | 1908-05-26 | Frank I Clark | Inhaler. |
US2672138A (en) | 1950-09-05 | 1954-03-16 | Carlock Marion Pomeroy | Device to promote nasal breathing and prevent snoring |
US3127893A (en) | 1960-11-23 | 1964-04-07 | Joseph F Montague | Injector |
US3198193A (en) * | 1962-10-12 | 1965-08-03 | Schwartzman Sam | Nasal inhaler |
DE2123252C3 (de) * | 1971-05-11 | 1975-02-20 | Carl Heyer Gmbh, Inhalationstechnik, 5427 Bad Ems | Nasenansatzstück für Inhalationsgeräte |
US4684362A (en) * | 1981-03-12 | 1987-08-04 | Holt James J | Method for collecting nasal secretions |
EP0683648B1 (fr) * | 1993-02-12 | 1998-09-16 | Minnesota Mining And Manufacturing Company | Appareil de distribution d'aerosol |
US5400797A (en) * | 1994-02-07 | 1995-03-28 | Ethridge; Michael | Nasal stethoscope |
US5788683A (en) * | 1994-03-23 | 1998-08-04 | Martin; Richard A. | Sinus aspiration/irrigation |
CZ294305B6 (cs) | 1995-01-23 | 2004-11-10 | Direct-Haler A/S | Inhalátor |
JP3320288B2 (ja) * | 1995-11-15 | 2002-09-03 | 株式会社ユニシアジェックス | 鼻腔用投薬器 |
US5797392C1 (en) | 1996-01-22 | 2001-01-09 | Direct Haler As | Inhaler |
US5797390A (en) * | 1996-03-06 | 1998-08-25 | Mcsoley; Thomas E. | Nasal inhaler having a directed spray pattern |
NZ501157A (en) | 1997-05-27 | 2001-04-27 | Direct Haler As | Inhaler, curved or flexible tube containing powdered medication, one end inserted into nostril, the other into patients mouth |
IS4516A (is) | 1997-07-01 | 1999-01-02 | Gizurarson Sveinbjörn | Nýtt lyfjaform |
US7799337B2 (en) | 1997-07-21 | 2010-09-21 | Levin Bruce H | Method for directed intranasal administration of a composition |
GB9806939D0 (en) * | 1998-03-31 | 1998-05-27 | Procter & Gamble | A spray device |
GB9806937D0 (en) † | 1998-03-31 | 1998-05-27 | Procter & Gamble | A spray device |
US6561193B1 (en) * | 1998-10-30 | 2003-05-13 | Linda J. Noble | Nasal gas delivery apparatus and a nasal vestibular airway |
US6637434B2 (en) * | 1998-10-30 | 2003-10-28 | Linda J. Noble | Nasal gas delivery system and method for use thereof |
US7178524B2 (en) † | 1998-10-30 | 2007-02-20 | Linda Noble | Nasal gas delivery system and method for use thereof |
GB0114272D0 (en) | 2001-06-12 | 2001-08-01 | Optinose As | Nasal delivery device |
GB0121568D0 (en) | 2001-09-06 | 2001-10-24 | Optinose As | Nasal delivery device |
EP3124067A3 (fr) | 1999-03-03 | 2017-05-24 | Optinose AS | Dispositif d'administration nasale |
GB0015309D0 (en) | 2000-06-21 | 2000-08-16 | Djupesland Per G | Apparatus |
IT1317998B1 (it) † | 2000-06-26 | 2003-07-21 | Medical Internat Licensing N V | Valvola erogatrice per spray nasale. |
ZA200306564B (en) | 2001-02-26 | 2004-10-15 | Optinose As | Nasal devices. |
US7225807B2 (en) * | 2001-03-15 | 2007-06-05 | Creare Incorporated | Systems and methods for aerosol delivery of agents |
AU2002340083A1 (en) * | 2001-09-28 | 2003-04-07 | Kurve Technology, Inc | Nasal nebulizer |
GB0207422D0 (en) | 2002-03-28 | 2002-05-08 | Optinose As | Nasal devices |
GB0207817D0 (en) | 2002-04-04 | 2002-05-15 | Optinose As | Nasal devices |
GB0209494D0 (en) | 2002-04-25 | 2002-06-05 | Optinose As | Nasal devices |
GB0215270D0 (en) | 2002-07-02 | 2002-08-14 | Optinose As | Nasal devices |
GB0215904D0 (en) | 2002-07-09 | 2002-08-21 | Team Holdings Uk Ltd | Drug delivery system and method |
GB0300008D0 (en) | 2003-01-02 | 2003-02-05 | Optinose As | Delivery devices |
FR2854574B1 (fr) * | 2003-05-06 | 2006-01-06 | Marc Francisque Durand | Dispositif pour le lavage des cavites naso-sinusiennes |
GB0311570D0 (en) | 2003-05-20 | 2003-06-25 | Optinose As | Delivery device and method |
GB0313355D0 (en) † | 2003-06-10 | 2003-07-16 | Glaxo Group Ltd | Nozzle |
GB0319119D0 (en) | 2003-08-14 | 2003-09-17 | Optinose As | Delivery devices |
GB0320171D0 (en) | 2003-08-28 | 2003-10-01 | Optinose As | Delivery devices |
USD530815S1 (en) | 2004-03-19 | 2006-10-24 | Optinose As | Nasal delivery device |
US20050287107A1 (en) * | 2004-06-25 | 2005-12-29 | Anthony Tuccelli | Odor control device |
GB0420513D0 (en) * | 2004-09-15 | 2004-10-20 | Optinose As | Powder delivery devices |
US8282594B2 (en) * | 2004-12-20 | 2012-10-09 | Bausch & Lomb Incorporated | Non-circular ported phacoemulsification irrigation sleeve |
US7347209B2 (en) * | 2005-01-20 | 2008-03-25 | Bovo Peter J | Free breathing apparatus |
GB0503738D0 (en) | 2005-02-23 | 2005-03-30 | Optinose As | Powder delivery devices |
US20070062538A1 (en) * | 2005-09-21 | 2007-03-22 | Dave Foggia | Undetectable nasal insert |
GB2448644A (en) * | 2006-01-19 | 2008-10-22 | John C Jeppesen Dmd Inc | Method and device for treating sleep apnea |
WO2007083073A1 (fr) | 2006-01-19 | 2007-07-26 | Optinose As | Administration nasale |
EP1988953B1 (fr) | 2006-02-14 | 2017-07-19 | Optinose AS | Dispositif d'administration |
GB0602980D0 (en) | 2006-02-14 | 2006-03-29 | Optinose As | Delivery device and method |
GB0604319D0 (en) | 2006-03-03 | 2006-04-12 | Optinose As | Nasal delivery |
GB0604444D0 (en) | 2006-03-06 | 2006-04-12 | Optinose As | Nasal devices |
GB0605799D0 (en) | 2006-03-23 | 2006-05-03 | Optinose As | Nasal delivery devices |
GB2437488A (en) | 2006-04-25 | 2007-10-31 | Optinose As | Pharmaceutical oily formulation for nasal or buccal administration |
GB2438834A (en) | 2006-06-08 | 2007-12-12 | Optinose As | Intranasal protein administration |
GB2440316A (en) | 2006-07-25 | 2008-01-30 | Optinose As | Nasal inhaler with scrubber |
GB0623728D0 (en) | 2006-11-28 | 2007-01-10 | Optinose As | Delivery devices |
GB0623731D0 (en) | 2006-11-28 | 2007-01-10 | Optinose As | Delivery device |
GB0623732D0 (en) | 2006-11-28 | 2007-01-10 | Optinose As | Powder delivery devices |
GB2448183A (en) | 2007-04-05 | 2008-10-08 | Optinose As | Nasal powder delivery device |
GB2448193A (en) | 2007-04-05 | 2008-10-08 | Optinose As | Nasal delivery device |
GB0719299D0 (en) | 2007-10-03 | 2007-11-14 | Optinose As | Nasal delivery devices |
NZ577415A (en) * | 2008-06-04 | 2011-01-28 | Resmed Ltd | Breathing apparatus attached to the face using a hook and loop fastener having one side adhered to the skin |
WO2010029441A2 (fr) | 2008-09-15 | 2010-03-18 | Optinose As | Administration par voie nasale |
GB201015371D0 (en) | 2010-09-14 | 2010-10-27 | Optinose As | Nasal delivery |
WO2012123819A1 (fr) * | 2011-03-15 | 2012-09-20 | Optinose As Et Al | Administration nasale |
SG11201405179VA (en) | 2012-02-24 | 2014-10-30 | Optinose As | Nasal delivery devices |
RU2644293C2 (ru) | 2012-02-24 | 2018-02-08 | Оптиноуз Ас | Устройство для назального введения |
DK2817052T3 (da) | 2012-02-24 | 2017-11-27 | Optinose As | Nasale indgivelsesindretninger |
US11554229B2 (en) | 2013-03-26 | 2023-01-17 | OptiNose Inc. | Nasal administration |
BR112015024869A8 (pt) | 2013-03-26 | 2019-12-17 | Optinose As | uso de um agente terapêutico e/ou de diôxido de carbono para tratar um paciente e aparelhos e métodos para tratar terapeuticamente um paciente |
USD761951S1 (en) | 2013-05-23 | 2016-07-19 | Optinose As | Nosepiece unit |
USD725769S1 (en) | 2013-05-23 | 2015-03-31 | Optinose As | Nasal delivery device |
USD723156S1 (en) | 2013-05-23 | 2015-02-24 | Optinose As | Nasal delivery device |
EP3220988B1 (fr) | 2014-11-19 | 2022-01-12 | Optinose AS | Administration intranasale |
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2008
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US20100282246A1 (en) | 2010-11-11 |
ES2947933T3 (es) | 2023-08-24 |
EP3777939A3 (fr) | 2021-05-12 |
US8978647B2 (en) | 2015-03-17 |
EP2136865B2 (fr) | 2023-05-10 |
WO2008122791A3 (fr) | 2009-06-25 |
GB0706863D0 (en) | 2007-05-16 |
ES2829915T3 (es) | 2021-06-02 |
US20160001022A1 (en) | 2016-01-07 |
GB2448193A (en) | 2008-10-08 |
WO2008122791A2 (fr) | 2008-10-16 |
EP2136865B1 (fr) | 2020-09-09 |
DK2136865T3 (da) | 2020-11-09 |
EP3777939A2 (fr) | 2021-02-17 |
US10076615B2 (en) | 2018-09-18 |
EP3777939C0 (fr) | 2023-06-07 |
US20220096763A1 (en) | 2022-03-31 |
EP2136865A2 (fr) | 2009-12-30 |
US20190117918A1 (en) | 2019-04-25 |
PL2136865T3 (pl) | 2021-03-08 |
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