EP3775267A4 - Novel angiopoietin 2, vegf dual antagonists - Google Patents

Novel angiopoietin 2, vegf dual antagonists Download PDF

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Publication number
EP3775267A4
EP3775267A4 EP19784270.1A EP19784270A EP3775267A4 EP 3775267 A4 EP3775267 A4 EP 3775267A4 EP 19784270 A EP19784270 A EP 19784270A EP 3775267 A4 EP3775267 A4 EP 3775267A4
Authority
EP
European Patent Office
Prior art keywords
dual antagonists
novel angiopoietin
vegf dual
vegf
angiopoietin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19784270.1A
Other languages
German (de)
French (fr)
Other versions
EP3775267A2 (en
Inventor
Yuefeng Lu
Jian-Feng Lu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Askgene Pharma Inc
Original Assignee
Askgene Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Askgene Pharma Inc filed Critical Askgene Pharma Inc
Publication of EP3775267A2 publication Critical patent/EP3775267A2/en
Publication of EP3775267A4 publication Critical patent/EP3775267A4/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
EP19784270.1A 2018-04-10 2019-04-10 Novel angiopoietin 2, vegf dual antagonists Pending EP3775267A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862655436P 2018-04-10 2018-04-10
PCT/US2019/026838 WO2019200006A2 (en) 2018-04-10 2019-04-10 Novel angiopoietin 2, vegf dual antagonists

Publications (2)

Publication Number Publication Date
EP3775267A2 EP3775267A2 (en) 2021-02-17
EP3775267A4 true EP3775267A4 (en) 2022-05-18

Family

ID=68164868

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19784270.1A Pending EP3775267A4 (en) 2018-04-10 2019-04-10 Novel angiopoietin 2, vegf dual antagonists

Country Status (3)

Country Link
EP (1) EP3775267A4 (en)
CN (1) CN112262158A (en)
WO (1) WO2019200006A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3454903A4 (en) * 2016-05-13 2020-08-19 Askgene Pharma, Inc. Novel angiopoietin 2, vegf dual antagonists
KR20230061458A (en) 2020-09-04 2023-05-08 에프. 호프만-라 로슈 아게 Antibodies that bind to VEGF-A and ANG2 and methods of use
CN117255809A (en) * 2021-03-31 2023-12-19 杭州嘉因生物科技有限公司 Fusion molecules targeting VEGF and angiogenin and uses thereof
US20220389120A1 (en) * 2021-06-03 2022-12-08 Gensun Biopharma Inc. Multispecific antagonists

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016073915A1 (en) * 2014-11-07 2016-05-12 Novartis Ag Stable protein solution formulation containing high concentration of an anti-vegf antibody
WO2017197199A1 (en) * 2016-05-13 2017-11-16 Askgene Pharma Inc. Novel angiopoietin 2, vegf dual antagonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR103477A1 (en) * 2015-01-28 2017-05-10 Lilly Co Eli VEGFA / ANG2 COMPOUNDS

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016073915A1 (en) * 2014-11-07 2016-05-12 Novartis Ag Stable protein solution formulation containing high concentration of an anti-vegf antibody
WO2017197199A1 (en) * 2016-05-13 2017-11-16 Askgene Pharma Inc. Novel angiopoietin 2, vegf dual antagonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SCHAUWVLIEGHE A. M. E. ET AL: "Comparing the Effectiveness of Bevacizumab to Ranibizumab in Patients with Exudative Age-Related Macular Degeneration. The BRAMD Study", PLOS ONE, vol. 11, no. 5, 1 May 2016 (2016-05-01), pages e0153052, XP055909670, DOI: 10.1371/journal.pone.0153052 *

Also Published As

Publication number Publication date
CN112262158A (en) 2021-01-22
EP3775267A2 (en) 2021-02-17
WO2019200006A2 (en) 2019-10-17

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Ipc: A61P 27/02 20060101ALI20220414BHEP

Ipc: A61K 39/00 20060101ALI20220414BHEP

Ipc: C07K 16/22 20060101AFI20220414BHEP