EP3773747A4 - Verwendung von exosomen zur gezielten abgabe von therapeutischen wirkstoffen - Google Patents
Verwendung von exosomen zur gezielten abgabe von therapeutischen wirkstoffen Download PDFInfo
- Publication number
- EP3773747A4 EP3773747A4 EP19776678.5A EP19776678A EP3773747A4 EP 3773747 A4 EP3773747 A4 EP 3773747A4 EP 19776678 A EP19776678 A EP 19776678A EP 3773747 A4 EP3773747 A4 EP 3773747A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- exosomes
- therapeutic agents
- targeted delivery
- targeted
- delivery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862649057P | 2018-03-28 | 2018-03-28 | |
PCT/US2019/024603 WO2019191444A1 (en) | 2018-03-28 | 2019-03-28 | Use of exosomes for targeted delivery of therapeutic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3773747A1 EP3773747A1 (de) | 2021-02-17 |
EP3773747A4 true EP3773747A4 (de) | 2022-02-23 |
Family
ID=68060505
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19776678.5A Pending EP3773747A4 (de) | 2018-03-28 | 2019-03-28 | Verwendung von exosomen zur gezielten abgabe von therapeutischen wirkstoffen |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP3773747A4 (de) |
JP (1) | JP2021519296A (de) |
KR (1) | KR20200136978A (de) |
CN (1) | CN112533643A (de) |
AU (1) | AU2019243179A1 (de) |
CA (1) | CA3095136A1 (de) |
WO (1) | WO2019191444A1 (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT201900007785A1 (it) * | 2019-05-31 | 2020-12-01 | Univ Degli Studi Milano | Vescicole extracellulari per veicolare farmaci terapeutici o diagnostici |
CN115297850A (zh) * | 2019-12-05 | 2022-11-04 | 得克萨斯州大学***董事会 | 用于肝纤维化和其他与纤维化相关的疾病的基于外排体的治疗 |
WO2021119552A1 (en) * | 2019-12-13 | 2021-06-17 | Lawrence Livermore National Security, Llc | Nanotube-vesicle compositions and uses thereof |
CN117860902B (zh) * | 2021-11-17 | 2024-07-16 | 中国人民解放军空军军医大学 | 一种***癌分子靶向***及其构建方法和应用 |
CN114774471A (zh) * | 2022-05-10 | 2022-07-22 | 厦门星际诺康细胞科技有限公司 | 一种呈现il27稳转细胞及其构建方法、呈现il27工程化外泌体及其制备方法和应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015085096A1 (en) * | 2013-12-04 | 2015-06-11 | Board Of Regents, The University Of Texas System | Analysis of genomic dna, rna, and proteins in exosomes for diagnosis and theranosis |
WO2016201323A1 (en) * | 2015-06-10 | 2016-12-15 | Board Of Regents, The University Of Texas System | Use of exosomes for the treatment of disease |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7473678B2 (en) * | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
US9085778B2 (en) * | 2006-05-03 | 2015-07-21 | VL27, Inc. | Exosome transfer of nucleic acids to cells |
GB201121069D0 (en) * | 2011-12-07 | 2012-01-18 | Isis Innovation | Delivery system |
CN105051192B (zh) * | 2012-11-13 | 2020-04-17 | 科迪艾克生物科学公司 | 治疗剂的递送 |
BR112015002626A2 (pt) * | 2012-11-29 | 2017-09-26 | Yeda Res & Dev | métodos para prevenção de metástases tumorais, tratamento e prognostico do câncer e identificação dos agentes que são inibidores da metástase putativa |
US20190008902A1 (en) * | 2015-12-30 | 2019-01-10 | The Regents Of The University Of California | Methods for enhanced production and isolation of cell-derived vesicles |
TWI601741B (zh) * | 2016-07-11 | 2017-10-11 | 財團法人國家衛生研究院 | 利用***素受體ep4-拮抗劑誘導幹細胞製造含有高囊泡含物之外泌體囊泡的方法及其應用 |
-
2019
- 2019-03-28 CA CA3095136A patent/CA3095136A1/en active Pending
- 2019-03-28 KR KR1020207030993A patent/KR20200136978A/ko unknown
- 2019-03-28 CN CN201980034058.9A patent/CN112533643A/zh active Pending
- 2019-03-28 EP EP19776678.5A patent/EP3773747A4/de active Pending
- 2019-03-28 JP JP2020551798A patent/JP2021519296A/ja active Pending
- 2019-03-28 WO PCT/US2019/024603 patent/WO2019191444A1/en unknown
- 2019-03-28 AU AU2019243179A patent/AU2019243179A1/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015085096A1 (en) * | 2013-12-04 | 2015-06-11 | Board Of Regents, The University Of Texas System | Analysis of genomic dna, rna, and proteins in exosomes for diagnosis and theranosis |
WO2016201323A1 (en) * | 2015-06-10 | 2016-12-15 | Board Of Regents, The University Of Texas System | Use of exosomes for the treatment of disease |
Non-Patent Citations (2)
Title |
---|
See also references of WO2019191444A1 * |
SHIN-ICHIRO OHNO ET AL: "Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells", MOLECULAR THERAPY, vol. 21, no. 1, 1 January 2013 (2013-01-01), US, pages 185 - 191, XP055501314, ISSN: 1525-0016, DOI: 10.1038/mt.2012.180 * |
Also Published As
Publication number | Publication date |
---|---|
KR20200136978A (ko) | 2020-12-08 |
WO2019191444A1 (en) | 2019-10-03 |
CN112533643A (zh) | 2021-03-19 |
CA3095136A1 (en) | 2019-10-03 |
EP3773747A1 (de) | 2021-02-17 |
AU2019243179A1 (en) | 2020-11-12 |
JP2021519296A (ja) | 2021-08-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP3548005A4 (de) | Exosome zur ausgabe von therapeutischen wirkstoffen | |
EP3840730A4 (de) | Zusammensetzungen zur abgabe von therapeutika und verfahren zu deren verwendung und herstellung | |
IL268999B (en) | Compounds and preparations for intracellular administration of medicinal agents | |
EP3386484A4 (de) | Zusammensetzungen und verfahren zur abgabe von therapeutischen wirkstoffen | |
EP3773747A4 (de) | Verwendung von exosomen zur gezielten abgabe von therapeutischen wirkstoffen | |
EP3471672B8 (de) | Injektionsvorrichtung zur subretinalen freisetzung eines therapeutikums | |
EP3749344A4 (de) | Verfahren zur therapeutischen verwendung von exosomen und y-rnas | |
EP3817747A4 (de) | Gezielte abgabe von therapeutischen mitteln an menschliche adipozyten | |
EP3512554A4 (de) | Plättchenzusammensetzungen und verfahren zur ausgabe von therapeutischen agenten | |
EP3735463A4 (de) | Zytotoxizitätsinduzierendes therapeutikum | |
IL251349A0 (en) | Routing of melanocytes to deliver medical or diagnostic agents using nanocage proteins | |
EP4021369A4 (de) | Medizinische vorrichtungen zur kontinuierlichen abgabe therapeutischer mittel | |
EP3927328A4 (de) | Inhalierbares therapeutikum | |
EP3525772A4 (de) | Formulierungen zur enterischen verabreichung von therapeutika | |
EP3777893A4 (de) | Verwendung von bis-iminobiotin-verbindung für wirkstofffreisetzungszwecke | |
IL275690A (en) | Nanoparticles for targeted delivery of therapeutic polypeptides | |
EP3773492A4 (de) | Therapeutisches targeting von onkogenen unter verwendung von exosomen | |
EP3836866A4 (de) | Systeme zur enterischen verabreichung von therapeutika | |
EP3171858A4 (de) | Verfahren und zusammensetzungen zur gezielten verabreichung von therapeutika | |
EP3651741A4 (de) | Zusammensetzungen und verfahren zur gezielten abgabe einer therapeutischen und / oder diagnostischen spezies | |
IL284411A (en) | Targeted transport of drug molecules | |
EP3886913A4 (de) | Verbesserte gezielte abgabe von therapeutika | |
EP3362096A4 (de) | Ophthalmische behandlungszusammensetzung und trägerstoff zur freisetzung von pharmazeutischen substanzen oder therapeutika | |
EP3781194A4 (de) | Zusammensetzungen und verfahren zur selektiven abgabe von therapeutischen und bildgebenden mitteln | |
EP3808356A4 (de) | Gewebetherapiemittel |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
17P | Request for examination filed |
Effective date: 20200930 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20220124 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12N 15/113 20100101ALI20220118BHEP Ipc: C12N 15/87 20060101ALI20220118BHEP Ipc: A61K 48/00 20060101AFI20220118BHEP |