EP3765525A4 - Biparatopische anti-her2-antikörper-wirkstoff-konjugate und verwendungsverfahren - Google Patents

Biparatopische anti-her2-antikörper-wirkstoff-konjugate und verwendungsverfahren Download PDF

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Publication number
EP3765525A4
EP3765525A4 EP19766478.2A EP19766478A EP3765525A4 EP 3765525 A4 EP3765525 A4 EP 3765525A4 EP 19766478 A EP19766478 A EP 19766478A EP 3765525 A4 EP3765525 A4 EP 3765525A4
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EP
European Patent Office
Prior art keywords
methods
drug conjugates
biparatopic antibody
her2 biparatopic
her2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19766478.2A
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English (en)
French (fr)
Other versions
EP3765525B1 (de
EP3765525A1 (de
Inventor
Kevin HAMBLETT
Rupert H. DAVIES
James R. RICH
Gerald J. ROWSE
Vincent K. C. FUNG
Stuart D. Barnscher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zymeworks BC Inc
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Zymeworks Inc Canada
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Filing date
Publication date
Application filed by Zymeworks Inc Canada filed Critical Zymeworks Inc Canada
Priority to EP23176808.6A priority Critical patent/EP4253421A3/de
Priority to HRP20231280TT priority patent/HRP20231280T1/hr
Priority to RS20230943A priority patent/RS64690B1/sr
Publication of EP3765525A1 publication Critical patent/EP3765525A1/de
Publication of EP3765525A4 publication Critical patent/EP3765525A4/de
Application granted granted Critical
Publication of EP3765525B1 publication Critical patent/EP3765525B1/de
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EP19766478.2A 2018-03-13 2019-03-12 Biparatopische anti-her2-antikörper-wirkstoff-konjugate und verwendungsverfahren Active EP3765525B1 (de)

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Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2968258A1 (en) * 2014-11-27 2016-06-02 Zymeworks Inc. Methods of using bispecific antigen-binding constructs targeting her2
CN117321086A (zh) * 2021-04-26 2023-12-29 轩竹生物科技股份有限公司 一种双特异抗体偶联物
WO2023141714A1 (en) * 2022-01-26 2023-08-03 Zymeworks Bc Inc. Methods of using anti-her2 biparatopic antibody-drug conjugates in the treatment of cancer

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2103059C (en) 1991-06-14 2005-03-22 Paul J. Carter Method for making humanized antibodies
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US6949245B1 (en) 1999-06-25 2005-09-27 Genentech, Inc. Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
AU2001259063A1 (en) 2000-04-12 2001-10-30 Human Genome Sciences, Inc. Albumin fusion proteins
FR2807767B1 (fr) 2000-04-12 2005-01-14 Lab Francais Du Fractionnement Anticorps monoclonaux anti-d
US7256257B2 (en) 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US6884869B2 (en) 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US7091186B2 (en) 2001-09-24 2006-08-15 Seattle Genetics, Inc. p-Amidobenzylethers in drug delivery agents
AU2003263964C1 (en) 2002-07-31 2010-08-19 Seagen Inc. Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
US8399618B2 (en) 2004-10-21 2013-03-19 Xencor, Inc. Immunoglobulin insertions, deletions, and substitutions
SI1725249T1 (sl) 2003-11-06 2014-04-30 Seattle Genetics, Inc. Spojine monometilvalina, sposobne konjugacije na ligande
WO2005082023A2 (en) 2004-02-23 2005-09-09 Genentech, Inc. Heterocyclic self-immolative linkers and conjugates
WO2006034488A2 (en) 2004-09-23 2006-03-30 Genentech, Inc. Cysteine engineered antibodies and conjugates
EP1871808A2 (de) 2005-03-31 2008-01-02 Xencor, Inc. Fc-varianten mit verbesserten eigenschaften
GB0619291D0 (en) 2006-09-29 2006-11-08 Ucb Sa Altered antibodies
CN103048578A (zh) * 2006-11-24 2013-04-17 杰米那资产管理（6）有限公司 供电监控***
PL2099823T5 (pl) 2006-12-01 2023-02-20 Seagen Inc. Wariant środków wiążących cel i jego zastosowania
CN102711810B (zh) 2009-11-30 2015-04-22 詹森生物科技公司 效应子功能已消除的抗体Fc区突变体
AU2010336029B2 (en) 2009-12-23 2011-10-13 Avipep Pty Ltd Immuno-conjugates and methods for producing them 2
CN102884084B (zh) * 2010-03-04 2016-12-07 西福根有限公司 抗her2抗体及组合物
WO2011135040A1 (en) 2010-04-30 2011-11-03 F. Hoffmann-La Roche Ag Fluorescent antibody fusion protein, its production and use
EP2579897A1 (de) 2010-06-08 2013-04-17 Genentech, Inc. Cystein-manipulierte antikörper und konjugate
RS59589B1 (sr) 2010-11-05 2019-12-31 Zymeworks Inc Dizajniranje stabilnog heterodimernog antitela sa mutacijama u fc domenu
ES2676878T3 (es) 2011-03-03 2018-07-25 Zymeworks Inc. Diseño de armazón de heteromultímero multivalente y constructos
KR20160044598A (ko) 2011-03-29 2016-04-25 로슈 글리카트 아게 항체 Fc 변이체
US20140170148A1 (en) 2011-04-20 2014-06-19 Genmab A/S Bispecific antibodies against her2
JP6014121B2 (ja) * 2011-04-29 2016-10-25 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ セルソータシステムおよび方法
CN104080811B (zh) * 2011-11-04 2019-09-27 酵活有限公司 在Fc结构域中具有突变的稳定异源二聚的抗体设计
BR112014031613A2 (pt) * 2012-06-19 2017-07-25 Polytherics Ltd processo para preparação de conjugados de anticorpos e conjugados de anticorpos
WO2014012082A2 (en) 2012-07-13 2014-01-16 Zymeworks Inc. Multivalent heteromultimer scaffold design an constructs
US10093740B2 (en) 2012-10-15 2018-10-09 Universitat Zurich Bispecific HER2 ligands for cancer therapy
SI3199552T1 (sl) 2012-11-20 2020-06-30 Sanofi Protitelesa proti-CEACAM5 in njihove uporabe
EP2777714A1 (de) 2013-03-15 2014-09-17 NBE-Therapeutics LLC Verfahren zur Herstellung eines Immunoliganden/Nutzlastkonjugats durch ein Sequenz-spezifisches Transpeptidase Enzym
JP2016519070A (ja) 2013-03-15 2016-06-30 アッヴィ・インコーポレイテッド 抗体薬物複合体（ａｄｃ）の精製
AU2014262566A1 (en) * 2013-05-08 2015-11-12 Zymeworks Inc. Bispecific HER2 and HER3 antigen binding constructs
RU2655439C2 (ru) 2013-05-31 2018-05-28 Займворкс Инк. Гетеромультимеры с уменьшенной или подавленной эффекторной функцией
US9877080B2 (en) * 2013-09-27 2018-01-23 Samsung Electronics Co., Ltd. Display apparatus and method for controlling thereof
AU2014357292B2 (en) 2013-11-27 2020-06-25 Zymeworks Bc Inc. Bispecific antigen-binding constructs targeting HER2
RU2016129517A (ru) 2013-12-20 2018-01-25 Ф. Хоффманн-Ля Рош Аг Биспецифические антитела к her2 и способы применения
EP3086815B1 (de) * 2013-12-27 2022-02-09 Zymeworks Inc. Sulfonamidhaltige verknüpfungssysteme für arzneimittelkonjugate
CA2935430C (en) 2014-01-10 2018-09-18 Synthon Biopharmaceuticals B.V. Duocarmycin adcs for use in treatment of endometrial cancer
TWI701042B (zh) * 2014-03-19 2020-08-11 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
JP2017512765A (ja) 2014-04-11 2017-05-25 メディミューン，エルエルシー 二重特異性ｈｅｒ２抗体
WO2015177360A1 (en) 2014-05-22 2015-11-26 Synthon Biopharmaceuticals B.V. Site-specific conjugation of linker drugs to antibodies and resulting adcs
EP4029873A1 (de) 2014-09-17 2022-07-20 Zymeworks Inc. Cytotoxische und antimitotische verbindungen und verfahren zur verwendung davon
CA2968258A1 (en) 2014-11-27 2016-06-02 Zymeworks Inc. Methods of using bispecific antigen-binding constructs targeting her2
AU2016262168B2 (en) 2015-05-13 2022-06-23 Zymeworks Bc Inc. Antigen-binding constructs targeting HER2
US10188660B2 (en) 2015-11-30 2019-01-29 Abbvie Inc. Anti-huLRRC15 antibody drug conjugates and methods for their use
US20200297862A1 (en) 2016-04-25 2020-09-24 Zymeworks Inc. Methods of using bispecific antigen-binding constructs targeting her2
PT3458102T (pt) 2016-05-17 2020-08-17 Abbvie Inc Conjugados de fármacos com anticorpo anti-cmet e métodos para o seu uso
CN107446045A (zh) 2016-07-22 2017-12-08 北京天广实生物技术股份有限公司 一种抗her2的抗体、其药物组合物及用途
US10377833B2 (en) 2016-07-22 2019-08-13 Beijing Mabworks Biotech Co., Ltd. Bispecific anti-HER2 antibody

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

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