EP3679404A1 - Dispositif de mesure optique par lumière polarisée de doses d'irradiation absorbée par un gel dosimétrique - Google Patents
Dispositif de mesure optique par lumière polarisée de doses d'irradiation absorbée par un gel dosimétriqueInfo
- Publication number
- EP3679404A1 EP3679404A1 EP18796700.5A EP18796700A EP3679404A1 EP 3679404 A1 EP3679404 A1 EP 3679404A1 EP 18796700 A EP18796700 A EP 18796700A EP 3679404 A1 EP3679404 A1 EP 3679404A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- light beam
- optical detector
- value
- polarization
- support
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
- G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
- G01T1/02—Dosimeters
- G01T1/04—Chemical dosimeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N2021/4792—Polarisation of scatter light
Definitions
- the present invention relates to a device for measuring at least one irradiation dose absorbed by a dosimetric gel, as well as to a method of implementing the measuring device for measuring the value of one or more absorbed doses. by the dosimetric gel.
- Radiotherapy can treat many conditions in a patient without it being necessary to resort to invasive operations. Radiotherapy therefore offers an alternative to surgical techniques to avoid postoperative trauma in the patient.
- radiotherapy treats tumor tissue in a patient by exposing them to sufficient radiation doses to irreversibly damage them.
- the effectiveness of this method therefore requires absolute control of the irradiated area so as not to damage the surrounding healthy tissues.
- metrological systems that verify the ballistics of the treatments.
- This analytical technique is also limited in evaluating the influence of low doses of irradiation on the structure of a dosimetric gel because of its low sensitivity and low response to low doses of irradiation.
- the sensitivity of the metrological system fluctuates according to the ambient temperature.
- Other optical reading techniques are also subject to artifacts and very long read times.
- the present invention therefore aims to provide a device and a method for measuring doses of radiation absorbed by a dosimetric gel that are more precise, faster, less expensive to implement, high availability and with a measurement range covering, on the one hand, the low doses (less than 1 Gy) but also the high doses administered at the target volume, and thus to perform the dosimetric mapping of all the doses administered.
- the invention proposes a device for measuring at least one irradiation dose absorbed by a dosimetric gel, comprising a light source emitting a light beam whose wavelength is modifiable in time, a support for positioning a dosimetric gel in the light beam emitted by the light source and an optical detector of the light beam positioned so that its detection axis forms a diffusion angle with the axis of the light beam at the support.
- the measuring device comprises:
- the polarization means for polarizing the light beam according to at least two distinct polarization angles, the polarization means being positioned between the light source and the optical detector;
- a unit for measuring the value of the intensity of the light beam measured by the optical detector a unit for measuring the value of the intensity of the light beam measured by the optical detector; and a unit for calculating the value of a ratio of intensities of the light beam, measured by the optical detector, for two distinct and successive polarization angles of the light beam selected by the polarization means.
- the measuring device makes it possible to calculate at least a ratio of two light intensities of the same zone in a dosimetric gel.
- Each light intensity corresponds to a specific polarization performed at a distinct moment of the light beam detected by the optical detector.
- the inventors have found that the value of this ratio depends directly on the structure of the dosimetric gel, a structure that changes as a function of the radiation dose absorbed by the gel.
- the measurement of this ratio advantageously makes it possible to obtain information on the radiation dose absorbed by the dosimetric gel in a simple, fast and much less expensive manner compared to an analysis technique using an MRI.
- the intensity measurements of the light beam are made for two distinct polarization angles and at two different times so as to guarantee a strict spatial correspondence between these two measurements.
- the value of the diffusion angle is between 10 ° and 350 °, preferably between 30 ° and 120 °, preferably between 30 and 85 ° and / or between 95 ° and 120 °.
- the optical detector is positioned so that its detection axis forms an acute angle, right or obtuse with the light beam at the support.
- the principle of the invention is to measure a ratio of intensities of the light beam diffused through a dosimetric gel, under one or more angles of observation, for two different polarizations of the incident light beam or two polarizations. different from the collected beam or any combination of these two situations.
- the calculation unit is configured to associate with at least one value of the intensity ratio calculated by the calculation unit, a radiation dose value absorbed by a dosimetric gel.
- the calculation unit comprises a memory unit in which is stored a correspondence table between at least one value of a report. of intensity calculated by the unit of measurement and a radiation dose value absorbed by a dosimetric gel.
- the light source comprises means for selecting at least two distinct wavelength ranges observable by the optical detector.
- the selection means comprises one or more optical filters enabling these selections.
- the light source comprises at least one laser source or an incoherent source.
- the biasing means comprises a first polarizer positioned between the light source and the support, and a second polarizer positioned between the support and the optical detector.
- the polarization means comprises a first polarizer and a second polarizer, both positioned between the light source and the support. This embodiment promotes the detection of a more intense light signal by the optical detector.
- the biasing means comprises a first polarizer and a second polarizer, both positioned between the support and the optical detector.
- the measuring device comprises a diffusing means positioned between the light source and the support, so as to standardize the polarization of the light beam emitted by the light source.
- this embodiment makes it possible to uniformize the polarization of the light beam before it illuminates a dosimetric gel placed on the support.
- the measuring device comprises means for moving the support relative to the detection axis of the detector, preferably preserving the value of the diffusion angle.
- the means for moving the support are preferably adapted to move a dosimetric gel positioned on the support, in at least two different directions, preferably in a three-dimensional space.
- the moving means can be configured to pivot the support.
- the measuring device comprises means for pivoting the optical detector relative to the support, so as to modify the value of the diffusion angle.
- the measuring device comprises two mirrors in linear or angular oscillations, at frequencies greater than the inverse of the measuring time of the measurement unit, positioned on the path of the light beam between the light source and the optical detector.
- the measuring device comprises in the path of the light beam between the light source and the optical detector, an oscillating mirror for generating a sheet of light in a dosimetric gel present on the support.
- an oscillating mirror for generating a sheet of light in a dosimetric gel present on the support.
- the measuring device may comprise several measurement units distributed around the support, so as to simultaneously perform measurements in different areas of the dosimetric gel.
- the invention also relates to a method for measuring at least one irradiation dose absorbed by a dosimetric gel using a measuring device described above, implementing the following steps:
- the invention provides a method for directly measuring an irradiation dose absorbed by a dosimetric gel, in the sense that no dose field reconstruction is necessary.
- a dosimetric gel unlike the indirect measurement methods of the absorption of an irradiation dose, based on a measurement of the absorption of the light intensity of a beam passing through a dosimetric gel, it is not necessary to perform a series of measurement lines in the entire volume of the gel, the results of which integrate the absorption of doses over the entire path of the light beam and therefore require a complex reconstruction to estimate a local irradiation value.
- the invention proposes a direct measurement method which is not based on a phenomenon of absorption of the light beam by the dosimetric gel.
- the measurements obtained by the invention do not exploit the variation of the absorption as a function of the wavelength of the light beam emitted by the light source.
- the preceding steps are repeated for a dosimetric gel irradiated at different and known doses, in order to establish a correspondence table.
- the present invention also relates to a method for calibrating or establishing a correspondence table for a type of dosimetric gel subjected to different known irradiation doses.
- the diffusion angle of the detector is changed according to the wavelength range of the selected light beam by a selection means.
- the support is moved between each measurement series so as to obtain the irradiation doses absorbed by the dosimetric gel in a two-dimensional plane, preferably in a volume in millimeters. three dimensions.
- FIG. 1 shows a top view of a measuring device according to the invention
- FIG. 2 illustrates a correspondence curve associating, at different values of ratio R, irradiation doses absorbed by a polymer-type dosimetric gel.
- the invention provides a device and a method for measuring radiation doses absorbed by a dosimetric gel that are more accurate, faster and less expensive to implement.
- Figure 1 illustrates an embodiment of a measuring device 2 according to the invention, radiation doses absorbed by a dosimetric gel 4.
- the measuring device comprises a light source 6 emitting a light beam 8 along an optical axis 9 towards a support 10.
- the light source is of white light type (for example a xenon source) which coupled with monochromatic filters selects a only wavelength between 200 nm and 700 nm or a system coupling lasers for wavelengths between 350 and 700 nm.
- the light source 6 comprises a selection means 7 making it possible to emit light beams in distinct wavelength ranges, for example at the following wavelengths: 350 nm, 432 nm, 534 nm, 576 nm and 634 nm. nm.
- the selection means 7 may comprise one or more narrow-band optical filters.
- the polarization of the incident beam must be known, in the absence of precision, it is assumed that the incident beam is unpolarized or of circular polarization.
- the measuring device 2 also comprises a divider 8A of the light beam 8, interposed between the light source 6 and the support 10.
- the divider 8A is configured to deflect a small portion 8B of the light beam 8 to an optical detector 8C to check the constancy of the light beam 8.
- the support 10 allows the positioning in the light beam 8 of a transparent container 12 containing the dosimetric gel 4.
- the support is a precision motorized plate allowing the displacement of the support along three distinct axes so to be able to expose different zones of the dosimetric gel 4 to the light beam 8.
- the support may comprise an axis of rotation in order to expose different faces of the dosimetric gel 4 to the light beam 8.
- the support 10 is motorized to allow remote modification of the area of the dosimetric gel 4 which is illuminated by the light beam 8.
- the measuring device 2 also comprises an optical detector 14 for measuring the luminous intensity of the filtered light beam (or not), according to the presence (or absence) of the elements 24 and 26.
- the optical detector 14 is mounted on an arm 16 pivoting around the support 10 so that the detection axis 18 of the optical detector forms a diffusion angle ⁇ with the axis 9 of the light beam 8 at the support 10
- the optical detector 14 is oriented so as to capture the intensity of a light beam 20 scattered by aggregates 21 present in the dosimetric gel 4.
- aggregate is also meant microdomains formed by radioformed polymers, or any element that has absorbed the radiation dose. The size of the aggregates depends on the dose of radiation received by the dosimetric gel.
- the arm 16 is motorized so as to be able to remotely modify the value of the diffusion angle a.
- the value of the diffusion angle ⁇ is between 10 ° and 170 °, preferably between 30 ° and 60 °. According to the present example, the value of the diffusion angle ⁇ is 90 °.
- the measuring device 2 also comprises a polarization means 22 of the light beam according to at least two distinct polarization angles.
- the biasing means 22 comprises a first linear polarizer 24 and a second linear polarizer 26 both mounted on the movable arm 16 so as to be positioned between the support 10 and the optical detector 14.
- the first and second polarizers are oriented so that their transmission axis forms a polarization angle ⁇ between 10 ° and 170 °, preferably of the order of 90 °.
- the polarizers make it possible to modify the polarization angle ⁇ of the light beam 20 diffused by the dosimetric gel 4 before being detected by the optical detector 14.
- the first polarizer 24 could be positioned between the light source 6 and the support 10 or the two polarizers could be positioned between the light source and the support.
- two polarizers could be positioned between the light source 6 and the support 10 and two other polarizers could be positioned between the support 10 and the optical detector 14.
- the optical detector 14 is thus oriented towards the support 10 so as to be able to capture the intensity of a light beam 20 scattered by aggregates 21 present in the dosimetric gel 4. To allow an accurate measurement of the value of this intensity, the optical detector 14 is connected to a measurement unit 28. It should be noted that according to the present example, the biasing means 22 makes it possible to choose two successive polarizations of the light beam 20 so as to guarantee a strict spatial correspondence between the light intensity measurements made by the measuring unit 28.
- the measurement unit 28 is connected to a calculation unit 30 configured to calculate the value of a ratio of intensities of the light beam 20 diffused by the dosimetric gel 4, measured by the optical detector 14, for two angles distinct polarization of the light beam selected by the biasing means 22.
- the computing unit 30 also comprises a memory unit 32 in which a correspondence table is stored between several values of intensity ratios calculated by the measurement unit and dose values of irradiation absorbed by a dosimetric gel.
- the measurement unit 28, the calculation unit 30 and the memory unit 32 are integrated in a central unit 34 computer or microcomputer type.
- the central unit 34 is connected to a display screen type display device 36, in order to enable a user of the measurement device 2 to read an irradiation dose value determined from the beam intensity measurements. bright 20 and correspondence table.
- the motorized stage, the motorized arm and the selection means are also connected to the central unit 34 in order to allow the automation by the central unit of a measurement method described herein. -Dessous.
- a measuring device 2 may simultaneously comprise a plurality of optical detectors 14 positioned around the support 10 so as to form observation angles of different values.
- This embodiment advantageously makes it possible to multiply the observation angles of the dosimetric gel 4 in order to reduce the acquisition time of the intensity measurements in order to establish more rapidly a spatial representation of the irradiation doses absorbed by the gel. dosimetry 4.
- the detection of the two polarizations can be carried out simultaneously by dividing the beam 20 according to its two polarization components and simultaneously using two optical detectors 14 (one for each component).
- the invention also relates to a method for measuring at least one irradiation dose absorbed by a dosimetric gel 4 using a measuring device 2 described above.
- the measurement method implements a step of positioning a dosimetric gel 4 on the support 10 so that the light beam 8 emitted by the light source 6 illuminates an area of the dosimetric gel 4 with a known polarization.
- the optical detector 14 is subsequently oriented so that its detection axis 18 passes through the dosimetric gel 4 and forms a diffusion angle ⁇ with the light beam 8 so as to detect a light beam 20 scattered by aggregates 21 present in the gel Dosimetry 4.
- the measurement unit 28 determines a first light intensity li observed by the optical detector 14 at a first polarization angle ⁇ 1 of the light beam by the polarization means 22.
- the polarization angle of the light beam 8 is then modified with the biasing means 22 to allow the measurement unit 28 to measure a new value of luminous intensity l 2 observed by the optical detector 14 according to a second angle ⁇ 2 of polarization.
- the computing unit 30 estimates the value of a ratio R between the two intensities measured for two distinct polarization angles. The value of this ratio is then compared by the calculation unit to a correspondence table in order to determine from the value of this ratio R an irradiation dose absorbed by the dosimetric gel 4. The value of this dose of irradiation is then displayed on the display device to communicate this information to a user of the measuring device 2.
- the computing unit 30 estimates the value of the ratio R between two light intensities by first subtracting the background noise of the optical detector 14, in one of the following ways:
- the invention also relates to a method of establishing a correspondence table mentioned above, consisting of reproducing the previous steps with dosimetric gels whose irradiation dose is known beforehand.
- the computing unit 30 may comprise an automated method of establishing correspondence tables by varying the value of the parameters. mentioned above.
- the measuring device 2 according to the invention allows a simple and fast determination of the optimal values of these parameters as a function of each type of dosimetric gel.
- the inventors have thus been able to establish a correspondence curve illustrated in FIG. 2, associating at different values of ratio R, irradiation doses absorbed by a polymer-type dosimetric gel. Specifically, these measurements were performed on a dosimetric gel of nMAG type polymers with 2% w / w, methacrylic acid (MMA), gelatin (% w / w) (Type A, 300, Sigma Aldrich).
- the dosimetric gel is illuminated by a laser light source or by a white light emitting a light beam at a power of between 0 and 150 mW, whose wavelength range is between 200 and 700 nm, in the the present case 634 nm for 11 and 532 nm for 12.
- the difference between the angles, polarization ⁇ and ⁇ 2 is of the order of 90 ° and the value of the diffusion angle a is centered on 90 °.
- the measuring device 2 described above makes it possible very quickly and easily to accurately measure the level of radiation doses absorbed by a dosimetric gel of the same nature, much cheaper by compared to currently used techniques.
- the calculation unit 30 performs several times the calculation of the ratio R described above for the same sample. Prior to calculating a new ratio R, the wavelength and / or the scattering angle of the light beam 20 are modified. We thus obtain a set of values of ratio R ( j j) kr as defined below (or in paragraph ⁇ [46]) and named polarization ratio ratio:
- li jk corresponding to a value of the intensity of the light beam measured by the optical detector 14, for a wavelength i, a diffusion angle j and a polarization angle of the light beam equal to k
- - Ij j r corresponding to a value of the intensity of the light beam measured by the optical detector 14, for a wavelength i, j a scattering angle and a polarization angle of the light beam equal to r, the value of r is different from the value of k.
- the calculation unit 30 performs a theoretical calculation of the value of this polarization rate as a function of the size of the structures. diffusing agents present in the dosimetric gel. This theoretical calculation is carried out using the TMatrix method as described in the following document: "Scattering, absorption and emission of light by small particles" - Michael I. Mishchenko, Larry D. Travis, Adrew A. Lacis - Cambridge University Press . Preferably, this theoretical calculation is carried out in the context of the Mie theory which corresponds to the limiting case where the diffusing structures have a size parameter tending towards 3.
- the computing unit 30 identifies the theoretical size of the diffusing structures common to each theoretical calculation of the polarization ratio ratio previously produced.
- the computing unit 30 associates with this theoretical size common to each theoretical calculation of the polarization ratio ratio, an irradiation dose present in a correspondence table associated with the dosimetric gel and prerecorded by the memory unit 32.
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- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Molecular Biology (AREA)
- High Energy & Nuclear Physics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Measurement Of Radiation (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1758268A FR3070769B1 (fr) | 2017-09-07 | 2017-09-07 | Dispositif de mesure optique par lumiere polarisee de doses d'irradiation absorbee par un gel dosimetrique |
PCT/FR2018/052193 WO2019048796A1 (fr) | 2017-09-07 | 2018-09-07 | Dispositif de mesure optique par lumière polarisée de doses d'irradiation absorbée par un gel dosimétrique |
Publications (1)
Publication Number | Publication Date |
---|---|
EP3679404A1 true EP3679404A1 (fr) | 2020-07-15 |
Family
ID=61027822
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18796700.5A Pending EP3679404A1 (fr) | 2017-09-07 | 2018-09-07 | Dispositif de mesure optique par lumière polarisée de doses d'irradiation absorbée par un gel dosimétrique |
Country Status (6)
Country | Link |
---|---|
US (1) | US11099278B2 (fr) |
EP (1) | EP3679404A1 (fr) |
JP (1) | JP2020533584A (fr) |
CA (1) | CA3075230A1 (fr) |
FR (1) | FR3070769B1 (fr) |
WO (1) | WO2019048796A1 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7366383B2 (ja) * | 2020-11-27 | 2023-10-23 | 国立研究開発法人理化学研究所 | 放射線線量測定用ゲル線量計 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6219783A (ja) * | 1985-07-18 | 1987-01-28 | Nippon Atom Ind Group Co Ltd | 着色線量計 |
US6218673B1 (en) * | 1996-09-06 | 2001-04-17 | Yale University | Optical scanning tomography for three-dimensional dosimetry and imaging of energy fields |
-
2017
- 2017-09-07 FR FR1758268A patent/FR3070769B1/fr active Active
-
2018
- 2018-09-07 EP EP18796700.5A patent/EP3679404A1/fr active Pending
- 2018-09-07 WO PCT/FR2018/052193 patent/WO2019048796A1/fr unknown
- 2018-09-07 JP JP2020514199A patent/JP2020533584A/ja active Pending
- 2018-09-07 CA CA3075230A patent/CA3075230A1/fr active Pending
- 2018-09-07 US US16/645,094 patent/US11099278B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA3075230A1 (fr) | 2019-03-14 |
FR3070769B1 (fr) | 2021-07-02 |
FR3070769A1 (fr) | 2019-03-08 |
US20200233097A1 (en) | 2020-07-23 |
US11099278B2 (en) | 2021-08-24 |
WO2019048796A1 (fr) | 2019-03-14 |
JP2020533584A (ja) | 2020-11-19 |
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