EP3645728A4 - Novel type vi crispr orthologs and systems - Google Patents

Novel type vi crispr orthologs and systems Download PDF

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Publication number
EP3645728A4
EP3645728A4 EP18824952.8A EP18824952A EP3645728A4 EP 3645728 A4 EP3645728 A4 EP 3645728A4 EP 18824952 A EP18824952 A EP 18824952A EP 3645728 A4 EP3645728 A4 EP 3645728A4
Authority
EP
European Patent Office
Prior art keywords
systems
novel type
crispr orthologs
orthologs
crispr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP18824952.8A
Other languages
German (de)
French (fr)
Other versions
EP3645728A1 (en
Inventor
Feng Zhang
Omar O. Abudayyeh
David Benjamin Turitz Cox
Jonathan S. Gootenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard College
Massachusetts Institute of Technology
Broad Institute Inc
Original Assignee
Harvard College
Massachusetts Institute of Technology
Broad Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Massachusetts Institute of Technology, Broad Institute Inc filed Critical Harvard College
Publication of EP3645728A1 publication Critical patent/EP3645728A1/en
Publication of EP3645728A4 publication Critical patent/EP3645728A4/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/85—Fusion polypeptide containing an RNA binding domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
EP18824952.8A 2017-06-26 2018-06-26 Novel type vi crispr orthologs and systems Pending EP3645728A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762525165P 2017-06-26 2017-06-26
US201762566851P 2017-10-02 2017-10-02
PCT/US2018/039595 WO2019005866A1 (en) 2017-06-26 2018-06-26 Novel type vi crispr orthologs and systems

Publications (2)

Publication Number Publication Date
EP3645728A1 EP3645728A1 (en) 2020-05-06
EP3645728A4 true EP3645728A4 (en) 2021-03-24

Family

ID=64741890

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18824952.8A Pending EP3645728A4 (en) 2017-06-26 2018-06-26 Novel type vi crispr orthologs and systems

Country Status (2)

Country Link
EP (1) EP3645728A4 (en)
WO (1) WO2019005866A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
CN105939767B (en) 2014-01-08 2018-04-06 弗洛设计声能学公司 Sound electrophoretic apparatus with alliteration electrophoresis chamber
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11104937B2 (en) 2017-03-15 2021-08-31 The Broad Institute, Inc. CRISPR effector system based diagnostics
US11174515B2 (en) 2017-03-15 2021-11-16 The Broad Institute, Inc. CRISPR effector system based diagnostics
WO2018183908A1 (en) 2017-03-31 2018-10-04 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating ovarian tumors
US11618928B2 (en) 2017-04-12 2023-04-04 The Broad Institute, Inc. CRISPR effector system based diagnostics for malaria detection
BR112020006757A2 (en) 2017-10-04 2020-10-06 The Broad Institute Inc. Crispr effector system based diagnostics
US11332736B2 (en) 2017-12-07 2022-05-17 The Broad Institute, Inc. Methods and compositions for multiplexing single cell and single nuclei sequencing
AU2018385759B2 (en) 2017-12-14 2021-10-21 Flodesign Sonics, Inc. Acoustic transducer driver and controller
US11957695B2 (en) 2018-04-26 2024-04-16 The Broad Institute, Inc. Methods and compositions targeting glucocorticoid signaling for modulating immune responses
EP3814520A1 (en) 2018-06-26 2021-05-05 The Broad Institute, Inc. Crispr double nickase based amplification compositions, systems, and methods
EP3814527B1 (en) 2018-06-26 2023-02-22 Massachusetts Institute of Technology Crispr effector system based amplification methods, systems, and diagnostics
WO2020124050A1 (en) 2018-12-13 2020-06-18 The Broad Institute, Inc. Tiled assays using crispr-cas based detection
US11739156B2 (en) 2019-01-06 2023-08-29 The Broad Institute, Inc. Massachusetts Institute of Technology Methods and compositions for overcoming immunosuppression
CN110157695A (en) * 2019-01-25 2019-08-23 南昌大学 A kind of system and method for plant RNA m5C methylation modification
WO2020186231A2 (en) 2019-03-14 2020-09-17 The Broad Institute, Inc. Crispr effector system based multiplex diagnostics
US20220177863A1 (en) 2019-03-18 2022-06-09 The Broad Institute, Inc. Type vii crispr proteins and systems
EP3979832A4 (en) * 2019-06-06 2023-06-21 Tata Consultancy Services Limited Method and system for identification of candidate target sites for combating pathogens
WO2021046257A1 (en) 2019-09-03 2021-03-11 The Broad Institute, Inc. Crispr effector system based multiplex cancer diagnostics
US11844800B2 (en) 2019-10-30 2023-12-19 Massachusetts Institute Of Technology Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia
WO2022040169A1 (en) * 2020-08-17 2022-02-24 University Of Maryland, College Park Compositions, systems, and methods for orthogonal genome engineering in plants
TW202313971A (en) 2021-06-01 2023-04-01 美商喬木生物技術公司 Gene editing systems comprising a crispr nuclease and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016205764A1 (en) * 2015-06-18 2016-12-22 The Broad Institute Inc. Novel crispr enzymes and systems
WO2016205749A1 (en) * 2015-06-18 2016-12-22 The Broad Institute Inc. Novel crispr enzymes and systems
WO2018107129A1 (en) * 2016-12-09 2018-06-14 The Broad Institute, Inc. Crispr effector system based diagnostics

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016205764A1 (en) * 2015-06-18 2016-12-22 The Broad Institute Inc. Novel crispr enzymes and systems
WO2016205749A1 (en) * 2015-06-18 2016-12-22 The Broad Institute Inc. Novel crispr enzymes and systems
WO2018107129A1 (en) * 2016-12-09 2018-06-14 The Broad Institute, Inc. Crispr effector system based diagnostics

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO2019005866A1 *
SHMAKOV SERGEY ET AL: "Diversity and evolution of class 2 CRISPR-Cas systems", NATURE REVIEWS. MICROBIOLOGY, NATURE PUBLISHING GROUP, ENGLAND, vol. 15, no. 3, 23 January 2017 (2017-01-23) - 1 March 2017 (2017-03-01), pages 169 - 182, XP002767857, ISSN: 1740-1534, DOI: 10.1038/NRMICRO.2016.184 *

Also Published As

Publication number Publication date
EP3645728A1 (en) 2020-05-06
WO2019005866A1 (en) 2019-01-03

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