EP3621643A4 - Anti-malarial antibodies that bind circumsporozoite protein - Google Patents

Anti-malarial antibodies that bind circumsporozoite protein Download PDF

Info

Publication number
EP3621643A4
EP3621643A4 EP18798204.6A EP18798204A EP3621643A4 EP 3621643 A4 EP3621643 A4 EP 3621643A4 EP 18798204 A EP18798204 A EP 18798204A EP 3621643 A4 EP3621643 A4 EP 3621643A4
Authority
EP
European Patent Office
Prior art keywords
bind
circumsporozoite protein
malarial antibodies
malarial
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP18798204.6A
Other languages
German (de)
French (fr)
Other versions
EP3621643A1 (en
Inventor
Qi LIANG
Sean Matthew CARROLL
Daniel Eric EMERLING
Allan Bradley
Paul Kellam
pela BINTER
Simon James Watson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kymab Ltd
Atreca Inc
Original Assignee
Kymab Ltd
Atreca Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kymab Ltd, Atreca Inc filed Critical Kymab Ltd
Publication of EP3621643A1 publication Critical patent/EP3621643A1/en
Publication of EP3621643A4 publication Critical patent/EP3621643A4/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/20—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
    • C07K16/205—Plasmodium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP18798204.6A 2017-05-11 2018-05-11 Anti-malarial antibodies that bind circumsporozoite protein Pending EP3621643A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762504863P 2017-05-11 2017-05-11
US201762560971P 2017-09-20 2017-09-20
US201762564066P 2017-09-27 2017-09-27
PCT/US2018/032366 WO2018209265A1 (en) 2017-05-11 2018-05-11 Anti-malarial antibodies that bind circumsporozoite protein

Publications (2)

Publication Number Publication Date
EP3621643A1 EP3621643A1 (en) 2020-03-18
EP3621643A4 true EP3621643A4 (en) 2021-07-21

Family

ID=64105059

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18798204.6A Pending EP3621643A4 (en) 2017-05-11 2018-05-11 Anti-malarial antibodies that bind circumsporozoite protein

Country Status (2)

Country Link
EP (1) EP3621643A4 (en)
WO (1) WO2018209265A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11066464B2 (en) 2016-03-21 2021-07-20 Kymab Limited Anti-malarial antibodies that bind circumsporozoite protein
GB201709970D0 (en) 2017-06-22 2017-08-09 Kymab Ltd Bispecific antigen-binding molecules
US20220064327A1 (en) 2018-12-21 2022-03-03 Kymab Limited Fixaxfx bispecific antibody with common light chain
WO2020227228A2 (en) * 2019-05-03 2020-11-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Neutralizing antibodies to plasmodium falciparum circumsporozoite protein and their use
GB2590642B (en) * 2019-12-20 2024-02-14 Kymab Ltd Improved lambda antibodies
WO2021001351A1 (en) * 2019-07-01 2021-01-07 Deutsches Krebsforschungszentrum Plasmodium antibodies

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014028644A1 (en) * 2012-08-15 2014-02-20 Cyvax, Inc. Methods and compositions for preventing a condition
WO2017163049A1 (en) * 2016-03-21 2017-09-28 Kymab Limited Anti-malarial antibodies that bind circumsporozoite protein

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0513421D0 (en) * 2005-06-30 2005-08-03 Glaxosmithkline Biolog Sa Vaccines
WO2015075070A1 (en) * 2013-11-20 2015-05-28 Cmc Biologics A/S A bioreactor system and method for producing a biopolymer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014028644A1 (en) * 2012-08-15 2014-02-20 Cyvax, Inc. Methods and compositions for preventing a condition
WO2017163049A1 (en) * 2016-03-21 2017-09-28 Kymab Limited Anti-malarial antibodies that bind circumsporozoite protein

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CRAIG PRZYSIECKI ET AL: "Sporozoite neutralizing antibodies elicited in mice and rhesus macaques immunized with a Plasmodium falciparum repeat peptide conjugated to meningococcal outer membrane protein complex", FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, vol. 2, 1 January 2012 (2012-01-01), pages 1 - 11, XP055375838, DOI: 10.3389/fcimb.2012.00146 *
ROBERTO ANKER ET AL: "VH and VL region structure of antibodies that recognize the (NANP)s dodecapeptide sequence in the circumsporozoite protein of Plasmodium falciparum", EUR. J. IMMUNOL, vol. 20, 1 January 1990 (1990-01-01), pages 2757 - 2761, XP055374618, DOI: 10.1002/eji.1830201233 *
See also references of WO2018209265A1 *

Also Published As

Publication number Publication date
EP3621643A1 (en) 2020-03-18
WO2018209265A1 (en) 2018-11-15

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Inventor name: WATSON, SIMON JAMES

Inventor name: LIANG, QI

Inventor name: EMERLING, DANIEL ERIC

Inventor name: CARROLL, SEAN MATTHEW

Inventor name: KELLAM, PAUL

Inventor name: BRADLEY, ALLAN

Inventor name: BINTER, PELA

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Owner name: ATRECA, INC.

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