EP3606929A4 - Beta-nicotinate ester nucleotides and processes for preparing same - Google Patents
Beta-nicotinate ester nucleotides and processes for preparing same Download PDFInfo
- Publication number
- EP3606929A4 EP3606929A4 EP18781797.8A EP18781797A EP3606929A4 EP 3606929 A4 EP3606929 A4 EP 3606929A4 EP 18781797 A EP18781797 A EP 18781797A EP 3606929 A4 EP3606929 A4 EP 3606929A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- beta
- processes
- preparing same
- nicotinate ester
- nucleotides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011664 nicotinic acid Substances 0.000 title 1
- 239000002773 nucleotide Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/02—Phosphorylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/316—Foods, ingredients or supplements having a functional effect on health having an effect on regeneration or building of ligaments or muscles
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/322—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the nervous system or on mental function
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI201830363T SI3606929T1 (en) | 2017-04-05 | 2018-04-05 | Beta-nicotinate ester nucleotides and processes for preparing same |
PL18781797T PL3606929T3 (en) | 2017-04-05 | 2018-04-05 | Beta-nicotinate ester nucleotides and processes for preparing same |
RS20211045A RS62284B1 (en) | 2017-04-05 | 2018-04-05 | Beta-nicotinate ester nucleotides and processes for preparing same |
HRP20211296TT HRP20211296T1 (en) | 2017-04-05 | 2021-08-11 | Beta-nicotinate ester nucleotides and processes for preparing same |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762481912P | 2017-04-05 | 2017-04-05 | |
PCT/US2018/026209 WO2018187540A1 (en) | 2017-04-05 | 2018-04-05 | Beta-nicotinate ester nucleotides and processes for preparing same |
Publications (3)
Publication Number | Publication Date |
---|---|
EP3606929A1 EP3606929A1 (en) | 2020-02-12 |
EP3606929A4 true EP3606929A4 (en) | 2020-05-06 |
EP3606929B1 EP3606929B1 (en) | 2021-06-02 |
Family
ID=63712318
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18781797.8A Active EP3606929B1 (en) | 2017-04-05 | 2018-04-05 | Beta-nicotinate ester nucleotides and processes for preparing same |
Country Status (18)
Country | Link |
---|---|
US (2) | US10961268B2 (en) |
EP (1) | EP3606929B1 (en) |
JP (1) | JP7182289B2 (en) |
KR (1) | KR102605369B1 (en) |
CN (1) | CN110709406B (en) |
AU (2) | AU2018250242B2 (en) |
CA (1) | CA3059228A1 (en) |
CY (1) | CY1124450T1 (en) |
DK (1) | DK3606929T3 (en) |
ES (1) | ES2887224T3 (en) |
HR (1) | HRP20211296T1 (en) |
HU (1) | HUE055521T2 (en) |
LT (1) | LT3606929T (en) |
PL (1) | PL3606929T3 (en) |
PT (1) | PT3606929T (en) |
RS (1) | RS62284B1 (en) |
SI (1) | SI3606929T1 (en) |
WO (1) | WO2018187540A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1957086T3 (en) | 2005-11-18 | 2018-06-06 | Cornell Res Foundation Inc | NICOTINOYL RIBOSIDE COMPOSITIONS AND METHODS OF USE |
WO2017024255A1 (en) | 2015-08-05 | 2017-02-09 | Metrobiotech, Llc | Nicotinamide mononucleotide derivatives and their uses |
LT3606929T (en) | 2017-04-05 | 2021-10-25 | Cornell University | Beta-nicotinate ester nucleotides and processes for preparing same |
WO2020072497A1 (en) * | 2018-10-01 | 2020-04-09 | Cornell University | Methyl and ethyl nicotinate-riboside-5-phosphates, preparation thereof and methods of use thereof |
KR102060374B1 (en) * | 2018-12-14 | 2019-12-30 | 주식회사 휴메딕스 | Nicotinamide Riboside Derivatives Conjugated with Fatty Alcohol |
US11939348B2 (en) | 2019-03-22 | 2024-03-26 | Metro International Biotech, Llc | Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide |
IL308577A (en) | 2021-05-27 | 2024-01-01 | Metro Int Biotech Llc | Crystalline solids of nicotinic acid mononucleotide and esters thereof and methods of making and use |
CN113527376A (en) * | 2021-08-06 | 2021-10-22 | 上海昶法新材料有限公司 | Preparation method of beta-nicotinamide mononucleotide |
CA3241560A1 (en) | 2021-12-22 | 2023-06-29 | James M. Mckearin | Compositions for treatment of inflammation |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011081942A1 (en) * | 2009-12-14 | 2011-07-07 | Cornell University | Activation and activators of sirt5 |
WO2015186114A1 (en) * | 2014-06-06 | 2015-12-10 | Glaxosmithkline Intellectual Property (No.2) Limited | Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3736314A (en) * | 1967-06-02 | 1973-05-29 | Syntex Corp | Unsaturated nucleoside phosphonates phosphonic acids and phosphonic acid salts |
DK1957086T3 (en) | 2005-11-18 | 2018-06-06 | Cornell Res Foundation Inc | NICOTINOYL RIBOSIDE COMPOSITIONS AND METHODS OF USE |
US9790252B2 (en) | 2009-07-01 | 2017-10-17 | Cornell University | 2-fluorinated riboses and arabinoses and methods of use and synthesis |
WO2011081945A2 (en) | 2009-12-14 | 2011-07-07 | Cornell University | Activation and activators of sirt6 |
WO2011146636A2 (en) | 2010-05-18 | 2011-11-24 | Cornell University | Reagents and methods for sirtuin capture |
EP2872128B1 (en) | 2012-07-16 | 2020-02-19 | Cornell University | Nicotinamide riboside to treat hearing loss |
US20160035539A1 (en) | 2014-07-30 | 2016-02-04 | Lauri SAINIEMI | Microfabrication |
WO2016130691A1 (en) | 2015-02-10 | 2016-08-18 | Duke University | Method of treating heart failure |
CN107613990B (en) | 2015-03-27 | 2021-03-26 | 康奈尔大学 | Efficient synthesis of nicotinamide mononucleotide |
CA2987986A1 (en) | 2015-06-04 | 2016-12-08 | Chromadex, Inc. | Selective solvent free phosphorylation |
EP3322419A4 (en) | 2015-07-15 | 2018-08-01 | Cornell University | Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives |
LT3606929T (en) | 2017-04-05 | 2021-10-25 | Cornell University | Beta-nicotinate ester nucleotides and processes for preparing same |
WO2020072497A1 (en) | 2018-10-01 | 2020-04-09 | Cornell University | Methyl and ethyl nicotinate-riboside-5-phosphates, preparation thereof and methods of use thereof |
-
2018
- 2018-04-05 LT LTEPPCT/US2018/026209T patent/LT3606929T/en unknown
- 2018-04-05 KR KR1020197032663A patent/KR102605369B1/en active IP Right Grant
- 2018-04-05 HU HUE18781797A patent/HUE055521T2/en unknown
- 2018-04-05 SI SI201830363T patent/SI3606929T1/en unknown
- 2018-04-05 WO PCT/US2018/026209 patent/WO2018187540A1/en unknown
- 2018-04-05 PT PT187817978T patent/PT3606929T/en unknown
- 2018-04-05 PL PL18781797T patent/PL3606929T3/en unknown
- 2018-04-05 AU AU2018250242A patent/AU2018250242B2/en active Active
- 2018-04-05 JP JP2019555021A patent/JP7182289B2/en active Active
- 2018-04-05 RS RS20211045A patent/RS62284B1/en unknown
- 2018-04-05 ES ES18781797T patent/ES2887224T3/en active Active
- 2018-04-05 CN CN201880036949.3A patent/CN110709406B/en active Active
- 2018-04-05 EP EP18781797.8A patent/EP3606929B1/en active Active
- 2018-04-05 CA CA3059228A patent/CA3059228A1/en active Pending
- 2018-04-05 US US16/603,164 patent/US10961268B2/en active Active
- 2018-04-05 DK DK18781797.8T patent/DK3606929T3/en active
-
2021
- 2021-03-29 US US17/216,533 patent/US11530233B2/en active Active
- 2021-08-11 HR HRP20211296TT patent/HRP20211296T1/en unknown
- 2021-08-19 CY CY20211100746T patent/CY1124450T1/en unknown
- 2021-10-15 AU AU2021250984A patent/AU2021250984B2/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011081942A1 (en) * | 2009-12-14 | 2011-07-07 | Cornell University | Activation and activators of sirt5 |
WO2015186114A1 (en) * | 2014-06-06 | 2015-12-10 | Glaxosmithkline Intellectual Property (No.2) Limited | Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof |
Non-Patent Citations (1)
Title |
---|
C. H. R. WINNÉ ET AL: "Synthesis of NAD+ Analogs. Part II. Synthesis and Anomeric Separation of 3-Benzoylpyridine Nucleotide", BULLETIN DES SOCIÉTÉS CHIMIQUES BELGES : VLAAMSE CHEMISCHE VERENIGING, vol. 92, no. 2, 1 January 1983 (1983-01-01), BE, pages 175 - 180, XP055500759, ISSN: 0037-9646, DOI: 10.1002/bscb.19830920211 * |
Also Published As
Publication number | Publication date |
---|---|
RS62284B1 (en) | 2021-09-30 |
US10961268B2 (en) | 2021-03-30 |
PL3606929T3 (en) | 2021-12-27 |
SI3606929T1 (en) | 2021-11-30 |
EP3606929B1 (en) | 2021-06-02 |
CY1124450T1 (en) | 2022-07-22 |
DK3606929T3 (en) | 2021-08-23 |
KR20190137133A (en) | 2019-12-10 |
PT3606929T (en) | 2021-09-02 |
AU2021250984A1 (en) | 2021-11-18 |
LT3606929T (en) | 2021-10-25 |
US20200031860A1 (en) | 2020-01-30 |
JP7182289B2 (en) | 2022-12-02 |
HRP20211296T1 (en) | 2021-11-12 |
AU2021250984B2 (en) | 2022-09-01 |
US11530233B2 (en) | 2022-12-20 |
WO2018187540A1 (en) | 2018-10-11 |
CN110709406B (en) | 2022-11-08 |
ES2887224T3 (en) | 2021-12-22 |
HUE055521T2 (en) | 2021-11-29 |
US20210214386A1 (en) | 2021-07-15 |
AU2018250242A1 (en) | 2019-10-31 |
AU2018250242B2 (en) | 2021-07-15 |
EP3606929A1 (en) | 2020-02-12 |
CA3059228A1 (en) | 2018-10-11 |
JP2020516619A (en) | 2020-06-11 |
CN110709406A (en) | 2020-01-17 |
KR102605369B1 (en) | 2023-11-24 |
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