EP3600319A4 - Neuartige alpha-hydroxy-carbonsäure und derivate und andere gras-basierte prodrugs von opioiden und verwendungen davon - Google Patents
Neuartige alpha-hydroxy-carbonsäure und derivate und andere gras-basierte prodrugs von opioiden und verwendungen davon Download PDFInfo
- Publication number
- EP3600319A4 EP3600319A4 EP18774382.8A EP18774382A EP3600319A4 EP 3600319 A4 EP3600319 A4 EP 3600319A4 EP 18774382 A EP18774382 A EP 18774382A EP 3600319 A4 EP3600319 A4 EP 3600319A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- gras
- opioids
- derivatives
- carboxylic acid
- hydroxy carboxylic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Addiction (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15/472,758 US10449190B2 (en) | 2015-04-27 | 2017-03-29 | Alpha-hydroxy carboxylic acid and derivatives and other GRAS-based prodrugs of opioids and uses thereof |
PCT/US2018/024476 WO2018183264A1 (en) | 2017-03-29 | 2018-03-27 | Novel alpha-hydroxy carboxylic acid and derivatives and other gras- based prodrugs of opioids and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3600319A1 EP3600319A1 (de) | 2020-02-05 |
EP3600319A4 true EP3600319A4 (de) | 2020-11-25 |
Family
ID=63676908
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18774382.8A Withdrawn EP3600319A4 (de) | 2017-03-29 | 2018-03-27 | Neuartige alpha-hydroxy-carbonsäure und derivate und andere gras-basierte prodrugs von opioiden und verwendungen davon |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP3600319A4 (de) |
WO (1) | WO2018183264A1 (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2969330A1 (en) * | 2014-12-01 | 2016-06-09 | Cellix Bio Private Limited | Compositions and methods for the treatment of multiple sclerosis |
US10226456B2 (en) | 2015-04-27 | 2019-03-12 | 3St Research Llc | Methods and compositions for preventing opioid abuse |
WO2022038365A2 (en) | 2020-08-21 | 2022-02-24 | Sitryx Therapeutics Limited | Novel compounds |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011002995A1 (en) * | 2009-07-02 | 2011-01-06 | Kempharm, Inc. | Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, methods of making and use thereof |
US20160326182A1 (en) * | 2015-04-27 | 2016-11-10 | Waterville Valley Technologies, Inc. | Methods and compositions for preventing opioid abuse |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040058946A1 (en) * | 2002-07-05 | 2004-03-25 | Buchwald Stephen L. | Abuse-resistant prodrugs of oxycodone and other pharmaceuticals |
CN1263760C (zh) * | 2002-11-12 | 2006-07-12 | 财团法人奇美医院 | 新颖的丁丙诺啡酯衍生物及其制备方法,以及长效作用镇痛药学组合物 |
WO2009130270A1 (en) * | 2008-04-24 | 2009-10-29 | Janssen Pharmaceutica Nv | Nalmefene di-ester prodrugs |
JP2013523599A (ja) * | 2009-04-02 | 2013-06-17 | シャイア エルエルシー | 新規なオピオイドのジカルボン酸結合アミノ酸及びペプチドプロドラッグ並びにその用途 |
US10449190B2 (en) * | 2015-04-27 | 2019-10-22 | John K. Thottathil | Alpha-hydroxy carboxylic acid and derivatives and other GRAS-based prodrugs of opioids and uses thereof |
-
2018
- 2018-03-27 EP EP18774382.8A patent/EP3600319A4/de not_active Withdrawn
- 2018-03-27 WO PCT/US2018/024476 patent/WO2018183264A1/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011002995A1 (en) * | 2009-07-02 | 2011-01-06 | Kempharm, Inc. | Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, methods of making and use thereof |
US20160326182A1 (en) * | 2015-04-27 | 2016-11-10 | Waterville Valley Technologies, Inc. | Methods and compositions for preventing opioid abuse |
Non-Patent Citations (2)
Title |
---|
See also references of WO2018183264A1 * |
SZABOLCS BÉNI ET AL: "Preparation of benzoate esters of morphine and its derivatives", MONATSHEFTE FÜR CHEMIE - CHEMICAL MONTHLY ; AN INTERNATIONAL JOURNAL OF CHEMISTRY, SPRINGER-VERLAG, AU, vol. 143, no. 10, 26 June 2012 (2012-06-26), pages 1431 - 1440, XP035116687, ISSN: 1434-4475, DOI: 10.1007/S00706-012-0803-8 * |
Also Published As
Publication number | Publication date |
---|---|
WO2018183264A1 (en) | 2018-10-04 |
EP3600319A1 (de) | 2020-02-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
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17P | Request for examination filed |
Effective date: 20190924 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
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AX | Request for extension of the european patent |
Extension state: BA ME |
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DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07D 489/04 20060101ALI20200710BHEP Ipc: A61P 25/36 20060101ALI20200710BHEP Ipc: C07D 489/08 20060101ALI20200710BHEP Ipc: A61K 31/485 20060101ALI20200710BHEP Ipc: C07D 489/02 20060101AFI20200710BHEP |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20201027 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07D 489/04 20060101ALI20201021BHEP Ipc: C07D 489/02 20060101AFI20201021BHEP Ipc: A61P 25/36 20060101ALI20201021BHEP Ipc: C07D 489/08 20060101ALI20201021BHEP Ipc: A61K 31/485 20060101ALI20201021BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20210526 |