EP3571222A4 - Procédés à base de spectrométrie de masse et hautement multiplexés permettant de mesurer 72 protéines humaines - Google Patents

Procédés à base de spectrométrie de masse et hautement multiplexés permettant de mesurer 72 protéines humaines Download PDF

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Publication number
EP3571222A4
EP3571222A4 EP18741778.7A EP18741778A EP3571222A4 EP 3571222 A4 EP3571222 A4 EP 3571222A4 EP 18741778 A EP18741778 A EP 18741778A EP 3571222 A4 EP3571222 A4 EP 3571222A4
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EP
European Patent Office
Prior art keywords
measuring
mass spectrometry
based methods
human proteins
highly multiplexed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP18741778.7A
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German (de)
English (en)
Other versions
EP3571222A1 (fr
Inventor
Jennifer Van Eyk
Qin Fu
Vidya VENKATRAMAN
Irina TCHERNYSHYOV
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cedars Sinai Medical Center
Original Assignee
Cedars Sinai Medical Center
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Filing date
Publication date
Application filed by Cedars Sinai Medical Center filed Critical Cedars Sinai Medical Center
Publication of EP3571222A1 publication Critical patent/EP3571222A1/fr
Publication of EP3571222A4 publication Critical patent/EP3571222A4/fr
Pending legal-status Critical Current

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21004Trypsin (3.4.21.4)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00Chemical aspects of mass spectrometric analysis of biological material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/32Cardiovascular disorders
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/50Determining the risk of developing a disease
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/60Complex ways of combining multiple protein biomarkers for diagnosis

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medicinal Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP18741778.7A 2017-01-19 2018-01-19 Procédés à base de spectrométrie de masse et hautement multiplexés permettant de mesurer 72 protéines humaines Pending EP3571222A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762448319P 2017-01-19 2017-01-19
PCT/US2018/014570 WO2018136825A1 (fr) 2017-01-19 2018-01-19 Procédés à base de spectrométrie de masse et hautement multiplexés permettant de mesurer 72 protéines humaines

Publications (2)

Publication Number Publication Date
EP3571222A1 EP3571222A1 (fr) 2019-11-27
EP3571222A4 true EP3571222A4 (fr) 2021-06-16

Family

ID=62908394

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18741778.7A Pending EP3571222A4 (fr) 2017-01-19 2018-01-19 Procédés à base de spectrométrie de masse et hautement multiplexés permettant de mesurer 72 protéines humaines

Country Status (3)

Country Link
US (1) US20190369114A1 (fr)
EP (1) EP3571222A4 (fr)
WO (1) WO2018136825A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11143659B2 (en) 2015-01-27 2021-10-12 Arterez, Inc. Biomarkers of vascular disease
JP7346300B2 (ja) 2017-03-23 2023-09-19 アボット・ラボラトリーズ 早期バイオマーカーであるユビキチンカルボキシ末端ヒドロラーゼl1を使用する、ヒト対象における外傷性脳損傷の程度の診断及び決定の一助となるための方法
US10877048B2 (en) 2017-04-15 2020-12-29 Abbott Laboratories Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury in a human subject using early biomarkers
WO2018200823A1 (fr) 2017-04-28 2018-11-01 Abbott Laboratories Méthodes d'aide au diagnostic et à la détermination hyperaigus d'une lésion cérébrale traumatique au moyen de biomarqueurs précoces sur au moins deux échantillons provenant du même sujet humain
CA3078725A1 (fr) 2017-05-25 2018-11-29 Abbott Laboratories Procedes d'aide a la determination de la realisation ou non d'une imagerie sur un sujet humain ayant subi ou susceptible d'avoir subi une lesion a la tete a l'aide de biomarqueurs precoces
EP3631467A1 (fr) 2017-05-30 2020-04-08 Abbott Laboratories Procédés d'aide au diagnostic et à l'évaluation d'une lésion cérébrale traumatique légère chez un patient humain à l'aide de troponine cardiaque i
CA3068041C (fr) 2017-07-03 2024-06-25 Abbott Laboratories Procedes ameliores de mesure de niveaux d'hydrolase a terminaison carboxy d'ubiquitine l1 dans le sang
CA3067057A1 (fr) 2017-12-09 2019-06-13 Abbott Laboratories Procedes d'aide au diagnostic et a l'evaluation d'un sujet qui a subi une lesion orthopedique et qui a subi ou peut avoir subi une lesion a la tete, telle qu'une lesion cerebrale traumatique legere (tbi), a l'aide d'une proteine acide fibrillaire gliale (gfap) et/ou d'hydrolase carboxy-terminale d'ubiquitine l1 (uch-l1)
EP3721234A1 (fr) 2017-12-09 2020-10-14 Abbott Laboratories Procédés d'aide au diagnostic et à l'évaluation d'un lésion cérébrale traumatique chez un sujet humain au moyen d'une combinaison de gfap et d'uch-l1
CN111699391A (zh) 2017-12-29 2020-09-22 雅培实验室 用于诊断和评估创伤性脑损伤的新型生物标志物和方法
DE102018116248A1 (de) * 2018-07-04 2020-01-09 Hochschule Bremerhaven Verfahren zum Nachweis, zur Unterscheidung und zur Quantifizierung von aktiven und inaktiven Formen von Gerinnungsfaktoren
EP3833775A1 (fr) * 2018-08-08 2021-06-16 Regeneron Pharmaceuticals, Inc. Utilisation de lc-ms/ms pour quantifier des biomarqueurs protéiques
CN109087352B (zh) * 2018-08-16 2021-07-13 数坤(北京)网络科技股份有限公司 一种心脏冠脉优势型自动判别方法
CN114269380A (zh) * 2019-08-23 2022-04-01 Igm生物科学股份有限公司 IgM糖变体
CN110669104B (zh) * 2019-10-30 2021-11-05 上海交通大学 一组来源于人外周血单核细胞的标志物及其应用
JP2023527062A (ja) 2020-05-26 2023-06-26 エフ. ホフマン-ラ ロシュ アーゲー 定量器-確認器比チェックのために顧客質量分析機器を較正するためのコンピュータ実装方法
WO2022026537A1 (fr) * 2020-07-28 2022-02-03 The Trustees Of Princeton University Méthode de détection et de surveillance quantitative d'infections par des virus de l'herpès
US20240053369A1 (en) * 2020-12-18 2024-02-15 University Of Washington Methods and Systems for Quantifying Lipoprotein(A) Using Candidate References
CA3239488A1 (fr) * 2021-11-30 2023-06-08 Daniel SERIE Diagnostic du cancer du pancreas a l'aide d'une quantification ciblee d'une glycosylation de proteine specifique a un site
CN117647606A (zh) * 2024-01-30 2024-03-05 西湖欧米(杭州)生物科技有限公司 适于lc-ms/ms能同时检测多种蛋白的试剂盒

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013019943A1 (fr) * 2011-08-04 2013-02-07 Hdl Apomics Llc. Procédés de mesure de sous-populations de hdl

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009006568A1 (fr) * 2007-07-03 2009-01-08 Northeastern University Biomarqueurs pour le diabète, l'obésité, et/ou l'hypertension
US9134326B2 (en) * 2013-03-14 2015-09-15 Battelle Memorial Institute Biomarkers for liver fibrosis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013019943A1 (fr) * 2011-08-04 2013-02-07 Hdl Apomics Llc. Procédés de mesure de sous-populations de hdl

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANDERSON L: "Candidate-based proteomics in the search for biomarker of cardiovascular disease", THE JOURNAL OF PHYSIOLOGY, WILEY-BLACKWELL PUBLISHING LTD, GB, vol. 563.1, 1 January 2005 (2005-01-01), pages 23 - 60, XP003008393, ISSN: 0022-3751, DOI: 10.1113/JPHYSIOL.2004.080473 *
BALESTRIERI M L ET AL: "Proteomics and cardiovascular disease: An update", CURRENT MEDICINAL CHEMISTRY, BENTHAM, NL, vol. 15, no. 6, 1 March 2008 (2008-03-01), pages 555 - 572, XP002632302, ISSN: 0929-8673 *
See also references of WO2018136825A1 *

Also Published As

Publication number Publication date
EP3571222A1 (fr) 2019-11-27
US20190369114A1 (en) 2019-12-05
WO2018136825A1 (fr) 2018-07-26

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