EP3571222A4 - Procédés à base de spectrométrie de masse et hautement multiplexés permettant de mesurer 72 protéines humaines - Google Patents
Procédés à base de spectrométrie de masse et hautement multiplexés permettant de mesurer 72 protéines humaines Download PDFInfo
- Publication number
- EP3571222A4 EP3571222A4 EP18741778.7A EP18741778A EP3571222A4 EP 3571222 A4 EP3571222 A4 EP 3571222A4 EP 18741778 A EP18741778 A EP 18741778A EP 3571222 A4 EP3571222 A4 EP 3571222A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- measuring
- mass spectrometry
- based methods
- human proteins
- highly multiplexed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000003839 Human Proteins Human genes 0.000 title 1
- 108090000144 Human Proteins Proteins 0.000 title 1
- 238000004949 mass spectrometry Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21004—Trypsin (3.4.21.4)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Medicinal Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762448319P | 2017-01-19 | 2017-01-19 | |
PCT/US2018/014570 WO2018136825A1 (fr) | 2017-01-19 | 2018-01-19 | Procédés à base de spectrométrie de masse et hautement multiplexés permettant de mesurer 72 protéines humaines |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3571222A1 EP3571222A1 (fr) | 2019-11-27 |
EP3571222A4 true EP3571222A4 (fr) | 2021-06-16 |
Family
ID=62908394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18741778.7A Pending EP3571222A4 (fr) | 2017-01-19 | 2018-01-19 | Procédés à base de spectrométrie de masse et hautement multiplexés permettant de mesurer 72 protéines humaines |
Country Status (3)
Country | Link |
---|---|
US (1) | US20190369114A1 (fr) |
EP (1) | EP3571222A4 (fr) |
WO (1) | WO2018136825A1 (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11143659B2 (en) | 2015-01-27 | 2021-10-12 | Arterez, Inc. | Biomarkers of vascular disease |
JP7346300B2 (ja) | 2017-03-23 | 2023-09-19 | アボット・ラボラトリーズ | 早期バイオマーカーであるユビキチンカルボキシ末端ヒドロラーゼl1を使用する、ヒト対象における外傷性脳損傷の程度の診断及び決定の一助となるための方法 |
US10877048B2 (en) | 2017-04-15 | 2020-12-29 | Abbott Laboratories | Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury in a human subject using early biomarkers |
WO2018200823A1 (fr) | 2017-04-28 | 2018-11-01 | Abbott Laboratories | Méthodes d'aide au diagnostic et à la détermination hyperaigus d'une lésion cérébrale traumatique au moyen de biomarqueurs précoces sur au moins deux échantillons provenant du même sujet humain |
CA3078725A1 (fr) | 2017-05-25 | 2018-11-29 | Abbott Laboratories | Procedes d'aide a la determination de la realisation ou non d'une imagerie sur un sujet humain ayant subi ou susceptible d'avoir subi une lesion a la tete a l'aide de biomarqueurs precoces |
EP3631467A1 (fr) | 2017-05-30 | 2020-04-08 | Abbott Laboratories | Procédés d'aide au diagnostic et à l'évaluation d'une lésion cérébrale traumatique légère chez un patient humain à l'aide de troponine cardiaque i |
CA3068041C (fr) | 2017-07-03 | 2024-06-25 | Abbott Laboratories | Procedes ameliores de mesure de niveaux d'hydrolase a terminaison carboxy d'ubiquitine l1 dans le sang |
CA3067057A1 (fr) | 2017-12-09 | 2019-06-13 | Abbott Laboratories | Procedes d'aide au diagnostic et a l'evaluation d'un sujet qui a subi une lesion orthopedique et qui a subi ou peut avoir subi une lesion a la tete, telle qu'une lesion cerebrale traumatique legere (tbi), a l'aide d'une proteine acide fibrillaire gliale (gfap) et/ou d'hydrolase carboxy-terminale d'ubiquitine l1 (uch-l1) |
EP3721234A1 (fr) | 2017-12-09 | 2020-10-14 | Abbott Laboratories | Procédés d'aide au diagnostic et à l'évaluation d'un lésion cérébrale traumatique chez un sujet humain au moyen d'une combinaison de gfap et d'uch-l1 |
CN111699391A (zh) | 2017-12-29 | 2020-09-22 | 雅培实验室 | 用于诊断和评估创伤性脑损伤的新型生物标志物和方法 |
DE102018116248A1 (de) * | 2018-07-04 | 2020-01-09 | Hochschule Bremerhaven | Verfahren zum Nachweis, zur Unterscheidung und zur Quantifizierung von aktiven und inaktiven Formen von Gerinnungsfaktoren |
EP3833775A1 (fr) * | 2018-08-08 | 2021-06-16 | Regeneron Pharmaceuticals, Inc. | Utilisation de lc-ms/ms pour quantifier des biomarqueurs protéiques |
CN109087352B (zh) * | 2018-08-16 | 2021-07-13 | 数坤(北京)网络科技股份有限公司 | 一种心脏冠脉优势型自动判别方法 |
CN114269380A (zh) * | 2019-08-23 | 2022-04-01 | Igm生物科学股份有限公司 | IgM糖变体 |
CN110669104B (zh) * | 2019-10-30 | 2021-11-05 | 上海交通大学 | 一组来源于人外周血单核细胞的标志物及其应用 |
JP2023527062A (ja) | 2020-05-26 | 2023-06-26 | エフ. ホフマン-ラ ロシュ アーゲー | 定量器-確認器比チェックのために顧客質量分析機器を較正するためのコンピュータ実装方法 |
WO2022026537A1 (fr) * | 2020-07-28 | 2022-02-03 | The Trustees Of Princeton University | Méthode de détection et de surveillance quantitative d'infections par des virus de l'herpès |
US20240053369A1 (en) * | 2020-12-18 | 2024-02-15 | University Of Washington | Methods and Systems for Quantifying Lipoprotein(A) Using Candidate References |
CA3239488A1 (fr) * | 2021-11-30 | 2023-06-08 | Daniel SERIE | Diagnostic du cancer du pancreas a l'aide d'une quantification ciblee d'une glycosylation de proteine specifique a un site |
CN117647606A (zh) * | 2024-01-30 | 2024-03-05 | 西湖欧米(杭州)生物科技有限公司 | 适于lc-ms/ms能同时检测多种蛋白的试剂盒 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013019943A1 (fr) * | 2011-08-04 | 2013-02-07 | Hdl Apomics Llc. | Procédés de mesure de sous-populations de hdl |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009006568A1 (fr) * | 2007-07-03 | 2009-01-08 | Northeastern University | Biomarqueurs pour le diabète, l'obésité, et/ou l'hypertension |
US9134326B2 (en) * | 2013-03-14 | 2015-09-15 | Battelle Memorial Institute | Biomarkers for liver fibrosis |
-
2018
- 2018-01-19 EP EP18741778.7A patent/EP3571222A4/fr active Pending
- 2018-01-19 WO PCT/US2018/014570 patent/WO2018136825A1/fr unknown
-
2019
- 2019-07-18 US US16/515,458 patent/US20190369114A1/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013019943A1 (fr) * | 2011-08-04 | 2013-02-07 | Hdl Apomics Llc. | Procédés de mesure de sous-populations de hdl |
Non-Patent Citations (3)
Title |
---|
ANDERSON L: "Candidate-based proteomics in the search for biomarker of cardiovascular disease", THE JOURNAL OF PHYSIOLOGY, WILEY-BLACKWELL PUBLISHING LTD, GB, vol. 563.1, 1 January 2005 (2005-01-01), pages 23 - 60, XP003008393, ISSN: 0022-3751, DOI: 10.1113/JPHYSIOL.2004.080473 * |
BALESTRIERI M L ET AL: "Proteomics and cardiovascular disease: An update", CURRENT MEDICINAL CHEMISTRY, BENTHAM, NL, vol. 15, no. 6, 1 March 2008 (2008-03-01), pages 555 - 572, XP002632302, ISSN: 0929-8673 * |
See also references of WO2018136825A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP3571222A1 (fr) | 2019-11-27 |
US20190369114A1 (en) | 2019-12-05 |
WO2018136825A1 (fr) | 2018-07-26 |
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Legal Events
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
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Effective date: 20190723 |
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AK | Designated contracting states |
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AX | Request for extension of the european patent |
Extension state: BA ME |
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DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20210518 |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07K 14/775 20060101AFI20210511BHEP Ipc: G01N 33/50 20060101ALI20210511BHEP Ipc: G01N 33/68 20060101ALI20210511BHEP |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |
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17Q | First examination report despatched |
Effective date: 20240328 |