EP3493814A4 - Lipid-substituted amino 1,2-and 1,3-diol compounds as modulators of tlr2 dimerization - Google Patents
Lipid-substituted amino 1,2-and 1,3-diol compounds as modulators of tlr2 dimerization Download PDFInfo
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- EP3493814A4 EP3493814A4 EP17837574.7A EP17837574A EP3493814A4 EP 3493814 A4 EP3493814 A4 EP 3493814A4 EP 17837574 A EP17837574 A EP 17837574A EP 3493814 A4 EP3493814 A4 EP 3493814A4
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- modulators
- lipid
- substituted amino
- diol compounds
- tlr2
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- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662370637P | 2016-08-03 | 2016-08-03 | |
PCT/US2017/044984 WO2018026866A1 (en) | 2016-08-03 | 2017-08-01 | Lipid-substituted amino 1,2-and 1,3-diol compounds as modulators of tlr2 dimerization |
Publications (2)
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EP3493814A1 EP3493814A1 (en) | 2019-06-12 |
EP3493814A4 true EP3493814A4 (en) | 2020-07-22 |
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EP17837574.7A Withdrawn EP3493814A4 (en) | 2016-08-03 | 2017-08-01 | Lipid-substituted amino 1,2-and 1,3-diol compounds as modulators of tlr2 dimerization |
Country Status (4)
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EP (1) | EP3493814A4 (en) |
JP (1) | JP2019524781A (en) |
CN (1) | CN109715167A (en) |
WO (1) | WO2018026866A1 (en) |
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US10821106B2 (en) | 2015-08-21 | 2020-11-03 | Srx Cardio, Llc | Composition and methods of use of novel phenylalanine small organic compounds to directly modulate PCSK9 protein activity |
US10865185B2 (en) | 2015-08-21 | 2020-12-15 | Srx Cardio, Llc | Composition and methods of use of tetrahydroisoquinoline small molecules to bind and modulate PCSK9 protein activity |
EP3337788A4 (en) | 2015-08-21 | 2019-03-27 | Portola Pharmaceuticals, Inc. | Phenylpiperazine proprotein convertase subtilisin/kexin type 9 (pcsk9) modulators and their use |
US20190119236A1 (en) | 2016-02-23 | 2019-04-25 | Portola Pharmaceuticals, Inc. | Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9) |
CA3133825A1 (en) | 2019-03-26 | 2020-10-01 | Neuropore Therapies, Inc. | Compounds and compositions as modulators of tlr signaling |
MX2021015652A (en) * | 2019-06-25 | 2022-02-03 | Amtixbio Co Ltd | Derivative compound introducing biphenyl group into novel aminoalkanoic acid and antifungal pharmaceutical composition comprising same. |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0451763A2 (en) * | 1990-04-09 | 1991-10-16 | Fuji Photo Film Co., Ltd. | Peptide derivatives with amphiphatic properties, intermediates thereof and liposomes and films comprising said derivatives |
WO2002072068A2 (en) * | 2001-03-12 | 2002-09-19 | Cancer Research Technology Limited | Lipids, lipid compositions, liposomes, and lipoplexes |
WO2013135360A1 (en) * | 2012-03-16 | 2013-09-19 | Merck Patent Gmbh | Aminoacid lipids |
Family Cites Families (4)
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US7803397B2 (en) * | 2003-09-15 | 2010-09-28 | Protiva Biotherapeutics, Inc. | Polyethyleneglycol-modified lipid compounds and uses thereof |
US7202234B2 (en) * | 2003-10-24 | 2007-04-10 | Eisai Co., Ltd. | Compounds and methods for treating Toll-like receptor 2-related diseases and conditions |
CN104105691A (en) * | 2011-11-08 | 2014-10-15 | 艾尼纳制药公司 | Modulators of the g protein-coupled mas receptor and the treatment of disorders related thereto |
WO2014113634A1 (en) * | 2013-01-17 | 2014-07-24 | University Of Kansas | Toll-like receptor 2-agonistic lipopeptides, and method of making the same |
-
2017
- 2017-08-01 WO PCT/US2017/044984 patent/WO2018026866A1/en unknown
- 2017-08-01 EP EP17837574.7A patent/EP3493814A4/en not_active Withdrawn
- 2017-08-01 CN CN201780048372.3A patent/CN109715167A/en active Pending
- 2017-08-01 JP JP2019505479A patent/JP2019524781A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0451763A2 (en) * | 1990-04-09 | 1991-10-16 | Fuji Photo Film Co., Ltd. | Peptide derivatives with amphiphatic properties, intermediates thereof and liposomes and films comprising said derivatives |
WO2002072068A2 (en) * | 2001-03-12 | 2002-09-19 | Cancer Research Technology Limited | Lipids, lipid compositions, liposomes, and lipoplexes |
WO2013135360A1 (en) * | 2012-03-16 | 2013-09-19 | Merck Patent Gmbh | Aminoacid lipids |
Non-Patent Citations (1)
Title |
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See also references of WO2018026866A1 * |
Also Published As
Publication number | Publication date |
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JP2019524781A (en) | 2019-09-05 |
CN109715167A (en) | 2019-05-03 |
EP3493814A1 (en) | 2019-06-12 |
WO2018026866A1 (en) | 2018-02-08 |
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