EP3422874A1 - Vibrationsvertropfung - Google Patents
VibrationsvertropfungInfo
- Publication number
- EP3422874A1 EP3422874A1 EP17707050.5A EP17707050A EP3422874A1 EP 3422874 A1 EP3422874 A1 EP 3422874A1 EP 17707050 A EP17707050 A EP 17707050A EP 3422874 A1 EP3422874 A1 EP 3422874A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- modified
- oil
- dispersion
- particles
- vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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Definitions
- the present invention relates to a method for the production of carotenoid and / or vitamin and / or omega-3 fatty acids and / or phytosterols and / or conjugated linoleic acid-containing particles with narrow particle size distribution and uniform spherical shape and density, as well as particles obtainable by this method and their use as dietary supplements, food, feed, personal care product and medicines.
- the particles according to the invention have an improved storage stability compared with the prior art.
- the carotenoid and / or vitamin-containing particles produced according to the process described in US Pat. No. 4,522,743 have a high proportion of air inclusions, which can amount to> 40% of the void volume based on the total volume of the particles. These air pockets make the particles less mechanically stable than massive particles. The particles can be damaged during further processing and thus deteriorate the product properties. In addition to the air inclusions, these particles are usually characterized by a broad particle size distribution, possibly paired with a rather uneven particle shape.
- these preparations due to breakage of the hollow spheres under mechanical stress, but also due to the broad particle size distribution and the associated fine dust content and the uneven particle shape, these preparations have a large surface area, which makes them sensitive to oxidative attack of oxygen on the carotenoids and vitamins contained in the particles.
- the object of the invention is therefore to provide a method which provides particles which do not possess these disadvantages of the prior art.
- the object is achieved by methods in which to produce spherical particles by dispersing carotenoid and / or vitamin and / or omega-3 fatty acids and / or phytosterols and / or conjugated linoleic acids in a hydrocolloid-containing solution and the dispersion formed by a Dropped Vibration dropping method and the resulting drops solidified by evaporation of the solvent and dried.
- Spherical in the sense of the invention means that the individual particles each have an aspect ratio of 1 to 1, 2. "Aspect Ratio" is the quotient of the largest and the smallest particle diameter.
- dispersion in the context of the present invention both emulsions and suspensions.
- the nozzle and / or the dispersion and / or a reservoir receiving the dispersion and / or a feed line feeding the dispersion of the nozzle are excited to vibrate.
- vibration exciter a me- mechanical oscillator, magnetic oscillator, pneumatic vibrator, piezoelectric transducer or electro-acoustic transducer.
- the vibration exciter can act on the nozzle and / or supply line and / or on the reservoir. It is also possible to directly sonicate the dispersion, for example with an electroacoustic transducer, or to excite it directly with a vibrating displacer / plunger in order to drop the dispersion emerging from the nozzle into uniform drops.
- the frequency which acts on the device or the dispersion is to be kept constant during the production process, wherein preferably excitation frequencies between 50 and 10000 Hz, preferably in the range 100 to 5000 Hz and particularly preferably in the range 400-4000 Hz are used.
- the viscosity of the dispersions is> 80 mPas at 40 ° C.
- the diameter of the nozzle should eventually be in the range between 50 and 1000 ⁇ .
- spherical particles can be produced with a narrow particle size distribution, with particles having a diameter between 100 and 1500 ⁇ m being achievable as a function of the frequency and the nozzle diameter.
- the process is preferably carried out in such a way that spherical particles with a particle size distribution of> 75% in the range of 150 to ⁇ , preferably> 85% in the range of 150 to 600 ⁇ and particularly preferably> 95% of 150 to 600 ⁇ are obtained.
- the process is characterized in that the polydispersity, measured as the range of the particle size distribution (X90-X10 divided by X50), is less than 1.0, preferably less than 0.8 and more preferably less than 0.6, the X50 value being the mean Particle size distribution and the difference X90-X10 represents the width of the particle size distribution.
- the content of the spherical particles consists of a hydrocolloid matrix in which homogeneously distributed carotenoid (s) and / or vitamin (s) and / or omega-3 fatty acids and / or phytosterols and / or conjugated linoleic acids are present. These particles are distinguished by the fact that the void volume trapped in the particles is ⁇ 40%, preferably ⁇ 30% and particularly preferably ⁇ 20% of the total volume of the particles.
- carotenoids and / or vitamins and / or omega-3 fatty acids and / or phytosterols and / or conjugated linoleic acids are vitamins A, D, E or K or their derivatives, for example vitamin A and vitamin E Esters such as retinyl acetate or tocopherol acetate, tocotrienol, vitamin K1, vitamin K2, and also carotenoids, such as Carotene, canthaxanthin, astaxanthin, citranaxanthin and ester derivatives, zeaxanthin and ester derivatives, lutein and ester derivatives, lycopene and apocarotenal.
- vitamins A, D, E or K or their derivatives for example vitamin A and vitamin E Esters such as retinyl acetate or tocopherol acetate, tocotrienol, vitamin K1, vitamin K2, and also carotenoids, such as Carotene, canthaxanthin, astaxanthin, citranaxanthin and ester
- Suitable hydrocolloids are according to the invention plant gums, modified plant gums, gelatin, modified gelatin, modified starch, lignosulfonate, chitosan, carrageenan, casein, caseinate, whey protein, zein, modified cellulose, pectin, modified pectin, vegetable proteins and modified vegetable proteins or mixtures thereof.
- the plant gums include agar, alginic acid, alginate, chicle, dammar, marshmallow extracts, gellan, guar gum, gum arabic, gum from plantar core, gum from spruce juice, locust bean gum, karaya, konjac flour, mastic, tara gum, tragacanth, xanthane.
- hydrocolloid is gelatin and / or plant gums and / or modified plant gums and, in particular, gum arabic among the plant gums.
- an antioxidant can be added to the hydrocolloid solution before or after addition of the carotenoid and / or vitamin and / or omega-3 fatty acids and / or phytosterols and / or conjugated linoleic acids to increase the stability of these against oxidative degradation.
- the antioxidant is selected from the group consisting of dl-a-tocopherol, tocopherol, ß-tocopherol, ⁇ -tocopherol, ⁇ -tocopherol, butylhydroxytoluene (BHT), butylhydroxyanisole, propyl gallate, octyl gallate, dodecyl gallate, extracts of rosemary , Extracts of green tea and other gallic acid derivatives, tert-butylhydroxyquinoline, ethoxyquin, carnosol, carnosic acid, ascorbyl palmitate and ascorbyl stearate or mixtures thereof.
- BHT butylhydroxytoluene
- the proportion of antioxidants in the particle composition is 0.1 to 10 wt .-%, preferably 0.5 to 8.5 wt .-%, based on the dry matter of the carotenoid and / or vitamin and / or omega-3 fatty acids and / or phytosterols and / or conjugated linoleic acid-containing particle composition (without powdering agent), the sum of the percentages of the individual components being 100%.
- a plasticizer such as sucrose, glucose, glucose syrup, lactose, invert sugar and other glucose fructose compositions, sorbitol, mannitol, glycerol, maltodextrins, isomaltose or isomalt.
- the designation voltage isomalt is a sugar substitute that also under the brand name Palatinit ® (Fa. Südzucker, Germany) is performed.
- Isomalt is a hydrogenated isomaltulose consisting of approximately equal parts of 6-OaD-glucopyranosyl-D-sorbitol and 1 -OaD-glucopyranosyl-D-mannitol.
- plasticizers are sucrose, glucose syrup, sorbitol and lactose.
- the ratio of protective colloid and plasticizer to carotenoid and / or vitamin and / or omega-3 fatty acids and / or phytosterols and / or conjugated linoleic acids is generally chosen so as to obtain a solid preparation containing between 0.01 and 50 wt .-% Ca contains redoid and / or vitamin, 10 to 65 wt .-%, preferably 15 to 60 wt .-% of a protective colloid and 5 to 60 wt .-%, preferably 10 to 50 wt .-% of a plasticizer, all percentages on refer to the dry matter of the particle composition (without powdering agent) and the sum of the percentages of the individual components is 100%.
- emulsifiers for example, ascorbyl palmitate, polyglycerol fatty acid esters, sorbitan fatty acid esters, propylene glycol fatty acid esters or lecithin in a concentration of 0 to 200 wt .-%, preferably 5 to 150 wt .-%, particularly preferably 10 to 80 wt .-%, based on the used carotenoids and / or vitamins.
- a physiologically approved oil such as sesame oil, corn oil, cottonseed oil, soybean oil, peanut oil, sunflower oil, rapeseed oil, coconut oil, palm oil, olive oil, animal fats, lard, tallow, modified oils or mixtures thereof in one concentration from 0 to 500 wt.%, Preferably 10 to 300 wt.%, Particularly preferably 20 to 100 wt.%, Based on the / the carotenoids and / or vitamins to use.
- a physiologically approved oil such as sesame oil, corn oil, cottonseed oil, soybean oil, peanut oil, sunflower oil, rapeseed oil, coconut oil, palm oil, olive oil, animal fats, lard, tallow, modified oils or mixtures thereof in one concentration from 0 to 500 wt.%, Preferably 10 to 300 wt.%, Particularly preferably 20 to 100 wt.%, Based on the / the carotenoids and / or vitamins to use.
- auxiliary agents and additives which are customary for the production of carotenoid and / or omega-3 fatty acids and / or phytosterols and / or conjugated linoleic acid particle compositions, such as e.g. inorganic and organic salts are added.
- the proportion of auxiliaries and additives is generally from 0.2 to 20 wt .-%, preferably 0.3 to 15 wt .-%, particularly preferably 0.4 to 10 wt .-%, most preferably 0.5 to 5% by weight, based on the dry mass of the particle composition (without powdering agent), the sum of the percentages of the individual components being 100%.
- a powdered preparation can be prepared in a manner known per se, e.g. according to the specifications of DE2534091 by spray drying or by spray cooling or by enveloping the particles, separating and drying in a fluidized bed.
- the droplets formed are thereby enveloped by a powdering agent which can be selected from hydrophobic silica, hydrophilic silica, starch, modified starch, corn starch, celluloses, modified celluloses, calcium silicate, calcium magnesium silicate, calcium carbonate, tricalcium phosphate, calcium adipate, magnesium adipate, titanium dioxide, lignins , fumed pectin, modified pectin, plant proteins, modified plant proteins, and combinations thereof.
- the inventive method is characterized in that the drops produced are coated with a powder at temperatures between 10 and 80 ° C and then solidified at inlet temperatures between 40 and 120 ° C and dried. Preference is given to a process procedure in which a dispersion containing carotenoid and / or omega-3 fatty acids and / or phytosterols and / or conjugated linoleic acids is sprayed into an inert gas atmosphere laden with the impregnating agents hydrophobic silica or cornstarch.
- a process procedure is preferred in which after spraying to a residual moisture content below 10% by weight, preferably below 6% by weight is dried.
- the invention also relates to particle compositions which contain, in addition to the constituents mentioned, 0.025 to 4 times by weight the active ingredient in powder or powder mixtures.
- the use of the preparation forms according to the invention as a dietary supplement, food, feed, personal care product and medicaments is claimed. pictures:
- FIG. 1 Scanning electron micrograph of the particles produced according to FIG. 1A.
- FIG. 2 Scanning electron micrograph of the particles produced according to FIG. 1B
- the molecular-disperse solution in mixing chamber B is mixed with a solution of 32 g of gelatin and 120 g of glucose syrup in 4000 g of water at a rate of 100 l / h of isopropanol.
- a drug dispersion is obtained, which can be converted by spray drying in a stable, water-soluble dry powder. After dissolution in water, a particle size of 150 nm is measured.
- the emulsion thus prepared was sprayed through a nozzle at 25 bar into a spray tower in which hydrophobic silica was fluidized at 60.degree.
- the still moist particles were after-dried for 5 h at 60 ° C air inlet temperature in the underlying fluidized bed.
- a broad particle size Distribution ( Figure 3) with a maximum at about 500 ⁇ associated with a high void fraction based on the total volume of the particles determined.
- Example 1A Determination of the hollow sphere portion of Example 1A In a 15 ml centrifuge tube 4 ml of the prepared particles were placed. Subsequently, n-pentane was added to the tube until a volume of 12 ml was reached. The tube was sealed and shaken until the particles whirled completely off the bottom. The tube was then placed upright and the measurement was evaluated after 5 minutes.
- the hollow sphere quantity was read off at a mm scale and indicated in millimeter steps.
- Example 1A an average of 6.2mm was measured in triplicate.
- Example 1 B was carried out analogously to Example 1A with the difference that a
- Vibrating nozzle with a pressure of 0.5bar was used.
- the device used was a Buchi Encapsulator B-390 with a 200 ⁇ nozzle opening at a frequency of 1400Hz.
- the flow rate for a nozzle was 30g per hour.
- a narrow particle size distribution (FIG. 3) was determined with a maximum at about 400 ⁇ m, combined with a very low void fraction based on the total volume of the particles.
- Example 1B According to the experimental procedure of Example 1A, the hollow sphere amount of Example 1B was determined.
- Example 1B an average of 0mm was measured in triplicate.
- test samples of 25 mg each of the prepared particles and 4 g premix mixture were weighed into 50 ml glass bottles.
- the premix mixture consisted of 20% wheat bran, 20% 50% silica supported choline chloride and 10% trace element mixture.
- the trace element mixture consisted of 46.78% FeS0 4 x7H 2 0, 37.43% CuS0 4 x5H 2 0, 1 1, 79% ZnO, 3.61% MnO and 0.39% COCO 3.
- the test samples were carefully mixed by hand. These test samples were stored in a climatic chamber at 40 ° C and 70% for 4 weeks. Before the storage and after the storage was completed, the Canthaxanthin content of the test samples determined. Retention was calculated from the ratio of canthaxanthin levels before and before storage.
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WO2018108639A1 (en) | 2016-12-13 | 2018-06-21 | Basf Se | Filaments for use as a support material in fused deposition modeling |
KR20210023890A (ko) | 2018-06-27 | 2021-03-04 | 바스프 에스이 | 더스트-프리 냉수-분산성 제제 |
AU2020365042A1 (en) * | 2019-10-11 | 2022-04-07 | Dsm Ip Assets B.V. | New feed additives of carotenoids |
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US3998753A (en) | 1974-08-13 | 1976-12-21 | Hoffmann-La Roche Inc. | Water dispersible carotenoid preparations and processes thereof |
DE3119383A1 (de) | 1981-05-15 | 1982-12-02 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinodpraeparaten |
DE19651681A1 (de) * | 1996-12-12 | 1998-06-18 | Basf Ag | Stabile, wäßrige Dispersionen und stabile, wasserdispergierbare Trockenpulver von Xanthopyllen, deren Herstellung und Verwendung |
ATE262976T1 (de) * | 1998-03-07 | 2004-04-15 | Inotech Ag | Verfahren und vorrichtung zum verkapseln von mikrobiellen, pflanzlichen und tierischen zellen bzw. von biologischen und chemischen substanzen |
US6328995B1 (en) * | 1999-09-24 | 2001-12-11 | Basf Aktiengesellschaft | Stable vitamin and/or carotenoid products in powder form and process for their production |
DE10158046A1 (de) * | 2001-11-27 | 2003-06-05 | Basf Ag | Formulierung für den Einsatz in Lebensmitteln, Nahrungsergänzungsmitteln, Futtermitteln, Futterzusatzstoffen, pharmazeutischen und kosmetischen Zubereitungen sowie Verfahren zu deren Herstellung |
EP1413298B1 (de) * | 2002-09-24 | 2007-11-21 | Cognis IP Management GmbH | Verfahren zur Herstellung von Makrokapseln |
ATE402758T1 (de) * | 2004-02-06 | 2008-08-15 | Basf Se | Wässrige dispersion und ihre verwendung |
DE102005030952A1 (de) * | 2005-06-30 | 2007-01-18 | Basf Ag | Verfahren zur Herstellung einer wässrigen Suspension und einer pulverförmigen Zubereitung eines oder mehrerer Carotinoide |
EP1964479B1 (en) * | 2007-02-14 | 2013-05-15 | DSM IP Assets B.V. | Process for the manufacture of a powder containing carotenoids |
US9445997B2 (en) * | 2007-12-21 | 2016-09-20 | Basf Se | Microcapsules comprising a fat-soluble active substance |
CN101480609B (zh) * | 2009-01-21 | 2010-08-11 | 上海三瑞高分子材料有限公司 | 一种合成生物柴油的核壳结构纳米固体碱催化剂制备方法 |
US20130251855A1 (en) * | 2012-03-21 | 2013-09-26 | Pepsico, Inc. | Aqueous product comprising oil-containing microcapsules and method for the manufacture thereof |
EP2925880B1 (en) * | 2012-11-27 | 2020-07-01 | DSM IP Assets B.V. | Process for the production of discrete solid extruded particles |
GB201509606D0 (en) * | 2015-06-03 | 2015-07-15 | Anabio Technologies Ltd | Microencapsulates containing stabilised marine-derived oil, and methods for production thereof |
-
2017
- 2017-02-28 JP JP2018545938A patent/JP2019516345A/ja active Pending
- 2017-02-28 WO PCT/EP2017/054586 patent/WO2017148907A1/de active Application Filing
- 2017-02-28 CN CN201780012640.6A patent/CN108697149A/zh active Pending
- 2017-02-28 EP EP17707050.5A patent/EP3422874A1/de not_active Withdrawn
- 2017-02-28 US US16/081,538 patent/US20190090529A1/en active Pending
Also Published As
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US20190090529A1 (en) | 2019-03-28 |
WO2017148907A1 (de) | 2017-09-08 |
CN108697149A (zh) | 2018-10-23 |
JP2019516345A (ja) | 2019-06-20 |
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