EP3400097A4 - Bifurcating mixers and methods of their use and manufacture - Google Patents

Bifurcating mixers and methods of their use and manufacture Download PDF

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Publication number
EP3400097A4
EP3400097A4 EP16882817.6A EP16882817A EP3400097A4 EP 3400097 A4 EP3400097 A4 EP 3400097A4 EP 16882817 A EP16882817 A EP 16882817A EP 3400097 A4 EP3400097 A4 EP 3400097A4
Authority
EP
European Patent Office
Prior art keywords
manufacture
methods
bifurcating
mixers
bifurcating mixers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP16882817.6A
Other languages
German (de)
French (fr)
Other versions
EP3400097A1 (en
EP3400097B1 (en
Inventor
Andre Wild
Timothy LEAVER
Robert James Taylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of British Columbia
Original Assignee
University of British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of British Columbia filed Critical University of British Columbia
Priority to EP20207659.2A priority Critical patent/EP3797860A1/en
Publication of EP3400097A1 publication Critical patent/EP3400097A1/en
Publication of EP3400097A4 publication Critical patent/EP3400097A4/en
Application granted granted Critical
Publication of EP3400097B1 publication Critical patent/EP3400097B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • B01F25/4317—Profiled elements, e.g. profiled blades, bars, pillars, columns or chevrons
    • B01F25/43172—Profiles, pillars, chevrons, i.e. long elements having a polygonal cross-section
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/432—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/432—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa
    • B01F25/4323—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa using elements provided with a plurality of channels or using a plurality of tubes which can either be placed between common spaces or collectors
    • B01F25/43231—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa using elements provided with a plurality of channels or using a plurality of tubes which can either be placed between common spaces or collectors the channels or tubes crossing each other several times
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4331—Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4338—Mixers with a succession of converging-diverging cross-sections, i.e. undulating cross-section
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/434—Mixing tubes comprising cylindrical or conical inserts provided with grooves or protrusions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0418—Geometrical information
    • B01F2215/0422—Numerical values of angles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0418—Geometrical information
    • B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0436—Operational information
    • B01F2215/0459—Numerical values of dimensionless numbers, i.e. Re, Pr, Nu, transfer coefficients
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • B01F25/4317—Profiled elements, e.g. profiled blades, bars, pillars, columns or chevrons

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Glanulating (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
EP16882817.6A 2016-01-06 2016-08-24 Bifurcating mixers and methods of their use and manufacture Active EP3400097B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP20207659.2A EP3797860A1 (en) 2016-01-06 2016-08-24 Bifurcating mixers and methods of their use and manufacture

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662275630P 2016-01-06 2016-01-06
PCT/CA2016/050997 WO2017117647A1 (en) 2016-01-06 2016-08-24 Bifurcating mixers and methods of their use and manufacture

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP20207659.2A Division-Into EP3797860A1 (en) 2016-01-06 2016-08-24 Bifurcating mixers and methods of their use and manufacture
EP20207659.2A Division EP3797860A1 (en) 2016-01-06 2016-08-24 Bifurcating mixers and methods of their use and manufacture

Publications (3)

Publication Number Publication Date
EP3400097A1 EP3400097A1 (en) 2018-11-14
EP3400097A4 true EP3400097A4 (en) 2019-09-04
EP3400097B1 EP3400097B1 (en) 2021-01-27

Family

ID=59273141

Family Applications (2)

Application Number Title Priority Date Filing Date
EP20207659.2A Pending EP3797860A1 (en) 2016-01-06 2016-08-24 Bifurcating mixers and methods of their use and manufacture
EP16882817.6A Active EP3400097B1 (en) 2016-01-06 2016-08-24 Bifurcating mixers and methods of their use and manufacture

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP20207659.2A Pending EP3797860A1 (en) 2016-01-06 2016-08-24 Bifurcating mixers and methods of their use and manufacture

Country Status (8)

Country Link
US (4) US10076730B2 (en)
EP (2) EP3797860A1 (en)
JP (2) JP7349788B2 (en)
KR (1) KR102361123B1 (en)
CN (1) CN108778477B (en)
AU (1) AU2016385135B2 (en)
CA (1) CA3009691C (en)
WO (1) WO2017117647A1 (en)

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AU2016222746A1 (en) 2015-02-24 2017-09-07 The University Of British Columbia Continuous flow microfluidic system
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CA3059714C (en) * 2017-04-13 2023-02-14 National University Corporation Hokkaido University Flow channel structure and lipid particle or micelle formation method using same
NL2019801B1 (en) * 2017-10-25 2019-05-02 Univ Leiden Delivery vectors
CA3097203C (en) 2018-04-29 2023-09-05 Precision Nanosystems Inc. Compositions for transfecting resistant cell types
US20200114323A1 (en) * 2018-10-12 2020-04-16 Feistel Holding Corp. Systems and methods for treating and conditioning small volume liquid samples
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CN113663573A (en) * 2020-05-15 2021-11-19 斯微(上海)生物科技有限公司 Mixer for particle generation
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CN114343526A (en) * 2021-12-31 2022-04-15 安克创新科技股份有限公司 Mixing tube, mixing device and cleaning equipment
CN115148330B (en) * 2022-05-24 2023-07-25 中国医学科学院北京协和医院 POP treatment scheme forming method and system
WO2024006863A1 (en) 2022-06-30 2024-01-04 Precision NanoSystems ULC Lipid nanoparticle formulations for vaccines
WO2024071987A1 (en) * 2022-09-30 2024-04-04 포항공과대학교 산학협력단 Microfluidic mixing structure and microfluidic mixing apparatus comprising same
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US10076730B2 (en) 2018-09-18
US20210023514A1 (en) 2021-01-28
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US10835878B2 (en) 2020-11-17
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US10688456B2 (en) 2020-06-23

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