EP3368059A4 - Traitement de l'hyperglycémie induite par des stéroïdes avec des analogues de facteur de croissance des fibroblastes (fgf) 1 - Google Patents
Traitement de l'hyperglycémie induite par des stéroïdes avec des analogues de facteur de croissance des fibroblastes (fgf) 1 Download PDFInfo
- Publication number
- EP3368059A4 EP3368059A4 EP16860818.0A EP16860818A EP3368059A4 EP 3368059 A4 EP3368059 A4 EP 3368059A4 EP 16860818 A EP16860818 A EP 16860818A EP 3368059 A4 EP3368059 A4 EP 3368059A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- fgf
- steroid
- analogs
- treatment
- growth factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000018233 Fibroblast Growth Factor Human genes 0.000 title 1
- 108050007372 Fibroblast Growth Factor Proteins 0.000 title 1
- 229940126864 fibroblast growth factor Drugs 0.000 title 1
- 201000001421 hyperglycemia Diseases 0.000 title 1
- 150000003431 steroids Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562248935P | 2015-10-30 | 2015-10-30 | |
PCT/US2016/059190 WO2017075260A1 (fr) | 2015-10-30 | 2016-10-27 | Traitement de l'hyperglycémie induite par des stéroïdes avec des analogues de facteur de croissance des fibroblastes (fgf) 1 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3368059A1 EP3368059A1 (fr) | 2018-09-05 |
EP3368059A4 true EP3368059A4 (fr) | 2019-03-27 |
Family
ID=58631193
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP16860818.0A Withdrawn EP3368059A4 (fr) | 2015-10-30 | 2016-10-27 | Traitement de l'hyperglycémie induite par des stéroïdes avec des analogues de facteur de croissance des fibroblastes (fgf) 1 |
Country Status (6)
Country | Link |
---|---|
US (1) | US10695404B2 (fr) |
EP (1) | EP3368059A4 (fr) |
JP (1) | JP2018535964A (fr) |
AU (1) | AU2016344134A1 (fr) |
CA (1) | CA3002400A1 (fr) |
WO (1) | WO2017075260A1 (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2011239386B2 (en) | 2010-04-16 | 2015-03-19 | Salk Institute For Biological Studies | Methods for treating metabolic disorders using FGF |
WO2017075260A1 (fr) | 2015-10-30 | 2017-05-04 | Salk Institute For Biological Studies | Traitement de l'hyperglycémie induite par des stéroïdes avec des analogues de facteur de croissance des fibroblastes (fgf) 1 |
WO2018112200A1 (fr) * | 2016-12-15 | 2018-06-21 | Salk Institute For Biological Studies | Utilisation du facteur 1 de croissance des fibroblastes (fgf1)-nerf vague ciblant des protéines chimériques pour traiter l'hyperglycémie |
AU2019359295A1 (en) * | 2018-10-09 | 2021-06-03 | The Board Of Trustees Of The Leland Stanford Junior University | Engineered fibroblast growth factor variants as receptor antagonists |
US11542309B2 (en) | 2019-07-31 | 2023-01-03 | Salk Institute For Biological Studies | Fibroblast growth factor 1 (FGF1) mutant proteins that selectively activate FGFR1B to reduce blood glucose |
PL244541B1 (pl) * | 2021-05-26 | 2024-02-05 | Celon Pharma Spolka Z Ograniczona Odpowiedzialnoscia | Muteiny ludzkiego czynnika wzrostu fibroblastów 1 (FGF-1), ich dimery i zastosowania |
WO2023019218A1 (fr) * | 2021-08-12 | 2023-02-16 | Trefoil Therapeutics, Inc. | Facteurs de croissance des fibroblastes modifiés pour le traitement de maladies fibrotiques |
EP4365192A1 (fr) * | 2022-11-04 | 2024-05-08 | DSM IP Assets B.V. | Production microbienne de facteurs de croissance |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011130729A2 (fr) * | 2010-04-16 | 2011-10-20 | Salk Institute For Biological Studies | Procédés de traitement de troubles métaboliques utilisant le fgf |
US20150111821A1 (en) * | 2013-10-21 | 2015-04-23 | Salk Institute For Biological Studies | Mutated fibroblast growth factor (fgf) 1 and methods of use |
Family Cites Families (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE108459T1 (de) | 1986-04-22 | 1994-07-15 | Salk Inst For Biological Studi | Antagonisten des fibroblasten-wachstumsfaktors. |
US5656458A (en) | 1988-11-04 | 1997-08-12 | Chiron Corporation | Expression and processing of amino terminus acetylated FGF's in yeast |
US5658889A (en) | 1989-01-24 | 1997-08-19 | Gensia Pharmaceuticals, Inc. | Method and compounds for aica riboside delivery and for lowering blood glucose |
JPH04164096A (ja) | 1989-09-29 | 1992-06-09 | Takeda Chem Ind Ltd | aFGFムテイン,DNAおよびその用途 |
EP0420222A1 (fr) | 1989-09-29 | 1991-04-03 | Takeda Chemical Industries, Ltd. | Mutéine du FGF acide, et sa production |
US5478804A (en) | 1990-09-19 | 1995-12-26 | The Salk Institute For Biological Studies | Treatment of tumorigenic pathophysiological conditions with FGF-cytoxic conjugates |
DE4132005A1 (de) | 1991-09-26 | 1993-04-01 | Merck Patent Gmbh | Kombination enthaltend wachstumsfaktoren und polyelektrolyte |
TW275068B (fr) | 1993-09-24 | 1996-05-01 | American Cyanamid Co | |
US5693775A (en) | 1995-05-12 | 1997-12-02 | The Johns Hopkins University School Of Medicine | Fibroblast growth factor homologous factor-1 (FHF-1) and methods of use |
US6326484B1 (en) | 1998-05-14 | 2001-12-04 | The Salk Institute For Biological Studies | Nucleic acids encoding regulators of FGF-2 transcription (RFT) and variants thereof |
US6800286B1 (en) | 1998-08-19 | 2004-10-05 | The Regents Of The University Of Colorado | Chimeric fibroblast growth factor proteins, nucleic acid molecules, and uses thereof |
US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
IL139380A0 (en) | 2000-10-31 | 2001-11-25 | Prochon Biotech Ltd | Active variants of fibroblast growth factor |
WO2002066034A1 (fr) | 2001-02-20 | 2002-08-29 | Chugai Seiyaku Kabushiki Kaisha | Methode de traitement de maladies metaboliques dans lesquelles sont utilises des inhibiteurs de malonyl-coa decarboxylase |
AU2002306921A1 (en) | 2001-03-27 | 2002-10-08 | Massachusetts Institute Of Technology | Methods and products related to fgf dimerization |
WO2003011213A2 (fr) | 2001-07-30 | 2003-02-13 | Eli Lilly And Company | Methode de traitement du diabete et de l'obesite |
US6982170B1 (en) | 2001-12-17 | 2006-01-03 | Maine Medical Center Research Institute | Compositions, methods and kits relating to thrombin degradation resistant fibroblast growth factor-1 |
US8142810B2 (en) | 2002-05-30 | 2012-03-27 | The Procter & Gamble Company | Dietary method for modulating glucose metabolism and associated conditions and increasing longevity |
NZ537208A (en) | 2002-06-27 | 2009-02-28 | Adipogen Pharmaceuticals Pty Ltd | Differentiation modulating agents and uses therefor |
NZ543717A (en) | 2003-06-05 | 2008-06-30 | Centelion | Administration of a plasmid encoding a fibroblast growth factor (FGF), wherein VEGF-A factor expression is not induced in the myocardial or skeletal muscle to treat myocardial or skeletal angiogenic disorders or defects associated with hypercholesterolemia or diabetes |
US7790682B1 (en) | 2003-12-02 | 2010-09-07 | The Florida State University Research Foundation, Inc. | Engineered human acidic fibroblast growth factors and associated methods |
JP4477013B2 (ja) | 2003-12-10 | 2010-06-09 | イーライ リリー アンド カンパニー | 線維芽細胞成長因子21の突然変異タンパク質 |
KR20070006714A (ko) | 2003-12-29 | 2007-01-11 | 센텔리옹 에스아에스 | 관상 동맥 또는 말초 허혈 치료 |
US20090111742A1 (en) | 2004-01-26 | 2009-04-30 | Alexei Kharitonenkov | Use of fgf-21 and thiazolidinedione for treating type 2 diabetes |
CA2557782A1 (fr) | 2004-03-17 | 2005-10-06 | Eli Lilly And Company | Composes fgf-21 lies au glycol |
JP2008506635A (ja) | 2004-05-13 | 2008-03-06 | イーライ リリー アンド カンパニー | Fgf−21融合タンパク質 |
ATE513823T1 (de) | 2004-08-17 | 2011-07-15 | Simpson Biotech Co Ltd | Mischung und verbindungen von mycelien von antrodia camphorata und deren verwendung |
WO2006028595A2 (fr) | 2004-09-02 | 2006-03-16 | Eli Lilly And Company | Muteines de facteur de croissance 21 de fibroblaste |
EP1789443A1 (fr) | 2004-09-02 | 2007-05-30 | Eli Lilly And Company | Muteines du facteur de croissance 21 du fibroblaste |
JP5948627B2 (ja) | 2004-10-29 | 2016-07-20 | レイショファーム ゲーエムベーハー | 線維芽細胞成長因子(fgf)のリモデリングと糖質ペグ化 |
EP1831371A2 (fr) | 2004-12-14 | 2007-09-12 | Eli Lilly And Company | Muteines du facteur de croissance fibroblastique 21 |
US20080261875A1 (en) | 2005-01-21 | 2008-10-23 | Eli Lilly And Company | Method For Treating Cardiovascular Disease |
US8119358B2 (en) | 2005-10-11 | 2012-02-21 | Tethys Bioscience, Inc. | Diabetes-related biomarkers and methods of use thereof |
US8168591B2 (en) | 2005-10-17 | 2012-05-01 | The Regents Of The University Of California | Compositions and methods related to anti-FGF agents |
EP2083846B1 (fr) | 2006-09-28 | 2015-07-15 | Hepacore Ltd. | Variantes fgf n-terminal à sélectivité de récepteur améliorée et ses utilisations |
US20100143330A1 (en) | 2006-10-16 | 2010-06-10 | Unversidadde Salamanca (O.T.R.I.) | Methods of treating disorders associated with fat storage |
US7595296B1 (en) | 2006-11-09 | 2009-09-29 | Florida State University Research Foundation, Inc. | Mutant polypeptides of fibroblast growth factor 1 |
WO2008092019A1 (fr) | 2007-01-25 | 2008-07-31 | Mayo Foundation For Medical Education And Research | Polypeptides du fgf-23 |
ES2385114T3 (es) | 2007-03-30 | 2012-07-18 | Ambrx, Inc. | Polipéptidos de FGF-21 modificados y sus usos |
EP2139508B1 (fr) | 2007-04-02 | 2013-05-08 | Genentech, Inc. | Un anticorps anti-klotho beta pour l'utilisation dans le traitement des tumeurs, de cancer ou d'un maladie de prolifération des cellules |
JP5187837B2 (ja) | 2007-04-06 | 2013-04-24 | 独立行政法人産業技術総合研究所 | 補助因子による受容体の活性化方法並びにリガンド活性の利用方法 |
US20080260703A1 (en) | 2007-04-23 | 2008-10-23 | Medistem Labortories | Treatment of Insulin Resistance and Diabetes |
WO2009048119A1 (fr) | 2007-10-12 | 2009-04-16 | National Institute Of Advanced Industrial Science And Technology | Composition médicinale contenant une protéine chimère extrêmement fonctionnalisée |
EP2234620B1 (fr) | 2008-01-03 | 2016-03-09 | Université d'Aix-Marseille | Tritherapie utilisable lors du traitement d'un patient infecte par le vih |
JOP20190083A1 (ar) | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
US7956033B2 (en) | 2008-06-10 | 2011-06-07 | Eu Sol Biotech Co., Ltd. | Modified peptide of human acidic fibroblast growth factor |
US8062632B2 (en) * | 2008-06-23 | 2011-11-22 | National Yang-Ming University | Systems and methods for making hepatocytes from extrahepatic somatic stem cells and use thereof |
WO2010075037A1 (fr) | 2008-12-15 | 2010-07-01 | University Of Rochester | Systèmes et procédés pour améliorer l'efficacité de vaccins |
JP5599822B2 (ja) | 2009-01-23 | 2014-10-01 | ノヴォ ノルディスク アー/エス | アルブミンバインダーa−b−c−d−e−を有するfgf21誘導体及びそれらの使用 |
CA2760674A1 (fr) | 2009-05-05 | 2010-11-11 | Amgen Inc. | Mutants de fgf21 et leurs utilisations |
PL3248610T3 (pl) | 2009-05-05 | 2024-04-02 | Amgen Inc. | Mutanty fgf21 i ich zastosowania |
US8461111B2 (en) | 2009-05-20 | 2013-06-11 | Florida State University Research Foundation | Fibroblast growth factor mutants having improved functional half-life and methods of their use |
EP2443145A1 (fr) | 2009-06-17 | 2012-04-25 | Amgen, Inc | Polypeptides fgf19 chimériques et leurs utilisations |
JP6016636B2 (ja) | 2009-10-15 | 2016-10-26 | ジェネンテック, インコーポレイテッド | 改変したレセプター特異性を持つキメラ線維芽細胞増殖因子 |
US8889621B2 (en) | 2009-10-30 | 2014-11-18 | New York University | Inhibiting binding of FGF23 to the binary FGFR-Klotho complex for the treatment of hypophosphatemia |
WO2011068893A1 (fr) | 2009-12-02 | 2011-06-09 | Amgen Inc. | Protéines de liaison qui se lient au fgfr1c humain, au β-klotho humain et à la fois au fgfr1c humain et au β-klotho humain |
US20110195077A1 (en) | 2010-01-29 | 2011-08-11 | Novartis Ag | Methods and compositions using fgf23 fusion ppolypeptides |
WO2012010553A1 (fr) | 2010-07-20 | 2012-01-26 | Novo Nordisk A/S | Composés fgf21 n-terminaux modifiés |
CN102464712A (zh) | 2010-11-11 | 2012-05-23 | 重庆富进生物医药有限公司 | 缺失型人成纤维细胞生长因子21变异体及其偶联物 |
US9023791B2 (en) | 2010-11-19 | 2015-05-05 | Novartis Ag | Fibroblast growth factor 21 mutations |
US8962546B2 (en) | 2011-03-01 | 2015-02-24 | Salk Institute For Biological Studies | Modulation of estrogen receptor-related receptor gamma (ERRγ) and uses therefor |
WO2012140650A2 (fr) | 2011-04-12 | 2012-10-18 | Hepacore Ltd. | Conjugués de carboxy polysaccharides avec des facteurs de croissance des fibroblastes et variants de ceux-ci |
PT2726511T (pt) | 2011-07-01 | 2019-10-14 | Ngm Biopharmaceuticals Inc | Composições, usos e métodos para o tratamento de distúrbios e doenças metabólicas |
AU2012301769B2 (en) | 2011-08-31 | 2016-05-19 | Amgen Inc. | FGF21 for use in treating type 1 diabetes |
US8772460B2 (en) | 2011-12-16 | 2014-07-08 | Wisconsin Alumni Research Foundation | Thermostable FGF-2 mutant having enhanced stability |
WO2013131091A1 (fr) | 2012-03-02 | 2013-09-06 | New York University | Protéines chimères fgf21 ayant une affinité de liaison augmentée pour le bêta-klotho dans le traitement du diabète de type ii, de l'obésité et des troubles métaboliques apparentés |
US20150079003A1 (en) | 2012-05-01 | 2015-03-19 | Univeristy of Washington through its Center for Commreicalization | Methods and Compositions for Cancer Diagnosis |
US9474785B2 (en) | 2012-06-07 | 2016-10-25 | New York University | Chimeric fibroblast growth factor 19 proteins and methods of use |
US9464126B2 (en) | 2012-06-07 | 2016-10-11 | New York University | Chimeric fibroblast growth factor 21 proteins and methods of use |
US9657075B2 (en) | 2012-06-07 | 2017-05-23 | New York University | Chimeric fibroblast growth factor 23 proteins and methods of use |
WO2014024173A2 (fr) | 2012-08-10 | 2014-02-13 | Florida State University Research Foundation | Facteur-1 de croissance fibroblastique humain recombinant en tant que nouveau produit thérapeutique pour des maladies ischémiques et procédés associés |
NZ630484A (en) | 2012-11-28 | 2017-04-28 | Ngm Biopharmaceuticals Inc | Compositions and methods for treatment of metabolic disorders and diseases |
US9550820B2 (en) | 2013-02-22 | 2017-01-24 | New York University | Chimeric fibroblast growth factor 23/fibroblast growth factor 19 proteins and methods of use |
WO2015061351A1 (fr) | 2013-10-21 | 2015-04-30 | Salk Institute For Biological Studies | Peptides du facteur de croissance des fibroblastes (fgf) 2/fgf1 chimères, et procédés pour leur utilisation |
WO2015061331A1 (fr) | 2013-10-21 | 2015-04-30 | Salk Institute For Biological Studies | Peptides de facteur de croissance des fibroblastes (fgf) 2/fgf1 chimériques et procédés d'utilisation |
JP6560202B2 (ja) | 2013-10-28 | 2019-08-21 | エヌジーエム バイオファーマシューティカルス,インコーポレーテッド | 癌モデル及び関連方法 |
WO2015149069A1 (fr) | 2014-03-28 | 2015-10-01 | New York University | Protéines de fusion fgf23 |
WO2015183890A2 (fr) | 2014-05-28 | 2015-12-03 | Ngm Biopharmaceuticals, Inc. | Méthodes et compositions pour le traitement de maladies et de troubles métaboliques |
JP2017521059A (ja) | 2014-06-17 | 2017-08-03 | ザイクローブ セラピューティクス, インク.Xycrobe Therapeutics, Inc. | 機械的に位置合わせされた光学的要素及びその製造方法 |
WO2015198175A1 (fr) | 2014-06-27 | 2015-12-30 | Florida State University Research Foundation, Inc. | Conception de mutants fgf-1 destinés à éliminer efficacement des résidus cystéine réactifs |
EP3227320B1 (fr) | 2014-12-03 | 2019-07-03 | Florida State University Research Foundation, Inc. | Polypeptides de facteur de croissance des fibroblastes 1 (fgf -1) modifié présentant une affinité de liaison accrue pour l'héparine et procédés associés |
WO2016100820A2 (fr) | 2014-12-19 | 2016-06-23 | Salk Institute For Biological Studies | Troncatures du fgf2 et mutants et utilisations de ceux-ci |
EP3285793A4 (fr) | 2015-04-20 | 2018-10-10 | Salk Institute for Biological Studies | Mutants du facteur de croissance des fibroblastes (fgf) 1 et leurs procédés d'utilisation pour réduire le glucose sanguin |
WO2016172153A2 (fr) | 2015-04-20 | 2016-10-27 | Salk Institute For Biological Studies | Facteur de croissance des fibroblastes (fgf) 1 à mutation dans le domaine de liaison à l'héparine et méthodes d'utilisation pour réduire la glycémie |
WO2016172290A1 (fr) | 2015-04-21 | 2016-10-27 | Salk Institute For Biological Studies | Procédés de traitement de la lipodystrophie à l'aide de composés fgf-1 |
WO2017075260A1 (fr) | 2015-10-30 | 2017-05-04 | Salk Institute For Biological Studies | Traitement de l'hyperglycémie induite par des stéroïdes avec des analogues de facteur de croissance des fibroblastes (fgf) 1 |
WO2018018010A1 (fr) | 2016-07-21 | 2018-01-25 | Metacrine, Inc. | Mutants de fgf et leurs utilisations |
EP3491011A1 (fr) | 2016-08-01 | 2019-06-05 | Salk Institute for Biological Studies | Protéines du facteur de croissance des fibroblastes (fgf) 1 ayant une capacité de réduction du glucose et une mitogénicité réduite |
-
2016
- 2016-10-27 WO PCT/US2016/059190 patent/WO2017075260A1/fr active Application Filing
- 2016-10-27 CA CA3002400A patent/CA3002400A1/fr not_active Abandoned
- 2016-10-27 AU AU2016344134A patent/AU2016344134A1/en not_active Abandoned
- 2016-10-27 JP JP2018521646A patent/JP2018535964A/ja active Pending
- 2016-10-27 EP EP16860818.0A patent/EP3368059A4/fr not_active Withdrawn
-
2018
- 2018-04-13 US US15/952,516 patent/US10695404B2/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011130729A2 (fr) * | 2010-04-16 | 2011-10-20 | Salk Institute For Biological Studies | Procédés de traitement de troubles métaboliques utilisant le fgf |
US20150111821A1 (en) * | 2013-10-21 | 2015-04-23 | Salk Institute For Biological Studies | Mutated fibroblast growth factor (fgf) 1 and methods of use |
Non-Patent Citations (4)
Title |
---|
ALEXEI KHARITONENKOV ET AL: "Break on Through to the Other 1", CELL METABOLISM, vol. 20, no. 4, 1 October 2014 (2014-10-01), United States, pages 554 - 555, XP055556121, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2014.09.009 * |
JAE MYOUNG SUH ET AL: "Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer", NATURE, vol. 513, no. 7518, 16 July 2014 (2014-07-16), London, pages 436 - 439, XP055335222, ISSN: 0028-0836, DOI: 10.1038/nature13540 * |
SACHIKO I. BLABER ET AL: "Accelerated healing in NONcNZO10/LtJ type 2 diabetic mice by FGF-1 : Wound healing in NONcNZO10/LtJ mice", WOUND REPAIR AND REGENERATION., vol. 23, no. 4, 1 July 2015 (2015-07-01), US, pages 538 - 549, XP055556160, ISSN: 1067-1927, DOI: 10.1111/wrr.12305 * |
See also references of WO2017075260A1 * |
Also Published As
Publication number | Publication date |
---|---|
JP2018535964A (ja) | 2018-12-06 |
US10695404B2 (en) | 2020-06-30 |
AU2016344134A1 (en) | 2018-05-31 |
CA3002400A1 (fr) | 2017-05-04 |
WO2017075260A1 (fr) | 2017-05-04 |
US20180228869A1 (en) | 2018-08-16 |
EP3368059A1 (fr) | 2018-09-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP3368059A4 (fr) | Traitement de l'hyperglycémie induite par des stéroïdes avec des analogues de facteur de croissance des fibroblastes (fgf) 1 | |
EP3331419A4 (fr) | Endoscope avec embout à profil variable | |
EP3060238A4 (fr) | Facteur de croissance de fibroblaste 1 (fgf) muté et méthodes d'utilisation | |
IL258471A (en) | 11,13-modified saxitoxins for the treatment of pain | |
EP3500194A4 (fr) | Canule avec caméra montée sur le côté proximal | |
EP3260139A4 (fr) | Insuline ou complexe analogue à l'insuline à action prolongée | |
EP3248640A4 (fr) | Collecteur/injecteur de liquide à usage médical | |
EP3781147A4 (fr) | Insuline sensible au glucose | |
EP3242605A4 (fr) | Traitement angiogénique d'une maladie cardiaque ischémique | |
EP3297653A4 (fr) | Traitement de l'hypoglycémie post-bariatrique avec des antagonistes glp-1 | |
EP3341404A4 (fr) | Nouveaux analogues d'insuline et leur utilisation | |
EP3603660A4 (fr) | Nouvelle application pour facteur de croissance des fibroblastes humains mutants à action prolongée | |
EP3285793A4 (fr) | Mutants du facteur de croissance des fibroblastes (fgf) 1 et leurs procédés d'utilisation pour réduire le glucose sanguin | |
EP3363450A4 (fr) | Composition de médecine traditionnelle chinoise pour le traitement du psoriasis | |
EP3515525A4 (fr) | Canule cardiaque | |
HK1244216A1 (zh) | 治療2型糖尿病患者 | |
EP3383370A4 (fr) | Formulation d'anesthésique local sur une durée prolongée | |
EP3049100A4 (fr) | Facteurs de croissance des fibroblastes modifiés pour le traitement de troubles oculaires | |
EP3340951A4 (fr) | Bandage chirurgical doté d'éléments de stabilisation | |
EP3190887A4 (fr) | Procédés de traitement et de prévention de maladies, de troubles et d'affections oculaires avec de la mélanine et des analogues, des précurseurs, et des dérivés de mélanine | |
IL254500A0 (en) | Treatment of patients with type 2 diabetes | |
GB201403996D0 (en) | Traditional chinese medicine composition for the treatment of diabetes | |
GB201707207D0 (en) | Treatment of type 1 diabetes | |
EP3524231A4 (fr) | Préparation stabilisée de variant d'interféron bêta | |
EP3487876A4 (fr) | Analogues de l'insuline |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20180420 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20190222 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 38/18 20060101AFI20190218BHEP Ipc: A61P 3/08 20060101ALI20190218BHEP Ipc: C07K 19/00 20060101ALI20190218BHEP Ipc: C07K 14/50 20060101ALI20190218BHEP Ipc: A61P 3/04 20060101ALI20190218BHEP |
|
17Q | First examination report despatched |
Effective date: 20200108 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20200603 |