EP3364983A4 - Vaccins contre les virus respiratoires - Google Patents
Vaccins contre les virus respiratoires Download PDFInfo
- Publication number
- EP3364983A4 EP3364983A4 EP16858406.8A EP16858406A EP3364983A4 EP 3364983 A4 EP3364983 A4 EP 3364983A4 EP 16858406 A EP16858406 A EP 16858406A EP 3364983 A4 EP3364983 A4 EP 3364983A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- virus vaccines
- respiratory virus
- respiratory
- vaccines
- virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000700605 Viruses Species 0.000 title 1
- 230000000241 respiratory effect Effects 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1002—Coronaviridae
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1027—Paramyxoviridae, e.g. respiratory syncytial virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6018—Lipids, e.g. in lipopeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18311—Metapneumovirus, e.g. avian pneumovirus
- C12N2760/18334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18611—Respirovirus, e.g. Bovine, human parainfluenza 1,3
- C12N2760/18634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20164728.6A EP3718565B1 (fr) | 2015-10-22 | 2016-10-21 | Vaccins contre le virus respiratoire |
EP23214667.0A EP4349404A3 (fr) | 2015-10-22 | 2016-10-21 | Vaccins contre le virus respiratoire |
EP21192208.3A EP4011451A1 (fr) | 2015-10-22 | 2016-10-21 | Vaccins contre le virus respiratoire |
EP23214669.6A EP4349405A3 (fr) | 2015-10-22 | 2016-10-21 | Vaccins contre le virus respiratoire |
DK20164728.6T DK3718565T3 (da) | 2015-10-22 | 2016-10-21 | Vacciner mod respiratorisk virus |
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562244813P | 2015-10-22 | 2015-10-22 | |
US201562244946P | 2015-10-22 | 2015-10-22 | |
US201562244837P | 2015-10-22 | 2015-10-22 | |
US201562245031P | 2015-10-22 | 2015-10-22 | |
US201562244802P | 2015-10-22 | 2015-10-22 | |
US201562247362P | 2015-10-28 | 2015-10-28 | |
US201562247297P | 2015-10-28 | 2015-10-28 | |
US201562247483P | 2015-10-28 | 2015-10-28 | |
US201562247394P | 2015-10-28 | 2015-10-28 | |
PCT/US2016/058327 WO2017070626A2 (fr) | 2015-10-22 | 2016-10-21 | Vaccins contre les virus respiratoires |
Related Child Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP23214669.6A Division EP4349405A3 (fr) | 2015-10-22 | 2016-10-21 | Vaccins contre le virus respiratoire |
EP21192208.3A Division EP4011451A1 (fr) | 2015-10-22 | 2016-10-21 | Vaccins contre le virus respiratoire |
EP23214667.0A Division EP4349404A3 (fr) | 2015-10-22 | 2016-10-21 | Vaccins contre le virus respiratoire |
EP20164728.6A Division EP3718565B1 (fr) | 2015-10-22 | 2016-10-21 | Vaccins contre le virus respiratoire |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3364983A2 EP3364983A2 (fr) | 2018-08-29 |
EP3364983A4 true EP3364983A4 (fr) | 2019-10-23 |
Family
ID=58558175
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP23214667.0A Pending EP4349404A3 (fr) | 2015-10-22 | 2016-10-21 | Vaccins contre le virus respiratoire |
EP23214669.6A Pending EP4349405A3 (fr) | 2015-10-22 | 2016-10-21 | Vaccins contre le virus respiratoire |
EP20164728.6A Active EP3718565B1 (fr) | 2015-10-22 | 2016-10-21 | Vaccins contre le virus respiratoire |
EP21192208.3A Pending EP4011451A1 (fr) | 2015-10-22 | 2016-10-21 | Vaccins contre le virus respiratoire |
EP16858406.8A Pending EP3364983A4 (fr) | 2015-10-22 | 2016-10-21 | Vaccins contre les virus respiratoires |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP23214667.0A Pending EP4349404A3 (fr) | 2015-10-22 | 2016-10-21 | Vaccins contre le virus respiratoire |
EP23214669.6A Pending EP4349405A3 (fr) | 2015-10-22 | 2016-10-21 | Vaccins contre le virus respiratoire |
EP20164728.6A Active EP3718565B1 (fr) | 2015-10-22 | 2016-10-21 | Vaccins contre le virus respiratoire |
EP21192208.3A Pending EP4011451A1 (fr) | 2015-10-22 | 2016-10-21 | Vaccins contre le virus respiratoire |
Country Status (16)
Country | Link |
---|---|
US (7) | US10064934B2 (fr) |
EP (5) | EP4349404A3 (fr) |
DE (1) | DE20164728T1 (fr) |
DK (1) | DK3718565T3 (fr) |
ES (1) | ES2922760T3 (fr) |
HR (1) | HRP20220872T1 (fr) |
HU (1) | HUE059127T2 (fr) |
LT (1) | LT3718565T (fr) |
MA (2) | MA52645B1 (fr) |
MD (1) | MD3718565T2 (fr) |
PL (1) | PL3718565T3 (fr) |
PT (1) | PT3718565T (fr) |
RS (1) | RS63381B1 (fr) |
SI (1) | SI3718565T1 (fr) |
TW (1) | TW201729835A (fr) |
WO (1) | WO2017070626A2 (fr) |
Families Citing this family (132)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012116714A1 (fr) | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination chez des patients âgés |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
WO2013120499A1 (fr) * | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Acide nucléique comprenant ou codant pour une tige-boucle d'histone et une séquence poly(a) ou un signal de polyadénylation pour augmenter l'expression d'un antigène pathogène codé |
EP3019619B1 (fr) | 2013-07-11 | 2021-08-25 | ModernaTX, Inc. | Compositions comprenant des polynucléotides synthétiques codant pour des protéines liées à crispr et des arnsg synthétiques et méthodes d'utilisation |
JP6881813B2 (ja) * | 2014-04-23 | 2021-06-02 | モデルナティーエックス, インコーポレイテッド | 核酸ワクチン |
MA42502A (fr) | 2015-07-21 | 2018-05-30 | Modernatx Inc | Vaccins contre une maladie infectieuse |
US11364292B2 (en) | 2015-07-21 | 2022-06-21 | Modernatx, Inc. | CHIKV RNA vaccines |
US11564893B2 (en) | 2015-08-17 | 2023-01-31 | Modernatx, Inc. | Methods for preparing particles and related compositions |
PL3350157T3 (pl) | 2015-09-17 | 2022-05-16 | Modernatx, Inc. | Związki i kompozycje do dostarczania wewnątrzkomórkowego środków terapeutycznych |
EP3364982A4 (fr) | 2015-10-22 | 2019-04-17 | ModernaTX, Inc. | Vaccins contre les maladies sexuellement transmissibles |
WO2017070613A1 (fr) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Vaccin contre le cytomégalovirus humain |
EP3364950A4 (fr) | 2015-10-22 | 2019-10-23 | ModernaTX, Inc. | Vaccins contre des maladies tropicales |
EP4349404A3 (fr) | 2015-10-22 | 2024-06-19 | ModernaTX, Inc. | Vaccins contre le virus respiratoire |
EA201891001A1 (ru) | 2015-10-22 | 2018-11-30 | МОДЕРНАТиЭкс, ИНК. | Вакцины на основе нуклеиновых кислот против вируса ветряной оспы (vzv) |
FI3368507T3 (fi) | 2015-10-28 | 2023-03-21 | Acuitas Therapeutics Inc | Uusia lipidejä ja lipidinanopartikkeliformulaatioita nukleiinihappojen annostelemiseksi |
DK3386484T3 (da) | 2015-12-10 | 2022-07-04 | Modernatx Inc | Sammensætninger og fremgangsmåder til afgivelse af terapeutiske midler |
US10465190B1 (en) | 2015-12-23 | 2019-11-05 | Modernatx, Inc. | In vitro transcription methods and constructs |
US10799573B2 (en) * | 2016-03-30 | 2020-10-13 | Regents Of The University Of Minnesota | Pertussis vaccines and methods of making and using |
US20190298657A1 (en) * | 2016-05-18 | 2019-10-03 | Modernatx, Inc. | Polynucleotides Encoding Acyl-CoA Dehydrogenase, Very Long-Chain for the Treatment of Very Long-Chain Acyl-CoA Dehydrogenase Deficiency |
BR112018073683A2 (pt) | 2016-05-18 | 2019-02-26 | Modernatx, Inc. | polinucleotídeos codificadores de relaxina |
EP3512944B1 (fr) | 2016-09-14 | 2022-07-06 | ModernaTX, Inc. | Compositions d'arn de haute pureté et procédés pour leur préparation |
AU2017345766A1 (en) | 2016-10-21 | 2019-05-16 | Modernatx, Inc. | Human cytomegalovirus vaccine |
EP3532095A1 (fr) * | 2016-10-25 | 2019-09-04 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Protéines de spicule de coronavirus de préfusion et utilisation associée |
EP3538146A4 (fr) | 2016-11-11 | 2020-07-15 | ModernaTX, Inc. | Vaccin antigrippal |
MA50335A (fr) | 2016-12-08 | 2020-08-19 | Modernatx Inc | Vaccins à acide nucléique contre des virus respiratoires |
EP3555289A1 (fr) | 2016-12-13 | 2019-10-23 | ModernaTX, Inc. | Purification par affinité d'arn |
EP3582790A4 (fr) | 2017-02-16 | 2020-11-25 | ModernaTX, Inc. | Compositions immunogènes très puissantes |
US11045540B2 (en) * | 2017-03-15 | 2021-06-29 | Modernatx, Inc. | Varicella zoster virus (VZV) vaccine |
DK3596042T3 (da) | 2017-03-15 | 2022-04-11 | Modernatx Inc | Krystalformer af aminolipider |
JP7332478B2 (ja) | 2017-03-15 | 2023-08-23 | モデルナティエックス インコーポレイテッド | 脂質ナノ粒子製剤 |
WO2018170245A1 (fr) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Vaccin à large spectre contre le virus de la grippe |
US11752206B2 (en) | 2017-03-15 | 2023-09-12 | Modernatx, Inc. | Herpes simplex virus vaccine |
MA47787A (fr) | 2017-03-15 | 2020-01-22 | Modernatx Inc | Vaccin contre le virus respiratoire syncytial |
EP3595676A4 (fr) * | 2017-03-17 | 2021-05-05 | Modernatx, Inc. | Vaccins à base d'arn contre des maladies zoonotiques |
EP3607074A4 (fr) | 2017-04-05 | 2021-07-07 | Modernatx, Inc. | Réduction ou élimination de réponses immunitaires à des protéines thérapeutiques administrées par voie non intraveineuse, par exemple par voie sous-cutanée |
EP4253544A3 (fr) | 2017-05-18 | 2023-12-20 | ModernaTX, Inc. | Arn messager modifié comprenant des éléments d'arn fonctionnels |
WO2018232357A1 (fr) | 2017-06-15 | 2018-12-20 | Modernatx, Inc. | Formulations d'arn |
WO2018232355A1 (fr) * | 2017-06-15 | 2018-12-20 | Modernatx, Inc. | Anticorps d'arn |
JP7355731B2 (ja) | 2017-08-16 | 2023-10-03 | アクイタス セラピューティクス インコーポレイテッド | 脂質ナノ粒子製剤における使用のための脂質 |
CN111212905A (zh) | 2017-08-18 | 2020-05-29 | 摩登纳特斯有限公司 | Rna聚合酶变体 |
EP3668522A4 (fr) * | 2017-08-18 | 2021-04-21 | Modernatx, Inc. | Vaccins à base d'arnm efficaces |
US11912982B2 (en) | 2017-08-18 | 2024-02-27 | Modernatx, Inc. | Methods for HPLC analysis |
MA49914A (fr) | 2017-08-18 | 2021-04-21 | Modernatx Inc | Procédés analytiques par hplc |
WO2019046809A1 (fr) | 2017-08-31 | 2019-03-07 | Modernatx, Inc. | Procédés de fabrication de nanoparticules lipidiques |
WO2019055807A1 (fr) | 2017-09-14 | 2019-03-21 | Modernatx, Inc. | Vaccins à arn contre le virus zika |
MA50802A (fr) * | 2017-11-22 | 2020-09-30 | Modernatx Inc | Polynucléotides codant pour des sous-unités alpha et bêta de propionyl-coa carboxylase pour le traitement de l'acidémie propionique |
WO2019148101A1 (fr) * | 2018-01-29 | 2019-08-01 | Modernatx, Inc. | Vaccins à base d'arn contre le vrs |
WO2019236673A1 (fr) | 2018-06-06 | 2019-12-12 | Massachusetts Institute Of Technology | Arn circulaire pour la traduction dans des cellules eucaryotes |
CN112805294A (zh) | 2018-09-28 | 2021-05-14 | 胡桃钳医疗公司 | 用于核酸递送的叔氨基脂化的阳离子肽 |
US11351242B1 (en) * | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
MX2021010075A (es) | 2019-02-20 | 2021-12-10 | Modernatx Inc | Variantes de arn polimerasa para la formacion de casquetes cotranscripcionales. |
US11851694B1 (en) | 2019-02-20 | 2023-12-26 | Modernatx, Inc. | High fidelity in vitro transcription |
JP2022524212A (ja) * | 2019-03-25 | 2022-04-28 | オハイオ・ステイト・イノベーション・ファウンデーション | 操作されたmRNA配列及びその使用 |
KR20220027855A (ko) | 2019-05-22 | 2022-03-08 | 매사추세츠 인스티튜트 오브 테크놀로지 | 원형 rna 조성물 및 방법 |
CN114728887A (zh) | 2019-09-19 | 2022-07-08 | 摩登纳特斯有限公司 | 用于治疗剂的细胞内递送的支链尾端脂质化合物和组合物 |
EP4289951A3 (fr) * | 2019-12-04 | 2024-03-13 | Orna Therapeutics, Inc. | Méthodes et compositions d'arn circulaire |
US20230053555A1 (en) | 2019-12-11 | 2023-02-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic | Mumps and measles virus immunogens and their use |
EP4096710A1 (fr) * | 2020-01-28 | 2022-12-07 | ModernaTX, Inc. | Vaccins à arn contre le coronavirus |
AU2021214774A1 (en) * | 2020-01-30 | 2022-08-25 | Modernatx, Inc. | Respiratory virus immunizing compositions |
US11241493B2 (en) | 2020-02-04 | 2022-02-08 | Curevac Ag | Coronavirus vaccine |
US11576966B2 (en) | 2020-02-04 | 2023-02-14 | CureVac SE | Coronavirus vaccine |
AU2021215938A1 (en) | 2020-02-07 | 2022-09-01 | Modernatx, Inc. | Sars-cov-2 mrna domain vaccines |
US12029786B2 (en) | 2020-02-07 | 2024-07-09 | RNAimmune, Inc. | Composition and method of mRNA vaccines against novel coronavirus infection |
US20230136960A1 (en) * | 2020-03-19 | 2023-05-04 | Nature's Toolbox, Inc. | Novel MRNA-Based COVID-19 Multi-Valent Vaccine and Methods of Scaled Production of the Same |
WO2021202923A1 (fr) | 2020-04-02 | 2021-10-07 | Nektar Therapeutics | Immunomodulateur pour la prévention et le traitement d'une infection par coronavirus et d'autres états de santé |
RU2747762C1 (ru) * | 2020-04-05 | 2021-05-13 | Илья Владимирович Духовлинов | Вакцина для профилактики или лечения коронавирусной инфекции на основе генетической конструкции |
WO2021204179A1 (fr) * | 2020-04-09 | 2021-10-14 | Suzhou Abogen Biosciences Co., Ltd. | Vaccins à base d'acide nucléique pour coronavirus |
FI20215508A1 (en) | 2020-04-09 | 2021-10-10 | Niemelae Erik Johan | Mimetic nanoparticles to prevent the spread of new coronaviruses and reduce the rate of infection |
FI20205382A1 (en) * | 2020-04-09 | 2021-05-07 | Niemelae Erik | Method for preventing the spread of pathogens and for reducing infections caused by them |
BR112022019781A2 (pt) | 2020-04-22 | 2022-12-13 | BioNTech SE | Vacina para o coronavírus |
WO2021222304A1 (fr) * | 2020-04-27 | 2021-11-04 | Modernatx, Inc. | Vaccins à arn contre le sars-cov-2 |
KR20210136998A (ko) * | 2020-05-08 | 2021-11-17 | 한림대학교 산학협력단 | 코로나 바이러스 억제용 펩타이드 및 그 용도 |
WO2021231560A1 (fr) * | 2020-05-12 | 2021-11-18 | Greffex, Inc. | Protéines de spicule de coronavirus d'ingénierie utilisées en tant qu'antigènes de vaccin, leur conception et leurs utilisations |
WO2021159130A2 (fr) * | 2020-05-15 | 2021-08-12 | Modernatx, Inc. | Vaccins a arn de coronavirus et procédés d'utilisation |
TW202206097A (zh) * | 2020-05-20 | 2022-02-16 | 美商旗艦先鋒創新有限責任公司 | 冠狀病毒抗原組成物及其用途 |
AU2021279312A1 (en) | 2020-05-29 | 2022-12-15 | CureVac SE | Nucleic acid based combination vaccines |
EP4175982A1 (fr) | 2020-06-30 | 2023-05-10 | Fondazione Toscana Life Sciences | Anticorps neutralisants dirigés contre le coronavirus 2 du sars |
WO2022011021A1 (fr) * | 2020-07-07 | 2022-01-13 | Ascendo Biotechnology, Inc. | Utilisation d'épitopes peptidiques conservés de sars-cov-2 pour le développement d'un vaccin à large spectre contre la covid-19 |
WO2022011092A1 (fr) * | 2020-07-08 | 2022-01-13 | The Trustees Of The University Of Pennsylvania | Arn modifié par nucléoside pour induire une réponse immunitaire contre le virus sars-cov-2 |
WO2022015513A2 (fr) | 2020-07-13 | 2022-01-20 | The Board Of Trustees Of The Leland Stanford Junior University | Systèmes et procédés d'évaluation de la stabilité de l'arn |
EP4196139A2 (fr) | 2020-08-12 | 2023-06-21 | Actym Therapeutics, Inc. | Vaccins à base de bactéries immunostimulatrices, agents thérapeutiques et plateformes d'administration d'arn |
US11406703B2 (en) | 2020-08-25 | 2022-08-09 | Modernatx, Inc. | Human cytomegalovirus vaccine |
EP4204015A2 (fr) | 2020-08-31 | 2023-07-05 | The Board of Trustees of the Leland Stanford Junior University | Systèmes et procédés de production de constructions d'arn présentant une traduction et une stabilité accrues |
WO2022043551A2 (fr) | 2020-08-31 | 2022-03-03 | Curevac Ag | Vaccins contre le coronavirus à base d'acides nucléiques multivalents |
EP4217371A1 (fr) | 2020-09-25 | 2023-08-02 | ModernaTX, Inc. | Vaccins à base de protéine de spicule de coronavirus à substitution multiproline |
TW202233232A (zh) | 2020-11-06 | 2022-09-01 | 法商賽諾菲公司 | 遞送mRNA疫苗的脂質奈米顆粒 |
CA3171051A1 (fr) * | 2020-12-22 | 2022-06-30 | Curevac Ag | Composition pharmaceutique comprenant des vecteurs lipidique encapsulant de l'arn pour une administration multidose |
US20240156946A1 (en) | 2020-12-22 | 2024-05-16 | CureVac SE | Rna vaccine against sars-cov-2 variants |
WO2022137133A1 (fr) * | 2020-12-22 | 2022-06-30 | Curevac Ag | Vaccin à arn contre des variants sras-cov-2 |
CA3208643A1 (fr) | 2021-01-18 | 2022-07-21 | Conserv Bioscience Limited | Compositions immunogenes de coronavirus, methodes et utilisations de celles-ci |
BR112023012422A2 (pt) | 2021-01-24 | 2023-12-12 | Michael David Forrest | Inibidores da atp sintase - usos cosmético e terapêutico |
US11524023B2 (en) | 2021-02-19 | 2022-12-13 | Modernatx, Inc. | Lipid nanoparticle compositions and methods of formulating the same |
EP4308156A1 (fr) | 2021-03-15 | 2024-01-24 | ModernaTX, Inc. | Utilisation thérapeutique de vaccins à domaine arnm de sars-cov-2 |
AU2022246895A1 (en) | 2021-03-31 | 2023-10-19 | Flagship Pioneering Innovations V, Inc. | Thanotransmission polypeptides and their use in treating cancer |
EP4070814A1 (fr) | 2021-04-07 | 2022-10-12 | Lama France | Polypeptides sars-cov-2 et leurs utilisations |
EP4322993A1 (fr) * | 2021-04-13 | 2024-02-21 | ModernaTX, Inc. | Vaccins associés contre des virus respiratoires |
WO2022232648A1 (fr) | 2021-04-29 | 2022-11-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Complexe de glycoprotéine du virus de lassa stabilisé par préfusion et son utilisation |
US20240228595A1 (en) * | 2021-05-11 | 2024-07-11 | Yale University | Methods for Monoclonal Antibody Generation |
TW202248421A (zh) * | 2021-06-11 | 2022-12-16 | 亞諾法生技股份有限公司 | 信使核糖核酸疫苗與在個體中誘發抗原特異性免疫反應之方法 |
CN113249408B (zh) * | 2021-06-23 | 2021-11-02 | 深圳湾实验室 | 一种靶向激活体液免疫和细胞免疫的核酸疫苗载体构建及应用 |
WO2023275538A1 (fr) | 2021-06-28 | 2023-01-05 | Diosynvax Ltd | Vaccins à coronavirus bêta |
EP4342929A1 (fr) | 2021-06-30 | 2024-03-27 | Jenkem Technology Co. Ltd. (Tianjin) | Lipide de polyéthylène glycol et son utilisation |
CN114149337B (zh) | 2021-07-07 | 2022-04-29 | 天津键凯科技有限公司 | 一种用于核酸递送的新型可电离脂质及其lnp组合物 |
WO2023019181A1 (fr) * | 2021-08-11 | 2023-02-16 | Modernatx, Inc. | Formulations de vaccin à nanoparticules lipidiques contre le sars-cov-2 |
AU2022336209A1 (en) | 2021-09-03 | 2024-01-18 | CureVac SE | Novel lipid nanoparticles for delivery of nucleic acids |
WO2023044346A2 (fr) | 2021-09-14 | 2023-03-23 | Ausper Biopharma Co., Ltd. | Vaccins pour la prévention et le traitement de coronavirus |
WO2023057766A1 (fr) | 2021-10-06 | 2023-04-13 | Diosynvax Ltd | Vaccins contre la grippe |
AU2022358982A1 (en) | 2021-10-06 | 2024-05-23 | Diosynvax Ltd | Coronavirus vaccines |
WO2023069498A1 (fr) | 2021-10-22 | 2023-04-27 | Senda Biosciences, Inc. | Composition de vaccin à base d'arnm |
WO2023067560A1 (fr) * | 2021-10-22 | 2023-04-27 | Seqirus Inc. | Composé cationique ionisable |
WO2023073228A1 (fr) | 2021-10-29 | 2023-05-04 | CureVac SE | Arn circulaire amélioré pour exprimer des protéines thérapeutiques |
AU2022382104A1 (en) * | 2021-11-05 | 2024-06-20 | Sanofi | Respiratory syncytial virus rna vaccine |
CA3235418A1 (fr) | 2021-11-09 | 2023-05-19 | Actym Therapeutics, Inc. | Bacteries immunostimulatrices pour convertir des macrophages en un phenotype pouvant etre traite, et diagnostic compagnon pour identifier des sujets pour un traitement |
WO2023086961A1 (fr) | 2021-11-12 | 2023-05-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Spike du sars-cov-2 fusionnée à un antigène de surface de l'hépatite b |
WO2023094980A1 (fr) | 2021-11-23 | 2023-06-01 | Fondazione Toscana Life Sciences | Anticorps contre le coronavirus |
CA3238764A1 (fr) | 2021-11-23 | 2023-06-01 | Siddharth Patel | Composition lipidique derivee de bacteries et son utilisation |
US20230338512A1 (en) * | 2021-11-29 | 2023-10-26 | BioNTech SE | Coronavirus vaccine |
WO2023094885A2 (fr) | 2021-11-29 | 2023-06-01 | Arabian Gulf University | Déterminants antigéniques, immunité protectrice, sérodiagnostic et sous-unités multivalentes de precision vaccine contre sars-cov-2 |
IT202100030398A1 (it) | 2021-12-01 | 2023-06-01 | Pomona Ricerca Srl | Minibody come vaccini per l’hiv |
WO2023104904A2 (fr) | 2021-12-08 | 2023-06-15 | Genclis | Sars-cov-2 et variants utilisant deux récepteurs cellulaires indépendants pour la réplication |
WO2023110422A1 (fr) | 2021-12-16 | 2023-06-22 | Stefan Grabuschnig | Préparation vaccinale |
WO2023144330A1 (fr) | 2022-01-28 | 2023-08-03 | CureVac SE | Inhibiteurs de facteurs de transcription codés par un acide nucleique |
KR102465349B1 (ko) | 2022-02-25 | 2022-11-11 | 주식회사 테르나테라퓨틱스 | 신규 이온화 지질 및 이를 포함하는 지질 나노입자 |
WO2023178182A1 (fr) | 2022-03-16 | 2023-09-21 | 10X Genomics, Inc. | Compositions et méthodes de détection et de traitement d'une infection à coronavirus |
WO2023196898A1 (fr) | 2022-04-07 | 2023-10-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Peptides mimétiques de la bêta globine et leur utilisation |
WO2023220645A1 (fr) | 2022-05-10 | 2023-11-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Vaccin contre le virus t-lymphotrope humain de type 1 |
WO2023227608A1 (fr) | 2022-05-25 | 2023-11-30 | Glaxosmithkline Biologicals Sa | Vaccin à base d'acide nucléique codant pour un polypeptide antigénique fimh d'escherichia coli |
US11878055B1 (en) | 2022-06-26 | 2024-01-23 | BioNTech SE | Coronavirus vaccine |
US20240174732A1 (en) | 2022-10-05 | 2024-05-30 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additional polypeptides and their use in treating cancer |
WO2024151685A1 (fr) | 2023-01-09 | 2024-07-18 | Beth Israel Deaconess Medical Center, Inc. | Molécules d'acide nucléique recombinant et leur utilisation dans la cicatrisation des plaies |
US20240238473A1 (en) | 2023-01-09 | 2024-07-18 | Beth Israel Deaconess Medical Center, Inc. | Recombinant nucleic acid molecules and their use in wound healing |
WO2024151687A1 (fr) | 2023-01-09 | 2024-07-18 | Flagship Pioneering Innovations V, Inc. | Commutateurs génétiques et leur utilisation dans le traitement du cancer |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013090648A1 (fr) * | 2011-12-16 | 2013-06-20 | modeRNA Therapeutics | Nucléoside, nucléotide, et compositions d'acide nucléique modifiés |
WO2013185069A1 (fr) * | 2012-06-08 | 2013-12-12 | Shire Human Genetic Therapies, Inc. | Administration pulmonaire d'arnm à des cellules cibles autres que pulmonaires |
WO2014089486A1 (fr) * | 2012-12-07 | 2014-06-12 | Shire Human Genetic Therapies, Inc. | Nanoparticules lipidiques pour administration de marn |
WO2014144196A1 (fr) * | 2013-03-15 | 2014-09-18 | Shire Human Genetic Therapies, Inc. | Stimulation synergique de l'administration d'acides nucléiques par le biais de formulations mélangées |
WO2014152774A1 (fr) * | 2013-03-14 | 2014-09-25 | Shire Human Genetic Therapies, Inc. | Procédés et compositions de délivrance d'anticorps codés par arnm |
Family Cites Families (397)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3906092A (en) | 1971-11-26 | 1975-09-16 | Merck & Co Inc | Stimulation of antibody response |
US4790987A (en) | 1985-11-15 | 1988-12-13 | Research Corporation | Viral glycoprotein subunit vaccine |
CA1335429C (fr) | 1986-03-07 | 1995-05-02 | Geoffrey L. Smith | Procedes de fabrication de glycoproteines hcmv, les anticorps et les vaccins diriges contre ces glycoproteines hcmv, et leurs vecteurs recombinants |
NZ224422A (en) | 1987-05-05 | 1990-11-27 | Molecular Eng Ass | Composition adapted for intranasal immunisation against viral infection comprising a glycoprotein complexed with a lipid |
AU611784B2 (en) | 1988-04-22 | 1991-06-20 | Pharmacia & Upjohn Company | Chimeric glycoproteins containing immunogenic segments of human parainfluenza virus type 3 |
ATE240401T1 (de) | 1989-03-21 | 2003-05-15 | Vical Inc | Expression von exogenen polynukleotidsequenzen in wirbeltieren |
GB9200117D0 (en) | 1992-01-06 | 1992-02-26 | Connaught Lab | Production of recombinant chimeric proteins for vaccine use |
CA2128616A1 (fr) | 1992-01-23 | 1993-08-05 | Gary H. Rhodes | Transfert de genes ex vivo |
IL112820A0 (en) | 1994-03-07 | 1995-05-26 | Merck & Co Inc | Coordinate in vivo gene expression |
WO1995026204A1 (fr) | 1994-03-25 | 1995-10-05 | Isis Pharmaceuticals, Inc. | Stimulation immunitaire par des analogues d'oligonucleotides de phosphorothioate |
US6355247B1 (en) | 1994-06-02 | 2002-03-12 | Chiron Corporation | Nucleic acid immunization using a virus-based infection/transfection system |
US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
US6019980A (en) | 1995-06-07 | 2000-02-01 | Connaught Laboratories Limited | Nucleic acid respiratory syncytial virus vaccines |
US6214966B1 (en) | 1996-09-26 | 2001-04-10 | Shearwater Corporation | Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution |
EP0855184A1 (fr) | 1997-01-23 | 1998-07-29 | Grayson B. Dr. Lipford | Composition pharmaceutique comprenant un polynucléotide et un antigène notamment pour la vaccination |
US7208161B1 (en) | 1997-05-23 | 2007-04-24 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Production of attenuated parainfluenza virus vaccines from cloned nucleotide sequences |
AU7983198A (en) | 1997-06-23 | 1999-01-04 | Ludwig Institute For Cancer Research | Improved methods for inducing an immune response |
WO1999018221A1 (fr) | 1997-10-07 | 1999-04-15 | University Of Maryland Biotechnology Institute | Procede d'introduction et d'expression d'arn dans des cellules animales |
WO1999033982A2 (fr) | 1997-12-23 | 1999-07-08 | Chiron Corporation | Genes humains et produits d'expression genique i |
US6514948B1 (en) | 1999-07-02 | 2003-02-04 | The Regents Of The University Of California | Method for enhancing an immune response |
EP1619254B1 (fr) | 1999-09-09 | 2010-12-22 | CureVac GmbH | Transfer de mARN à l'aide de composés polycationiques |
WO2001023002A1 (fr) | 1999-09-30 | 2001-04-05 | National Jewish Medical And Research Center | Methode d'inhibition de micro-organismes pathogenes |
US7060291B1 (en) | 1999-11-24 | 2006-06-13 | Transave, Inc. | Modular targeted liposomal delivery system |
US6998115B2 (en) | 2000-10-10 | 2006-02-14 | Massachusetts Institute Of Technology | Biodegradable poly(β-amino esters) and uses thereof |
US7708915B2 (en) | 2004-05-06 | 2010-05-04 | Castor Trevor P | Polymer microspheres/nanospheres and encapsulating therapeutic proteins therein |
KR100964413B1 (ko) | 2001-01-19 | 2010-06-15 | 비로노바티브 비.브이. | 감응성 포유류에서 호흡계 질환을 유발하는 바이러스 |
US20030232061A1 (en) | 2001-10-18 | 2003-12-18 | Fouchier Ronaldus Adrianus Maria | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus |
ES2344078T3 (es) | 2001-06-05 | 2010-08-17 | Curevac Gmbh | Arnm estabilizado con un contenido de g/c aumentado para la terapia genetica. |
EP1412065A2 (fr) | 2001-07-27 | 2004-04-28 | President And Fellows Of Harvard College | Appareil et procedes de melange de flux laminaires |
WO2003028657A2 (fr) | 2001-10-03 | 2003-04-10 | The Johns Hopkins University | Compositions pour therapie genique orale et procedes d'utilisation associes |
DE10162480A1 (de) | 2001-12-19 | 2003-08-07 | Ingmar Hoerr | Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen |
EP2327418A1 (fr) | 2002-02-21 | 2011-06-01 | MedImmune, LLC | Vecteurs d'expression recombinants du virus de la parainfluenza et vaccins comprenant des antigènes hétérologues dérivés d'autres virus |
AU2003217531A1 (en) | 2002-05-02 | 2003-11-17 | Massachusetts Eye And Ear Infirmary | Ocular drug delivery systems and use thereof |
DE10221836A1 (de) | 2002-05-16 | 2003-12-04 | Lohmann Animal Health Gmbh | Attenuierung von Metapneumovirus |
DE10229872A1 (de) | 2002-07-03 | 2004-01-29 | Curevac Gmbh | Immunstimulation durch chemisch modifizierte RNA |
TW200501985A (en) | 2002-07-25 | 2005-01-16 | Medimmune Inc | Methods of treating and preventing RSV, hMPV, and PIV using anti-RSV, anti-hMPV, and anti-PIV antibodies |
US20040228842A1 (en) | 2003-02-27 | 2004-11-18 | Shan Lu | Compositions and methods for cytomegalovirus treatment |
EP1622574A4 (fr) | 2003-04-25 | 2006-10-18 | Medimmune Vaccines Inc | Systemes d'expression de virus parainfluenza recombinant et vaccins comportant des antigenes heterologues derives du metapneumovirus |
EP2494986A1 (fr) | 2003-04-25 | 2012-09-05 | MedImmune Vaccines, Inc. | Souches de métapneumovirus et leur utilisation dans des formulations de vaccins et en tant que vecteurs pour l'expression de séquences antigéniques et procédés pour propager des virus |
EP1636385A4 (fr) | 2003-06-24 | 2010-06-02 | Mirus Bio Corp | Inhibition d'une fonction genique par distribution in vivo d'inhibiteurs d'expression genique a base de polynucleotides dans des cellules mammiferes |
KR100992646B1 (ko) | 2003-07-09 | 2010-11-05 | 제이에스알 가부시끼가이샤 | 파장판 |
DE10335833A1 (de) | 2003-08-05 | 2005-03-03 | Curevac Gmbh | Transfektion von Blutzellen mit mRNA zur Immunstimulation und Gentherapie |
WO2005027963A2 (fr) * | 2003-09-15 | 2005-03-31 | The United States Of America As Represented By Thesecretary Of Health And Human Services, Nih | Procedes et compositions permettant de generer une reponse immunitaire protectrice contre sars-cov |
WO2005072710A2 (fr) | 2004-01-28 | 2005-08-11 | Johns Hopkins University | Medicaments et particules de transport de genes se deplaçant rapidement a travers les barrieres muqueuses |
MXPA06011871A (es) | 2004-04-15 | 2007-10-08 | Chiasma Inc | Composiciones capaces de facilitar la penetracion a traves de una barrera biologica. |
WO2005118813A2 (fr) | 2004-06-04 | 2005-12-15 | Institut Pasteur | Acides nucleiques, polypeptides, methodes d'expression, et compositions immunogenes associees a la proteine spike du coronavirus sras |
DE102004035227A1 (de) | 2004-07-21 | 2006-02-16 | Curevac Gmbh | mRNA-Gemisch zur Vakzinierung gegen Tumorerkrankungen |
DE102004042546A1 (de) | 2004-09-02 | 2006-03-09 | Curevac Gmbh | Kombinationstherapie zur Immunstimulation |
US7976845B2 (en) | 2004-11-29 | 2011-07-12 | The Council Of The Queensland Institute Of Medical Research | Human cytomegalovirus immunotherapy |
US8354476B2 (en) | 2004-12-10 | 2013-01-15 | Kala Pharmaceuticals, Inc. | Functionalized poly(ether-anhydride) block copolymers |
US9068969B2 (en) | 2004-12-28 | 2015-06-30 | Ptc Therapeutics, Inc. | Cell based methods and systems for the identification of RNA regulatory sequences and compounds that modulate their functions |
GB0504436D0 (en) | 2005-03-03 | 2005-04-06 | Glaxosmithkline Biolog Sa | Vaccine |
EP2287608B1 (fr) | 2005-03-11 | 2014-01-08 | Firalis SAS | Biomarqueurs pour des effets secondaires cardio-vasculaires induits par des composés inhibiteurs de cox-2 |
NZ562064A (en) | 2005-04-01 | 2011-03-31 | Intezyne Technologies Inc | Polymeric micelles for drug delivery |
WO2006110214A2 (fr) | 2005-04-08 | 2006-10-19 | Medimmune, Inc. | Anticorps diriges contre le metapneumovirus du mammifere |
US8273339B2 (en) | 2005-04-12 | 2012-09-25 | Nektar Therapeutics | Polymer-based compositions and conjugates of antimicrobial agents |
CN101242858B (zh) | 2005-06-16 | 2012-12-19 | 尼克塔治疗公司 | 具有可降解键的轭合物以及用于制备这种轭合物的聚合物试剂 |
ES2735531T3 (es) | 2005-08-23 | 2019-12-19 | Univ Pennsylvania | ARN que contiene nucleósidos modificados y métodos de uso del mismo |
CA2624291A1 (fr) | 2005-10-03 | 2007-04-12 | Seneca College Of Applied Arts & Technology | Composition immunologique d'acides nucleiques contre le metapneumovirus humain |
CA2646623A1 (fr) | 2005-12-14 | 2007-08-23 | The Board Of Regents Of The University Of Oklahoma | Vaccins a base de virus a arn et procedes |
DE102006007433A1 (de) | 2006-02-17 | 2007-08-23 | Curevac Gmbh | Adjuvanz in Form einer Lipid-modifizierten Nukleinsäure |
WO2007098466A2 (fr) | 2006-02-21 | 2007-08-30 | Nektar Therapeutics Al, Corporation | Polymeres segmentes degradables et conjugues obtenus a partir de ces polymeres |
CA2648291A1 (fr) | 2006-04-04 | 2007-11-01 | Stc.Unm | Particules gonflantes pour l'administration d'un medicament |
FR2899902B1 (fr) | 2006-04-18 | 2012-01-27 | Agronomique Inst Nat Rech | Proteines de fusion proteine n d'un virus de la famille des paramyxoviridae-proteine d'interet et leurs utilisations pour la vaccination et la vectorisation intra-cellulaire. |
US8367113B2 (en) | 2006-05-15 | 2013-02-05 | Massachusetts Institute Of Technology | Polymers for functional particles |
WO2008014979A2 (fr) | 2006-07-31 | 2008-02-07 | Curevac Gmbh | Acide nucléique de formule (i): gixmgn, ou(ii): cixmcn, en particulier en tant qu'agent/adjuvant immunostimulant |
WO2008030557A2 (fr) | 2006-09-08 | 2008-03-13 | Johns Hopkins University | Compositions et méthodes destinées à améliorer le transport à travers le mucus |
JP2010505876A (ja) * | 2006-10-04 | 2010-02-25 | ザ スクリプス リサーチ インスティテュート | ヒトメタニューモウイルスを中和するヒト抗体 |
CN101583379B (zh) | 2006-10-05 | 2013-04-03 | 约翰斯霍普金斯大学 | 使用优良聚合物纳米粒子的水溶性差药物的水可分散性口服,肠胃外和局部制剂 |
DE102006051516A1 (de) | 2006-10-31 | 2008-05-08 | Curevac Gmbh | (Basen-)modifizierte RNA zur Expressionssteigerung eines Proteins |
US8399007B2 (en) | 2006-12-05 | 2013-03-19 | Landec Corporation | Method for formulating a controlled-release pharmaceutical formulation |
JP5452230B2 (ja) | 2006-12-21 | 2014-03-26 | ストライカー コーポレイション | 生物学的因子の結晶、高分子ゲルおよび粒子懸濁液を含む持続放出処方物 |
DE102007001370A1 (de) | 2007-01-09 | 2008-07-10 | Curevac Gmbh | RNA-kodierte Antikörper |
WO2009030254A1 (fr) | 2007-09-04 | 2009-03-12 | Curevac Gmbh | Complexes d'arn et de peptides cationiques pour transfection et immunostimulation |
US20090162395A1 (en) | 2007-09-26 | 2009-06-25 | Crowe Jr James E | Vaccine for rsv and mpv |
HUE035101T2 (hu) | 2007-09-28 | 2018-05-02 | Pfizer | Ráksejtek célzása nanorészecskék alkalmazásával |
WO2009046738A1 (fr) | 2007-10-09 | 2009-04-16 | Curevac Gmbh | Composition pour traiter le cancer du poumon, notamment les cancers du poumon non à petites cellules (nsclc) |
WO2009046739A1 (fr) | 2007-10-09 | 2009-04-16 | Curevac Gmbh | Composition pour traiter le cancer de la prostate (pca) |
CN101932707B (zh) | 2008-01-31 | 2013-08-21 | 库瑞瓦格有限责任公司 | 作为免疫刺激剂/佐剂的式(I)(NuGlXmGnNv)a的核酸及其衍生物 |
WO2009127230A1 (fr) | 2008-04-16 | 2009-10-22 | Curevac Gmbh | Arn(m) modifié pour supprimer ou éviter une réponse immunostimulante et composition immunosuppressive |
WO2010005725A2 (fr) | 2008-06-16 | 2010-01-14 | Bind Biosciences, Inc. | Nanoparticules polymères thérapeutiques comprenant des alcaloïdes vinca et procédés de fabrication et d’utilisation associés |
DK2285350T3 (en) | 2008-06-16 | 2017-12-11 | Pfizer | PROCEDURES FOR THE PREPARATION OF DIBLOCK COPOLYMERS FUNCTIONALIZED WITH TARGETING AGENT FOR USE IN THE MANUFACTURE OF THERAPEUTIC NANOPARTICLES |
US8613951B2 (en) | 2008-06-16 | 2013-12-24 | Bind Therapeutics, Inc. | Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same |
EP2309990B2 (fr) | 2008-06-16 | 2017-03-15 | Pfizer Inc. | Nanoparticules polymères pharmacologiquement chargées et leurs méthodes de fabrication et d'utilisation |
WO2010030763A2 (fr) | 2008-09-10 | 2010-03-18 | Bind Biosciences, Inc. | Fabrication de nanoparticles à rendement élevé |
WO2010037408A1 (fr) | 2008-09-30 | 2010-04-08 | Curevac Gmbh | Composition comprenant un arnm complexé et un arnm nu pour déclencher ou augmenter une réponse immunostimulante chez un mammifère et utilisations de ladite composition |
AU2015210364B2 (en) | 2008-10-09 | 2017-03-09 | Arbutus Biopharma Corporation | Improved amino lipids and methods for the delivery of nucleic acids |
CN104119242B (zh) | 2008-10-09 | 2017-07-07 | 泰米拉制药公司 | 改善的氨基脂质和递送核酸的方法 |
CA3039251C (fr) | 2008-11-10 | 2024-01-09 | Arbutus Biopharma Corporation | Nouveaux lipides et nouvelles compositions pour l'administration d'agents therapeutiques |
US8734853B2 (en) | 2008-11-17 | 2014-05-27 | University Of North Texas Health Science Center At Fort Worth | HDL particles for delivery of nucleic acids |
ES2776126T3 (es) | 2008-12-15 | 2020-07-29 | Pfizer | Nanopartículas de circulación prolongada para la liberación sostenida de agentes terapéuticos |
CA2751342C (fr) | 2009-01-29 | 2019-05-07 | Alnylam Pharmaceuticals, Inc. | Formules lipides renfermant un lipide cationique et un lipide cible renfermant de la galactosamine n-acetyle pour la livraison d'acide nucleique |
WO2010088927A1 (fr) | 2009-02-09 | 2010-08-12 | Curevac Gmbh | Utilisation de pei pour l'amélioration de la libération endosomale et de l'expression d'acides nucléiques transfectés, complexés par des composés cationiques ou polycationiques |
CN107375919B (zh) | 2009-03-27 | 2022-07-29 | 台湾地区“中央研究院” | 抗病毒免疫的方法和组合物 |
JP5622254B2 (ja) | 2009-03-31 | 2014-11-12 | 国立大学法人東京大学 | 二本鎖リボ核酸ポリイオンコンプレックス |
AU2010239689A1 (en) | 2009-04-21 | 2011-11-03 | Selecta Biosciences, Inc. | Immunonanotherapeutics providing a Th1-biased response |
US8460680B2 (en) * | 2009-04-24 | 2013-06-11 | National Health Research Institutes | Polyvalent chimeric rubella virus-based vaccines |
WO2010127159A2 (fr) | 2009-04-30 | 2010-11-04 | Intezyne Technologies, Incorporated | Micelles polymères pour l'encapsulation de polynucléotides |
SG10201911942UA (en) | 2009-05-05 | 2020-02-27 | Muthiah Manoharan | Lipid compositions |
EA028288B1 (ru) | 2009-05-27 | 2017-10-31 | Селекта Байосайенсиз, Инк. | Наноносители, имеющие компоненты с различными скоростями высвобождения |
LT2440183T (lt) | 2009-06-10 | 2018-08-10 | Arbutus Biopharma Corporation | Patobulinta lipido kompozicija |
US9937196B2 (en) | 2009-06-19 | 2018-04-10 | University Of Maryland, College Park | Genomic sequence of avian paramyxovirus type 2 and uses thereof |
KR20120093811A (ko) | 2009-06-24 | 2012-08-23 | 아이디 바이오메디컬 코포레이션 오브 퀘벡 | 백신 |
ES2613498T3 (es) | 2009-07-01 | 2017-05-24 | Protiva Biotherapeutics Inc. | Nuevas formulaciones de lípidos para el suministro de agentes terapéuticos a tumores sólidos |
US20110300205A1 (en) | 2009-07-06 | 2011-12-08 | Novartis Ag | Self replicating rna molecules and uses thereof |
US20110053829A1 (en) | 2009-09-03 | 2011-03-03 | Curevac Gmbh | Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids |
CA2816925C (fr) | 2009-11-04 | 2023-01-10 | The University Of British Columbia | Particules lipidiques contenant des acides nucleiques et procedes associes |
US8449916B1 (en) | 2009-11-06 | 2013-05-28 | Iowa State University Research Foundation, Inc. | Antimicrobial compositions and methods |
GB0920304D0 (en) | 2009-11-20 | 2010-01-06 | Medical Res Council | Novel liposome nanoparticles for tumour magnetic resonance imaging |
ES2734973T3 (es) | 2009-12-01 | 2019-12-13 | Translate Bio Inc | Administración de ARNm para el aumento de proteínas y enzimas en enfermedades genéticas humanas |
WO2011069529A1 (fr) | 2009-12-09 | 2011-06-16 | Curevac Gmbh | Solution contenant du mannose pour la lyophilisation, la transfection et/ou l'injection d'acides nucléiques |
EA201290499A1 (ru) | 2009-12-15 | 2013-01-30 | Байнд Байосайенсиз, Инк. | Композиции терапевтических полимерных наночастиц с высокой температурой стеклования и высокомолекулярными сополимерами |
EP2512459A4 (fr) | 2009-12-15 | 2013-08-07 | Nanoparticules polymères thérapeutiques comportant de l'épothilone et leurs procédés de fabrication et d'utilisation | |
EA201290497A1 (ru) | 2009-12-15 | 2013-01-30 | Байнд Байосайенсиз, Инк. | Терапевтические полимерные наночастицы, включающие кортикостероиды, и способы получения таковых |
DE102009058769A1 (de) | 2009-12-16 | 2011-06-22 | MagForce Nanotechnologies AG, 10589 | Temperaturabhängige Aktivierung von katalytischen Nukleinsäuren zur kontrollierten Wirkstofffreisetzung |
EP2525815B1 (fr) | 2010-01-24 | 2015-02-25 | Novartis AG | Microparticles polymériques biodégradables irradiées |
US20110262491A1 (en) | 2010-04-12 | 2011-10-27 | Selecta Biosciences, Inc. | Emulsions and methods of making nanocarriers |
EP2387999A1 (fr) | 2010-05-21 | 2011-11-23 | CureVac GmbH | Solution contenant de l'histidine pour la transfection et/ou l'injection d'acides nucléiques et utilisations associées |
US8802863B2 (en) | 2010-05-24 | 2014-08-12 | Sirna Therapeutics, Inc. | Amino alcohol cationic lipids for oligonucleotide delivery |
KR20130108983A (ko) | 2010-05-26 | 2013-10-07 | 셀렉타 바이오사이언시즈, 인크. | 커플링되지 않은 애주번트를 갖는 나노담체 조성물 |
WO2011150320A2 (fr) | 2010-05-27 | 2011-12-01 | University Of Georgia Research Foundation, Inc. | Activateurs de l'immunité innée |
US8748667B2 (en) | 2010-06-04 | 2014-06-10 | Sirna Therapeutics, Inc. | Low molecular weight cationic lipids for oligonucleotide delivery |
BRPI1001959A2 (pt) | 2010-06-15 | 2012-03-06 | Instituto De Pesquisas Tecnológicas Do Est. S. Paulo S/a - Ipt | Nanocarreadores coloidais para ativos hidrofílicos e processo de produção |
US20130196948A1 (en) | 2010-06-25 | 2013-08-01 | Massachusetts Insitute Of Technology | Polymers for biomaterials and therapeutics |
KR101130137B1 (ko) | 2010-07-02 | 2012-03-28 | 연세대학교 산학협력단 | 발광다이오드 모듈 |
JP5940064B2 (ja) * | 2010-07-06 | 2016-06-29 | ノバルティス アーゲー | 低用量のrnaを用いた大型哺乳動物の免疫化 |
US9192661B2 (en) | 2010-07-06 | 2015-11-24 | Novartis Ag | Delivery of self-replicating RNA using biodegradable polymer particles |
LT3243526T (lt) | 2010-07-06 | 2020-02-10 | Glaxosmithkline Biologicals S.A. | Rnr pristatymas, skirtas keleto imuninio atsako paleidimui |
US9770463B2 (en) * | 2010-07-06 | 2017-09-26 | Glaxosmithkline Biologicals Sa | Delivery of RNA to different cell types |
MX336839B (es) | 2010-07-30 | 2016-02-03 | Curevac Gmbh | Formacion de complejos de acidos nucleicos con componentes cationicos entrelazados por disulfuro para transfeccion e inmunoestimulacion. |
WO2012019168A2 (fr) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Acides nucléiques modifiés et leurs procédés d'utilisation |
WO2012021516A2 (fr) | 2010-08-09 | 2012-02-16 | The Trustees Of The University Of Pennsylvania | Structures hybrides nanoparticulaires-oligonucléotidiques et leurs méthodes d'utilisation |
WO2012019630A1 (fr) | 2010-08-13 | 2012-02-16 | Curevac Gmbh | Acide nucléique comprenant ou codant pour une tige-boucle d'histone et une séquence poly(a) ou un signal de polyadénylation pour augmenter l'expression d'une protéine codée |
US8956646B2 (en) | 2010-08-14 | 2015-02-17 | The Regents Of The University Of California | Zwitterionic lipids |
US20120064110A1 (en) | 2010-08-20 | 2012-03-15 | Selecta Biosciences, Inc. | Synthetic nanocarrier vaccines comprising peptides obtained or derived from human influenza a virus hemagglutinin |
TR201908635T4 (tr) | 2010-08-31 | 2019-07-22 | Glaxosmithkline Biologicals Sa | Protein kodlayıcı rna?nın lipozomal verilmesine uygun lipitler. |
RS63983B1 (sr) * | 2010-08-31 | 2023-03-31 | Glaxosmithkline Biologicals Sa | Pegilovani lipozomi za isporuku rnk koja kodira imunogen |
HUE061275T2 (hu) | 2010-08-31 | 2023-06-28 | Glaxosmithkline Biologicals Sa | Kis liposzómák immunogént kódoló RNS bejuttatására |
US10307372B2 (en) | 2010-09-10 | 2019-06-04 | The Johns Hopkins University | Rapid diffusion of large polymeric nanoparticles in the mammalian brain |
CA2821992A1 (fr) | 2010-10-01 | 2012-04-05 | Moderna Therapeutics, Inc. | Synthese d'acides nucleiques et methodes d'utilisation associees |
US20150056300A1 (en) | 2010-10-22 | 2015-02-26 | Bind Therapeutics, Inc. | Therapeutic nanoparticles with high molecular weight copolymers |
WO2012061703A1 (fr) | 2010-11-05 | 2012-05-10 | The Johns Hopkins University | Compositions et procédés visant à une réduction de la mucoadhérence |
WO2012089231A1 (fr) * | 2010-12-30 | 2012-07-05 | Okairòs Ag | Vaccins contre les paramyxovirus |
US20120177701A1 (en) | 2010-12-31 | 2012-07-12 | Selecta Biosciences, Inc. | Compositions comprising immunostimulatory nucleic acids and related methods |
CA2824526C (fr) | 2011-01-11 | 2020-07-07 | Alnylam Pharmaceuticals, Inc. | Lipides pegyles et leur utilisation pour une administration de medicament |
US20120189700A1 (en) | 2011-01-19 | 2012-07-26 | Zoraida Aguilar | Nanoparticle Based Immunological Stimulation |
BR112013018845A2 (pt) | 2011-01-28 | 2016-07-19 | Medimmune Llc | expressão de glicoproteínas de fusão viral solúveis em células de mamífero |
WO2012109121A1 (fr) | 2011-02-07 | 2012-08-16 | Purdue Research Foundation | Nanoparticules glucidiques pour une efficacité prolongée d'un peptide antimicrobien |
WO2012116715A1 (fr) | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination chez des nouveaux-nés et des enfants en bas âge |
WO2012116714A1 (fr) | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination chez des patients âgés |
EP2691078A1 (fr) | 2011-03-31 | 2014-02-05 | Ingell Technologies Holding B.V. | Compositions biodégradables appropriées pour une libération contrôlée |
AU2012237260A1 (en) | 2011-03-31 | 2013-11-14 | Ingell Technologies Holding B.V. | Biodegradable compositions suitable for controlled release |
CA2831613A1 (fr) | 2011-03-31 | 2012-10-04 | Moderna Therapeutics, Inc. | Administration et formulation d'acides nucleiques genetiquement modifies |
BR112013029490A2 (pt) | 2011-05-17 | 2019-09-24 | Moderna Therapeutics Inc | ácidos nucleicos projetados e métodos de uso dos mesmos para vertebrados não humanos |
US8691750B2 (en) | 2011-05-17 | 2014-04-08 | Axolabs Gmbh | Lipids and compositions for intracellular delivery of biologically active compounds |
WO2012166923A2 (fr) | 2011-05-31 | 2012-12-06 | Bind Biosciences | Nanoparticules polymères chargées de médicament et leurs procédés de fabrication et d'utilisation |
WO2013052167A2 (fr) | 2011-06-02 | 2013-04-11 | The Regents Of The University Of California | Nanoparticules encapsulées dans une membrane et leur procédé d'utilisation |
US8916696B2 (en) | 2011-06-12 | 2014-12-23 | City Of Hope | Aptamer-mRNA conjugates for targeted protein or peptide expression and methods for their use |
CN103732211B (zh) | 2011-07-21 | 2017-03-01 | 禾大国际股份公开有限公司 | 支化的聚醚‑聚酰胺嵌段共聚物及其制造与使用方法 |
CN103702687A (zh) | 2011-07-29 | 2014-04-02 | 西莱克塔生物科技公司 | 产生体液和细胞毒性t淋巴细胞(ctl)免疫应答的合成纳米载体 |
KR20140051357A (ko) | 2011-08-26 | 2014-04-30 | 애로우헤드 리서치 코오포레이션 | In Vivo 핵산 전달용 폴리(비닐 에스테르) 고분자 |
TR201900264T4 (tr) | 2011-08-31 | 2019-02-21 | Glaxosmithkline Biologicals Sa | İmmünojen şifreleyici rna'nın verilmesi için pegile edilmiş lipozomlar. |
JP2014527071A (ja) | 2011-08-31 | 2014-10-09 | マリンクロッド エルエルシー | H−ホスホネートによるナノ粒子pegの改変 |
WO2013039861A2 (fr) | 2011-09-12 | 2013-03-21 | modeRNA Therapeutics | Acides nucléiques modifiés et leurs procédés d'utilisation |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
EP2747761A1 (fr) | 2011-09-22 | 2014-07-02 | Bind Therapeutics, Inc. | Méthodes de traitement de cancers au moyen de nanoparticules thérapeutiques |
WO2013072929A2 (fr) | 2011-09-23 | 2013-05-23 | Indian Institute Of Technology | Composition cosmétique à base d'articles nanoparticulaires |
ES2911677T3 (es) | 2011-10-03 | 2022-05-20 | Modernatx Inc | Nucleósidos, nucleótidos y ácidos nucleicos modificados, y sus usos |
RU2014118727A (ru) | 2011-10-11 | 2015-11-20 | Новартис Аг | Рекомбинантные самореплицирующиеся полицистронные молекулы рнк |
CA2852064A1 (fr) | 2011-10-14 | 2013-04-18 | Stc.Unm | Bicouches lipidiques supportees par des nanoparticules poreuses (protocellules) pour l'administration ciblee, comprenant une administration transdermique d'une molecule cargo, etprocedes associes |
WO2013059496A1 (fr) | 2011-10-18 | 2013-04-25 | Dicerna Pharmaceuticals, Inc. | Lipides cationiques aminés et utilisations associées |
WO2013059922A1 (fr) | 2011-10-25 | 2013-05-02 | The University Of British Columbia | Nanoparticules lipides de taille limite, et procédés correspondants |
EA032088B1 (ru) | 2011-10-27 | 2019-04-30 | Массачусетс Инститьют Оф Текнолоджи | Аминокислотные производные, функционализованные на n-конце, способные образовывать микросферы, инкапсулирующие лекарственное средство |
EP2771043A4 (fr) | 2011-10-28 | 2015-04-29 | Presage Biosciences Inc | Procédés d'administration de médicament |
WO2013078199A2 (fr) | 2011-11-23 | 2013-05-30 | Children's Medical Center Corporation | Méthodes pour une administration in vivo améliorée d'arn synthétiques modifiés |
EP2785326A2 (fr) | 2011-11-29 | 2014-10-08 | The University of North Carolina at Chapel Hill | Particules manipulées de façon géométrique et procédés de modulation de réponses des macrophages ou immunitaires |
US20140308304A1 (en) | 2011-12-07 | 2014-10-16 | Alnylam Pharmaceuticals, Inc. | Lipids for the delivery of active agents |
US20140343129A1 (en) | 2011-12-14 | 2014-11-20 | Moderna Therapeutics, Inc. | Modified nucleic acids, and acute care uses thereof |
US20140378538A1 (en) | 2011-12-14 | 2014-12-25 | Moderma Therapeutics, Inc. | Methods of responding to a biothreat |
WO2013090601A2 (fr) | 2011-12-16 | 2013-06-20 | Massachusetts Institute Of Technology | Nanoparticules compactes pour des applications biologiques |
EP2793906A4 (fr) | 2011-12-21 | 2016-01-13 | Moderna Therapeutics Inc | Procédés d'augmentation de la viabilité ou de la longévité d'un organe ou d'un explant d'organe |
EP2798064B1 (fr) | 2011-12-30 | 2016-08-31 | Cellscript, Llc | Fabrication et utilisation d'arnss synthétisés in vitro pour introduction dans des cellules mammaliennes afin d'induire un effet biologique ou biochimique |
WO2013105101A1 (fr) | 2012-01-13 | 2013-07-18 | Department Of Biotechnology | Nanoparticules lipidiques solides encapsulant un médicament hydrophile/amphiphile et leur procédé de préparation |
CA2863632C (fr) | 2012-01-19 | 2017-07-11 | The Johns Hopkins University | Formulations de nanoparticules presentant une penetration amelioree dans les muqueuses |
US9416090B2 (en) | 2012-02-03 | 2016-08-16 | Rutgers, The State University Of New Jersey | Polymeric biomaterials derived from phenolic monomers and their medical uses |
KR102019297B1 (ko) | 2012-02-09 | 2019-09-06 | 라이프 테크놀로지스 코포레이션 | 친수성 중합체성 입자 및 그의 제조 방법 |
CN104105750A (zh) | 2012-02-10 | 2014-10-15 | 纳幕尔杜邦公司 | 高-x两嵌段共聚物的制备、纯化和使用 |
WO2013120497A1 (fr) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Acide nucléique comprenant ou codant pour une tige-boucle d'histone et une séquence poly(a) ou un signal de polyadénylation pour l'augmentation de l'expression d'une protéine thérapeutique codée |
WO2013120499A1 (fr) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Acide nucléique comprenant ou codant pour une tige-boucle d'histone et une séquence poly(a) ou un signal de polyadénylation pour augmenter l'expression d'un antigène pathogène codé |
US10398905B2 (en) | 2012-02-19 | 2019-09-03 | Nvigen, Inc. | Uses of porous nanostructure in delivery |
US10322089B2 (en) | 2012-03-14 | 2019-06-18 | The Board Of Trustees Of The Leland Stanford Junior University | Nanoparticles, nanoparticle delivery methods, and systems of delivery |
JP6211054B2 (ja) | 2012-03-29 | 2017-10-11 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | 脂質誘導される中性ナノ粒子 |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
EP3501550A1 (fr) | 2012-04-02 | 2019-06-26 | Moderna Therapeutics, Inc. | Polynucléotides modifiés pour la production de protéines associées à une maladie humaine |
US10501513B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides for the production of oncology-related proteins and peptides |
US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
KR20150020288A (ko) | 2012-06-08 | 2015-02-25 | 에트리스 게엠베하 | 메신저 rna의 폐전달 |
US9512456B2 (en) | 2012-08-14 | 2016-12-06 | Modernatx, Inc. | Enzymes and polymerases for the synthesis of RNA |
WO2014093924A1 (fr) | 2012-12-13 | 2014-06-19 | Moderna Therapeutics, Inc. | Molécules d'acide nucléique modifiées et leurs utilisations |
US9597380B2 (en) | 2012-11-26 | 2017-03-21 | Modernatx, Inc. | Terminally modified RNA |
WO2014089239A1 (fr) | 2012-12-07 | 2014-06-12 | Alnylam Pharmaceuticals, Inc. | Formulations de particules lipidiques d'acide nucléique améliorées |
US20150315541A1 (en) | 2012-12-13 | 2015-11-05 | Moderna Therapeutics, Inc. | Modified polynucleotides for altering cell phenotype |
JP6352950B2 (ja) | 2013-03-08 | 2018-07-04 | ノバルティス アーゲー | 活性薬物の送達のための脂質と脂質組成物 |
WO2014159813A1 (fr) | 2013-03-13 | 2014-10-02 | Moderna Therapeutics, Inc. | Molécules polynucléotidiques à longue durée de vie |
RU2761631C2 (ru) | 2013-03-13 | 2021-12-13 | Дзе Юнайтед Стэйтс Оф Америка, Эс Репрезентед Бай Дзе Секретэри, Департмент Оф Хелт Энд Хьюман Сервисиз | Белки rsv в предшествующей слиянию конформации и их применение |
WO2014160243A1 (fr) | 2013-03-14 | 2014-10-02 | The Trustees Of The University Of Pennsylvania | Purification et évaluation de la pureté de molécules d'arn synthétisées comprenant des nucléosides modifiés |
EP2971010B1 (fr) | 2013-03-14 | 2020-06-10 | ModernaTX, Inc. | Formulation et administration de compositions de nucléosides, de nucléotides, et d'acides nucléiques modifiés |
US20160184458A1 (en) | 2013-03-14 | 2016-06-30 | Shire Human Genetic Therapies, Inc. | Mrna therapeutic compositions and use to treat diseases and disorders |
US10077439B2 (en) | 2013-03-15 | 2018-09-18 | Modernatx, Inc. | Removal of DNA fragments in mRNA production process |
US11377470B2 (en) | 2013-03-15 | 2022-07-05 | Modernatx, Inc. | Ribonucleic acid purification |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
WO2014144767A1 (fr) | 2013-03-15 | 2014-09-18 | Moderna Therapeutics, Inc. | Purification d'arnm par échange d'ions |
EP2971013B1 (fr) | 2013-03-15 | 2020-08-19 | The University Of British Columbia | Nanoparticules lipidiques pour la transfection et procédés associés |
US20160032273A1 (en) | 2013-03-15 | 2016-02-04 | Moderna Therapeutics, Inc. | Characterization of mrna molecules |
US9693958B2 (en) | 2013-03-15 | 2017-07-04 | Cureport, Inc. | Methods and devices for preparation of lipid nanoparticles |
WO2014144711A1 (fr) | 2013-03-15 | 2014-09-18 | Moderna Therapeutics, Inc. | Analyse de l'hétérogénéité et de la stabilité d'arnm |
WO2014144153A2 (fr) | 2013-03-15 | 2014-09-18 | Ohio State Innovation Foundation | Immunogènes de métapneumovirus et matériels et méthodes associés |
EP2971033B8 (fr) | 2013-03-15 | 2019-07-10 | ModernaTX, Inc. | Procédés de fabrication pour la production de transcrits d'arn |
TW201534578A (zh) | 2013-07-08 | 2015-09-16 | Daiichi Sankyo Co Ltd | 新穎脂質 |
EP3019619B1 (fr) | 2013-07-11 | 2021-08-25 | ModernaTX, Inc. | Compositions comprenant des polynucléotides synthétiques codant pour des protéines liées à crispr et des arnsg synthétiques et méthodes d'utilisation |
AU2014310935B2 (en) | 2013-08-21 | 2019-11-21 | CureVac SE | Combination vaccine |
JP6648019B2 (ja) | 2013-08-21 | 2020-02-14 | キュアバック アーゲー | Rnaコードされたタンパク質の発現を促進するための医薬的組成物、医薬的組成物の製造のための修飾rnaの使用、および、医薬的組成物を含むパーツキット |
AU2014310934B2 (en) | 2013-08-21 | 2019-09-12 | CureVac SE | Respiratory syncytial virus (RSV) vaccine |
EP3041938A1 (fr) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Polynucléotides circulaires |
US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
US10385088B2 (en) | 2013-10-02 | 2019-08-20 | Modernatx, Inc. | Polynucleotide molecules and uses thereof |
EP3052521A1 (fr) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucléotides codant pour un récepteur de lipoprotéines de faible densité |
US20160243221A1 (en) | 2013-10-18 | 2016-08-25 | Moderna Therapeutics, Inc. | Compositions and methods for tolerizing cellular systems |
IL305392A (en) * | 2013-11-29 | 2023-10-01 | Inovio Pharmaceuticals Inc | MERS-COV vaccine |
PT3083556T (pt) * | 2013-12-19 | 2020-03-05 | Novartis Ag | Lípidos e composições lipídicas para a entrega de agentes ativos |
US10426737B2 (en) | 2013-12-19 | 2019-10-01 | Novartis Ag | Lipids and lipid compositions for the delivery of active agents |
WO2015101415A1 (fr) | 2013-12-30 | 2015-07-09 | Curevac Gmbh | Molécules d'acides nucléiques artificielles |
KR102399799B1 (ko) | 2013-12-30 | 2022-05-18 | 큐어백 아게 | 인공 핵산 분자 |
EP3110401A4 (fr) * | 2014-02-25 | 2017-10-25 | Merck Sharp & Dohme Corp. | Adjuvants de vaccins sous forme de nanoparticules lipidiques et systèmes d'administration d'antigènes |
WO2015143335A1 (fr) | 2014-03-20 | 2015-09-24 | The University Of North Carolina At Chapel Hill | Méthodes et compositions pour protéines spike de coronavirus chimère |
JP6881813B2 (ja) | 2014-04-23 | 2021-06-02 | モデルナティーエックス, インコーポレイテッド | 核酸ワクチン |
EP3157573A4 (fr) | 2014-06-19 | 2018-02-21 | Moderna Therapeutics, Inc. | Molécules d'acide nucléique alternatives et leurs utilisations |
AU2015289583A1 (en) | 2014-07-16 | 2017-02-02 | Modernatx, Inc. | Chimeric polynucleotides |
WO2016011306A2 (fr) | 2014-07-17 | 2016-01-21 | Moderna Therapeutics, Inc. | Modifications de terminal de polynucléotides |
WO2016103238A1 (fr) | 2014-12-24 | 2016-06-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Protéines du métapneumovirus f recombinant et leur utilisation |
EP3247363A4 (fr) | 2015-01-21 | 2018-10-03 | Moderna Therapeutics, Inc. | Compositions de nanoparticules lipidiques |
WO2016123864A1 (fr) | 2015-02-08 | 2016-08-11 | Tongli Biomedical Co., Ltd. | Nanoparticules de lipides et utilisations desdites nanoparticules |
US10301377B2 (en) | 2015-02-24 | 2019-05-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Middle east respiratory syndrome coronavirus immunogens, antibodies, and their use |
WO2016164762A1 (fr) | 2015-04-08 | 2016-10-13 | Moderna Therapeutics, Inc. | Polynucléotides codant pour des mutants, au niveau des domaines egf-a et intracellulaire, du récepteur des lipoprotéines basse densité et et leurs procédés d'utilisation |
WO2016201377A1 (fr) | 2015-06-10 | 2016-12-15 | Moderna Therapeutics, Inc. | Vaccins adaptatifs ciblés |
WO2017011773A2 (fr) | 2015-07-15 | 2017-01-19 | Modernatx, Inc. | Acides nucléiques à codons optimisés codant des anticorps |
WO2017015457A1 (fr) | 2015-07-21 | 2017-01-26 | Modernatx, Inc. | Vaccin contre le virus ebola |
MA42502A (fr) | 2015-07-21 | 2018-05-30 | Modernatx Inc | Vaccins contre une maladie infectieuse |
EP3328394A4 (fr) | 2015-07-30 | 2019-03-13 | ModernaTX, Inc. | Arn épitope peptidiques concatémériques |
US20190008887A1 (en) | 2015-07-30 | 2019-01-10 | ModernaTX Inc. | Multimeric mrna |
US11564893B2 (en) | 2015-08-17 | 2023-01-31 | Modernatx, Inc. | Methods for preparing particles and related compositions |
US20180237849A1 (en) | 2015-08-17 | 2018-08-23 | Modernatx, Inc. | Rna mapping/fingerprinting |
US11311615B2 (en) | 2015-09-16 | 2022-04-26 | Shin Nippon Biomedical Laboratories, Ltd. | Vaccine compositions |
PL3350157T3 (pl) | 2015-09-17 | 2022-05-16 | Modernatx, Inc. | Związki i kompozycje do dostarczania wewnątrzkomórkowego środków terapeutycznych |
US10849920B2 (en) | 2015-10-05 | 2020-12-01 | Modernatx, Inc. | Methods for therapeutic administration of messenger ribonucleic acid drugs |
WO2017066789A1 (fr) | 2015-10-16 | 2017-04-20 | Modernatx, Inc. | Analogues de coiffe d'arnm avec sucre modifié |
WO2017070620A2 (fr) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Vaccin contre le virus de la grippe à large spectre |
JP2018536023A (ja) | 2015-10-22 | 2018-12-06 | モデルナティーエックス, インコーポレイテッド | 単純ヘルペスウイルスワクチン |
MA46317A (fr) | 2015-10-22 | 2019-08-07 | Modernatx Inc | Vaccin contre le virus respiratoire syncytial |
EP3364982A4 (fr) | 2015-10-22 | 2019-04-17 | ModernaTX, Inc. | Vaccins contre les maladies sexuellement transmissibles |
WO2017070613A1 (fr) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Vaccin contre le cytomégalovirus humain |
JP2018532777A (ja) | 2015-10-22 | 2018-11-08 | モデルナティーエックス, インコーポレイテッド | 癌ワクチン |
EP4349404A3 (fr) | 2015-10-22 | 2024-06-19 | ModernaTX, Inc. | Vaccins contre le virus respiratoire |
EA201891001A1 (ru) | 2015-10-22 | 2018-11-30 | МОДЕРНАТиЭкс, ИНК. | Вакцины на основе нуклеиновых кислот против вируса ветряной оспы (vzv) |
EP3364950A4 (fr) | 2015-10-22 | 2019-10-23 | ModernaTX, Inc. | Vaccins contre des maladies tropicales |
CA3003267A1 (fr) | 2015-10-26 | 2017-05-04 | Translate Bio Ma, Inc. | Formulations de nanoparticules pour l'administration de complexes d'acide nucleique |
FI3368507T3 (fi) | 2015-10-28 | 2023-03-21 | Acuitas Therapeutics Inc | Uusia lipidejä ja lipidinanopartikkeliformulaatioita nukleiinihappojen annostelemiseksi |
EP3374504A2 (fr) | 2015-11-09 | 2018-09-19 | CureVac AG | Molécules d'acide nucléique optimisées |
DK3386484T3 (da) | 2015-12-10 | 2022-07-04 | Modernatx Inc | Sammensætninger og fremgangsmåder til afgivelse af terapeutiske midler |
CA3007108A1 (fr) | 2015-12-17 | 2017-06-22 | Modernatx, Inc. | Polynucleotides codant pour la methylmalonyl-coa mutase |
JP7114465B2 (ja) | 2015-12-22 | 2022-08-08 | モデルナティエックス インコーポレイテッド | 薬剤の細胞内送達のための化合物および組成物 |
US10465190B1 (en) | 2015-12-23 | 2019-11-05 | Modernatx, Inc. | In vitro transcription methods and constructs |
US20210206818A1 (en) | 2016-01-22 | 2021-07-08 | Modernatx, Inc. | Messenger ribonucleic acids for the production of intracellular binding polypeptides and methods of use thereof |
EA201892250A1 (ru) | 2016-04-05 | 2019-03-29 | Янссен Вэксинс Энд Превеншн Б.В. | Вакцина против rsv |
EP3896164A1 (fr) | 2016-05-18 | 2021-10-20 | ModernaTX, Inc. | Polynucléotides codant pour l'alpha-galactosidase a pour le traitement de la maladie de fabry |
EP3458106A4 (fr) | 2016-05-18 | 2020-03-18 | Modernatx, Inc. | Polynucléotides codant pour la lipoprotéine lipase destinés au traitement de l'hyperlipidémie |
RS63912B1 (sr) | 2016-05-18 | 2023-02-28 | Modernatx Inc | Polinukleotidi koji kodiraju interleukin-12 (il12) i njihove upotrebe |
AU2017268399B2 (en) | 2016-05-18 | 2023-01-12 | Modernatx, Inc. | mRNA combination therapy for the treatment of cancer |
US11001861B2 (en) | 2016-05-18 | 2021-05-11 | Modernatx, Inc. | Polynucleotides encoding galactose-1-phosphate uridylyltransferase for the treatment of galactosemia type 1 |
MA45052A (fr) | 2016-05-18 | 2019-03-27 | Modernatx Inc | Polynucléotides codant pour jagged1 pour le traitement du syndrome d'alagille |
US20190382774A1 (en) | 2016-05-18 | 2019-12-19 | Modernatx, Inc. | Polyribonucleotides containing reduced uracil content and uses thereof |
WO2017201349A1 (fr) | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Polynucléotides codant pour la citrine pour le traitement de la citrullinémie de type 2 |
EP3458108A4 (fr) | 2016-05-18 | 2020-04-22 | ModernaTX, Inc. | Polynucléotides codant pour un régulateur de conductance transmembranaire de fibrose kystique pour le traitement de la fibrose kystique |
BR112018073683A2 (pt) | 2016-05-18 | 2019-02-26 | Modernatx, Inc. | polinucleotídeos codificadores de relaxina |
JP2019519601A (ja) | 2016-05-18 | 2019-07-11 | モダーナティエックス・インコーポレイテッドModernaTX, Inc. | 急性間欠性ポルフィリン症の治療のためのポルホビリノゲン脱アミノ酵素をコードするポリヌクレオチド |
US20190298657A1 (en) | 2016-05-18 | 2019-10-03 | Modernatx, Inc. | Polynucleotides Encoding Acyl-CoA Dehydrogenase, Very Long-Chain for the Treatment of Very Long-Chain Acyl-CoA Dehydrogenase Deficiency |
JP2019525901A (ja) | 2016-06-14 | 2019-09-12 | モデルナティエックス インコーポレイテッドModernaTX,Inc. | 脂質ナノ粒子の安定化製剤 |
CA3034681A1 (fr) | 2016-06-30 | 2018-01-04 | Arbutus Biopharma Corporation | Compositions et procedes pour l'administration d'arn messager |
EP3512944B1 (fr) | 2016-09-14 | 2022-07-06 | ModernaTX, Inc. | Compositions d'arn de haute pureté et procédés pour leur préparation |
AU2017345766A1 (en) | 2016-10-21 | 2019-05-16 | Modernatx, Inc. | Human cytomegalovirus vaccine |
EP3532070A1 (fr) | 2016-10-26 | 2019-09-04 | Modernatx, Inc. | Acides ribonucléiques messagers pour l'amélioration de réponses immunitaires et leurs méthodes d'utilisation |
MA46643A (fr) | 2016-10-26 | 2019-09-04 | Modernatx Inc | Méthodes et compositions pour le mappage d'arn |
CN110352071A (zh) | 2016-10-26 | 2019-10-18 | 库瑞瓦格股份公司 | 脂质纳米颗粒mRNA疫苗 |
US11583504B2 (en) | 2016-11-08 | 2023-02-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
EP3538146A4 (fr) | 2016-11-11 | 2020-07-15 | ModernaTX, Inc. | Vaccin antigrippal |
MA50335A (fr) | 2016-12-08 | 2020-08-19 | Modernatx Inc | Vaccins à acide nucléique contre des virus respiratoires |
EP3555289A1 (fr) | 2016-12-13 | 2019-10-23 | ModernaTX, Inc. | Purification par affinité d'arn |
EP3558355A2 (fr) | 2016-12-23 | 2019-10-30 | CureVac AG | Vaccin contre l'hénipavirus |
US20180243225A1 (en) | 2017-01-25 | 2018-08-30 | Modernatx, Inc. | Ebola/marburg vaccines |
US20200032274A1 (en) | 2017-02-01 | 2020-01-30 | Moderna TX, Inc. | Polynucleotide secondary structure |
AU2017397458A1 (en) | 2017-02-01 | 2019-08-15 | Modernatx, Inc. | RNA cancer vaccines |
BR112019015797A2 (pt) | 2017-02-01 | 2020-03-17 | Modernatx, Inc. | Composições de mrna terapêuticas imunomoduladoras que codificam peptídeos de mutação de oncogene de ativação |
EP3582790A4 (fr) | 2017-02-16 | 2020-11-25 | ModernaTX, Inc. | Compositions immunogènes très puissantes |
WO2018157009A1 (fr) | 2017-02-24 | 2018-08-30 | Modernatx, Inc. | Thérapie de dystrophies musculaires à base d'acide nucléique |
WO2018170245A1 (fr) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Vaccin à large spectre contre le virus de la grippe |
FI3596041T3 (fi) | 2017-03-15 | 2023-01-31 | Yhdiste ja koostumuksia terapeuttisten aineiden antamiseen solun sisään | |
MA47787A (fr) | 2017-03-15 | 2020-01-22 | Modernatx Inc | Vaccin contre le virus respiratoire syncytial |
US11045540B2 (en) | 2017-03-15 | 2021-06-29 | Modernatx, Inc. | Varicella zoster virus (VZV) vaccine |
US11752206B2 (en) | 2017-03-15 | 2023-09-12 | Modernatx, Inc. | Herpes simplex virus vaccine |
JP7332478B2 (ja) | 2017-03-15 | 2023-08-23 | モデルナティエックス インコーポレイテッド | 脂質ナノ粒子製剤 |
EP3595676A4 (fr) | 2017-03-17 | 2021-05-05 | Modernatx, Inc. | Vaccins à base d'arn contre des maladies zoonotiques |
WO2018175783A1 (fr) | 2017-03-22 | 2018-09-27 | Modernatx, Inc. | Vaccins antibactériens à arn |
EP3607074A4 (fr) | 2017-04-05 | 2021-07-07 | Modernatx, Inc. | Réduction ou élimination de réponses immunitaires à des protéines thérapeutiques administrées par voie non intraveineuse, par exemple par voie sous-cutanée |
MA49463A (fr) | 2017-04-26 | 2021-05-05 | Modernatx Inc | Vaccin contre le virus de l'herpès simplex |
WO2018232355A1 (fr) | 2017-06-15 | 2018-12-20 | Modernatx, Inc. | Anticorps d'arn |
WO2018232357A1 (fr) | 2017-06-15 | 2018-12-20 | Modernatx, Inc. | Formulations d'arn |
EP3668522A4 (fr) | 2017-08-18 | 2021-04-21 | Modernatx, Inc. | Vaccins à base d'arnm efficaces |
CN111212905A (zh) | 2017-08-18 | 2020-05-29 | 摩登纳特斯有限公司 | Rna聚合酶变体 |
MA49914A (fr) | 2017-08-18 | 2021-04-21 | Modernatx Inc | Procédés analytiques par hplc |
US11912982B2 (en) | 2017-08-18 | 2024-02-27 | Modernatx, Inc. | Methods for HPLC analysis |
WO2019046809A1 (fr) | 2017-08-31 | 2019-03-07 | Modernatx, Inc. | Procédés de fabrication de nanoparticules lipidiques |
WO2019055807A1 (fr) | 2017-09-14 | 2019-03-21 | Modernatx, Inc. | Vaccins à arn contre le virus zika |
IL274230B2 (en) | 2017-10-31 | 2023-12-01 | Modernatx Inc | Lipid nanoparticles for delivery of modified RNA encoding VEGF-A polypeptide |
US20190192646A1 (en) | 2017-11-03 | 2019-06-27 | Modernatx, Inc. | Salmonella vaccines |
JP2021504445A (ja) | 2017-11-21 | 2021-02-15 | モデルナティーエックス, インコーポレイテッド | エプスタイン−バーウイルスワクチン |
WO2019148101A1 (fr) | 2018-01-29 | 2019-08-01 | Modernatx, Inc. | Vaccins à base d'arn contre le vrs |
EP4227319A1 (fr) | 2018-04-17 | 2023-08-16 | CureVac SE | Nouvelles molécules d'arn rsv et compositions pour vaccination |
KR20210038886A (ko) | 2018-06-27 | 2021-04-08 | 모더나티엑스, 인크. | 개인화된 암 백신 에피토프 선택 |
WO2020056370A1 (fr) | 2018-09-13 | 2020-03-19 | Modernatx, Inc. | Arnm modifié pour le traitement de troubles de la cholestase intrahépatique familiale progressive |
CA3113353A1 (fr) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Lipides peg de haute purete et leurs utilisations |
CA3113025A1 (fr) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Lipides peg et leurs utilisations |
JP7410135B2 (ja) | 2018-09-19 | 2024-01-09 | モデルナティエックス インコーポレイテッド | 治療薬の細胞内送達のための化合物及び組成物 |
EP3852728A1 (fr) | 2018-09-20 | 2021-07-28 | Modernatx, Inc. | Préparation de nanoparticules lipidiques et leurs méthodes d'administration |
US20220125899A1 (en) | 2018-11-07 | 2022-04-28 | Modernatx, Inc. | Rna cancer vaccines |
KR20210135494A (ko) | 2019-01-31 | 2021-11-15 | 모더나티엑스, 인크. | 지질 나노입자의 제조 방법 |
US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
MX2021010075A (es) | 2019-02-20 | 2021-12-10 | Modernatx Inc | Variantes de arn polimerasa para la formacion de casquetes cotranscripcionales. |
KR20210149727A (ko) | 2019-03-11 | 2021-12-09 | 모더나티엑스, 인크. | 유가식(fed-batch) 시험관내 전사 공정 |
EP3938379A4 (fr) | 2019-03-15 | 2023-02-22 | ModernaTX, Inc. | Vaccins à base d'arn contre le vih |
SG11202110036RA (en) | 2019-03-19 | 2021-10-28 | Arcturus Therapeutics Inc | Method of making lipid-encapsulated rna nanoparticles |
JP2022535006A (ja) | 2019-05-31 | 2022-08-04 | モデルナティエックス インコーポレイテッド | 増殖t細胞アッセイ |
JP2022544416A (ja) | 2019-08-14 | 2022-10-18 | モデルナティエックス インコーポレイテッド | in vitro転写の下流生成物を精製するプロセス |
EP4028030A4 (fr) | 2019-09-11 | 2023-09-27 | ModernaTX, Inc. | Vaccin contre le cytomégalovirus humain |
CN114728887A (zh) | 2019-09-19 | 2022-07-08 | 摩登纳特斯有限公司 | 用于治疗剂的细胞内递送的支链尾端脂质化合物和组合物 |
JP2022548957A (ja) | 2019-09-19 | 2022-11-22 | モデルナティエックス インコーポレイテッド | キャップガイド及びrnaマッピングのためのその使用方法 |
CN110974954B (zh) | 2019-12-24 | 2021-03-16 | 珠海丽凡达生物技术有限公司 | 一种用于增强核酸疫苗免疫效果的脂质纳米颗粒及其制备方法 |
US20210217484A1 (en) | 2020-01-10 | 2021-07-15 | Modernatx, Inc. | Variational autoencoder for biological sequence generation |
US20210228707A1 (en) | 2020-01-28 | 2021-07-29 | Modernatx, Inc. | Coronavirus rna vaccines |
AU2021214774A1 (en) | 2020-01-30 | 2022-08-25 | Modernatx, Inc. | Respiratory virus immunizing compositions |
MX2022009410A (es) | 2020-01-31 | 2022-10-18 | Modernatx Inc | Metodos de preparacion de nanoparticulas lipidicas. |
AU2021215938A1 (en) | 2020-02-07 | 2022-09-01 | Modernatx, Inc. | Sars-cov-2 mrna domain vaccines |
JP2023529522A (ja) | 2020-04-09 | 2023-07-11 | スージョウ・アボジェン・バイオサイエンシズ・カンパニー・リミテッド | 脂質ナノ粒子組成物 |
WO2021211343A1 (fr) | 2020-04-13 | 2021-10-21 | Modernatx, Inc. | Vaccins à arnm contre le virus zika |
JP2023526178A (ja) | 2020-04-22 | 2023-06-21 | ファイザー・インク | コロナウイルスワクチン |
WO2021222304A1 (fr) | 2020-04-27 | 2021-11-04 | Modernatx, Inc. | Vaccins à arn contre le sars-cov-2 |
EP4149425A1 (fr) | 2020-05-15 | 2023-03-22 | Translate Bio, Inc. | Formulations de nanoparticules lipidiques pour l'administration d'arnm |
WO2021159130A2 (fr) | 2020-05-15 | 2021-08-12 | Modernatx, Inc. | Vaccins a arn de coronavirus et procédés d'utilisation |
US20230181481A1 (en) | 2020-05-15 | 2023-06-15 | Modernatx, Inc. | Rna formulations for high volume distribution, and methods of using the same for treating covid-19 |
US20230190761A1 (en) | 2020-05-21 | 2023-06-22 | Modernatx, Inc. | Methylene blue stabilized mrna compositions |
AU2021283934A1 (en) | 2020-06-05 | 2023-01-19 | Modernatx, Inc. | Bacterial strains for DNA production |
US20230285310A1 (en) | 2020-08-06 | 2023-09-14 | Modernatx, Inc. | Compositions for the delivery of payload molecules to airway epithelium |
US11406703B2 (en) | 2020-08-25 | 2022-08-09 | Modernatx, Inc. | Human cytomegalovirus vaccine |
EP4217371A1 (fr) | 2020-09-25 | 2023-08-02 | ModernaTX, Inc. | Vaccins à base de protéine de spicule de coronavirus à substitution multiproline |
CA3194863A1 (fr) | 2020-10-06 | 2022-04-14 | Shrirang KARVE | Procede ameliore et formulation de nanoparticules lipidiques |
TW202233232A (zh) | 2020-11-06 | 2022-09-01 | 法商賽諾菲公司 | 遞送mRNA疫苗的脂質奈米顆粒 |
US20240041785A1 (en) | 2020-11-16 | 2024-02-08 | BioNTech SE | Compositions and methods for stabilization of lipid nanoparticle mrna vaccines |
WO2022137133A1 (fr) | 2020-12-22 | 2022-06-30 | Curevac Ag | Vaccin à arn contre des variants sras-cov-2 |
EP4274607A1 (fr) | 2021-01-11 | 2023-11-15 | ModernaTX, Inc. | Vaccins contre le virus de la grippe à arn saisonnière |
JP2024503699A (ja) | 2021-01-15 | 2024-01-26 | モデルナティエックス インコーポレイテッド | バリアント株ベースのコロナウイルスワクチン |
EP4277655A1 (fr) | 2021-01-15 | 2023-11-22 | ModernaTX, Inc. | Vaccins anti-coronavirus à base de souche variante |
US20240100145A1 (en) | 2021-03-05 | 2024-03-28 | Moderna TX, Inc. | Vlp enteroviral vaccines |
US20240181030A1 (en) | 2021-03-26 | 2024-06-06 | Modernatx, Inc. | Pertussis vaccine |
EP4314000A1 (fr) | 2021-03-31 | 2024-02-07 | ModernaTX, Inc. | Synthèse de coiffes trinucléotidiques et tétranucléotidiques pour la production d'arnm |
JP2024512780A (ja) | 2021-04-01 | 2024-03-19 | モデルナティエックス インコーポレイテッド | 多価rna組成物中のrna種の識別及び比率決定のための方法 |
JP2024515035A (ja) | 2021-04-01 | 2024-04-04 | モデルナティエックス インコーポレイテッド | mRNAによる抗体構造及びアイソタイプの粘膜発現 |
WO2022221359A1 (fr) | 2021-04-13 | 2022-10-20 | Modernatx, Inc. | Vaccins à arnm du virus d'epstein-barr |
WO2022221336A1 (fr) | 2021-04-13 | 2022-10-20 | Modernatx, Inc. | Vaccins contre l'arnm du virus respiratoire syncytial |
EP4322993A1 (fr) | 2021-04-13 | 2024-02-21 | ModernaTX, Inc. | Vaccins associés contre des virus respiratoires |
AU2022258463A1 (en) | 2021-04-14 | 2023-11-23 | Modernatx, Inc. | Influenza-coronavirus combination vaccines |
WO2022232585A1 (fr) | 2021-04-29 | 2022-11-03 | Modernatx, Inc. | Méthodes de lyophilisation pour la préparation d'agents thérapeutiques formulés à partir de lipides |
US20220363937A1 (en) | 2021-05-14 | 2022-11-17 | Armstrong World Industries, Inc. | Stabilization of antimicrobial coatings |
WO2022266012A1 (fr) | 2021-06-14 | 2022-12-22 | Modernatx, Inc. | Vaccins contre les variants de glycosylation de coronavirus |
EP4355761A1 (fr) | 2021-06-14 | 2024-04-24 | ModernaTX, Inc. | Vaccins à arnm codant pour des protéines de spicule de coronavirus flexibles |
US20240218353A1 (en) | 2021-06-17 | 2024-07-04 | Modernatx, Inc. | Alternative rna purification strategies |
EP4366768A1 (fr) | 2021-07-09 | 2024-05-15 | ModernaTX, Inc. | Vaccins pan-coronavirus humains |
WO2023283645A1 (fr) | 2021-07-09 | 2023-01-12 | Modernatx, Inc. | Vaccins à domaine de coronavirus pan-humain |
WO2023283642A2 (fr) | 2021-07-09 | 2023-01-12 | Modernatx, Inc. | Vaccins concatémères à coronavirus pan-humain |
EP4381059A1 (fr) | 2021-08-02 | 2024-06-12 | ModernaTX, Inc. | Chromatographie en phase inverse (rp) sans extraction d'arnm encapsulé dans des nanoparticules lipidiques pour une évaluation de pureté d'arnm |
WO2023018773A1 (fr) | 2021-08-11 | 2023-02-16 | Modernatx, Inc. | Formulations de nanoparticules lipidiques et leurs méthodes de synthèse |
WO2023019181A1 (fr) | 2021-08-11 | 2023-02-16 | Modernatx, Inc. | Formulations de vaccin à nanoparticules lipidiques contre le sars-cov-2 |
EP4384613A1 (fr) | 2021-08-13 | 2024-06-19 | ModernaTX, Inc. | Purification d'arnm par chromatographie multicolonnes |
WO2023092069A1 (fr) | 2021-11-18 | 2023-05-25 | Modernatx, Inc. | Vaccins à domaine arnm de sars-cov-2 et méthodes d'utilisation |
WO2023107999A2 (fr) | 2021-12-08 | 2023-06-15 | Modernatx, Inc. | Vaccins à arnm contre le virus de l'herpès simplex |
WO2023114307A1 (fr) | 2021-12-15 | 2023-06-22 | Modernatx, Inc. | Détermination de l'efficacité d'encapsulation de nanoparticules lipidiques |
WO2023132885A1 (fr) | 2022-01-04 | 2023-07-13 | Modernatx, Inc. | Procédés de purification d'adn pour la synthèse de gènes |
WO2023137149A1 (fr) | 2022-01-14 | 2023-07-20 | Modernatx, Inc. | Purification et recyclage d'adn de transcription in vitro |
WO2023150256A1 (fr) | 2022-02-03 | 2023-08-10 | Modernatx, Inc. | Précipitation continue pour la purification d'arnm |
-
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-
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013090648A1 (fr) * | 2011-12-16 | 2013-06-20 | modeRNA Therapeutics | Nucléoside, nucléotide, et compositions d'acide nucléique modifiés |
WO2013185069A1 (fr) * | 2012-06-08 | 2013-12-12 | Shire Human Genetic Therapies, Inc. | Administration pulmonaire d'arnm à des cellules cibles autres que pulmonaires |
WO2014089486A1 (fr) * | 2012-12-07 | 2014-06-12 | Shire Human Genetic Therapies, Inc. | Nanoparticules lipidiques pour administration de marn |
WO2014152774A1 (fr) * | 2013-03-14 | 2014-09-25 | Shire Human Genetic Therapies, Inc. | Procédés et compositions de délivrance d'anticorps codés par arnm |
WO2014144196A1 (fr) * | 2013-03-15 | 2014-09-18 | Shire Human Genetic Therapies, Inc. | Stimulation synergique de l'administration d'acides nucléiques par le biais de formulations mélangées |
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