EP3242671A4 - Ex vivo methods for minimizing risks and maximizing benefits of allogeneic blood and marrow transplantation - Google Patents

Ex vivo methods for minimizing risks and maximizing benefits of allogeneic blood and marrow transplantation Download PDF

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Publication number
EP3242671A4
EP3242671A4 EP16735447.1A EP16735447A EP3242671A4 EP 3242671 A4 EP3242671 A4 EP 3242671A4 EP 16735447 A EP16735447 A EP 16735447A EP 3242671 A4 EP3242671 A4 EP 3242671A4
Authority
EP
European Patent Office
Prior art keywords
marrow transplantation
vivo methods
allogeneic blood
minimizing risks
maximizing benefits
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP16735447.1A
Other languages
German (de)
French (fr)
Other versions
EP3242671A1 (en
Inventor
Jenny Zilberberg
Woo Lee
Robert Korngold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stevens Institute of Technology
Hackensack University Medical Center
Original Assignee
Hackensack University Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hackensack University Medical Center filed Critical Hackensack University Medical Center
Publication of EP3242671A1 publication Critical patent/EP3242671A1/en
Publication of EP3242671A4 publication Critical patent/EP3242671A4/en
Withdrawn legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4615—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622—Antigen presenting cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/46434—Antigens related to induction of tolerance to non-self
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/26—Universal/off- the- shelf cellular immunotherapy; Allogenic cells or means to avoid rejection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • G01N2800/245—Transplantation related diseases, e.g. graft versus host disease

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
EP16735447.1A 2015-01-08 2016-01-08 Ex vivo methods for minimizing risks and maximizing benefits of allogeneic blood and marrow transplantation Withdrawn EP3242671A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562101181P 2015-01-08 2015-01-08
PCT/US2016/012573 WO2016112245A1 (en) 2015-01-08 2016-01-08 Ex vivo methods for minimizing risks and maximizing benefits of allogeneic blood and marrow transplantation

Publications (2)

Publication Number Publication Date
EP3242671A1 EP3242671A1 (en) 2017-11-15
EP3242671A4 true EP3242671A4 (en) 2018-08-08

Family

ID=56356448

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16735447.1A Withdrawn EP3242671A4 (en) 2015-01-08 2016-01-08 Ex vivo methods for minimizing risks and maximizing benefits of allogeneic blood and marrow transplantation

Country Status (3)

Country Link
EP (1) EP3242671A4 (en)
CA (1) CA2972846A1 (en)
WO (1) WO2016112245A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI808055B (en) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Combination therapies of hdac inhibitors and pd-1 inhibitors
TWI794171B (en) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Combination therapies of hdac inhibitors and pd-l1 inhibitors
CN109401971B (en) * 2018-12-28 2024-01-30 江苏省人民医院（南京医科大学第一附属医院） Multifunctional automatic independent/combined co-culture device

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827642A (en) * 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
US20040259177A1 (en) * 2003-05-06 2004-12-23 Lowery Robert G. Three dimensional cell cultures in a microscale fluid handling system
WO2008060449A2 (en) * 2006-11-09 2008-05-22 President And Fellows Of Harvard College Microfluidic detector
US20110027804A1 (en) * 2008-01-10 2011-02-03 Hurel Corporation Immune system modeling devices and methods
US20140038279A1 (en) * 2011-02-28 2014-02-06 President And Fellows Of Harvard College Cell culture system

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827642A (en) * 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
US20040259177A1 (en) * 2003-05-06 2004-12-23 Lowery Robert G. Three dimensional cell cultures in a microscale fluid handling system
WO2008060449A2 (en) * 2006-11-09 2008-05-22 President And Fellows Of Harvard College Microfluidic detector
US20110027804A1 (en) * 2008-01-10 2011-02-03 Hurel Corporation Immune system modeling devices and methods
US20140038279A1 (en) * 2011-02-28 2014-02-06 President And Fellows Of Harvard College Cell culture system

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CARLENS STEFAN ET AL: "Ex vivo T lymphocyte expansion for retroviral transduction: Influence of serum-free media on variations in cell expansion rates and lymphocyte subset distribution", EXPERIMENTAL HEMATO, ELSEVIER INC, US, vol. 28, no. 10, 1 October 2000 (2000-10-01), pages 1137 - 1146, XP009165868, ISSN: 0301-472X, DOI: 10.1016/S0301-472X(00)00526-9 *
DMITRY SAMSONOV ET AL: "Differential activation of human T cells to allogeneic endothelial cells, epithelial cells and fibroblasts in vitro", TRANSPLANTATION RESEARCH, BIOMED CENTRAL LTD, LONDON, UK, vol. 1, no. 1, 24 April 2012 (2012-04-24), pages 4, XP021124468, ISSN: 2047-1440, DOI: 10.1186/2047-1440-1-4 *
See also references of WO2016112245A1 *
STYBAYEVA G ET AL: "Micropatterned co-cultures of T-lymphocytes and epithelial cells as a model of mucosal immune system", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 380, no. 3, 13 March 2009 (2009-03-13), pages 575 - 580, XP026422257, ISSN: 0006-291X, [retrieved on 20090131], DOI: 10.1016/J.BBRC.2009.01.164 *
VÉRONIQUE LECAULT ET AL: "Microfluidic cell culture arrays for clonal expansion and characterization of mammalian cells", 1 January 2012 (2012-01-01), XP055487736, Retrieved from the Internet <URL:http://dataaccess-p.internal.epo.org/dal/data/documents/nonpatent> *

Also Published As

Publication number Publication date
CA2972846A1 (en) 2016-07-14
WO2016112245A1 (en) 2016-07-14
EP3242671A1 (en) 2017-11-15

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