EP3190888A4 - Probes for imaging huntingtin protein - Google Patents

Probes for imaging huntingtin protein Download PDF

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Publication number
EP3190888A4
EP3190888A4 EP15836157.6A EP15836157A EP3190888A4 EP 3190888 A4 EP3190888 A4 EP 3190888A4 EP 15836157 A EP15836157 A EP 15836157A EP 3190888 A4 EP3190888 A4 EP 3190888A4
Authority
EP
European Patent Office
Prior art keywords
probes
huntingtin protein
imaging
imaging huntingtin
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP15836157.6A
Other languages
German (de)
French (fr)
Other versions
EP3190888A1 (en
EP3190888B1 (en
Inventor
Celia Dominguez
John Wityak
Jonathan Bard
Christopher John Brown
Michael Edward PRIME
Derek Alexander WEDDELL
Daryl Simon Walter
Paul Richard Giles
Ian James WIGGINTON
Malcolm George Taylor
Sébastien René Gabriel GALAN
Peter David Johnson
Thomas Martin KRÜLLE
Inaki MORAO
Daniel CLARK-FREW
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CHDI Foundation Inc
Original Assignee
CHDI Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CHDI Foundation Inc filed Critical CHDI Foundation Inc
Publication of EP3190888A1 publication Critical patent/EP3190888A1/en
Publication of EP3190888A4 publication Critical patent/EP3190888A4/en
Application granted granted Critical
Publication of EP3190888B1 publication Critical patent/EP3190888B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/0412—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K51/0419—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6823—Release of bound markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
EP15836157.6A 2014-08-29 2015-08-28 Probes for imaging huntingtin protein Active EP3190888B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462043617P 2014-08-29 2014-08-29
PCT/US2015/047427 WO2016033460A1 (en) 2014-08-29 2015-08-28 Probes for imaging huntingtin protein

Publications (3)

Publication Number Publication Date
EP3190888A1 EP3190888A1 (en) 2017-07-19
EP3190888A4 true EP3190888A4 (en) 2018-05-09
EP3190888B1 EP3190888B1 (en) 2020-06-10

Family

ID=55400659

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15836157.6A Active EP3190888B1 (en) 2014-08-29 2015-08-28 Probes for imaging huntingtin protein

Country Status (14)

Country Link
US (1) US10907197B2 (en)
EP (1) EP3190888B1 (en)
JP (1) JP2017528520A (en)
KR (1) KR20170047341A (en)
CN (1) CN107105655A (en)
AU (2) AU2015308709B2 (en)
BR (1) BR112017004134A2 (en)
CA (1) CA2959505A1 (en)
EA (1) EA201790408A1 (en)
ES (1) ES2818107T3 (en)
IL (1) IL250804A0 (en)
MX (1) MX2017002705A (en)
SG (1) SG11201701580XA (en)
WO (1) WO2016033460A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3186233T3 (en) 2014-08-29 2021-11-22 Chdi Foundation Inc PROBS FOR IMAGINATION OF HUNTINGTIN PROTEIN
US11104691B2 (en) 2014-08-29 2021-08-31 Chdi Foundation, Inc. Probes for imaging huntingtin protein
JP2017527559A (en) 2014-08-29 2017-09-21 シーエイチディーアイ ファウンデーション，インコーポレーテッド Huntington protein imaging probe
RU2721419C2 (en) 2015-08-28 2020-05-19 СиЭйчДиАй ФАУНДЕЙШН, ИНК. Probing proteins of hentingin protein
CN106632002A (en) * 2016-09-28 2017-05-10 贵州大学 Preparation technology of etoricoxib and reference substance 5-chloro-3-(4-(methyl sulphonyl)phenyl)-2,3-bipyridine of etoricoxib
GB201617339D0 (en) 2016-10-12 2016-11-23 Lytix Biopharma As Therapeutic compounds
CN108178764A (en) * 2018-01-09 2018-06-19 天津科技大学 Furans simultaneously [2,3-b] pyridine compounds and their and the synthetic method without metal catalytic
WO2020176424A1 (en) 2019-02-25 2020-09-03 Chdi Foundation, Inc. Compounds for targeting mutant huntingtin protein and uses thereof

Citations (2)

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US20060018825A1 (en) * 2003-08-13 2006-01-26 Bf Research Institute, Inc. Probe for diseases with amyloid accumulation, amyloid-staining agent, remedy and preventive for diseases with amyloid accumulation and diagnostic probe and staining agent for neurofibrillary change
US20110160543A1 (en) * 2008-05-28 2011-06-30 The Trustees Of Columbia University In The City Of New York Voxel-based methods for assessing subjects using positron emission tomography

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FR2524468B1 (en) * 1982-04-06 1985-10-18 Sandoz Sa NOVEL CONDENSED THIOPHENE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS OPTICAL BRIGHTENERS
JPS60146877A (en) * 1984-01-11 1985-08-02 Chisso Corp 2-substituted-6-(5-substituted-2-pyrimidinyl)naphthalene
JPH11171886A (en) * 1997-12-08 1999-06-29 Mitsui Chem Inc Pyprolylbenzimidazole derivative having amidine or guanidine in side chain
CA2470863C (en) 2001-12-20 2012-05-15 Wyeth Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
RU2440995C2 (en) * 2003-03-14 2012-01-27 Юнивесити Оф Питсбэг Benzothiazole derivatives, pharmaceutical composition exhibiting property to bind amyloid and method for detecting amyloid deposits in mammal
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WO2005040337A2 (en) 2003-05-20 2005-05-06 The Regents Of The University Of California METHODS FOR BINDING AGENTS TO β-AMYLOID PLAQUES
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US11104691B2 (en) 2014-08-29 2021-08-31 Chdi Foundation, Inc. Probes for imaging huntingtin protein
JP2017527559A (en) 2014-08-29 2017-09-21 シーエイチディーアイ ファウンデーション，インコーポレーテッド Huntington protein imaging probe
DK3186233T3 (en) 2014-08-29 2021-11-22 Chdi Foundation Inc PROBS FOR IMAGINATION OF HUNTINGTIN PROTEIN
RU2721419C2 (en) 2015-08-28 2020-05-19 СиЭйчДиАй ФАУНДЕЙШН, ИНК. Probing proteins of hentingin protein

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Publication number Priority date Publication date Assignee Title
US20060018825A1 (en) * 2003-08-13 2006-01-26 Bf Research Institute, Inc. Probe for diseases with amyloid accumulation, amyloid-staining agent, remedy and preventive for diseases with amyloid accumulation and diagnostic probe and staining agent for neurofibrillary change
US20110160543A1 (en) * 2008-05-28 2011-06-30 The Trustees Of Columbia University In The City Of New York Voxel-based methods for assessing subjects using positron emission tomography

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KIM SERDONS ET AL: "Synthesis and Evaluation of Three 18 F-Labeled Aminophenylbenzothiazoles as Amyloid Imaging Agents", JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, no. 22, 26 November 2009 (2009-11-26), pages 7090 - 7102, XP055460677, ISSN: 0022-2623, DOI: 10.1021/jm900871v *
MATHIS C A ET AL: "Synthesis and Evaluation of 11C-Labeled 6-Substituted 2-Arylbenzothiazoles as amyloid Imaging Agents", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 46, 19 June 2003 (2003-06-19), pages 2740 - 2754, XP002285914, ISSN: 0022-2623, DOI: 10.1021/JM030026B *
See also references of WO2016033460A1 *

Also Published As

Publication number Publication date
AU2020202226A1 (en) 2020-04-16
EP3190888A1 (en) 2017-07-19
BR112017004134A2 (en) 2017-12-12
IL250804A0 (en) 2017-04-30
SG11201701580XA (en) 2017-03-30
AU2015308709A1 (en) 2017-03-23
AU2015308709B2 (en) 2020-01-02
KR20170047341A (en) 2017-05-04
MX2017002705A (en) 2017-12-20
EP3190888B1 (en) 2020-06-10
EA201790408A1 (en) 2017-09-29
CA2959505A1 (en) 2016-03-03
JP2017528520A (en) 2017-09-28
ES2818107T3 (en) 2021-04-09
US20170292150A1 (en) 2017-10-12
WO2016033460A1 (en) 2016-03-03
US10907197B2 (en) 2021-02-02
CN107105655A (en) 2017-08-29

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