EP3181164B1 - Apparatus for the decapneization of blood - Google Patents
Apparatus for the decapneization of blood Download PDFInfo
- Publication number
- EP3181164B1 EP3181164B1 EP16204182.6A EP16204182A EP3181164B1 EP 3181164 B1 EP3181164 B1 EP 3181164B1 EP 16204182 A EP16204182 A EP 16204182A EP 3181164 B1 EP3181164 B1 EP 3181164B1
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- European Patent Office
- Prior art keywords
- blood
- filtering device
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- section
- main section
- Prior art date
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- 239000008280 blood Substances 0.000 title claims description 44
- 210000004369 blood Anatomy 0.000 title claims description 44
- 238000001914 filtration Methods 0.000 claims description 36
- 238000006213 oxygenation reaction Methods 0.000 claims description 20
- 238000005086 pumping Methods 0.000 claims description 17
- 239000000126 substance Substances 0.000 claims description 9
- 238000011144 upstream manufacturing Methods 0.000 claims description 7
- 238000001802 infusion Methods 0.000 claims description 6
- 238000000926 separation method Methods 0.000 claims description 4
- 239000002699 waste material Substances 0.000 claims description 4
- 238000002560 therapeutic procedure Methods 0.000 description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 238000002644 respiratory therapy Methods 0.000 description 2
- 239000001569 carbon dioxide Substances 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000002618 extracorporeal membrane oxygenation Methods 0.000 description 1
- 238000002615 hemofiltration Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000012959 renal replacement therapy Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1698—Blood oxygenators with or without heat-exchangers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/20—Type thereof
- A61M60/205—Non-positive displacement blood pumps
- A61M60/216—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
- A61M60/226—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller the blood flow through the rotating member having mainly radial components
- A61M60/232—Centrifugal pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/32—Oxygenators without membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3403—Regulation parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3424—Substitution fluid path
- A61M1/3437—Substitution fluid path downstream of the filter, e.g. post-dilution with filtrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/104—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body
- A61M60/109—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems
- A61M60/113—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/20—Type thereof
- A61M60/247—Positive displacement blood pumps
- A61M60/253—Positive displacement blood pumps including a displacement member directly acting on the blood
- A61M60/268—Positive displacement blood pumps including a displacement member directly acting on the blood the displacement member being flexible, e.g. membranes, diaphragms or bladders
- A61M60/279—Peristaltic pumps, e.g. roller pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
- A61M60/36—Medical purposes thereof other than the enhancement of the cardiac output for specific blood treatment; for specific therapy
- A61M60/37—Haemodialysis, haemofiltration or diafiltration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
- A61M60/36—Medical purposes thereof other than the enhancement of the cardiac output for specific blood treatment; for specific therapy
- A61M60/38—Blood oxygenation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
- A61M2205/7581—General characteristics of the apparatus with filters with means for switching over to a fresh filter on clogging or saturation
Definitions
- the present invention relates to an apparatus for the decapneization of blood.
- decapneization is a substitutive respiratory therapy during which oxygen is supplied to the blood and, at the same time, carbon dioxide in excess is eliminated.
- This type of therapy is generally implemented by means of the so-called “oxygenators”, which are precisely suitable for removing CO2 from the incoming blood and enriching it with oxygen.
- Therapies are also known for the filtering of blood providing for the removal of waste substances that have accumulated in the blood for various reasons such as: pathological causes, surgical causes, administration of substances or other. These therapies are performed by means of so-called “blood-filtering machines", which implement the functions normally carried out by healthy kidneys in correct working conditions.
- CRRT cronym for Continuous Renal Replacement Therapy
- This kind of machines to which the patient remains connected also for long periods of time, comprise a filtering device, through which the blood to be treated is conveyed and which is connected to the patient by means of a supply line, adapted to transport the blood to be purified that is drawn from a vein of the patient, and a return line, by means of which the purified blood is reinfused into the patient.
- the extra-renal therapy often needs to be associated with the substitutive respiratory therapy.
- the relevant machines generally comprise a circuit that is composed of a supply line of the blood to be treated, a device for the oxygenation of blood, a filtering device, adapted to remove the waste substances present in the patient, and of a return line for the reinfusion of the treated blood into the patient.
- EP 1 415 673 and EP 1 698 362 Some types of apparatus for the decapneization of blood are known from EP 1 415 673 and EP 1 698 362 .
- EP 1 415 673 describes an apparatus for the decapneization in which the blood to be treated is pushed, by means of a pump, in sequence through the oxygenator and the hemofilter before being reinfused into the patient.
- EP 1 698 362 describes, on the other hand, an apparatus for the decapneization in which the oxygenator and the hemofilter are locked together to form a single body piece.
- the hemofilter can be by-passed, which can, however, lead to the formation of blood stasis and clots which can impair the correct operation of the oxygenator.
- Yorgin et al. discloses a circuit for blood oxygenation with a hemofilter along a bypass line upstream from the oxygenator.
- the main aim of the present invention is to provide an apparatus for the decapneization of blood which allows controlling the filtration of blood irrespective of the oxygenation thereof.
- one object of the present invention is to maintain the oxygenator functioning also during the replacement or maintenance of the hemofilter.
- one object of the present invention is to avoid, during the operation of the oxygenator and the simultaneous exclusion of the hemofilter, the formation of blood stasis.
- Another object of the present invention is to provide an apparatus for the decapneization of blood which allows to overcome the mentioned drawbacks of the prior art within the ambit of a simple, rational, easy, effective to use and affordable solution.
- Figure 1 is a schematic view of an apparatus according to the invention.
- reference numeral 1 is an apparatus for the decapneization of blood.
- the apparatus 1 comprises a supply line 2 of the blood to be treated taken from a patient, at least an oxygenation device 3 for the blood connected at input to the supply line 2, at least a filtering device 4 arranged along the supply line itself and at least a return line 5 connected at output to the oxygenation device 3 and adapted to transport the treated blood to the patient.
- the oxygenation device 3 and the filtering device 4 are therefore both arranged along the supply line 2.
- the supply line 2 comprises a main section, identified in the figures with reference numeral 2a, connectable on one side to the patient and connected on the opposite side to the input of the oxygenation device 3, and a by-pass section, identified in the figures with reference numeral 2b, arranged parallel to the main section 2a and along which the filtering device 4 is arranged.
- the by-pass section 2b therefore has a delivery branch connected on one side to the main section 2a and on the opposite side to the input of the filtering device 4, and a return branch connected on one side to the output of the filtering device 4 and on the opposite side to the main section 2a.
- the delivery branch and the return branch are identified in the figures with reference numerals 6 and 7, respectively.
- the apparatus 1 comprises first pumping means 8 arranged along the main section 2a and adapted to convey the blood to be treated towards the oxygenation device 3.
- the first pumping means 8 are arranged upstream of the by-pass section 2b, i.e. upstream of the delivery branch 6, with respect to the direction of advancement of the blood towards the oxygenation device 3.
- the first pumping means 8 are of the type of a peristaltic pump or, alternatively, of a centrifugal pump. In the latter case, the centrifugal pump allows a prolonged use of the apparatus 1.
- the apparatus 1 also comprises second pumping means 9 arranged along the by-pass section 2b and adapted to convey the blood towards the filtering device 4.
- removable connection means 10 are arranged along the delivery branch 6 and along the return branch 7, which are adapted to allow the separation of a first portion 11 of each of the branches 6 and 7 from a relevant second portion 12, where the second portions 12 are connectable to each other by means of the connection means themselves following the separation from the relevant first portions 11.
- a section is therefore defined that extends parallel to the main section 2a and which is devoid of blood treatment devices.
- the second pumping means 9 are arranged along the first portion 11 of the delivery branch 6, upstream of the filtering device 4 with respect to the direction of blood flow.
- closing means 13 are arranged, of the type of clamps or the like, operable to block the relevant blood passage channels and consequently isolate the filtering device 4.
- the closing means 13 are therefore arranged along the delivery branch 6 and along the return branch 7, respectively upstream and downstream of the relevant connection means 10.
- the closing means 13 are again operated to allow the passage of blood through the relevant second portions 12.
- the apparatus 1 also comprises a discharge line 14 of the waste substances filtered by the filtering device 4, also called ultrafiltrate, which is connected on one side to the filtering device itself and on the other side to a collection bag 15.
- a discharge line 14 of the waste substances filtered by the filtering device 4 also called ultrafiltrate
- an infusion line 16 is also provided of at least one balancing or restoring substance connected to the by-pass section 2b.
- the infusion line 16 is connected on one side to a bag 17 containing the balancing substance to infuse and on the opposite side to the by-pass section 2b, at the first portion 11 of the return branch 7, downstream of the filtering device 4.
- third pumping means 18 are arranged along the infusion line 16 adapted to convey the balancing substance from the bag 17 towards the by-pass section 2b.
- the blood taken from the patient is sent through the first pumping means 8 along the main section 2a towards the oxygenation device 3.
- one part of the blood that runs through the main section 2a reaches the oxygenation device 3 and one part is deflected, through the second pumping means 9, along the by-pass section 2b.
- the part of blood that runs through the delivery branch 6 of the by-pass section 2b is therefore sent by the second pumping means 9 towards the filtering device 4, later on going back inside the main section 2a through the return branch 7.
- first portions 11 together with the filtering device 4 are removed from the connection means 10 and the second portions 12 are connected to one another.
- the second portions 12 connected in this manner then define a section parallel to the main section 2a and devoid of blood treatment devices.
- the passage channel defined by the second portions 12 is reopened, again through the closing means 13, the blood taken from the patient is then entirely sent to the oxygenation device 3 by means of the first pumping means 8.
- the second portions 12 are blocked by means of the closing means 13, so as to prevent the passage of blood through the by-pass section 2b, and the second portions are separated from each other by means of the connection means 10. Subsequently the first portions 11, along which a new filtering device 4 and the second pumping means 9 are positioned, are connected again to the relevant second portions 12 by means of the connection means 10.
- the described invention achieves the intended objects and in particular the fact is underlined that the presence of a by-pass section arranged parallel to the main section and connecting the patient to the oxygenation device allows using the filtering device as an optional treatment, without therefore constraining the filtering step to the oxygenation one.
- the presence of the second pumping means arranged along the by-pass section allows controlling the blood flow rate which undergoes the filtering treatment according to the specific requirements.
- a further advantage of the apparatus to which the present invention relates consists in the fact that the presence of the connection means arranged along the by-pass section allows separating the latter from the main section, in order to allow the replacement of the filtering device, at the same time maintaining the oxygenation device functioning.
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Description
- The present invention relates to an apparatus for the decapneization of blood. As known, decapneization is a substitutive respiratory therapy during which oxygen is supplied to the blood and, at the same time, carbon dioxide in excess is eliminated.
- This type of therapy is generally implemented by means of the so-called "oxygenators", which are precisely suitable for removing CO2 from the incoming blood and enriching it with oxygen.
- Therapies are also known for the filtering of blood providing for the removal of waste substances that have accumulated in the blood for various reasons such as: pathological causes, surgical causes, administration of substances or other. These therapies are performed by means of so-called "blood-filtering machines", which implement the functions normally carried out by healthy kidneys in correct working conditions.
- One therapy of this type is, e.g., CRRT (acronym for Continuous Renal Replacement Therapy).
- This kind of machines, to which the patient remains connected also for long periods of time, comprise a filtering device, through which the blood to be treated is conveyed and which is connected to the patient by means of a supply line, adapted to transport the blood to be purified that is drawn from a vein of the patient, and a return line, by means of which the purified blood is reinfused into the patient.
- The extra-renal therapy often needs to be associated with the substitutive respiratory therapy.
- The relevant machines generally comprise a circuit that is composed of a supply line of the blood to be treated, a device for the oxygenation of blood, a filtering device, adapted to remove the waste substances present in the patient, and of a return line for the reinfusion of the treated blood into the patient.
- Some types of apparatus for the decapneization of blood are known from
EP 1 415 673EP 1 698 362 -
EP 1 415 673 -
EP 1 698 362 - These apparatuses of known type do have some drawbacks.
- One drawback consists in the fact that the blood running through the supply line is constrained to pass through both the oxygenator and the hemofilter in sequence. This makes, however, impractical the simultaneous use of the two devices for a long time, because the oxygenator and the hemofilter are characterized by different operating ranges, in particular the oxygenator has a greater operating range (4/5 days approx.) than the hemofilter (24 hours approx.).
- This drawback implies using the machine for the decapneization depending on the operating range of the hemofilter or replacing or by-passing the hemofilter while maintaining, at the same time, the oxygenator functioning.
- In the cases in which the circuit configuration makes this possible, the hemofilter can be by-passed, which can, however, lead to the formation of blood stasis and clots which can impair the correct operation of the oxygenator. Yorgin et al. (Where should the hemofiltration circuit be placed in relation to the extracorporeal membrane oxygenation circuit?; ASAIO JOURNAL, vol. 38, no. 4; 1992-10-01) discloses a circuit for blood oxygenation with a hemofilter along a bypass line upstream from the oxygenator. The main aim of the present invention is to provide an apparatus for the decapneization of blood which allows controlling the filtration of blood irrespective of the oxygenation thereof.
- Within this aim, one object of the present invention is to maintain the oxygenator functioning also during the replacement or maintenance of the hemofilter.
- More particularly, one object of the present invention is to avoid, during the operation of the oxygenator and the simultaneous exclusion of the hemofilter, the formation of blood stasis.
- Another object of the present invention is to provide an apparatus for the decapneization of blood which allows to overcome the mentioned drawbacks of the prior art within the ambit of a simple, rational, easy, effective to use and affordable solution.
- The above mentioned objects are achieved by the present apparatus according to
claim 1. - Other characteristics and advantages of the present invention will become better evident from the description of a preferred, but not exclusive, embodiment of an apparatus for the decapneization of blood, illustrated by way of an indicative, but non-limiting, example in the accompanying drawings, wherein:
Figure 1 is a schematic view of an apparatus according to the invention. - With particular reference to such illustrations, globally indicated with
reference numeral 1 is an apparatus for the decapneization of blood. - The
apparatus 1 comprises asupply line 2 of the blood to be treated taken from a patient, at least anoxygenation device 3 for the blood connected at input to thesupply line 2, at least a filtering device 4 arranged along the supply line itself and at least a return line 5 connected at output to theoxygenation device 3 and adapted to transport the treated blood to the patient. - The
oxygenation device 3 and the filtering device 4 are therefore both arranged along thesupply line 2. - The
supply line 2 comprises a main section, identified in the figures withreference numeral 2a, connectable on one side to the patient and connected on the opposite side to the input of theoxygenation device 3, and a by-pass section, identified in the figures withreference numeral 2b, arranged parallel to themain section 2a and along which the filtering device 4 is arranged. - The by-
pass section 2b therefore has a delivery branch connected on one side to themain section 2a and on the opposite side to the input of the filtering device 4, and a return branch connected on one side to the output of the filtering device 4 and on the opposite side to themain section 2a. The delivery branch and the return branch are identified in the figures withreference numerals - Advantageously, the
apparatus 1 comprises first pumping means 8 arranged along themain section 2a and adapted to convey the blood to be treated towards theoxygenation device 3. - The first pumping means 8 are arranged upstream of the by-
pass section 2b, i.e. upstream of thedelivery branch 6, with respect to the direction of advancement of the blood towards theoxygenation device 3. - The first pumping means 8 are of the type of a peristaltic pump or, alternatively, of a centrifugal pump. In the latter case, the centrifugal pump allows a prolonged use of the
apparatus 1. - Conveniently, the
apparatus 1 also comprises second pumping means 9 arranged along the by-pass section 2b and adapted to convey the blood towards the filtering device 4. - According to the invention, removable connection means 10 are arranged along the
delivery branch 6 and along thereturn branch 7, which are adapted to allow the separation of afirst portion 11 of each of thebranches second portion 12, where thesecond portions 12 are connectable to each other by means of the connection means themselves following the separation from the relevantfirst portions 11. - By joining the
second portions 12 together, a section is therefore defined that extends parallel to themain section 2a and which is devoid of blood treatment devices. - Conveniently, the second pumping means 9 are arranged along the
first portion 11 of thedelivery branch 6, upstream of the filtering device 4 with respect to the direction of blood flow. - Along the by-
pass section 2b, and more particularly along the relevantsecond portions 12,closing means 13 are arranged, of the type of clamps or the like, operable to block the relevant blood passage channels and consequently isolate the filtering device 4. Theclosing means 13 are therefore arranged along thedelivery branch 6 and along thereturn branch 7, respectively upstream and downstream of the relevant connection means 10. - Following the mutual linkage of the connection means 10, the closing means 13 are again operated to allow the passage of blood through the relevant
second portions 12. - The
apparatus 1 also comprises adischarge line 14 of the waste substances filtered by the filtering device 4, also called ultrafiltrate, which is connected on one side to the filtering device itself and on the other side to acollection bag 15. Preferably aninfusion line 16 is also provided of at least one balancing or restoring substance connected to the by-pass section 2b. - More particularly, the
infusion line 16 is connected on one side to abag 17 containing the balancing substance to infuse and on the opposite side to the by-pass section 2b, at thefirst portion 11 of thereturn branch 7, downstream of the filtering device 4. - Conveniently, third pumping means 18 are arranged along the
infusion line 16 adapted to convey the balancing substance from thebag 17 towards the by-pass section 2b. - The operation of the present invention is as follows.
- In normal operating conditions, i.e. in the case in which the
oxygenation device 3 and the filtering device 4 are both functioning, the blood taken from the patient is sent through the first pumping means 8 along themain section 2a towards theoxygenation device 3. - More in detail, one part of the blood that runs through the
main section 2a reaches theoxygenation device 3 and one part is deflected, through the second pumping means 9, along the by-pass section 2b. The part of blood that runs through thedelivery branch 6 of the by-pass section 2b is therefore sent by the second pumping means 9 towards the filtering device 4, later on going back inside themain section 2a through thereturn branch 7. - When it is necessary to replace the filtering device 4, in order to maintain the
oxygenation device 3 functioning, the by-pass section 2b is blocked by means of the closing means 13. - Subsequently the
first portions 11 together with the filtering device 4 are removed from the connection means 10 and thesecond portions 12 are connected to one another. Thesecond portions 12 connected in this manner then define a section parallel to themain section 2a and devoid of blood treatment devices. Once the passage channel defined by thesecond portions 12 is reopened, again through the closing means 13, the blood taken from the patient is then entirely sent to theoxygenation device 3 by means of the first pumping means 8. - When the operator wishes to restore the complete functionality of the
apparatus 1, by inserting again the filtering device 4, he/she should perform the aforementioned operations but in the reverse sequence. More in detail, thesecond portions 12 are blocked by means of the closing means 13, so as to prevent the passage of blood through the by-pass section 2b, and the second portions are separated from each other by means of the connection means 10. Subsequently thefirst portions 11, along which a new filtering device 4 and the second pumping means 9 are positioned, are connected again to the relevantsecond portions 12 by means of the connection means 10. - It has in practice been ascertained that the described invention achieves the intended objects and in particular the fact is underlined that the presence of a by-pass section arranged parallel to the main section and connecting the patient to the oxygenation device allows using the filtering device as an optional treatment, without therefore constraining the filtering step to the oxygenation one.
- More in particular, the presence of the second pumping means arranged along the by-pass section allows controlling the blood flow rate which undergoes the filtering treatment according to the specific requirements.
- A further advantage of the apparatus to which the present invention relates consists in the fact that the presence of the connection means arranged along the by-pass section allows separating the latter from the main section, in order to allow the replacement of the filtering device, at the same time maintaining the oxygenation device functioning.
Claims (10)
- Apparatus (1) for the decapneization of blood, comprising:- a supply line (2) of the blood to be treated taken from a patient and at least a return line (5) adapted to transport the treated blood to the patient;- at least an oxygenation device (3) and at least a filtering device (4) of the blood positioned between said supply line (2) and said return line (5);where said supply line (2) comprises a main section (2a), connectable on one side to the patient and connected on the opposite side to said oxygenation device (3), and a by-pass section (2b), arranged parallel to said main section (2a) and along which said filtering device (4) is arranged,
characterized by the fact that said by-pass section (2b) comprises a delivery branch (6), connected on one side to said main section (2a) and on the other side to the input of said filtering device (4), and a return branch (7), connected on one side to the output of the filtering device (4) and on the other side to said main section (2a), and by the fact that it comprises removable connection means (10), arranged along said branches (6, 7) and adapted to allow the separation of a first portion (11) of the branches themselves which is connected to said filtering device (4), from a respective second portion (12) connected to said main section (2a), said second portions (12) being connectable to each other by means of the connection means themselves following the separation from their respective first portions (11). - Apparatus (1) according to claim 1, characterized by the fact that it comprises first pumping means (8) arranged along said main section (2a), upstream of said by-pass section (2b), and adapted to convey the blood to be treated towards said oxygenation device (3).
- Apparatus (1) according to claim 2, characterized by the fact that said first pumping means (8) are of the type of a centrifugal pump.
- Apparatus (1) according to one or more of the preceding claims, characterized by the fact that it comprises second pumping means (9) arranged along said by-pass section (2b) and adapted to convey the blood to be treated towards said filtering device (4).
- Apparatus (1) according to one or more of the preceding claims, characterized by the fact that said second pumping means (9) are arranged downstream of said connection means (10) along the first portion (11) of said delivery branch and upstream of the filtering device (4).
- Apparatus (1) according to one or more of the preceding claims, characterized by the fact that it comprises closing means (13) of said by-pass section (2b) arranged along said second portions (12).
- Apparatus (1) according to one or more of the preceding claims, characterized by the fact that it comprises at least a discharge line (14) of the waste substances filtered by said filtering device (4), connected on one side to the filtering device itself and connectable on the other side to a collection bag (15).
- Apparatus (1) according to one or more of the preceding claims, characterized by the fact that it comprises at least one infusion line (16) of at least one balancing substance connected to said by-pass section (2b).
- Apparatus (1) according to claim 8, characterized by the fact that said infusion line (16) is connected to said by-pass section (2b) at the first portion (11) of said return branch (7), downstream of said filtering device (4).
- Apparatus (1) according to claim 8 or 9, characterized by the fact that it comprises third pumping means (18) arranged along said infusion line (16).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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ITUB2015A009161A ITUB20159161A1 (en) | 2015-12-18 | 2015-12-18 | EQUIPMENT FOR BLOOD DECAPNIZATION |
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EP3181164A1 EP3181164A1 (en) | 2017-06-21 |
EP3181164B1 true EP3181164B1 (en) | 2018-08-15 |
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EP16204182.6A Active EP3181164B1 (en) | 2015-12-18 | 2016-12-14 | Apparatus for the decapneization of blood |
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IT (1) | ITUB20159161A1 (en) |
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DE102021109242A1 (en) | 2021-04-13 | 2022-10-13 | B.Braun Avitum Ag | Extracorporeal circuit for decapneization of organic fluids |
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ITFI20020208A1 (en) * | 2002-10-31 | 2004-05-01 | Torre Florenziano Della | EQUIPMENT USED IN HEMOFILTRATION TREATMENTS. |
ITMI20030696A1 (en) * | 2003-04-08 | 2004-10-09 | Crb Nederland B V | EQUIPMENT AND PROCEDURE PARTICULARLY FOR THE REPLACEMENT OF CLOSED CIRCUIT ELEMENTS FOR EXTRA-BODY CIRCULATION |
ITTO20030785A1 (en) | 2003-10-03 | 2005-04-04 | Mri S R L Societa Unipersonale | BLOOD FILTERING UNIT IN AN EMOFILTRATION MACHINE. |
JP2007167672A (en) * | 2007-02-09 | 2007-07-05 | Senko Medical Instr Mfg Co Ltd | Extracorporeal circulation circuit |
JP2010528781A (en) * | 2007-06-06 | 2010-08-26 | ジョージア テック リサーチ コーポレーション | A novel fluid management system for precise and continuous hemofiltration in extracorporeal membrane oxygenation therapy |
CN202270211U (en) * | 2011-09-28 | 2012-06-13 | 虞文魁 | Integral device of extracorporeal membrane oxygenation oxygenator and hemofiltration machine |
EP3237034A1 (en) * | 2014-12-22 | 2017-11-01 | Extra Corporeal Solutions S.r.l. | Apparatus for the treatment of blood |
-
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