EP3177322A4 - Anticorps anti-trem2 et leurs procédés d'utilisation - Google Patents
Anticorps anti-trem2 et leurs procédés d'utilisation Download PDFInfo
- Publication number
- EP3177322A4 EP3177322A4 EP15830235.6A EP15830235A EP3177322A4 EP 3177322 A4 EP3177322 A4 EP 3177322A4 EP 15830235 A EP15830235 A EP 15830235A EP 3177322 A4 EP3177322 A4 EP 3177322A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- methods
- trem2 antibodies
- trem2
- antibodies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP21189092.6A EP4066859A1 (fr) | 2014-08-08 | 2015-08-08 | Anticorps anti-trem2 et leurs procédés d'utilisation |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462035336P | 2014-08-08 | 2014-08-08 | |
US201562135122P | 2015-03-18 | 2015-03-18 | |
US201562135110P | 2015-03-18 | 2015-03-18 | |
PCT/US2015/044396 WO2016023019A2 (fr) | 2014-08-08 | 2015-08-08 | Anticorps anti-trem2 et leurs procédés d'utilisation |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP21189092.6A Division EP4066859A1 (fr) | 2014-08-08 | 2015-08-08 | Anticorps anti-trem2 et leurs procédés d'utilisation |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3177322A2 EP3177322A2 (fr) | 2017-06-14 |
EP3177322A4 true EP3177322A4 (fr) | 2018-07-18 |
Family
ID=55264791
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP21189092.6A Pending EP4066859A1 (fr) | 2014-08-08 | 2015-08-08 | Anticorps anti-trem2 et leurs procédés d'utilisation |
EP15830235.6A Ceased EP3177322A4 (fr) | 2014-08-08 | 2015-08-08 | Anticorps anti-trem2 et leurs procédés d'utilisation |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP21189092.6A Pending EP4066859A1 (fr) | 2014-08-08 | 2015-08-08 | Anticorps anti-trem2 et leurs procédés d'utilisation |
Country Status (12)
Country | Link |
---|---|
US (4) | US20170240631A1 (fr) |
EP (2) | EP4066859A1 (fr) |
JP (3) | JP6669749B2 (fr) |
CN (1) | CN107106679B (fr) |
AU (2) | AU2015300787A1 (fr) |
CA (2) | CA2955086A1 (fr) |
EA (1) | EA201790342A1 (fr) |
HK (1) | HK1243006A1 (fr) |
IL (2) | IL279606B (fr) |
MX (2) | MX2017001531A (fr) |
SG (2) | SG10201913611QA (fr) |
WO (1) | WO2016023019A2 (fr) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG10201913611QA (en) | 2014-08-08 | 2020-03-30 | Alector Llc | Anti-trem2 antibodies and methods of use thereof |
KR20240056629A (ko) * | 2014-09-28 | 2024-04-30 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 자극성 및 비자극성 골수성 세포의 조절 |
WO2017058866A1 (fr) * | 2015-09-28 | 2017-04-06 | Precision Immune, Inc. | Anticorps anti-trem2 et leurs utilisations |
KR20180068999A (ko) * | 2015-10-06 | 2018-06-22 | 알렉터 엘엘씨 | 항-trem2 항체 및 그의 사용방법 |
AR107505A1 (es) | 2016-01-22 | 2018-05-09 | Merck Sharp & Dohme | Anticuerpos anti-factor de la coagulación xi |
TN2018000417A1 (en) | 2016-06-14 | 2020-06-15 | Adimab Llc | Anti-coagulation factor xi antibodies. |
EP3487886A2 (fr) | 2016-07-22 | 2019-05-29 | Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) | Modulateurs du clivage de trem2 et leurs utilisations |
JOP20190243A1 (ar) * | 2017-04-12 | 2019-10-13 | Medimmune Llc | علاج الربو بجسم مضاد لـ tslp |
CN108727489B (zh) * | 2017-04-19 | 2021-02-09 | 广州市第八人民医院 | 一种单克隆抗体zk2c2及应用 |
JOP20190248A1 (ar) | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
EP3625258A1 (fr) | 2017-05-16 | 2020-03-25 | Alector LLC | Anticorps anti-siglec-5 et leurs procédés d'utilisation |
WO2019014667A1 (fr) | 2017-07-14 | 2019-01-17 | The Regents Of The University Of California | Nouveaux procédés de prédiction du risque de rejet de greffe |
BR112019022752A2 (pt) | 2017-08-03 | 2020-05-19 | Alector Llc | anticorpos anti-trem2 e métodos de uso dos mesmos |
CN111448212A (zh) * | 2017-09-14 | 2020-07-24 | 戴纳立制药公司 | 抗trem2抗体及其使用方法 |
KR20220015499A (ko) * | 2017-10-03 | 2022-02-08 | 프리베일 테라퓨틱스, 인크. | 리소좀 장애를 위한 유전자 요법 |
CA3083660A1 (fr) * | 2017-12-12 | 2019-06-20 | Pionyr Immunotherapeutics, Inc. | Anticorps anti-trem2 et methodes associees |
CN111699003B (zh) | 2017-12-19 | 2024-05-03 | 瑟罗泽恩奥普瑞汀公司 | 抗lrp5/6抗体和使用方法 |
EP3728323A4 (fr) * | 2017-12-19 | 2022-01-26 | Surrozen Operating, Inc. | Anticorps anti-fzd et méthodes d'utilisation |
EP3732201A4 (fr) * | 2017-12-19 | 2022-04-20 | Surrozen Operating, Inc. | Molécules de substitution de wnt et leurs utilisations |
CN111886246A (zh) * | 2017-12-29 | 2020-11-03 | 艾莱克特有限责任公司 | 抗tmem106b抗体及其使用方法 |
CN112566934A (zh) * | 2018-01-23 | 2021-03-26 | 奈斯科尔公司 | B7-h4抗体及其使用方法 |
MA52753A (fr) | 2018-05-25 | 2021-04-21 | Alector Llc | Anticorps anti-sirpa et leurs procédés d'utilisation |
SG11202100555PA (en) * | 2018-07-27 | 2021-02-25 | Alector Llc | Anti-siglec-5 antibodies and methods of use thereof |
MX2021002616A (es) * | 2018-09-11 | 2021-05-12 | Washington University St Louis | Anticuerpos agonistas anti receptor desencadenante expresado en celulas mieloides 2 (trem-2). |
UY38407A (es) * | 2018-10-15 | 2020-05-29 | Novartis Ag | Anticuerpos estabilizadores de trem2 |
KR102156165B1 (ko) * | 2018-10-29 | 2020-09-15 | 재단법인대구경북과학기술원 | 인간 trem2 세포막 단백질에 대한 단일클론항체, 이를 생산하는 하이브리도마 세포주 및 이의 용도 |
MA54296A (fr) | 2018-11-26 | 2021-10-06 | Denali Therapeutics Inc | Procédés de traitement du métabolisme lipidique dérégulé |
WO2020121195A1 (fr) * | 2018-12-10 | 2020-06-18 | Mor Research Applications | Anticorps trem2 et leurs utilisations |
WO2020123664A1 (fr) * | 2018-12-11 | 2020-06-18 | Pionyr Immunotherapeutics, Inc. | Méthodes d'utilisation d'anticorps anti-trem2 |
CN109646668B (zh) * | 2019-01-04 | 2019-10-18 | 厦门大学 | 一种多肽用于制备防治阿尔茨海默病药物的用途 |
MA55025A (fr) * | 2019-02-20 | 2021-12-29 | Denali Therapeutics Inc | Anticorps anti-trem2 et leurs procédés d'utilisation |
WO2020194317A1 (fr) * | 2019-03-28 | 2020-10-01 | Yeda Research And Development Co. Ltd. | Méthode de traitement de troubles liés aux lipides |
CN110320368A (zh) * | 2019-05-30 | 2019-10-11 | 广州医科大学附属第一医院(广州呼吸中心) | 基于trem2的诊断试剂盒及其在帕金森病诊断产品上的应用 |
EP3994159A4 (fr) * | 2019-07-05 | 2023-08-09 | University of Florida Research Foundation, Incorporated | Méthodes de traitement de maladies neurologiques associées à la protéine ran |
JP2022540674A (ja) * | 2019-07-15 | 2022-09-16 | ブリストル-マイヤーズ スクイブ カンパニー | 抗trem-1抗体およびその使用 |
EP4031178A1 (fr) * | 2019-09-16 | 2022-07-27 | Surface Oncology, Inc. | Compositions d'anticorps anti-cd39 et procédés associés |
EP4061842A1 (fr) | 2019-11-22 | 2022-09-28 | Eli Lilly and Company | Anticorps trem2 et leurs utilisations |
CN111000978B (zh) * | 2019-11-22 | 2023-03-10 | 中山大学附属第五医院 | Tlt-2在制备治疗结核病药物中的应用 |
BR112022013756A2 (pt) | 2020-01-13 | 2022-10-11 | Denali Therapeutics Inc | Anticorpos anti-trem2 e métodos de uso dos mesmos |
IL272390A (en) | 2020-01-30 | 2021-08-31 | Yeda Res & Dev | Cancer treatment methods |
WO2021174003A2 (fr) * | 2020-02-26 | 2021-09-02 | Washington University | Compositions et méthodes pour réduire la résistance à l'immunothérapie ou améliorer celle-ci |
CA3190581A1 (fr) * | 2020-08-05 | 2022-02-10 | Vigil Neuroscience, Inc. | Traitement de maladies associees au dysfonctionnement du recepteur de facteur 1 de stimulation des colonies au moyen d'agonistes de trem2 |
CN112526143B (zh) * | 2020-12-03 | 2021-08-03 | 中山大学附属第五医院 | 髓系细胞触发受体2作为新型冠状病毒肺炎诊断或治疗靶点的应用 |
CN115109150A (zh) * | 2021-01-31 | 2022-09-27 | 中南大学湘雅医院 | 新型冠状病毒单克隆抗体xy10及其应用 |
WO2023092146A1 (fr) * | 2021-11-22 | 2023-05-25 | Vigil Neuroscience, Inc. | Anticorps anti-trem2 et ses utilisations |
WO2023114499A1 (fr) | 2021-12-17 | 2023-06-22 | Denali Therapeutics Inc. | Ingénierie polypeptidique, bibliothèques et polypeptides ingéniérisés de liaison de chaîne lourde cd98 et de récepteur de transferrine |
JP7452918B2 (ja) | 2021-12-22 | 2024-03-19 | 国立大学法人 鹿児島大学 | マクロファージの製造方法、分化誘導剤、分化誘導キット、マクロファージの分化誘導方法、マクロファージの増殖促進剤、マクロファージの増殖促進キット、マクロファージの増殖方法及びマクロファージ |
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CN114395034B (zh) * | 2022-03-24 | 2022-08-05 | 中国科学院微生物研究所 | 一种高效中和新型冠状病毒的人源抗体及其应用 |
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Publication number | Publication date |
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US20230107639A1 (en) | 2023-04-06 |
CA2955086A1 (fr) | 2016-02-11 |
MX2023000334A (es) | 2023-02-09 |
WO2016023019A2 (fr) | 2016-02-11 |
EA201790342A1 (ru) | 2017-07-31 |
MX2017001531A (es) | 2017-05-15 |
IL250115B (en) | 2021-01-31 |
JP2022081543A (ja) | 2022-05-31 |
JP7326135B2 (ja) | 2023-08-15 |
US20190315858A1 (en) | 2019-10-17 |
IL279606A (en) | 2021-03-01 |
IL250115A0 (en) | 2017-03-30 |
CN107106679B (zh) | 2022-07-26 |
SG10201913611QA (en) | 2020-03-30 |
US11084875B2 (en) | 2021-08-10 |
WO2016023019A3 (fr) | 2016-07-28 |
US20190010230A1 (en) | 2019-01-10 |
EP4066859A1 (fr) | 2022-10-05 |
JP2017523814A (ja) | 2017-08-24 |
CA3090240A1 (fr) | 2016-02-11 |
AU2015300787A1 (en) | 2017-02-02 |
CN107106679A (zh) | 2017-08-29 |
US20170240631A1 (en) | 2017-08-24 |
EP3177322A2 (fr) | 2017-06-14 |
SG11201700901SA (en) | 2017-03-30 |
IL279606B (en) | 2022-08-01 |
JP2020063268A (ja) | 2020-04-23 |
JP6669749B2 (ja) | 2020-03-18 |
AU2021202840A1 (en) | 2021-06-03 |
HK1243006A1 (zh) | 2018-07-06 |
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