EP3146455A4 - Molecular signatures for distinguishing liver transplant rejections or injuries - Google Patents

Molecular signatures for distinguishing liver transplant rejections or injuries Download PDF

Info

Publication number
EP3146455A4
EP3146455A4 EP15795453.8A EP15795453A EP3146455A4 EP 3146455 A4 EP3146455 A4 EP 3146455A4 EP 15795453 A EP15795453 A EP 15795453A EP 3146455 A4 EP3146455 A4 EP 3146455A4
Authority
EP
European Patent Office
Prior art keywords
injuries
liver transplant
molecular signatures
transplant rejections
distinguishing liver
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP15795453.8A
Other languages
German (de)
French (fr)
Other versions
EP3146455A2 (en
Inventor
Daniel R. Salomon
Josh LEVITSKY
Sunil KURIAN
Michael Abecassis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Northwestern University
Original Assignee
Scripps Research Institute
Northwestern University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2014/054735 external-priority patent/WO2015035367A1/en
Application filed by Scripps Research Institute, Northwestern University filed Critical Scripps Research Institute
Priority to EP20193129.2A priority Critical patent/EP3825418A3/en
Publication of EP3146455A2 publication Critical patent/EP3146455A2/en
Publication of EP3146455A4 publication Critical patent/EP3146455A4/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • G01N2800/245—Transplantation related diseases, e.g. graft versus host disease

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP15795453.8A 2014-05-22 2015-05-22 Molecular signatures for distinguishing liver transplant rejections or injuries Ceased EP3146455A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP20193129.2A EP3825418A3 (en) 2014-05-22 2015-05-22 Molecular signatures for distinguishing liver transplant rejections or injuries

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462001902P 2014-05-22 2014-05-22
US201462001909P 2014-05-22 2014-05-22
US201462001889P 2014-05-22 2014-05-22
US201462029038P 2014-07-25 2014-07-25
PCT/US2014/054735 WO2015035367A1 (en) 2013-09-09 2014-09-09 Methods and systems for analysis of organ transplantation
US14/481,167 US20150167085A1 (en) 2013-09-09 2014-09-09 Methods and Systems for Analysis of Organ Transplantation
PCT/US2015/032191 WO2015179771A2 (en) 2014-05-22 2015-05-22 Molecular signatures for distinguishing liver transplant rejections or injuries

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP20193129.2A Division EP3825418A3 (en) 2014-05-22 2015-05-22 Molecular signatures for distinguishing liver transplant rejections or injuries

Publications (2)

Publication Number Publication Date
EP3146455A2 EP3146455A2 (en) 2017-03-29
EP3146455A4 true EP3146455A4 (en) 2018-05-02

Family

ID=54554839

Family Applications (2)

Application Number Title Priority Date Filing Date
EP15795453.8A Ceased EP3146455A4 (en) 2014-05-22 2015-05-22 Molecular signatures for distinguishing liver transplant rejections or injuries
EP20193129.2A Pending EP3825418A3 (en) 2014-05-22 2015-05-22 Molecular signatures for distinguishing liver transplant rejections or injuries

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP20193129.2A Pending EP3825418A3 (en) 2014-05-22 2015-05-22 Molecular signatures for distinguishing liver transplant rejections or injuries

Country Status (6)

Country Link
EP (2) EP3146455A4 (en)
CN (1) CN106661628A (en)
AU (2) AU2015263998A1 (en)
CA (1) CA2949959A1 (en)
GB (1) GB2538006A (en)
WO (1) WO2015179771A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
DE102020205364B4 (en) * 2020-04-28 2022-01-20 Universität Rostock Method of monitoring the progress of cardiomyocyte transplantation and method of determining whether a subject is eligible for cardiomyocyte transplantation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010083121A1 (en) * 2009-01-15 2010-07-22 The Board Of Trustees Of The Leland Stanford Junior University Biomarker panel for diagnosis and prediction of graft rejection

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US5922615A (en) 1990-03-12 1999-07-13 Biosite Diagnostics Incorporated Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
WO1992005282A1 (en) 1990-09-14 1992-04-02 Biosite Diagnostics, Inc. Antibodies to complexes of ligand receptors and ligands and their utility in ligand-receptor assays
CA2107894C (en) 1991-04-10 2003-10-14 Kenneth F. Buechler Crosstalk inhibitors and their uses
AU1911592A (en) 1991-04-10 1992-11-17 Biosite Diagnostics Incorporated Novel conjugates and assays for simultaneous detection of multiple ligands
US5885527A (en) 1992-05-21 1999-03-23 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membrances
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US6143576A (en) 1992-05-21 2000-11-07 Biosite Diagnostics, Inc. Non-porous diagnostic devices for the controlled movement of reagents
US5824799A (en) 1993-09-24 1998-10-20 Biosite Diagnostics Incorporated Hybrid phthalocyanine derivatives and their uses
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
AU2253397A (en) 1996-01-23 1997-08-20 Affymetrix, Inc. Nucleic acid analysis techniques
US6113855A (en) 1996-11-15 2000-09-05 Biosite Diagnostics, Inc. Devices comprising multiple capillarity inducing surfaces
US5947124A (en) 1997-03-11 1999-09-07 Biosite Diagnostics Incorporated Diagnostic for determining the time of a heart attack
US5863736A (en) 1997-05-23 1999-01-26 Becton, Dickinson And Company Method, apparatus and computer program products for determining quantities of nucleic acid sequences in samples
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
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DE10238922A1 (en) * 2002-08-22 2004-03-04 Universitätsklinikum Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin Immune markers for diagnosis and therapy in connection with graft reactions
CA2511501A1 (en) 2002-12-24 2004-07-15 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
GB0419728D0 (en) * 2004-09-06 2004-10-06 Novartis Ag Organic compounds
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WO2009143624A1 (en) * 2008-05-30 2009-12-03 The University Of British Columbia Methods of diagnosing rejection of a kidney allograft using genomic or proteomic expression profiling
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CA2767616A1 (en) * 2009-07-09 2011-01-13 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
EP2550371A4 (en) * 2010-03-25 2013-11-20 Univ Leland Stanford Junior Protein and gene biomarkers for rejection of organ transplants
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CN102854305B (en) * 2011-12-23 2013-08-07 中国人民解放军第三〇九医院 Prewarning kit for transplant kidney rejection and use method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010083121A1 (en) * 2009-01-15 2010-07-22 The Board Of Trustees Of The Leland Stanford Junior University Biomarker panel for diagnosis and prediction of graft rejection

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
OMAR MASSOUD ET AL: "Noninvasive diagnosis of acute cellular rejection in liver transplant recipients: A proteomic signature validated by enzyme-linked immunosorbent assay", LIVER TRANSPLANTATION, vol. 17, no. 6, June 2011 (2011-06-01), US, pages 723 - 732, XP055429735, ISSN: 1527-6465, DOI: 10.1002/lt.22266 *
RICARDO GEHRAU ET AL: "Molecular Pathways Differentiate Hepatitis C Virus (HCV) Recurrence from Acute Cellular Rejection in HCV Liver Recipients", MOLECULAR MEDICINE, vol. 17, no. 7-8, 2011, WASHINGTON, DC; US, pages 1, XP055429673, ISSN: 1076-1551, DOI: 10.2119/molmed.2011.00072 *
V. DEFAMIE ET AL: "Gene Expression Profiling of Human Liver Transplants Identifies an Early Transcriptional Signature Associated with Initial Poor Graft Function", AMERICAN JOURNAL OF TRANSPLANTATION, vol. 8, no. 6, June 2008 (2008-06-01), DK, pages 1221 - 1236, XP055429716, ISSN: 1600-6135, DOI: 10.1111/j.1600-6143.2008.02249.x *
WAQAR R. R. FARID ET AL: "Hepatocyte-derived microRNAs as serum biomarkers of hepatic injury and rejection after liver transplantation", LIVER TRANSPLANTATION, vol. 18, no. 3, March 2012 (2012-03-01), US, pages 290 - 297, XP055429767, ISSN: 1527-6465, DOI: 10.1002/lt.22438 *

Also Published As

Publication number Publication date
EP3146455A2 (en) 2017-03-29
CN106661628A (en) 2017-05-10
GB201609984D0 (en) 2016-07-20
EP3825418A3 (en) 2021-09-15
EP3825418A2 (en) 2021-05-26
CA2949959A1 (en) 2015-11-26
WO2015179771A3 (en) 2016-01-14
WO2015179771A2 (en) 2015-11-26
GB2538006A (en) 2016-11-02
AU2021221905A1 (en) 2021-09-23
AU2015263998A1 (en) 2016-12-08

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