EP3145401A1 - VERFAHREN UND ANORDNUNG ZUR VERGRÖßERUNG DES SIGNAL-RAUSCHABSTANDES VON EVOZIERTEN UND EREIGNISKORRELIERTEN POTENZIALEN IN DEN ABLEITUNGEN EINER NEURONALEN AKTIVITÄT - Google Patents
VERFAHREN UND ANORDNUNG ZUR VERGRÖßERUNG DES SIGNAL-RAUSCHABSTANDES VON EVOZIERTEN UND EREIGNISKORRELIERTEN POTENZIALEN IN DEN ABLEITUNGEN EINER NEURONALEN AKTIVITÄTInfo
- Publication number
- EP3145401A1 EP3145401A1 EP15727570.2A EP15727570A EP3145401A1 EP 3145401 A1 EP3145401 A1 EP 3145401A1 EP 15727570 A EP15727570 A EP 15727570A EP 3145401 A1 EP3145401 A1 EP 3145401A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- signals
- single sweep
- signal
- phase
- phases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title claims abstract description 46
- 230000000763 evoking effect Effects 0.000 title claims abstract description 30
- 230000001537 neural effect Effects 0.000 title claims abstract description 23
- 230000001965 increasing effect Effects 0.000 title claims abstract description 13
- 239000011159 matrix material Substances 0.000 claims abstract description 27
- 230000009466 transformation Effects 0.000 claims abstract description 12
- 230000008859 change Effects 0.000 claims description 8
- 238000001514 detection method Methods 0.000 claims description 6
- 238000012935 Averaging Methods 0.000 claims description 5
- 238000000605 extraction Methods 0.000 claims description 5
- 238000009499 grossing Methods 0.000 claims description 5
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- 238000004590 computer program Methods 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 230000001105 regulatory effect Effects 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 2
- 230000002123 temporal effect Effects 0.000 claims description 2
- 230000008901 benefit Effects 0.000 abstract description 4
- 230000001131 transforming effect Effects 0.000 abstract 1
- 238000010586 diagram Methods 0.000 description 10
- 230000009467 reduction Effects 0.000 description 9
- 238000004458 analytical method Methods 0.000 description 8
- 230000000638 stimulation Effects 0.000 description 6
- 210000004556 brain Anatomy 0.000 description 5
- 230000019771 cognition Effects 0.000 description 5
- 238000001228 spectrum Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 210000000133 brain stem Anatomy 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 2
- 238000009795 derivation Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 230000001960 triggered effect Effects 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010972 statistical evaluation Methods 0.000 description 1
- 238000012549 training Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/16—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
- A61B5/372—Analysis of electroencephalograms
- A61B5/374—Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
- A61B5/377—Electroencephalography [EEG] using evoked responses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/7253—Details of waveform analysis characterised by using transforms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7271—Specific aspects of physiological measurement analysis
- A61B5/7278—Artificial waveform generation or derivation, e.g. synthesising signals from measured signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/12—Audiometering
- A61B5/121—Audiometering evaluating hearing capacity
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F2218/00—Aspects of pattern recognition specially adapted for signal processing
- G06F2218/02—Preprocessing
- G06F2218/04—Denoising
Definitions
- the invention relates to a method and an arrangement for increasing the signal-to-noise ratio at evoked and event-related potentials in the derivatives of a neuronal activity, for example of the brain.
- Evoked and event-related potentials indicate potential differences or waveforms in the electroencephalogram (EEG), which are triggered either by stimulation of a sensory organ or a peripheral nerve, or with cognitive processes, such as
- EKPs in the EEG have a very small amplitude of a few ⁇ . Therefore, the EKPs in event-independent
- the measured EEG signals must be evaluated by means of signal analysis methods.
- the spontaneous EEG is considered as a stochastic interference signal, that of the stimulus or the cognitive Process independent and whose mean is zero.
- the EKPs of interest are temporally coupled to the stimulus or the cognitive process. After each stimulus or cognitive process, the EKP shows almost the same course.
- the independent activity tends to zero as the ECP accumulates.
- the number of realizations required in practice depends on the signal-to-noise ratio and is dependent on the sense modality and physical characteristics
- Vibration levels time-frequency analysis, wavelet analysis, in synchronization or in coherence over the
- Fig. 1 shows the upper left in the amplitude A in mV more
- Single sweeps are individual responses to, for example, an auditory burst stimulus, where N is the number of the sweep
- FIG. 1 shows a single sweep arranged in a matrix.
- the trace of the dominant Nl and P2 wave of this potential can be clearly seen.
- Information about latency and amplitude variations may be in contrast to the averaged potential from the single sweep matrix
- Matrix representation consisting of an Auditory Streaming
- Target syllables can be detected in Babble Noise. The recognition of the target syllable is confirmed by pressing a button. In the upper diagram of Fig. 2, single sweeps N in
- Components (P300) are clearly recognizable complex 2D structures, some of which, for example, with
- Phase traces are defined by similar phase values in the N sweeps resulting structure in the instantaneous phase transformed version of the single sweep matrix indication.
- the evaluation of EKPs can also be used for the
- Adjustment of hearing aids are used.
- published patent application DE 10 2009 060 093 A1 discloses a method and an arrangement for automatic, recursive Adaptation of a hearing aid worn by a person.
- the arrangement comprises a stimuli generator unit, which emits an acoustic stimulus to the hearing aid, and a stimuli generator unit, which emits an acoustic stimulus to the hearing aid, and a stimuli generator unit, which emits an acoustic stimulus to the hearing aid, and a
- Signal acquisition unit with a sensor that detects neural activity of the brain due to the acoustic stimulus
- the arrangement further comprises a computing and control unit, which is a measure of the listening effort from the
- Hearing aid control unit that changes the hearing aid parameters.
- the computing and control unit repeatedly causes the
- Stimuli generator unit for dispensing a hearing stimulus and the hearing aid control unit for changing a hearing aid parameter until the amount of hearing effort falls below a predefinable threshold value.
- Reverse transformation in the time domain changed so that the circular variance along at least one phase trace is reduced in the 2D single sweep matrix.
- the invention claims a method for increasing the signal-to-noise ratio of evoked potential signals and event-related potential signals of neural activity.
- the method comprises the following steps:
- Potential signals of neural activity is significantly improved.
- the method after the transformation comprises the following steps:
- the method after the change of the instantaneous phases comprises the following step:
- Merging or combining with absolute values are in complex signal processing synonyms for the formation of a complex signal (an analytic signal) of magnitude and phase
- the method has the following additional step:
- phase-regularized single sweep signals into a resulting evoked potential signal or a resulting event-related potential signal.
- an isotropic anisotropic smoothing, regularization or filtering of the magnitude values takes place.
- the change of the instantaneous phases is effected by an isotropic or anisotropic
- the N individual sweep signals can be predefined, systematically divided, split and split back-transformed and the coherence or
- Correlation of the split-determined phase-regulated single sweep signals is determined. In a further training, it is in the
- the invention also claims a digital storage medium having electronically readable control signals which can cooperate with a programmable computer or digital signal processor such that the method according to the invention is carried out.
- the invention also claims a computer program
- Program code means for performing all method steps according to the method of the invention when the program is executed on a computer or a digital signal processor.
- Potential signals and event-related potential signals of a neural activity comprising:
- a stimulus generator unit configured to provide at least one stimulus
- a signal detection unit having at least one sensor configured to detect a neural activity due to the stimulus
- Fig. 2 Auditory evoked Einzelsweep signals in one
- FFT Fast Fourier Transformation
- step 102 a frequency band of interest is extracted and the difference spectrum for each line
- the frequency band of interest is subtracted from the original spectrum.
- step 103 the analytical signal of each individual line is determined, from which also the
- step 104 a noise reduction is performed
- Phase regulation of the instantaneous phase of the analytical signals i. each line of the single sweep matrix. This is an isotropic or anisotropic regularization or
- step 105 the so-phase-regulated
- Step 103 then applying an FFT and adding the difference spectrum from step 102, so that a combined spectrum of the phase-regulated lines
- Gabor frames For example, Gabor frames, complex wavelets, a Hilbert transformation without FFT and possibly also
- Pre-filtering used.
- the measured single sweep signals can also be split up and subjected to the described procedure. Subsequently, the coherence or correlation of the thus determined separately determined mean value signals can be determined.
- even and odd single sweep signals can be evaluated separately.
- FIG. 5 shows two diagrams of the instantaneous phases in FIG.
- Matrix representation for 100 measured single sweep signals as a function of time t in milliseconds The gray levels of the graphs indicate the value of the instantaneous phase, with the color "black” for "- Pi" and the color “white” for "+ pi".
- the left-hand diagram of FIG. 5 shows the instantaneous phases without phase regulation, and the right-hand diagram shows the instantaneous phases denuded by a method according to FIG. 4.
- FIGS. 6 to 9 show diagrams of averaged
- Stimuli generator unit 1 auditory stimuli (stimuli) of a test person 2 are presented by means of headphones 6.
- EEG unit comprising a signal detection unit 3 with
- a screen 7 shows the mean value of the real part of the so-called single swept signals in the time domain.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Signal Processing (AREA)
- Psychology (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Artificial Intelligence (AREA)
- Physiology (AREA)
- Child & Adolescent Psychology (AREA)
- Developmental Disabilities (AREA)
- Educational Technology (AREA)
- Hospice & Palliative Care (AREA)
- Social Psychology (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102014007647.4A DE102014007647A1 (de) | 2014-05-23 | 2014-05-23 | Verfahren und Anordnung zur Vergrößerung des Signal-Rauschabstandes von evozierten und ereigniskorrelierten Potenzialen in den Abteilungen einer neuronalen Aktivität |
PCT/EP2015/060866 WO2015177080A1 (de) | 2014-05-23 | 2015-05-18 | VERFAHREN UND ANORDNUNG ZUR VERGRÖßERUNG DES SIGNAL-RAUSCHABSTANDES VON EVOZIERTEN UND EREIGNISKORRELIERTEN POTENZIALEN IN DEN ABLEITUNGEN EINER NEURONALEN AKTIVITÄT |
Publications (1)
Publication Number | Publication Date |
---|---|
EP3145401A1 true EP3145401A1 (de) | 2017-03-29 |
Family
ID=53365973
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP15727570.2A Withdrawn EP3145401A1 (de) | 2014-05-23 | 2015-05-18 | VERFAHREN UND ANORDNUNG ZUR VERGRÖßERUNG DES SIGNAL-RAUSCHABSTANDES VON EVOZIERTEN UND EREIGNISKORRELIERTEN POTENZIALEN IN DEN ABLEITUNGEN EINER NEURONALEN AKTIVITÄT |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP3145401A1 (de) |
DE (1) | DE102014007647A1 (de) |
WO (1) | WO2015177080A1 (de) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102017005867A1 (de) | 2017-06-22 | 2018-12-27 | Hochschule RheinMain | Automatisierte Analyse von evozierten Potenzial-Signalen oder ereigniskorrelierten Potenzial-Signalen einer neuronalen Aktivität |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4705049A (en) * | 1986-08-04 | 1987-11-10 | John Erwin R | Intraoperative monitoring or EP evaluation system utilizing an automatic adaptive self-optimizing digital comb filter |
US20090062676A1 (en) * | 2003-05-06 | 2009-03-05 | George Mason Intellectual Property | Phase and state dependent eeg and brain imaging |
WO2006034024A2 (en) * | 2004-09-16 | 2006-03-30 | Everest Biomedical Instruments | Method for adaptive complex wavelet based filtering of eeg signals |
DE102009060093B4 (de) | 2009-12-22 | 2011-11-17 | Siemens Medical Instruments Pte. Ltd. | Verfahren und Anordnung zum Einstellen eines Hörgeräts durch Erfassung der Höranstrengung |
DE102011114045B4 (de) | 2011-09-22 | 2015-04-02 | Hochschule Für Technik Und Wirtschaft Des Saarlandes | Verfahren, Anordnung und Computerprogramm zur Erkennung von Ableitungen ereigniskorrelierter Potenziale einer neuronalen Aktivität |
-
2014
- 2014-05-23 DE DE102014007647.4A patent/DE102014007647A1/de not_active Withdrawn
-
2015
- 2015-05-18 WO PCT/EP2015/060866 patent/WO2015177080A1/de active Application Filing
- 2015-05-18 EP EP15727570.2A patent/EP3145401A1/de not_active Withdrawn
Non-Patent Citations (1)
Title |
---|
F. CORONA-STRAUSS ET AL.: "Phase Stability Analysis of Chirp Evoked Auditory Brainstem Response by Gabor Frame Operators", IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING, vol. 17, no. 6, December 2009 (2009-12-01) * |
Also Published As
Publication number | Publication date |
---|---|
WO2015177080A1 (de) | 2015-11-26 |
DE102014007647A1 (de) | 2015-11-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2704629B1 (de) | Verfahren zur bewusstseins- sowie schmerzüberwachung, modul zur analyse von eeg-signalen und eeg-narkosemonitor | |
DE102016123159A1 (de) | Vorrichtung und Verfahren zum Detektieren eines Fahrerzustands basierend auf biometrischen Signalen des Fahrers | |
EP2811898B1 (de) | Verfahren zur bestimmung des physischen und/oder psychischen zustands eines probanden | |
EP0355506A1 (de) | Anordnung zum Messen lokaler bioelektrischer Ströme in biologischen Gewebekomplexen | |
DE102016003133B4 (de) | Verfahren zur automatischen Bestimmung einer individuellen Funktion einer DPOAE-Pegelkarte eines menschlichen oder tierischen Gehörs | |
Mammone et al. | Enhanced automatic artifact detection based on independent component analysis and Renyi’s entropy | |
WO2003085546A1 (de) | Verfahren und vorrichtung zur elektromagnetischen modifikation von hirnaktivität | |
DE102015116044A1 (de) | Verfahren und Vorrichtung zur Quantifizierung einer respiratorischen Sinusarrhythmie sowie Verwendung eines derartigen Verfahrens oder einer derartigen Vorrichtung [ | |
EP3338297B1 (de) | Verfahren zur analyse eines datensatzes einer flugzeit-massenspektrometrie-messung und eine vorrichtung | |
EP1794601B1 (de) | Verfahren und vorrichtung zur spektrumanalyse in mehreren frequenzbändern mit verschiedener frequenzauflösung | |
AT504147B1 (de) | Verfahren sowie einrichtung zur steuerung von geräten mit hilfe von elektroenzephalogrammen (eeg) bzw. elektrokortikogrammen (ecog) | |
EP3145401A1 (de) | VERFAHREN UND ANORDNUNG ZUR VERGRÖßERUNG DES SIGNAL-RAUSCHABSTANDES VON EVOZIERTEN UND EREIGNISKORRELIERTEN POTENZIALEN IN DEN ABLEITUNGEN EINER NEURONALEN AKTIVITÄT | |
DE102005011125A1 (de) | Verfahren und Vorrichtung zur inkrementellen Berechnung des General Linear Model bei zeitweiser Korrelation der Modellfunktionen | |
DE102011114045B4 (de) | Verfahren, Anordnung und Computerprogramm zur Erkennung von Ableitungen ereigniskorrelierter Potenziale einer neuronalen Aktivität | |
DE102020003691A1 (de) | Verfahren zur Ermittlung einer Belastung eines Fahrers beim Befahren einer Strecke | |
AT518532B1 (de) | Vorrichtung und Verfahren zur Elektrostimulation eines Probanden | |
DE10125347B4 (de) | Verfahren zum Auswerten einer Folge von diskreten Meßwerten | |
EP2793693B1 (de) | Vorrichtung und system zur bestimmung von gehirnaktivitäten | |
DE102020107176A1 (de) | Fourier-Transformations-Freie Messung von Auditory Steady-State Responses | |
DE202020005493U1 (de) | Vorhersage der langfristigen hedonischen Reaktion auf einen Sinnesreiz | |
DE102014100609B4 (de) | Verfahren zur Formanalyse eindimensionaler Messkurven | |
WO2019046870A1 (de) | Bestimmung der rangfolge der wahrnehmungsintensität von stimuli aus einer testmenge von stimuli bei einem probanden | |
DE102015206450A1 (de) | Verfahren zur rechnergestützten Verarbeitung von mit einer Mehrzahl von Elektroden gemessenen Aktionspotentialen des menschlichen oder tierischen Körpers | |
AT506113B1 (de) | Verfahren zur umwandlung von durch ein eeg gemessenen elektrischen hirnströmen in eine quadratische abbildung | |
DE102010003230A1 (de) | Verfahren zum Steuern oder Regeln einer Maschine |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
17P | Request for examination filed |
Effective date: 20161206 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |
|
17Q | First examination report despatched |
Effective date: 20200707 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20210119 |