EP3049332A1 - Installation for aseptic filling of a receptacle - Google Patents
Installation for aseptic filling of a receptacleInfo
- Publication number
- EP3049332A1 EP3049332A1 EP14771881.1A EP14771881A EP3049332A1 EP 3049332 A1 EP3049332 A1 EP 3049332A1 EP 14771881 A EP14771881 A EP 14771881A EP 3049332 A1 EP3049332 A1 EP 3049332A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- container
- sealing
- filling
- filling nozzle
- channel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000009434 installation Methods 0.000 title claims abstract 8
- 238000012371 Aseptic Filling Methods 0.000 title abstract description 18
- 238000007789 sealing Methods 0.000 claims abstract description 229
- 238000011049 filling Methods 0.000 claims abstract description 209
- 238000000034 method Methods 0.000 claims abstract description 30
- 235000016709 nutrition Nutrition 0.000 claims abstract description 27
- 239000003206 sterilizing agent Substances 0.000 claims abstract description 15
- 239000012528 membrane Substances 0.000 claims description 45
- 230000001681 protective effect Effects 0.000 claims description 30
- 230000001954 sterilising effect Effects 0.000 claims description 28
- 238000004140 cleaning Methods 0.000 claims description 24
- 238000006073 displacement reaction Methods 0.000 claims description 18
- 238000001035 drying Methods 0.000 claims description 13
- 230000035764 nutrition Effects 0.000 abstract description 10
- 108091006146 Channels Proteins 0.000 description 58
- 238000004659 sterilization and disinfection Methods 0.000 description 20
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 244000052616 bacterial pathogen Species 0.000 description 8
- 239000007788 liquid Substances 0.000 description 7
- 238000010926 purge Methods 0.000 description 7
- 238000005520 cutting process Methods 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 238000003825 pressing Methods 0.000 description 6
- 238000005429 filling process Methods 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 239000004033 plastic Substances 0.000 description 5
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
- 238000011010 flushing procedure Methods 0.000 description 4
- 239000012212 insulator Substances 0.000 description 4
- 238000011109 contamination Methods 0.000 description 3
- 230000002906 microbiologic effect Effects 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 238000011012 sanitization Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000036829 Device dislocation Diseases 0.000 description 1
- 108090000862 Ion Channels Proteins 0.000 description 1
- 102000004310 Ion Channels Human genes 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000006911 nucleation Effects 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 230000035040 seed growth Effects 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 238000012859 sterile filling Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
- B65B55/02—Sterilising, e.g. of complete packages
- B65B55/04—Sterilising wrappers or receptacles prior to, or during, packaging
- B65B55/10—Sterilising wrappers or receptacles prior to, or during, packaging by liquids or gases
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
- B65B55/02—Sterilising, e.g. of complete packages
- B65B55/022—Sterilising, e.g. of complete packages of flexible containers having a filling and dispensing spout, e.g. containers of the "bag-in-box"-type
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B39/00—Nozzles, funnels or guides for introducing articles or materials into containers or wrappers
- B65B39/06—Nozzles, funnels or guides for introducing articles or materials into containers or wrappers adapted to support containers or wrappers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B43/00—Forming, feeding, opening or setting-up containers or receptacles in association with packaging
- B65B43/42—Feeding or positioning bags, boxes, or cartons in the distended, opened, or set-up state; Feeding preformed rigid containers, e.g. tins, capsules, glass tubes, glasses, to the packaging position; Locating containers or receptacles at the filling position; Supporting containers or receptacles during the filling operation
- B65B43/46—Feeding or positioning bags, boxes, or cartons in the distended, opened, or set-up state; Feeding preformed rigid containers, e.g. tins, capsules, glass tubes, glasses, to the packaging position; Locating containers or receptacles at the filling position; Supporting containers or receptacles during the filling operation using grippers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B7/00—Closing containers or receptacles after filling
- B65B7/16—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
- B65B7/28—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C7/00—Concurrent cleaning, filling, and closing of bottles; Processes or devices for at least two of these operations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
- B67C3/02—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus
- B67C3/22—Details
- B67C2003/228—Aseptic features
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
- B67C3/02—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus
- B67C3/22—Details
- B67C3/26—Filling-heads; Means for engaging filling-heads with bottle necks
- B67C2003/2688—Means for filling containers in defined atmospheric conditions
- B67C2003/2697—Means for filling containers in defined atmospheric conditions by enclosing the container partly in a chamber
Definitions
- the present invention relates to a method and a system for aseptically filling a container with a, preferably enteral, nutritional solution.
- Availability is significantly lower than that of conventional non-aseptic filling systems.
- these bottling plants are usually subjected to a cleaning and sterilization process after several hours of production, depending on the microbiological sensitivity of the product.
- aseptic filling plants are arranged within an insulator, which can be regarded as a reduced aseptic clean room within the aseptic filling plants.
- the interior of the insulator is protected from possible contamination by a positive displacement flow.
- the document DE 69810235 T2 relates to such aseptic filling machine for flexible containers with a pressure cap.
- This filling machine includes a
- EP 1 067052 A1 describes an apparatus and a method for the sterile filling of a bag, which has a filler neck and a cap.
- the device comprises a filling valve and a chamber, which are formed by an integral unit. About an open bottom of the chamber of the bag to be filled is introduced by means of jaws in the chamber. In the Chamber is a sterilization of the bag, the filler neck and the cap. After the cap is removed, the bag is passed through the chamber to the filling nozzle and then filled. With increasing size of the surface to be cleaned within the insulator, however, increases the cleaning effort. Depending on the sensitivity of the product to be processed this cleaning and sterilization process is after a
- the product-carrying pipelines and the interior of the insulator within which the filling takes place are to be cleaned and sterilized.
- the size of the inner surface of the aseptic zone takes such a
- Sterilization processes can even reduce the availability of an aseptic filling line to 60 - 70%. It is an object of the invention to provide an aseptic filling system which allows for higher availability.
- the present invention relates to a method for aseptically filling a container with a nutritional solution.
- the nutritional solution is intended for enteral nutrition.
- the method comprises the following steps:
- Sealing device in which at least one filling nozzle, preferably stationary, is arranged and in which a first aseptic zone can be provided or, and wherein the first sealing means is in a position having an opening and thus the first sealing means and the first aseptic zone are in an open position;
- Gripping a container which comprises at least one connecting piece with a channel for filling the container, with a gripper;
- Container in particular the connecting piece of the container, sealingly abuts the opening of the first sealing means and the first aseptic zone, in which at least the connecting piece of the container is arranged at least in sections, closed or formed;
- Can fill container and preferably the first sealing device is reduced in its longitudinal extent
- Connecting piece in an aseptic environment preferably in one
- Closing device so that the filled container is aseptically sealed.
- the aseptic environment is provided by a second aseptic zone, which may be created in a second sealing device disposed in the closure device (see below in the description).
- Nutritional solution The system includes:
- a filling device having a first, a closable opening and preferably changeable in the longitudinal extension
- Sealing device in which at least one filling nozzle, preferably stationary, is arranged and in which a closing of the opening a first
- aseptic zone can be provided
- a gripper for gripping and for bringing the container to the first sealing device in a first movement such that the
- Container in particular the connecting piece of the container, sealingly applied to the opening of the first sealing means and the first aseptic zone can be closed, in which at least the connecting piece of the container is arranged at least in sections;
- the gripper is adapted to advance the container to the filling nozzle within the first aseptic zone in one of the first
- the filling device of the system comprises a device for feeding a sterilizing agent into the provided first aseptic zone, so that at least the channel of the connecting piece of the container can be sterilized at least in sections.
- the plant also includes a
- Closing device for applying a closure to the connection piece of the container.
- the process according to the invention can be carried out in particular by means of the plant according to the invention.
- the system according to the invention is in particular designed for carrying out the method according to the invention.
- the plant and / or the process according to the present invention can be used in particular for microbiologically sensitive products with a pH greater than 4, for example for the filling of enteral nutrition, especially for the clinical nutrition, whose pH is in the range of 6 to 7.
- An aseptic zone is one
- Germs are microorganisms that exist in others
- Organisms can cause unhealthy processes.
- the number of reproductive remaining after sterilization may be a
- Microorganisms do not exceed a certain limit.
- the sterile, aseptic, or aseptic, or sterile, aseptic, or germ-free environment is defined as requirements or standards to be met for enteral clinical nutrition.
- the, preferably substantially all, reproducible microorganisms are killed.
- the components or areas that have undergone sterilization or exposure and / or those performed in a sterile environment are defined as requirements or standards to be met for enteral clinical nutrition.
- the longitudinal extension of the first sealing device describes, so to speak, the height of the first sealing device. This is changeable here.
- the longitudinal extent preferably extends in the direction of the filling nozzle axis and / or in the direction of the first and / or the second movement.
- the variable in the longitudinal extension of the first sealing device is in particular ensures that when approaching the container to the filling nozzle and / or the removal of the container from the filling nozzle, a self-contained unit is formed. Thereby, the tightness of the first sealing device, in which the first aseptic zone is provided, is increased.
- the first sealing device is designed to be compressed when the container is brought to the filling nozzle.
- the first aseptic zone of the filling device is reduced in its longitudinal extent by the second movement, in which the container is brought to the filling nozzle.
- the first sealing device is limited by a side wall, which is variable in height. By compressing the first sealing device or by reducing the side wall height of the first sealing device, the container can be moved to the filling nozzle.
- the side wall of the first sealing device is formed in a first variant at least in sections by a, in particular the filling nozzle circulating bellows. In a second variant of the side wall, this is at least partially formed by a, in particular the filling nozzle rotating, telescopic system of mutually displaceable tubes.
- the container to be filled is provided with a
- the closed membrane and at least one lying above the closed membrane channel of the connector are by the
- the means for delivering the sterilizing agent is provided by the filling nozzle itself.
- the filling nozzle can sealingly come to rest on the container, preferably on the channel or the connecting piece.
- the container is preferably brought to the filling nozzle such that the filling nozzle projects at least in sections into the channel of the connecting piece of the container.
- the sterilized membrane is opened before filling the container.
- the filling nozzle is designed as a mandrel for opening, preferably piercing, the membrane of the connection piece of the container.
- the filling nozzle preferably the
- the filling nozzle is moved so far into the connecting piece of the container that an outer side of the filling nozzle, preferably a sealing cone of the filling nozzle, rests against the connecting piece and closes off the channel in the connecting piece, preferably sealingly.
- Filling nozzle preferably the outer tube of the filling nozzle, in one embodiment, an outer sealing cone for sealing the filling nozzle relative to the
- the filling nozzle in one embodiment comprises a first channel for delivering a preferably enteral sterile nutritional solution and a second channel for delivering a sterilizing agent.
- the filling nozzle has a first channel for supplying a sterilizing agent and / or a sterile nutritional solution and a second channel for aspirating a sterilizing agent and / or one
- the first channel of the filling nozzle is formed by an inner tube and the second channel of the filling nozzle by a, preferably concentric, outer tube.
- the closure is preferably provided as a closure cap which is placed on the channel of the connector of the container.
- the closure is a tamper-evident closure, for example with a snap-off and / or twist-off cap.
- the closure is applied to the channel of the connector of the container in a closing device.
- the filled container is transported from the filling device to the closing device, preferably by means of the gripper.
- the closing device is provided with a second sealing device
- a closure gripper preferably movable
- a second aseptic zone can be or is provided.
- the system for aseptic filling thus comprises in this embodiment a closing device for applying or placing a
- Closure on the channel of the connector of the container with a closable opening comprising a second sealing device.
- the second aseptic zone can be provided by closing the opening.
- the second sealing device is in one embodiment a protective bell.
- the protective bell on a bottom on said closable opening.
- the closure gripper with which by means of a device, preferably pneumatic, the closure can be placed or pressed onto the channel of the connection piece, is movably arranged in the second sealing device.
- a conveyor system for providing a closure and a, preferably separate, gripping element for removing the closure from the conveyor system and for transferring the closure to the closure gripper positioned in the closure device are provided.
- the second sealing device of the closing device is opened to receive the closure and the, preferably sterile, closure which is applied to the connecting piece is removed from the conveying system with the gripping element and transferred to the closing gripper positioned in the closing device in the closing device.
- the opening of the second sealing device takes place
- VerBankgeifer while the container for the introduction to the opening of the first aseptic zone is provided and / or while the container is brought in the first movement to the opening of the first aseptic zone and / or during the second movement, when the container to the filling nozzle is introduced.
- the second sealing device of the closing device are closed and the closure, in particular already while the container is being filled in the filling device, it is cleaned, sterilized and / or dried in the closed second sealing device. This is done by means for cleaning, sterilizing and / or drying.
- the filled container is moved in a third movement away from the filling nozzle. In a third movement, preferably immediately followed by a fourth movement, the filled container is removed from the first sealing device, so that the first aseptic zone is opened.
- the filled container is moved in one of the fourth movement, preferably immediately, subsequent fifth movement of the filling device to the closing device so that at least the region of
- the protective atmosphere can be provided by a protective gas, for example comprising nitrogen and / or sterile air.
- the protective gas atmosphere can be provided as a displacement flow.
- the sealed container with the closure is removed in one of the sixth, preferably immediately, subsequent seventh movement of the second sealing means, so that the second aseptic zone is opened.
- the filled and now closed container can then be supplied to further processing, for example the labeling and / or the packaging. Parallel or at the same time for closing the container in the
- Closing can be carried out a cleaning, sterilization and / or drying at least the filling nozzle in the filling device. Also, parallel to or simultaneously with the filling of the container in the filling device, a cleaning, sterilization and / or drying of at least the closure in the closing device can be carried out. This is in one
- Embodiment of the invention provided a movably arranged means for cleaning, sterilizing and / or drying, which at the first sealing means of the filling device and / or on the second
- Sealing device of the closing device can be applied.
- the first and / or the second sealing device and the components contained therein, such as, for example, the filling nozzle and / or the closure can be cleaned, sterilized and / or dried after each filling or closing process.
- the means for cleaning, sterilizing and / or drying is between the first sealing means
- the device for cleaning, sterilizing and / or drying is arranged on the sealing plate, preferably fastened.
- about a displacement of the sealing plate is the means for
- Sealing device of the closing device moves back and forth.
- Drying also provide the displacement flow in the gap formed between the sealing plate and the support plate.
- the container in particular the connection piece of the container, can rest directly or indirectly against the opening of the first and / or the second sealing device for closing the first aseptic zone and / or the second aseptic zone.
- the sealing plate and later the carrier plate is the Container, in particular the connecting piece of the container, indirectly at the opening of the first sealing means and / or at the opening of the second sealing means.
- the system comprises a sealing plate, wherein the
- Container preferably the connector of the container sealingly to an opening of the sealing plate, in particular by means of the gripper, can be maintained.
- the sealing plate for forming or closing the first aseptic zone may be sealingly applied to the first sealing device.
- the sealing plate is a sliding sealing plate.
- Container which is held sealingly at the opening of the sealing plate, from the first sealing means, in particular by means of the gripper, away and moved towards the closing device and applied to form or close the second aseptic zone sealingly against the second sealing means.
- the first sealing device is the
- the first sealing device is connected to the carrier plate.
- the sealing plate for sealing the first aseptic zone is sealingly applied to the carrier plate, in particular by means of the gripper.
- the second sealing device of the closing device is applied to the carrier plate for closing or forming the second, aseptic zone.
- the protective bell will be down on the
- Carrier plate moves and sealingly brought to the plant to provide the second aseptic zone.
- the sealing plate for closing the second aseptic zone is sealingly applied to the carrier plate, in particular by means of the gripper.
- the second sealing device of the closing device for forming the second, aseptic zone can thus be applied to the carrier plate.
- the sealing plate is, in particular together with the container which is sealingly held at the opening of the sealing plate, from the filling device to the closing device and / or vice versa, in particular by means of the gripper, forming a gap between the sealing plate and the carrier plate, preferably laterally, postponed.
- the protective atmosphere is at least in the gap, for example by a displacement flow to the outside,
- the displacement flow for example, a
- the first, second, third, fourth, fifth, sixth and seventh movement are used to distinguish the individual process steps and, where appropriate, the
- the movements do not have to be separate or discrete movements.
- the movements can also merge into each other.
- Movement can be carried out by the gripper one behind the other without interruption.
- the sealing plate together with the container which is sealingly held at the opening of the sealing plate, perform the first movement, in particular by means of the gripper, with which the first aseptic zone is provided or closed and / or
- the sealing plate is joined with the container, which seals against the
- the sealing plate is carried out together with the container, which is sealingly held on the opening of the sealing plate, and the carrier plate, the third movement, in particular by means of the gripper, in which the container of the Filling nozzle is removed and / or
- the sealing plate together with the container which is sealingly held at the opening of the sealing plate, perform the fourth movement, in particular by means of the gripper, with which the first aseptic zone is opened and / or
- the sealing plate is, together with the container, which is sealingly held at the opening of the sealing plate, the fifth movement, in particular by means of the gripper perform, with which the filled container of the
- Filling device is moved to the closing device and / or
- the sealing plate is joined with the container, which seals against the
- Sealing device of the closing device introduced and sealing applied to form the second aseptic zone or close and / or
- the sealing plate together with the container held sealingly against the opening of the sealing plate, will carry out the seventh movement, in particular by means of the gripper, with which the container closed with the closure is removed from the second sealing device, so that the second aseptic zone is opened.
- the movement can also be done without the help of the gripper.
- the gripper essentially serves to hold the container.
- the movement can take place, for example, via a movement provided by means of the sealing plate and / or by means of the carrier plate.
- the sealing plate and / or the carrier plate may have its own drive.
- the container is preferably a bag or stand-up pouch.
- the present invention is based on the idea of initially providing a closed, empty container for a, preferably enteral, food, the interior of which is sterile and hermetically sealed to the environment on the one hand.
- Nutritional agent is then filled under aseptic conditions by means of the plant and / or the method according to the present invention in the sterile interior of the container and then sealed.
- a container with a germ-free feeding agent is provided, without the hitherto usual final autoclaving of the entire, filled
- FIG. 1 shows a cross-sectional view of a filling device of a system for aseptically filling a container with an enteral nutrition solution
- Figure 2 is an enlarged cross-sectional view of the filling nozzle and the container with a closed membrane and not introduced filling nozzle (left figure) and pierced, here opened membrane and inserted filling nozzle (right figure).
- FIG 3 is a cross-sectional view of a closing device of the plant for aseptic filling with recorded cap and not yet brought up container.
- the plant according to the invention for the aseptic filling of a container 105 with an enteral nutritional solution is improved for the sake of betterment Overview not shown in their entirety in the figures.
- the components of the system namely the filling device 100 and the closing device 200 are shown and described individually here.
- the system may include other components.
- the filling device 100 and the closing device 200 can be arranged, for example, on a rotary machine.
- Figure 1 shows a cross-sectional view of a filling device 100 of a system for aseptic filling a container 105 with an enteral
- the filling device 100 serves for the aseptic filling of the container 105 with a liquid, preferably for enteral, clinical nutrition.
- the container 105 is a presterilized container 105 which is closed by a membrane 103.
- the container 105 has a connection piece 129 with a channel 130 which is closed by the membrane 103.
- Container 105 and arranged in the connector 129 and not yet open here membrane 103 shown.
- the container 105 itself is not shown in FIG.
- the container 105 may, for example, a plastic bag, a
- Plastic bottle plastic bottle, a bag, a stand-up pouch or any other
- the connector 129 of the container 105 may be formed, for example, by a plastic body, which is a,
- the connector 129 may also be referred to as a port
- the filling device 100 comprises a first sealing device 125.
- a first aseptic zone 127 can be provided.
- the first aseptic zone 127 is characterized by an enclosed or lockable space.
- the aseptic filling of the container 105 takes place in this first aseptic zone 127.
- the filling nozzle 111 is arranged in the interior of the first aseptic zone 127 formed or provided by the first sealing device 125.
- the first sealing device 125 is variable in its longitudinal extent.
- the first sealing device 125 in particular axially and / or vertically,
- the first sealing device 125 comprises side walls 125a, which are variable in their longitudinal extent 125h.
- the side walls 125a of the first sealing device 125 are provided by a bellows.
- the bellows is an elastic, accordion-like
- collapsing hose for example made of rubber or plastic, which is attached around the filling nozzle 111 in order to protect it from contamination with germs and to seal it from the environment.
- Sealing device 125 may be formed for example by a rubber bellows, which is mounted on its upper side on a base plate 145. in the
- Sealing device 125 are used, which are suitable to prevent penetration of germs or contaminants.
- the side walls 125a of the first sealing device 125 are provided by a telescopic system of mutually displaceable tubes. Towards the top, the first aseptic zone 127 is bounded by the
- the first sealing device 125 is here connected to the base plate 145 via an annular flange 146.
- the base plate 145 here has a passage. Through the implementation of the filling nozzle 111 is guided.
- the filling nozzle 111 is disposed inside the first aseptic zone 127 and will be explained in detail below.
- the first aseptic zone 127 is bounded by a
- Support plate 131 This can also be referred to as a bellows plate.
- the first sealing device 125 is connected to the here vertically displaceable support plate 131.
- the support plate 131 includes an opening 133 for
- This opening 133 here represents the opening of the first aseptic zone 127.
- a sealing plate 135 is below the Support plate 131 is arranged. The sealing plate 135 is opposite to the here
- Support plate 131 arranged horizontally displaceable.
- FIG. 1 shows the filling device 100 during and / or shortly before the first movement.
- the container 105 is above its connector 129 and the
- Sealing plate 135 sealingly to the opening 135 in the support plate 131 at.
- the opening 135 is closed.
- the first aseptic zone 127 is in this
- a gap 137 is formed between the sealing plate 135 and the carrier plate 131. Through the gap 137, a displacement flow is passed to the outside to the outside. As a result, the first aseptic zone 127 is shielded from the environment.
- Displacement flow may be, for example, a nitrogen flow.
- a flushing line 143 in particular a Cl P / Sl P flushing line, may be provided in the sealing plate 135, for example as a device for cleaning, sterilizing and / or drying.
- the sterilization takes place, for example, by means of a steam pulse and / or by means of
- the sealing plate 135 has an opening 139 for passing the filling nozzle 111 and / or for the sealed insertion of a connecting piece 129 of the
- Container 105 on. At the top of the sealing plate 135, a sealing ring 149 is provided. On the underside of the sealing plate 135, a cutting edge 147 is provided, which contacts the flange surface of the container 105 and seals by superficial material displacement.
- the container 105 is held on the connecting piece 129 by a movement device 104, for example a gripper.
- the gripper 104 is disposed below the sealing plate 135.
- the first aseptic zone 127 is essentially formed or delimited by the inner sides of the bellows 125, the lower side of the base plate 145, the inner jacket surfaces in the openings of the carrier plate 131 and the sealing plate 135 and the connecting piece 129 of the container 105 and its membrane 103.
- the first sealing device 125 thereby forms a first aseptic zone 127 around the connecting piece 129 of the container 105 and around the filling nozzle 111.
- the filling device 100 comprises a sterilization device 107 for sterilizing at least the membrane 103 in order to kill germs on the membrane 103, and a puncture device 109 for puncturing the membrane 103 in the first aseptic environment 127, around the container 105
- Sterilmaschinesm ittel may be, for example, steam and / or hydrogen peroxide. In general, however, others can
- Sterilizing agent be used, which are suitable for germs on the
- At least the membrane 103 and the channel 130 in the connection part 129 above the membrane 103 are sterilized.
- the filling nozzle 111 is provided with a first channel 113 and a second channel 115.
- the first channel 113 is formed by an inner tube 117 and the second channel 115 is formed by a here, preferably concentric, outer tube 119.
- the second channel 115 is provided by the annular gap formed between the inner tube 117 and the outer tube 119.
- the inner tube 117 and the outer tube 119 are by means of the base plate 145 and the
- the first channel 113 is a channel for delivering the sterile nutritional fluid and the second channel 115 is a channel for delivering the sterilizing agent.
- the first channel 113 is a channel for feeding the Sterilizing agent and for supplying the sterile nutritional fluid.
- the second channel 115 is a channel for aspirating the sterilizing agent. In this case, sterilization of the membrane with the sterilizing agent is first carried out via the first channel 113 and then the container 105 is filled via the same channel 113. The second channel 115 is used to aspirate the sterilizing agent before filling.
- the inner tube 117 and / or the Au JO 119 are, for example, by a metal or
- the filling device 100 may have suitable valve control.
- the connector 129 of the pre-sterilized container 105 is provided with the thin membrane 103.
- the membrane 103 may be a non-reclosable or resealable membrane. Through the annular gap, for example, a jet of steam is brought to the membrane 103 in order to kill germs on the membrane 103 and inside the connecting piece 129 of the container 105.
- the outer tube 119 of the filling nozzle 111 has an outer sealing cone 121 for sealing the filling nozzle 111 relative to the connecting piece 129.
- the outer tube 119 has a chamfered end 123 for piercing or opening the membrane 103.
- the filling nozzle 111 and the connecting piece 129 of the container 105 are matched with respect to their dimensions.
- Figure 2 shows an enlarged cross-sectional view of the filling nozzle 111 and connected via the connector 129 container 105 before (left figure) and after (right figure) a piercing of the membrane 103 of the connector 129.
- the opening 139 in the sealing plate 135 is here schematically as a Pipe shown.
- the opening 139 in the sealing plate 135 is executed at its end with a cutting edge 147.
- the completion of the first aseptic zone 127 is provided along with the connector 129 of the container 105.
- the upper flange surface of the connecting piece 129 serves as a sealing plane
- the cutting edge 147 is flange-like on the connecting piece 129, which serves as a sealing plane. This connection forms the lower end of the aseptic zone 127.
- the filling nozzle 111 is composed of the inner tube 117 and the outer tube 119.
- the inner tube 117 and the outer tube 119 are concentrically arranged in the illustrated example.
- the Au .rohr 119 serves to perforate or to open the membrane 103 of the connector 129.
- the filling of the container 105 is carried out. When using a bag as a container 105 is ensured that the bag unfolds by the filling pressure.
- the movement device 104 is preferably designed as a movable gripper 104.
- the connecting piece 129 located in the movement device 104 is moved upward until the cutting edge 147 of the sealing plate 135 contacts the flange surface.
- the further upward movement closes the sealing gap 137, which protects the inner first aseptic zone 127 in the open state by a displacement flow to the outside.
- the first aseptic zone 127 is closed.
- the upward movement to bring the cutting edge 147 to the connecting piece 129 of the container 105 and closing the sealing gap 137 takes place in the context of the first movement, with which the first aseptic zone 127 is closed.
- the inside of the connecting piece 129 and the membrane 103 are steamed for a short time, preferably with water vapor.
- the steaming is provided, for example, for a time interval of 0.1 second to 5 seconds.
- the steam is supplied via the annular gap 115 between the preferably concentric inner tube 117 and the outer tube 119.
- the chamfered end 123 of the outer tube 119 lies above the not yet pierced and thus still closed membrane 103.
- the container 105 is brought to the filling nozzle 111 so far that the filling nozzle 111 at least partially protrudes into the channel of the connecting piece 129 of the container 105.
- the filling nozzle 111 is inserted into the connecting piece 129 so far that the membrane 103 is opened by the filling nozzle 111.
- the membrane 103 is perforated by the tip 123 of the outer filling nozzle 119 and pushed to the side. This is the movement device
- the bellows as the first sealing device 125 is thereby reduced in its longitudinal extent.
- the side wall 125a, which limits the bellows 125, is variable in height.
- About a compression of the bellows 125 is the container
- the membrane 103 of the connecting piece 129 is perforated by the chamfered end 123 of the outer tube 119 of the filling nozzle 111 fixed here.
- the filling nozzle 111 with the inner tube 117 is moved so far into the container 105, that the sealing cone 121 of the outer filling nozzle 119 terminates the connecting piece 129 at the upper edge.
- the filling of the container 105 takes place with the sterile liquid.
- the filling takes place here via the inner tube 117.
- the movement device 104 is moved together with the
- Sealing plate 135 and the support plate 131 moves in a third movement down until the sealing gap 137 opens again.
- the shielding of the displacement flow for example with nitrogen, the
- the filling nozzle 111 is cleaned, sterilized and / or dried after the filling process, preferably with the device 143.
- the further method steps, in particular the closing of the container 105 by the closing device 200, will be explained below in connection with FIG.
- FIG. 3 shows a cross-sectional view of a closing device 200. This serves to close the container 105 in a second aseptic zone 204 with a closure cap 141.
- the closing device is 200 together with the filling device 100 part of a
- FIG. 3 shows the closing device 200 with its inserted, but not yet on the connecting piece 129 of FIG
- Container 105 mounted cap 141.
- the container 105 is not yet positioned below the closing device 200 here.
- the gripper 104 with received container 105 is shown in simplified form in the figure 3 with a box (see bottom right).
- the closing device 200 is fastened on a base plate 145.
- the closing device 200 and the filling device 100 are assigned the same base plate 145 and / or the same carrier plate 131.
- the closing device 200 comprises a second sealing device 203 for forming a second aseptic zone 204, in particular at least around the connecting piece 129 of the container 105.
- the second sealing device 203 here comprises a protective bell 203 or is designed as a protective bell 203.
- the protective bell 203 is open to the bottom. It forms at least the side walls of the second sealing device 203.
- the protective bell 203 shown here is designed as a type of tube which extends through the base plate 145. The walls of the protective bell 203 are not changeable in their length.
- the protective bell 203 is connected to the base plate 145 via a closing unit 210 arranged above the base plate 145.
- the protective bell 203 is movably arranged within the closing device 200.
- a cap gripper 207 is arranged within the protective bell 203.
- the cap gripper 207 serves to grip the closure cap 141. It is connected via a, preferably vertically, displaceable boundary with a pneumatic device 213 for pressing on the closure cap 141.
- the slidable boundary 213 is designed as a bellows 213 in the illustrated example. In the interior of the bellows 213 and in the adjoining channel, for example, the compressed air can be performed.
- the pneumatic device 213 for placing, preferably for pressing, the cap a pneumatic cylinder 213. The positioning or
- FIG. 3 shows the closing device 200 and thus also the second one
- Sealing device 203 in the open state. In the closed state of the second sealing device 203, the underside of the protective bell 203 sealingly on the top of the support plate 131. This is at the
- the protective bell 203 is indirectly on the top of the support plate 131. It lies on a connecting member 215 sealingly on the support plate 131.
- the connecting member 215 at least one channel is arranged. Shown here are two channels 209 and 211. Via the channel 211 shown on the left, for example, sterile air for drying and / or be removed. For example, steam can be added and / or removed for sterilization via the channel 209 shown on the right. As an alternative or in addition, they can also be supplied and / or removed via the device 143 for cleaning, sterilizing and / or drying.
- the sealing plate 135 is arranged below the support plate 131. Between the two plates 131 and 135, a gap 137 for a displacement flow is formed in an opened state of the second aseptic zone 204.
- Cl P / Sl P purge lines 143 are arranged, via which the first and / or the second aseptic zone 127, 204 a sterilizing agent can be supplied and / or removed again.
- Laterally offset, here right, of the Cl P / Sl P purge lines 143 is the gripper 104 for the connector 129 of the container 105. They are positioned below the opening 139 in the sealing plate 135, on the horizontal movement to the left, the connector 129th of the
- FIG. 3 shows the second sealing device 203 in an open position. It can be opened, for example, by the protective bell 203 is moved upward and / or by the support plate 131 is moved upward. To provide or close the second aseptic zone 204, the protective bell 203 is moved downwards until its underside rests sealingly on the carrier plate 131.
- the second aseptic zone 204 is essentially formed or bounded by the inner sides of the protective bell 203, the outer side of the bellows 213, the inner side of the connecting component 215, the inner jacket surfaces in the openings 140 and 139 of the carrier plate 131 and the sealing plate 135 and the connector 129 of the container 105th
- the second sealing device 203 thereby forms an aseptic zone 204 around the connecting piece 129 of the container 105.
- the second sealing device 203 of the closing device 200 is opened for insertion of the closure 141. It is opened in the present example according to Figure 3 by the protective bell 203 is moved upward. This happens in particular while the container 105 is inserted into the gripper 104 below the filling device 100 in the context of the first movement.
- the cap gripper 207 is from above moved to the shutter 141 to take over this after opening a separate pivoting gripper.
- the closure 141 is introduced into the opened, second aseptic zone 204.
- Protective bell 203 moves down and closes the second aseptic zone 204. To achieve a hermetic seal, the second
- Sealing device 203 at the lower end of the sealing ring 205 which is indirectly brought to the plant when closing the second aseptic zone 204 with the support plate 131 here.
- Sealing device 203 and the pneumatic cylinder 213 for pressing on the closure 141 takes place, for example, via an electromechanical cylinder.
- a rinse line 143 for example a Cl P / Sl P rinse line, is made to coincide.
- Closure 141 substantially parallel to the filling of the container 105 to shortly before pressing, preferably by steam, sterilized and dried by, preferably sterile air.
- the right channel 209 for introducing steam into the second aseptic zone 204 and the left channel 211 for introducing sterile air into the second aseptic zone 204 are substantially parallel to the filling of the container 105 to shortly before pressing, preferably by steam, sterilized and dried by, preferably sterile air.
- Displacement flow in the seal gap 137 protects the second aseptic zone 203 from contamination.
- the purge line 143 can be used in the sealing plate 135.
- the gripper 104 After completion of the filling process in the filling device 100 of the gripper 104 is moved together with the sealing plate 135 and the support plate 131 down until the sealing gap 137 opens again. This happens in a third and fourth movement. Under the shielding of the displacement flow, in particular with nitrogen, the gripper 104 and the sealing plate 135, preferably horizontally, are arranged in the direction of the laterally arranged here
- Closing device 200 moved.
- the opening 139 of the sealing plate 135 is moved under the closure device 200 in the protection of a displacement flow.
- the container 105 which has just been filled is brought to the closing device 200 in alignment under a protective atmosphere in this way. This happens as part of a fifth movement.
- the gripper 104 is brought up again, so that the support plate 131 and the sealing plate 135 close the gap 137 via the sealing ring 149 and the second aseptic zone 204 is closed within the closing device 200. This happens as part of a sixth movement.
- the closure 141 is pressed inside the closed, second aseptic zone 204, for example by a pneumatic pressing on the closure cap 141.
- the container closed with the closure cap 141 is moved by the second sealing device 203 a downward movement of the gripper 104, so that the second aseptic zone 204 is opened.
- the filled and now closed container 105 can be fed away from the closing device 200 to subsequent processing, for example the labeling and / or further packaging.
- Closing device 200 can now start from the beginning, in particular with the introduction of the closure 141 from the feeding and conveying system with the separate pivoting gripper.
- Closing 200 at least one cleaning and / or sterilization, in particular impulse cleaning and / or sterilization, the filling nozzle 111 performed in the filling device 100. This is not shown in the figures.
- Plant productivity is thereby made possible. Only during a format and / or batch change, the bottling plant of an intensive cleaning and steam sterilization of all product-carrying parts and the minimized
- a short-term cleaning and sanitization of the filling nozzle 111 is achieved after each filling process. Seed growth on the inner surfaces of the filling nozzle 111 can be substantially eliminated. The formation of deposits is essentially prevented. Due to the condensing water vapor, a thermal impulse is applied for sanitization.
- a small volume and a small surface of the aseptic zones 127 and 204 are achieved, which amount to only a fraction of the volume or the surface in conventional filling plants. This allows the aseptic zone to be sterilized easily and quickly.
- the volume of the first aseptic zone 127 and / or the second aseptic zone 204 is only a few cubic centimeters.
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
- Basic Packing Technique (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14771881.1A EP3049332B1 (en) | 2013-09-25 | 2014-09-22 | Installation for aseptic filling of a container |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13185858 | 2013-09-25 | ||
PCT/EP2014/070135 WO2015044088A1 (en) | 2013-09-25 | 2014-09-22 | Installation for aseptic filling of a receptacle |
EP14771881.1A EP3049332B1 (en) | 2013-09-25 | 2014-09-22 | Installation for aseptic filling of a container |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3049332A1 true EP3049332A1 (en) | 2016-08-03 |
EP3049332B1 EP3049332B1 (en) | 2017-08-30 |
Family
ID=49293449
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP14771881.1A Active EP3049332B1 (en) | 2013-09-25 | 2014-09-22 | Installation for aseptic filling of a container |
Country Status (4)
Country | Link |
---|---|
US (1) | US10377519B2 (en) |
EP (1) | EP3049332B1 (en) |
CN (1) | CN105579347B (en) |
WO (1) | WO2015044088A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102016122542A1 (en) * | 2016-11-22 | 2018-05-24 | Krones Ag | Distributor for distributing flowable media |
CN110759302B (en) * | 2019-10-29 | 2022-04-15 | 江苏新美星包装机械股份有限公司 | Negative pressure filling valve |
WO2023148321A1 (en) | 2022-02-04 | 2023-08-10 | Fresenius Kabi Deutschland Gmbh | System and method for filling pouches with a medical liquid |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2930170A (en) * | 1954-03-29 | 1960-03-29 | Aseptic Food Fillers Inc | Means and method for aseptic packaging |
US3350839A (en) * | 1963-07-24 | 1967-11-07 | Kenneth B Ray | Apparatus for packaging fruit juices and similar products |
GB1128323A (en) * | 1964-10-30 | 1968-09-25 | Nat Res Dev | Sterilising and filling bottles |
SE355339B (en) * | 1967-03-06 | 1973-04-16 | Tetra Pak Int | |
US4283901A (en) * | 1979-12-20 | 1981-08-18 | Liqui-Box Corporation | Continuous rotary machine for uncapping, filling and recapping flexible bags having separable caps |
PT74267B (en) * | 1981-01-13 | 1983-08-23 | Wrightcel Ltd | Liquid filling apparatus |
EP0072699B1 (en) | 1981-08-18 | 1986-07-23 | Wrightcel Ltd. | Method and system for aseptically filling a container with fluid |
US4494363A (en) * | 1982-08-20 | 1985-01-22 | Franrica Mfg. Inc. | Method and apparatus for aseptically filling containers |
CH673819A5 (en) * | 1987-03-02 | 1990-04-12 | Nestle Sa | |
CH674637A5 (en) * | 1987-11-25 | 1990-06-29 | Nestle Sa | |
CN1011873B (en) * | 1988-02-26 | 1991-03-06 | 雀巢制品公司 | Apparatus for filling package |
DE4304220C2 (en) * | 1993-02-12 | 1997-09-18 | Tetra Laval Holdings & Finance | Process for sterilizing and filling plasticizer packs, device therefor and use for a special pack |
US6070622A (en) * | 1998-05-07 | 2000-06-06 | Packaging Systems, L.L.C. | High speed aseptic filling machine |
GB9916215D0 (en) * | 1999-07-09 | 1999-09-15 | Smith David S Packaging | Apparatus and method for filling |
BRPI0407383A (en) * | 2003-02-19 | 2006-02-07 | Coca Cola Co | A system for aseptically filling a package having a filling opening and method of adapting a non-aseptic filling line to be an aseptic filling line. |
GB2452055A (en) * | 2007-08-22 | 2009-02-25 | Flexifill Ltd | Aseptic container filling |
DE102008031680A1 (en) * | 2008-07-04 | 2010-01-07 | Krones Ag | Device for filling containers with magnetically operated cap |
FR2954935B1 (en) * | 2010-01-06 | 2012-04-20 | Hema | METHOD AND DEVICE FOR PROCESSING CONTAINERS |
ITRE20110111A1 (en) * | 2011-12-23 | 2013-06-24 | Alfa Laval Parma S R L | ASEPTIC FILLING MACHINE |
-
2014
- 2014-09-22 WO PCT/EP2014/070135 patent/WO2015044088A1/en active Application Filing
- 2014-09-22 EP EP14771881.1A patent/EP3049332B1/en active Active
- 2014-09-22 US US15/024,911 patent/US10377519B2/en active Active
- 2014-09-22 CN CN201480052632.0A patent/CN105579347B/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2015044088A1 (en) | 2015-04-02 |
US10377519B2 (en) | 2019-08-13 |
US20160244195A1 (en) | 2016-08-25 |
CN105579347B (en) | 2018-03-27 |
EP3049332B1 (en) | 2017-08-30 |
CN105579347A (en) | 2016-05-11 |
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