EP2968609A4 - Vecteurs et méthodes pour traiter l'ischémie - Google Patents
Vecteurs et méthodes pour traiter l'ischémieInfo
- Publication number
- EP2968609A4 EP2968609A4 EP14765183.0A EP14765183A EP2968609A4 EP 2968609 A4 EP2968609 A4 EP 2968609A4 EP 14765183 A EP14765183 A EP 14765183A EP 2968609 A4 EP2968609 A4 EP 2968609A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- vectors
- methods
- treat ischemia
- ischemia
- treat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
- A61K38/1866—Vascular endothelial growth factor [VEGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1891—Angiogenesic factors; Angiogenin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gynecology & Obstetrics (AREA)
- Toxicology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/844,138 US20140065110A1 (en) | 2012-08-31 | 2013-03-15 | Genetically modified msc and therapeutic methods |
PCT/US2013/057721 WO2014036524A2 (fr) | 2012-08-31 | 2013-08-30 | Cellules souches mésenchymateuses (msc) génétiquement modifiées et méthodes thérapeutiques |
PCT/US2014/029386 WO2014144815A2 (fr) | 2013-03-15 | 2014-03-14 | Vecteurs et méthodes pour traiter l'ischémie |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2968609A2 EP2968609A2 (fr) | 2016-01-20 |
EP2968609A4 true EP2968609A4 (fr) | 2016-11-30 |
Family
ID=51538378
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP14765183.0A Ceased EP2968609A4 (fr) | 2013-03-15 | 2014-03-14 | Vecteurs et méthodes pour traiter l'ischémie |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2968609A4 (fr) |
AU (2) | AU2014228526A1 (fr) |
WO (1) | WO2014144815A2 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20140065110A1 (en) | 2012-08-31 | 2014-03-06 | The Regents Of The University Of California | Genetically modified msc and therapeutic methods |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7700359B2 (en) * | 2000-06-02 | 2010-04-20 | Novartis Vaccines And Diagnostics, Inc. | Gene products differentially expressed in cancerous cells |
US7297536B2 (en) * | 2003-01-23 | 2007-11-20 | Wisconsin Alumni Research Foundation | Inducible protein expression system |
WO2007047963A2 (fr) * | 2005-10-20 | 2007-04-26 | Caritas St. Elizabeth Medical Center Of Boston, Inc. | Utilisation de cellules souches derivees de la moelle osseuse dans le traitement de l'ischemie |
US9096827B2 (en) * | 2008-09-02 | 2015-08-04 | Pluristem Ltd. | Adherent cells from placenta tissue and use thereof in therapy |
WO2010127166A2 (fr) * | 2009-04-30 | 2010-11-04 | The Regents Of The University Of California | Vecteurs d'association anti-vih, vecteurs de ciblage, et procédés d'utilisation |
AU2011265733B2 (en) * | 2010-06-14 | 2014-04-17 | Iowa State University Research Foundation, Inc. | Nuclease activity of TAL effector and Foki fusion protein |
-
2014
- 2014-03-14 AU AU2014228526A patent/AU2014228526A1/en not_active Abandoned
- 2014-03-14 EP EP14765183.0A patent/EP2968609A4/fr not_active Ceased
- 2014-03-14 WO PCT/US2014/029386 patent/WO2014144815A2/fr active Application Filing
-
2019
- 2019-03-18 AU AU2019201858A patent/AU2019201858A1/en not_active Abandoned
Non-Patent Citations (8)
Title |
---|
AFRAMIAN D J ET AL: "Using HSV-thymidine kinase for safety in an allogeneic salivary graft cell line", TISSUE ENGINEERING, vol. 7, no. 4, 1 August 2001 (2001-08-01), LARCHMONT, NY, US, pages 405 - 413, XP002761134, ISSN: 1076-3279 * |
AKESON ANN L ET AL: "Temporal and spatial regulation of VEGF-A controls vascular patterning in the embryonic lung.", DEVELOPMENTAL BIOLOGY, vol. 264, no. 2, 15 December 2003 (2003-12-15), pages 443 - 455, XP002762759, ISSN: 0012-1606 * |
CHANG DAVID S ET AL: "Adeno-associated viral vector-mediated gene transfer of VEGF normalizes skeletal muscle oxygen tension and induces arteriogenesis in ischemic rat hindlimb.", MOLECULAR THERAPY : THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY, vol. 7, no. 1, January 2003 (2003-01-01), pages 44 - 51, XP002717242, ISSN: 1525-0016 * |
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; May 2010 (2010-05-01), FANG YU XIANG ET AL: "Development of Chimeric Gene Regulators for Cancer-specific Gene Therapy with both Transcriptional and Translational Targeting", XP002762768, Database accession no. PREV201000282618 * |
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; September 1996 (1996-09-01), ZHOU A ET AL: "[Molecular bypass, the application of VEGF to gene therapy of limb ischemia].", XP002762757, Database accession no. NLM9275547 * |
FIERRO FERNANDO A ET AL: "Effects on Proliferation and Differentiation of Multipotent Bone Marrow Stromal Cells Engineered to Express Growth Factors for Combined Cell and Gene Therapy", STEM CELLS (MIAMISBURG), vol. 29, no. 11, November 2011 (2011-11-01), pages 1727 - 1737, XP002717241 * |
MOLECULAR BIOTECHNOLOGY, vol. 45, no. 1, May 2010 (2010-05-01), pages 71 - 81, ISSN: 1073-6085, DOI: 10.1007/S12033-010-9244-Y * |
NAIDOO JERUSHA ET AL: "Gene regulation systems for gene therapy applications in the central nervous system.", NEUROLOGY RESEARCH INTERNATIONAL, vol. 2012, 595410, 2012, pages 1 - 10, XP002762760, ISSN: 2090-1860, DOI: 10.1155/2012/595410 * |
Also Published As
Publication number | Publication date |
---|---|
AU2019201858A1 (en) | 2019-04-11 |
AU2014228526A1 (en) | 2015-11-05 |
WO2014144815A2 (fr) | 2014-09-18 |
WO2014144815A3 (fr) | 2014-11-06 |
EP2968609A2 (fr) | 2016-01-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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17P | Request for examination filed |
Effective date: 20151013 |
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AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
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AX | Request for extension of the european patent |
Extension state: BA ME |
|
DAX | Request for extension of the european patent (deleted) | ||
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12N 15/867 20060101AFI20161017BHEP Ipc: A61K 48/00 20060101ALI20161017BHEP |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20161031 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 48/00 20060101ALI20161024BHEP Ipc: C12N 15/867 20060101AFI20161024BHEP |
|
17Q | First examination report despatched |
Effective date: 20170906 |
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REG | Reference to a national code |
Ref country code: DE Ref legal event code: R003 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED |
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18R | Application refused |
Effective date: 20190124 |