EP2928300A4 - Traitement de troubles du spectre autistique à l'aide de l'acide glycyl-l-2-méthylprolyl-l-glutamique - Google Patents

Traitement de troubles du spectre autistique à l'aide de l'acide glycyl-l-2-méthylprolyl-l-glutamique

Info

Publication number
EP2928300A4
EP2928300A4 EP13858943.7A EP13858943A EP2928300A4 EP 2928300 A4 EP2928300 A4 EP 2928300A4 EP 13858943 A EP13858943 A EP 13858943A EP 2928300 A4 EP2928300 A4 EP 2928300A4
Authority
EP
European Patent Office
Prior art keywords
methylprolyl
glycyl
treatment
glutamic acid
autism spectrum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP13858943.7A
Other languages
German (de)
English (en)
Other versions
EP2928300A1 (fr
Inventor
Lawrence Irwin Glass
Michael John Bickerdike
Michael Frederick Snape
Cogram Patricia Perez De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neuren Pharmaceuticals Ltd
Original Assignee
Neuren Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuren Pharmaceuticals Ltd filed Critical Neuren Pharmaceuticals Ltd
Publication of EP2928300A1 publication Critical patent/EP2928300A1/fr
Publication of EP2928300A4 publication Critical patent/EP2928300A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06Tripeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0804Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychiatry (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
EP13858943.7A 2012-11-28 2013-11-26 Traitement de troubles du spectre autistique à l'aide de l'acide glycyl-l-2-méthylprolyl-l-glutamique Withdrawn EP2928300A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261730829P 2012-11-28 2012-11-28
PCT/US2013/072049 WO2014085480A1 (fr) 2012-11-28 2013-11-26 Traitement de troubles du spectre autistique à l'aide de l'acide glycyl-l-2-méthylprolyl-l-glutamique

Publications (2)

Publication Number Publication Date
EP2928300A1 EP2928300A1 (fr) 2015-10-14
EP2928300A4 true EP2928300A4 (fr) 2016-07-13

Family

ID=50828422

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13858943.7A Withdrawn EP2928300A4 (fr) 2012-11-28 2013-11-26 Traitement de troubles du spectre autistique à l'aide de l'acide glycyl-l-2-méthylprolyl-l-glutamique

Country Status (6)

Country Link
EP (1) EP2928300A4 (fr)
JP (1) JP2016506380A (fr)
AU (1) AU2013352294A1 (fr)
BR (1) BR112015012506A2 (fr)
CA (1) CA2929286A1 (fr)
WO (1) WO2014085480A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016004111A1 (fr) * 2014-06-30 2016-01-07 Cerora, Inc. Système et procédés de synchronisation d'un pc à système d'exploitation non en temps réel avec un microcontrôleur de collecte de données à distance en temps réel
EP4356964A3 (fr) * 2018-08-10 2024-06-19 New York University Utilisation de ligands agonistes du récepteur de l'igf-2 pour le traitement du syndrome d'angelman et de l'autisme

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002094856A2 (fr) * 2001-05-24 2002-11-28 Neuronz Limited Peptidomimetiques et analogues de gpe
US20110112033A1 (en) * 2001-05-24 2011-05-12 Peter David Gluckman Cognitive enhancement and cognitive therapy using glycyl-l-2-methylprolyl-l-glutamic acid
WO2011146109A2 (fr) * 2010-05-17 2011-11-24 Mount Sinai School Of Medicine Procédés et tests pour le traitement de sujets présentant une délétion, une mutation ou une expression réduite de shank3

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006127702A2 (fr) * 2005-05-23 2006-11-30 Neuren Pharmaceuticals Limited Analogues de glycyl-prolyl-glutamate
EP1793671B1 (fr) * 2004-09-20 2011-04-27 Mount Sinai School of Medicine Utilisation de memantine (namenda) pour traiter l'autisme, les etats compulsifs et impulsifs
ES2487493T3 (es) * 2006-03-14 2014-08-21 Neuren Pharmaceuticals Limited Formulaciones orales de glicil-2-metilprolil-glutamato
WO2008066750A1 (fr) * 2006-11-22 2008-06-05 Seaside Therapeutics, Llc Procédés de traitement du retard mental, du syndrome de down, du syndrome de l'x fragile et de l'autisme
CA2689549A1 (fr) * 2007-06-08 2008-12-18 Massachusetts Institute Of Technology Traitement du syndrome de rett et d'autres troubles
JP6348283B2 (ja) * 2011-01-27 2018-06-27 ニューレン ファーマシューティカルズ リミテッド グリシル−l−2−メチルプロリル−l−グルタミン酸を用いる自閉症スペクトラム障害の治療

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002094856A2 (fr) * 2001-05-24 2002-11-28 Neuronz Limited Peptidomimetiques et analogues de gpe
US20110112033A1 (en) * 2001-05-24 2011-05-12 Peter David Gluckman Cognitive enhancement and cognitive therapy using glycyl-l-2-methylprolyl-l-glutamic acid
WO2011146109A2 (fr) * 2010-05-17 2011-11-24 Mount Sinai School Of Medicine Procédés et tests pour le traitement de sujets présentant une délétion, une mutation ou une expression réduite de shank3

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ADRIAN BIRD: "The methyl-CpG-binding protein MeCP2 and neurological disease", BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 36, no. 4, 1 August 2008 (2008-08-01), GB, pages 575 - 583, XP055276490, ISSN: 0300-5127, DOI: 10.1042/BST0360575 *
See also references of WO2014085480A1 *
WENLIN LIAO ET AL: "MeCP2+/ mouse model of RTT reproduces auditory phenotypes associated with Rett syndrome and replicate select EEG endophenotypes of autism spectrum disorder", NEUROBIOLOGY OF DISEASE, BLACKWELL SCIENTIFIC PUBLICATIONS, OXFORD, GB, vol. 46, no. 1, 31 December 2011 (2011-12-31), pages 88 - 92, XP028467473, ISSN: 0969-9961, [retrieved on 20120109], DOI: 10.1016/J.NBD.2011.12.048 *

Also Published As

Publication number Publication date
EP2928300A1 (fr) 2015-10-14
AU2013352294A1 (en) 2015-07-09
CA2929286A1 (fr) 2014-06-05
JP2016506380A (ja) 2016-03-03
BR112015012506A2 (pt) 2017-07-11
WO2014085480A1 (fr) 2014-06-05

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