EP2922826A4 - Methods of treating a disease or disorder associated with bruton's tyrosine kinase - Google Patents

Methods of treating a disease or disorder associated with bruton's tyrosine kinase

Info

Publication number
EP2922826A4
EP2922826A4 EP13856920.7A EP13856920A EP2922826A4 EP 2922826 A4 EP2922826 A4 EP 2922826A4 EP 13856920 A EP13856920 A EP 13856920A EP 2922826 A4 EP2922826 A4 EP 2922826A4
Authority
EP
European Patent Office
Prior art keywords
bruton
disease
treating
methods
tyrosine kinase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP13856920.7A
Other languages
German (de)
French (fr)
Other versions
EP2922826A2 (en
Inventor
Tom Daniel
Kenichi Takeshita
Kenneth Foon
Jay Mei
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celgene Avilomics Research Inc
Original Assignee
Celgene Avilomics Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Avilomics Research Inc filed Critical Celgene Avilomics Research Inc
Publication of EP2922826A2 publication Critical patent/EP2922826A2/en
Publication of EP2922826A4 publication Critical patent/EP2922826A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
EP13856920.7A 2012-11-20 2013-11-19 Methods of treating a disease or disorder associated with bruton's tyrosine kinase Withdrawn EP2922826A4 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261728701P 2012-11-20 2012-11-20
US201261728703P 2012-11-20 2012-11-20
US201361799761P 2013-03-15 2013-03-15
US201361870718P 2013-08-27 2013-08-27
US201361870720P 2013-08-27 2013-08-27
PCT/US2013/070766 WO2014081709A2 (en) 2012-11-20 2013-11-19 Methods of treating a disease or disorder associated with bruton's tyrosine kinase

Publications (2)

Publication Number Publication Date
EP2922826A2 EP2922826A2 (en) 2015-09-30
EP2922826A4 true EP2922826A4 (en) 2016-08-03

Family

ID=50776661

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13856920.7A Withdrawn EP2922826A4 (en) 2012-11-20 2013-11-19 Methods of treating a disease or disorder associated with bruton's tyrosine kinase

Country Status (3)

Country Link
EP (1) EP2922826A4 (en)
TW (1) TW201427666A (en)
WO (1) WO2014081709A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2922546A4 (en) * 2012-11-20 2016-06-08 Celgene Avilomics Res Inc Methods of treating a disease or disorder associated with bruton's tyrosine kinase
US9145387B2 (en) 2013-02-08 2015-09-29 Celgene Avilomics Research, Inc. ERK inhibitors and uses thereof
US9492471B2 (en) 2013-08-27 2016-11-15 Celgene Avilomics Research, Inc. Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
WO2016025561A1 (en) 2014-08-13 2016-02-18 Celgene Avilomics Research, Inc. Forms and compositions of an erk inhibitor
CN111057021B (en) * 2019-12-11 2023-05-23 中国药科大学 S-triazine compound, preparation method and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011153514A2 (en) * 2010-06-03 2011-12-08 Pharmacyclics, Inc. The use of inhibitors of bruton's tyrosine kinase (btk)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1949912A3 (en) * 1998-11-09 2008-08-13 Biogen Idec, Inc. Treatment of chronic lymphcytic leukemia (CLL) using chimeric anti-CD20 antibody
US8338439B2 (en) * 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
BR112013003388A2 (en) * 2010-08-10 2016-07-12 Celgene Avilomics Res Inc besylate salt of a btk inhibitor
US20140031325A1 (en) * 2010-12-06 2014-01-30 Celgene Corporation Combination therapy with lenalidomide and a cdk inhibitor for treating multiple myeloma
CN102093421B (en) * 2011-01-28 2014-07-02 北京康辰药业有限公司 Phosphorus substituent group-containing quinoline compound and preparation method of quinoline compound as well as pharmaceutical composition containing quinoline compound and application of pharmaceutical composition
EP2694486B1 (en) * 2011-04-01 2018-01-10 University of Utah Research Foundation Substituted n-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase btk inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011153514A2 (en) * 2010-06-03 2011-12-08 Pharmacyclics, Inc. The use of inhibitors of bruton's tyrosine kinase (btk)

Also Published As

Publication number Publication date
TW201427666A (en) 2014-07-16
WO2014081709A2 (en) 2014-05-30
EP2922826A2 (en) 2015-09-30
WO2014081709A3 (en) 2015-07-16

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20150615

AK Designated contracting states

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Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20160630

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 35/00 20060101ALI20160624BHEP

Ipc: A61K 31/675 20060101AFI20160624BHEP

17Q First examination report despatched

Effective date: 20170921

17Q First examination report despatched

Effective date: 20170927

STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 20180208