EP2793870A4 - Transmucosal drug delivery devices for use in chronic pain relief - Google Patents

Transmucosal drug delivery devices for use in chronic pain relief

Info

Publication number: EP2793870A4
Authority: EP; European Patent Office
Prior art keywords: drug delivery; delivery devices; chronic pain; pain relief; transmucosal drug
Prior art date: 2011-12-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

EP12860757.9A

Other languages

German (de)

French (fr)

Other versions

EP2793870A2 (en

Inventor

Andrew Finn

Niraj Vasisht

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Biodelivery Sciences International Inc

Original Assignee

Biodelivery Sciences International Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-12-21

Filing date

2012-12-21

Publication date

2016-02-17

2012-12-21 Application filed by Biodelivery Sciences International Inc filed Critical Biodelivery Sciences International Inc

2014-10-29 Publication of EP2793870A2 publication Critical patent/EP2793870A2/en

2016-02-17 Publication of EP2793870A4 publication Critical patent/EP2793870A4/en

Status Pending legal-status Critical Current

Links

208000000094 Chronic Pain Diseases 0.000 title 1
208000002193 Pain Diseases 0.000 title 1
238000012377 drug delivery Methods 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones

EP12860757.9A 2011-12-21 2012-12-21 Transmucosal drug delivery devices for use in chronic pain relief Pending EP2793870A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201161578755P	2011-12-21	2011-12-21
PCT/US2012/071330 WO2013096811A2 (en)	2011-12-21	2012-12-21	Transmucosal drug delivery devices for use in chronic pain relief

Publications (2)

Publication Number	Publication Date
EP2793870A2 EP2793870A2 (en)	2014-10-29
EP2793870A4 true EP2793870A4 (en)	2016-02-17

Family

ID=48669710

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP12860757.9A Pending EP2793870A4 (en)	2011-12-21	2012-12-21	Transmucosal drug delivery devices for use in chronic pain relief

Country Status (16)

Country	Link
EP (1)	EP2793870A4 (en)
JP (1)	JP6255349B2 (en)
KR (4)	KR20190110628A (en)
CN (2)	CN110123792A (en)
AU (4)	AU2012358308A1 (en)
BR (1)	BR112014015329A8 (en)
CA (1)	CA2859859A1 (en)
EA (2)	EA201992762A1 (en)
HK (1)	HK1203365A1 (en)
IL (2)	IL233075A0 (en)
IN (1)	IN2014DN06117A (en)
MX (2)	MX362217B (en)
SG (3)	SG10201710667YA (en)
UA (1)	UA118540C2 (en)
WO (1)	WO2013096811A2 (en)
ZA (1)	ZA201804381B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2021163529A2 (en) *	2020-02-13	2021-08-19	Biodelivery Sciences International, Inc.	Methods of treatment with buprenorphine

Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001058447A1 (en) *	2000-02-08	2001-08-16	Euro-Celtique, S.A.	Controlled-release compositions containing opioid agonist and antagonist
WO2007070632A2 (en) *	2005-12-13	2007-06-21	Biodelivery Sciences International, Inc.	Abuse resistant transmucosal drug delivery device
WO2008011194A2 (en) *	2006-07-21	2008-01-24	Biodelivery Sciences International, Inc.	Transmucosal delivery devices with enhanced uptake
WO2008025791A1 (en) *	2006-08-30	2008-03-06	Euro-Celtique S.A.	Buprenophine-wafer for drug substitution therapy
WO2008047163A1 (en) *	2006-10-18	2008-04-24	Pharmasol Limited	Buprenorphine-containing non-pressurised spray composition for transmucosal administration
US20080160068A1 (en) *	2005-02-21	2008-07-03	Lts Lohmann Therapie-Systeme Ag	Method for a Medicinal Combination Treatment, and Medicament Combinations Suitable Therefor

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US5800832A (en)	1996-10-18	1998-09-01	Virotex Corporation	Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces
DE19652188C2 (en) *	1996-12-16	2002-02-14	Lohmann Therapie Syst Lts	Flat drug preparation for application and release of buprenorphine or a pharmacologically comparable substance in the oral cavity and process for its preparation
US5968547A (en) *	1997-02-24	1999-10-19	Euro-Celtique, S.A.	Method of providing sustained analgesia with buprenorphine
DE19960154A1 (en) *	1999-12-14	2001-07-12	Lohmann Therapie Syst Lts	Flat pharmaceutical preparation for transmucosal administration of oxycodone or a comparable active ingredient in the oral cavity, for use in pain therapy and addiction therapy
EP1389621A4 (en)	2001-04-27	2005-05-11	Ajinomoto Kk	N-substituted pyrazolyl-o-glycoside derivatives and remedial agent for diabetes containing the same
US20110033542A1 (en)	2009-08-07	2011-02-10	Monosol Rx, Llc	Sublingual and buccal film compositions
US20060281775A1 (en) *	2005-06-14	2006-12-14	Applied Pharmacy Services, Inc.	Two-component pharmaceutical composition for the treatment of pain
CA2649107A1 (en)	2006-04-12	2007-10-25	Spinal Motion, Inc.	Posterior spinal device and method
US20090270438A1 (en) *	2006-10-18	2009-10-29	Clive Booles	Novel compositions and formulations
GB2447016A (en) *	2007-03-01	2008-09-03	Reckitt Benckiser Healthcare	Buprenorphine/naloxone compositions
CN105833420A (en) *	2008-06-23	2016-08-10	生物递送科学国际公司	Multidirectional mucosal delivery devices and methods of use
US8475832B2 (en)	2009-08-07	2013-07-02	Rb Pharmaceuticals Limited	Sublingual and buccal film compositions

2012
- 2012-12-21 KR KR1020197027379A patent/KR20190110628A/en active Application Filing
- 2012-12-21 IN IN6117DEN2014 patent/IN2014DN06117A/en unknown
- 2012-12-21 EA EA201992762A patent/EA201992762A1/en unknown
- 2012-12-21 KR KR1020227011298A patent/KR20220047889A/en not_active Application Discontinuation
- 2012-12-21 SG SG10201710667YA patent/SG10201710667YA/en unknown
- 2012-12-21 JP JP2014548962A patent/JP6255349B2/en active Active
- 2012-12-21 WO PCT/US2012/071330 patent/WO2013096811A2/en active Application Filing
- 2012-12-21 SG SG10202012743WA patent/SG10202012743WA/en unknown
- 2012-12-21 KR KR1020147020237A patent/KR102026321B1/en active IP Right Grant
- 2012-12-21 AU AU2012358308A patent/AU2012358308A1/en not_active Abandoned
- 2012-12-21 EA EA201491046A patent/EA034529B1/en unknown
- 2012-12-21 CN CN201910440007.8A patent/CN110123792A/en active Pending
- 2012-12-21 CA CA2859859A patent/CA2859859A1/en not_active Abandoned
- 2012-12-21 UA UAA201406826A patent/UA118540C2/en unknown
- 2012-12-21 EP EP12860757.9A patent/EP2793870A4/en active Pending
- 2012-12-21 MX MX2014007350A patent/MX362217B/en active IP Right Grant
- 2012-12-21 BR BR112014015329A patent/BR112014015329A8/en not_active Application Discontinuation
- 2012-12-21 KR KR1020207038099A patent/KR20210003313A/en not_active Application Discontinuation
- 2012-12-21 CN CN201280070389.6A patent/CN104125828A/en active Pending
- 2012-12-21 SG SG11201403075XA patent/SG11201403075XA/en unknown
2014
- 2014-06-11 IL IL233075A patent/IL233075A0/en unknown
- 2014-06-18 MX MX2021012154A patent/MX2021012154A/en unknown
2015
- 2015-04-22 HK HK15103881.9A patent/HK1203365A1/en unknown
2017
- 2017-11-09 AU AU2017258916A patent/AU2017258916B2/en active Active
2018
- 2018-06-29 ZA ZA2018/04381A patent/ZA201804381B/en unknown
2019
- 2019-04-15 AU AU2019202602A patent/AU2019202602A1/en not_active Abandoned
2021
- 2021-04-01 AU AU2021202042A patent/AU2021202042A1/en active Pending
- 2021-07-23 IL IL285091A patent/IL285091A/en unknown

Patent Citations (6)

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Publication number	Priority date	Publication date	Assignee	Title
WO2001058447A1 (en) *	2000-02-08	2001-08-16	Euro-Celtique, S.A.	Controlled-release compositions containing opioid agonist and antagonist
US20080160068A1 (en) *	2005-02-21	2008-07-03	Lts Lohmann Therapie-Systeme Ag	Method for a Medicinal Combination Treatment, and Medicament Combinations Suitable Therefor
WO2007070632A2 (en) *	2005-12-13	2007-06-21	Biodelivery Sciences International, Inc.	Abuse resistant transmucosal drug delivery device
WO2008011194A2 (en) *	2006-07-21	2008-01-24	Biodelivery Sciences International, Inc.	Transmucosal delivery devices with enhanced uptake
WO2008025791A1 (en) *	2006-08-30	2008-03-06	Euro-Celtique S.A.	Buprenophine-wafer for drug substitution therapy
WO2008047163A1 (en) *	2006-10-18	2008-04-24	Pharmasol Limited	Buprenorphine-containing non-pressurised spray composition for transmucosal administration

Non-Patent Citations (1)

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Title
See also references of WO2013096811A2 *

Also Published As

Publication number	Publication date
KR20220047889A (en)	2022-04-19
JP2015500886A (en)	2015-01-08
UA118540C2 (en)	2019-02-11
HK1203365A1 (en)	2015-10-30
IN2014DN06117A (en)	2015-08-14
EA201992762A1 (en)	2020-07-31
MX2014007350A (en)	2014-09-15
SG11201403075XA (en)	2014-07-30
KR102026321B1 (en)	2019-09-27
MX2021012154A (en)	2021-11-03
AU2019202602A1 (en)	2019-05-02
AU2017258916A1 (en)	2017-11-30
AU2021202042A1 (en)	2021-04-29
CN110123792A (en)	2019-08-16
BR112014015329A2 (en)	2017-06-13
IL233075A0 (en)	2014-07-31
AU2012358308A1 (en)	2014-07-24
ZA201804381B (en)	2022-12-21
SG10202012743WA (en)	2021-01-28
MX362217B (en)	2019-01-09
CA2859859A1 (en)	2013-06-27
AU2017258916B2 (en)	2019-01-17
WO2013096811A3 (en)	2014-07-24
KR20140106720A (en)	2014-09-03
EP2793870A2 (en)	2014-10-29
CN104125828A (en)	2014-10-29
EA201491046A1 (en)	2014-11-28
EA034529B1 (en)	2020-02-18
KR20210003313A (en)	2021-01-11
KR20190110628A (en)	2019-09-30
WO2013096811A2 (en)	2013-06-27
IL285091A (en)	2021-08-31
JP6255349B2 (en)	2017-12-27
SG10201710667YA (en)	2018-02-27
BR112014015329A8 (en)	2017-06-13

Legal Events

Date	Code	Title	Description
2014-09-26	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2014-10-29	17P	Request for examination filed	Effective date: 20140702
2014-10-29	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2015-07-01	DAX	Request for extension of the european patent (deleted)
2015-10-28	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 9/70 20060101AFI20150918BHEP
2015-10-30	REG	Reference to a national code	Ref country code: HK Ref legal event code: DE Ref document number: 1203365 Country of ref document: HK
2016-02-17	A4	Supplementary search report drawn up and despatched	Effective date: 20160120
2016-02-17	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 9/70 20060101AFI20160114BHEP
2016-09-28	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: BIODELIVERY SCIENCES INTERNATIONAL, INC.
2019-07-09	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: EXAMINATION IS IN PROGRESS
2019-08-14	17Q	First examination report despatched	Effective date: 20190712
2020-04-24	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: EXAMINATION IS IN PROGRESS
2021-09-10	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: EXAMINATION IS IN PROGRESS
2024-01-03	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 47/32 20060101ALI20231129BHEP Ipc: A61K 47/38 20060101ALI20231129BHEP Ipc: A61P 29/00 20060101ALI20231129BHEP Ipc: A61P 25/04 20060101ALI20231129BHEP Ipc: A61P 19/00 20060101ALI20231129BHEP Ipc: A61K 9/70 20060101AFI20231129BHEP

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