EP2714909A4 - Method of producing factor viii proteins by recombinant methods - Google Patents

Method of producing factor viii proteins by recombinant methods

Info

Publication number: EP2714909A4
Authority: EP; European Patent Office
Prior art keywords: factor viii; recombinant methods; producing factor; viii proteins; proteins
Prior art date: 2011-06-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP12796718.0A

Other languages

German (de)

French (fr)

Other versions

EP2714909A1 (en

Inventor

Randal J Kaufman

Steven W Pipe

Michael Griffith

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Cangene Corp

University of Michigan

Original Assignee

Cangene Corp

University of Michigan

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-06-03

Filing date

2012-06-01

Publication date

2014-12-17

2011-06-03 Priority claimed from US13/153,040 external-priority patent/US20120028900A1/en

2012-06-01 Application filed by Cangene Corp, University of Michigan filed Critical Cangene Corp

2014-04-09 Publication of EP2714909A1 publication Critical patent/EP2714909A1/en

2014-12-17 Publication of EP2714909A4 publication Critical patent/EP2714909A4/en

Status Withdrawn legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

EP12796718.0A 2011-06-03 2012-06-01 Method of producing factor viii proteins by recombinant methods Withdrawn EP2714909A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US13/153,040 US20120028900A1 (en)	2006-06-30	2011-06-03	Method of producing factor viii proteins by recombinant methods
PCT/US2012/040376 WO2012170289A1 (en)	2011-06-03	2012-06-01	Method of producing factor viii proteins by recombinant methods

Publications (2)

Publication Number	Publication Date
EP2714909A1 EP2714909A1 (en)	2014-04-09
EP2714909A4 true EP2714909A4 (en)	2014-12-17

Family

ID=47296374

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP12796718.0A Withdrawn EP2714909A4 (en)	2011-06-03	2012-06-01	Method of producing factor viii proteins by recombinant methods

Country Status (3)

Country	Link
EP (1)	EP2714909A4 (en)
CA (1)	CA2837995A1 (en)
WO (1)	WO2012170289A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI3889173T1 (en)	2013-02-15	2023-11-30	Bioverativ Therapeutics Inc.	Optimized factor viii gene
US10308705B2 (en) *	2015-02-06	2019-06-04	The University Of North Carolina At Chapel Hill	Optimized human clotting factor VIII gene expression cassettes and their use
KR20180038448A (en) *	2015-08-06	2018-04-16	글리코토페 게엠베하	Heteromers including antibody domain fusion proteins
JP7217630B2 (en)	2016-02-01	2023-02-03	バイオベラティブセラピューティクスインコーポレイテッド	Optimized Factor VIII gene
CN111183151A (en) *	2017-06-23	2020-05-19	百深公司	Purification of factor VIII subspecies
JP2022512787A (en) *	2018-10-23	2022-02-07	ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア	Compositions and Methods for Modulating Factor VIII Function
EP3785726A1 (en) *	2019-09-02	2021-03-03	Biotest AG	Factor viii protein with increased half-life
CN114391024A (en) *	2019-09-02	2022-04-22	生物测试股份公司	Factor VIII proteins with increased half-life
CN117192132B (en) *	2023-11-03	2024-02-02	庄亚(北京)生物科技有限公司	vWF fragment residue detection kit and method

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2008005847A2 (en) *	2006-06-30	2008-01-10	The Regents Of The University Of Michigan	Method of producing factor viii proteins by recombinant methods

2012
- 2012-06-01 CA CA2837995A patent/CA2837995A1/en not_active Abandoned
- 2012-06-01 WO PCT/US2012/040376 patent/WO2012170289A1/en active Application Filing
- 2012-06-01 EP EP12796718.0A patent/EP2714909A4/en not_active Withdrawn

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2008005847A2 (en) *	2006-06-30	2008-01-10	The Regents Of The University Of Michigan	Method of producing factor viii proteins by recombinant methods

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
KERRY L. DOORISS ET AL: "Comparison of Factor VIII Transgenes Bioengineered for Improved Expression in Gene Therapy of Hemophilia A", HUMAN GENE THERAPY, vol. 20, no. 5, 1 May 2009 (2009-05-01), pages 465 - 478, XP055136766, ISSN: 1043-0342, DOI: 10.1089/hum.2008.150 *
MIAO HONGZHI Z ET AL: "Bioengineering of coagulation factor VIII for improved secretion", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 103, no. 9, 1 May 2004 (2004-05-01), pages 3412 - 3419, XP002452857, ISSN: 0006-4971, DOI: 10.1182/BLOOD-2003-10-3591 *
N. J. WARD ET AL: "Codon optimization of human factor VIII cDNAs leads to high-level expression", BLOOD, vol. 117, no. 3, 20 January 2011 (2011-01-20), pages 798 - 807, XP055052195, ISSN: 0006-4971, DOI: 10.1182/blood-2010-05-282707 *
See also references of WO2012170289A1 *

Also Published As

Publication number	Publication date
EP2714909A1 (en)	2014-04-09
WO2012170289A1 (en)	2012-12-13
CA2837995A1 (en)	2012-12-13

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Legal Events

Date	Code	Title	Description
2014-03-07	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2014-04-09	17P	Request for examination filed	Effective date: 20131216
2014-04-09	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2014-07-30	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: CANGENE CORPORATION Owner name: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
2014-09-10	DAX	Request for extension of the european patent (deleted)
2014-12-17	A4	Supplementary search report drawn up and despatched	Effective date: 20141117
2014-12-17	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 38/37 20060101ALI20141111BHEP Ipc: C07K 14/755 20060101ALI20141111BHEP Ipc: C12Q 1/68 20060101ALI20141111BHEP Ipc: A61P 7/04 20060101ALI20141111BHEP Ipc: C12N 15/12 20060101AFI20141111BHEP
2015-11-27	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2015-12-30	18D	Application deemed to be withdrawn	Effective date: 20150616