EP2703084B1 - Insert de centrifugation et support à cet effet - Google Patents

Insert de centrifugation et support à cet effet Download PDF

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Publication number
EP2703084B1
EP2703084B1 EP12006215.3A EP12006215A EP2703084B1 EP 2703084 B1 EP2703084 B1 EP 2703084B1 EP 12006215 A EP12006215 A EP 12006215A EP 2703084 B1 EP2703084 B1 EP 2703084B1
Authority
EP
European Patent Office
Prior art keywords
carrier
centrifuge insert
centrifuge
base
insert
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP12006215.3A
Other languages
German (de)
English (en)
Other versions
EP2703084A1 (fr
Inventor
Sandra David
Sylke Grune
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eppendorf SE
Original Assignee
Eppendorf SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eppendorf SE filed Critical Eppendorf SE
Priority to EP17182672.0A priority Critical patent/EP3254761B1/fr
Priority to PL17182672T priority patent/PL3254761T3/pl
Priority to EP12006215.3A priority patent/EP2703084B1/fr
Publication of EP2703084A1 publication Critical patent/EP2703084A1/fr
Application granted granted Critical
Publication of EP2703084B1 publication Critical patent/EP2703084B1/fr
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Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/523—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for multisample carriers, e.g. used for microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B04B5/0414—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles comprising test tubes
    • B04B5/0421—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles comprising test tubes pivotably mounted
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B04B2005/0435—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles with adapters for centrifuge tubes or bags

Definitions

  • the present invention relates to a centrifuge insert for sample holders according to the preamble of claim 1 and to a carrier for a centrifuge insert for sample holders according to the preamble of claim 10.
  • centrifuge inserts are known for various sample receptacles, such as microtiter plates, deep well plates, PCR (Polymerase Chain Reaction) plates and cell culture plates in different configurations.
  • centrifuge cup for microtiter plates, which is attached as a microtiter swing to a centrifuge rotor.
  • This centrifuge insert has a carrier which is inserted on the bottom of the centrifuge insert.
  • the carrier is a microtiter plate carrier which can be adjusted into the centrifuge insert and which can be removed from the centrifuge insert with the aid of holding straps.
  • centrifuge inserts must always be provided with a removal or placement aid for the sample recordings, since otherwise no sample recordings can be used or removed.
  • centrifuge cups are relatively heavy due to their closed-to-the-side configuration, which requires a restriction on the permissible rotational speed or RZB (Relative Centrifugal Acceleration) values in order to avoid excessive loading of the rotor.
  • centrifuge inserts have no circumferentially closed side walls. They have a significant weight advantage over centrifuge cups and can thus be used in faster rotating centrifuges. Besides, they are Removal aids not required because the sample holders can be removed by hand or used.
  • a screwed carrier for the sample holders is required, which serves both the exact positioning and the fixation of the sample holders, so that they can not fall out of the centrifuge insert, for example, when swinging. This carrier also serves to damp the sample intake.
  • a disadvantage of the known open centrifuge inserts is that such a firmly screwed, fixing carrier at least greatly complicates the cleaning of the centrifuge insert.
  • such known carriers are designed such that all possible sample receptacles, so for example PCR plates, microtiter plates, deep well plates and cell culture plates can be placed on them. They must therefore be equally suitable for all plates in the sense of a "greatest common denominator" and thus have no geometry adapted or optimized to the specific type of plate.
  • the US 6 045 760 A discloses a microplate carrier which is resilient and integral with a centrifuge insert to prevent breakage of stacked microplates.
  • the US 2004/0184968 A1 relates to a multiwell centrifuge insert in which a carrier is used to dispose injection plates.
  • the DE 20 2009 000 613 U1 discloses a stacking adapter for placement in a centrifuge tray in which individual carriers on which samples are locatable can be stacked one above the other. Between the individual carriers bsteht a clip connection.
  • the object of the present invention is therefore to specify a centrifuge insert with which easy cleanability and adaptability to various sample receptacles can be provided.
  • a centrifuge insert is to be specified, with which the load of the rotor remains relatively low or high RZB values can be used.
  • the inventors have recognized that the stated object can be achieved in a particularly simple and cost-effective manner by providing a fastening that can be released without tools between the carrier and the centrifuge insert.
  • "Removable without tools” means in this context that a user does not need specially designed tools, but can solve the carrier by hand alone or possibly with the help of a pen or other hard objects.
  • the inventive design also ensures a secure fixation of the sample holders on the centrifuge insert continues. Due to the fact that the carrier is fastened detachably in the centrifuge insert at any time by the user, it is possible on the one hand to design the carrier as an adapter for different sample receptacles for different sample containers so that it can be exchanged very quickly if required.
  • the carrier can therefore be designed for stationary fixing, for example, of one or more microtiter plates, deepwell plates, PCR plates or cell culture plates. On the other hand, if wear occurs, the carriers can be replaced quickly and easily. The cleaning of the carrier and the centrifuge insert is made possible by the detachable connection, which increases the life.
  • the releasable attachment is formed via at least one clip connection between the carrier and the body of the centrifuge insert.
  • a clip connection can be very convenient for the user both in fixing as well use when loosening.
  • screw connections such a clip connection also has the advantage that at the connection point per se, no such high forces occur during centrifuging and thus the wear of the carrier is kept lower.
  • additional material savings are possible both on the carrier and on the centrifuge insert, since it is no longer necessary for the screw connection to make possible critical mass of material. This leads to the fact that the carrier and the centrifuge insert can be made simpler and thus higher centrifuging speeds can be realized.
  • the attachment of the carrier with a single holder take place in that the carrier has a einclipsbares element on the bottom side, which corresponds with a corresponding receptacle in the bottom of the centrifuge insert and penetrates it. If this einclipsbare element is not rotationally symmetrical, then there is a complete location of the carrier relative to the centrifuge insert.
  • At least one snap hook is arranged on the carrier, which engages in a corresponding recess of the body, wherein the snap hook is preferably arranged laterally on the carrier and extends substantially vertically with respect to the bottom of the centrifuge insert.
  • the clip connection can be particularly simple constructively implement.
  • the recess is formed as an opening, whereby the snap hook can be easily pushed out of the recess by the user. This flexibility of the snap hook is due to its dimensions.
  • the recess is arranged on a flexible element of the carrier, so that the recess can be so far complained of a arranged on the body corresponding snap hook that the snap hook is no longer in the recess engages.
  • the elastic element is arranged on the body and the substantially rigid element on the carrier.
  • the snap hook is designed as a retaining tab, which is formed at its end facing away from the base end inwardly angled.
  • the retaining tabs simultaneously serve as a support for the carrier and by internal pressures of the retaining tabs the clip connection can be solved.
  • the corresponding recesses on the centrifuge insert are not formed as perforations.
  • the releasable attachment is arranged in the swing-out direction of the centrifuge insert, whereby a particularly secure and locally fixed attachment of the carrier on the centrifuge insert is also possible during centrifuging.
  • a releasable attachment is perpendicular to the swing-out direction to set the wearer on all sides of the centrifuge insert.
  • the centrifuge insert is particularly advantageous for the centrifuge insert to be rounded at least in regions in a plane perpendicular to the swing-out direction.
  • the holder of the centrifuge insert is preferably rounded rounded on the bottom side of the rotor. This additionally reduces the mass.
  • the centrifuge insert has a lower flow resistance in the swing-out direction and turbulences are prevented by the rounded configurations.
  • At least one stiffening element preferably in the form of a rib or a web is arranged on the side facing away from the carrier of the bottom.
  • this stiffening element should also be rounded off in a direction perpendicular to the swing-out direction in order to keep the mass low and, if necessary, to minimize air resistance and to prevent turbulence.
  • a plurality of stiffening elements are provided, wherein preferably at least two stiffening elements are arranged perpendicular to one another with respect to the ground. This results in an overlap of the stiffening elements, which causes a particularly high stiffening.
  • the lightweight construction of the centrifuge insert further supported, which is reduced due to the reduced mass of energy and higher centrifuging speeds are possible.
  • At least the base of the carrier is at least partially elastic, because thereby the resulting during centrifugation loads are damped by the recorded sample receptacles in particular during the input and decay. This can be achieved for example by an applied elastic material.
  • At least one cavity extends below the base surface of the carrier, whereby on the one hand the carrier can be made even lighter.
  • the loads are introduced particularly favorable during centrifugation in the soil.
  • a support structure is arranged in the cavity for supporting the base surface with respect to the ground.
  • the support structure is preferably designed to be stiff.
  • the density of the support points (support points per unit area) of the support on the ground edge is higher than in the middle of the floor, because then the loads are increasingly initiated at the edge in the ground, so that the load in the relatively weaker trained center of the soil is reduced.
  • Self-contained protection is claimed for such a carrier for a centrifuge insert for sample receptacles, which is releasably attachable without tools in the centrifuge insert.
  • the centrifuge insert has a body 2 and a carrier 4 for sample receptacles.
  • two brackets 6 are provided for attachment to the rotor 59 of the centrifuge 50, so that the centrifuge insert 1 is a swingable centrifuge insert.
  • the carrier 4 is arranged on a bottom 10 of the body 2 and itself has a base 12, on which the sample holder 61 is arranged.
  • clip connections 14 are provided for releasably securing the carrier 4 on the floor 10 clip connections 14 are provided.
  • the carrier 4 has two oppositely arranged snap hooks 16, which engage in apertures 18 which are arranged on lugs 20 of the body 2.
  • the tabs 20 extend substantially vertically from the bottom 10 of the body 2.
  • the snap hooks 16 are arranged on a lateral arm 16a of the carrier 4 and have a curvature 16b and an adjoining, substantially vertically arranged portion 16c, both of which have a smaller material thickness than the lateral arm 16a.
  • the user may also take an aid such as a ballpoint pen or the like instead of his finger to help when greater forces are required.
  • the locking of the snap-action hook 16 with respect to the opening 18 takes place by means of the substantially horizontally extending hook element 16d.
  • the centrifuge insert 1 is in a lightweight construction with relatively low material thicknesses and, for example, made of aluminum, as is familiar to the expert.
  • To stiffen the body 2 are arranged perpendicular to the swing-A direction webs 21, 22 and arranged parallel to the swing-A direction webs 23 on the underside of the centrifuge insert 1 are provided, which intersect.
  • the webs 22 in this case have lateral rounded portions 24, so that the weight is reduced and the flow resistance of the centrifuge insert 1 in the swinging down direction A is reduced.
  • this web 22 may also be formed beveled.
  • the bracket 6 has with its webs 21 bottom side a rounding 26, so that also reduces the flow resistance and in addition the weight of the centrifuge insert 1 is reduced.
  • the centrifuge insert is characterized very lightweight and compact, wherein he still has a sufficiently high stiffness by the webs 21, 22, 23, even under high loads, so that the bottom 10 can not bend.
  • the webs 21 take over the main load and pass it to the holder 6 and the webs 22 stiffen the bottom 10 on the outside, so that it does not kink under high loads.
  • clip connections between the carrier 4 and the brackets 6 could be provided so that an all-sided determination on the body 2, but this is not absolutely necessary.
  • the carrier 4 has a located between the base 12 and the lateral boom 16 a stage 28 which extends around the support 4.
  • This stage 28 serves to define microtiter plates 61, which have a corresponding peripheral edge, which is attached to the step 28.
  • the microtiter plates 61 are fixed directly on the carrier 4 and do not touch the clip connection 14 or the holders 6. If no microtiter plates 61 are to be used, but other sample holders (not shown), then specially adapted carriers (not shown) may be used for this purpose. be used.
  • the snap hook 16 has a laterally outwardly inclined position relative to the vertical V. This results in a bias of the snap hook 16 relative to the tab 20, so that the hook member 16 d is securely fixed in the opening 18, but can be solved by overcoming the bias again.
  • the base 12 of the carrier 4 is arranged elevated relative to the bottom 10 of the centrifuge insert 1, so that cavities 30 are formed, which are arranged honeycomb-shaped. Between the cavities 30 rigid supports 32 are arranged. This gives the base 12 a high stability, with a defined force introduction takes place in the bottom 10.
  • the base 12 is provided with a flexible support (not shown) for receiving load peaks occurring during centrifugation.
  • the honeycomb structure increases toward the center of the base area 12, so that the Edge the density of support points of the support 4 on the floor 10 is higher than in the center of the bottom 10 and thereby loads are increasingly initiated at the edge in the bottom 10, so that the load in the relatively weaker trained center of the bottom 10 is reduced.
  • centrifuge insert 1 in the Fig. 5a and in this regard enlarged in part Fig. 5b Now is the interaction of the centrifuge insert 1 according to the invention with a centrifuge 50, which has a centrifuge housing 51 with a centrifuge lid 53 and ventilation slots 55 and an operating unit 57 shown. It can be seen that the centrifuge insert 1 with its holders 6 is arranged swingably on a rotor 59, wherein the rotor 59 is provided for receiving four centrifuge inserts 1 and on each centrifuge insert 1 designed as a microtiter plate sample holder 61 is arranged.
  • centrifuge insert 1 according to the invention, significant advantages over the known centrifuge insert result. These consist not only in that the carrier 4 is particularly easy and comfortable to attach and detach. It is also possible to use different carriers 4 for different sample receptacles 61.
  • the centrifuge insert 1 according to the invention is designed to be particularly lightweight and compact, so that the load of the rotor 59 at the same centrifuging power is significantly lower or significantly higher RCF values can be achieved.

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  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Centrifugal Separators (AREA)

Claims (11)

  1. Insert de centrifugation (1) pour des réceptacles d'échantillons en forme de plaques tels que plaques microtitres, plaques Deepwell, plaques PCR et plaques de cultures cellulaires, avec un corps (2) présentant un fond (10) et au moins un élément de retenue (6) destiné à la fixation sur un rotor (8), un support (4) étant disposé de façon détachable sur le fond (10), le support (4) présentant une surface de base (12) destinée à recevoir les réceptacles d'échantillons, le support (4) étant raccordé au corps (2) par le biais d'une fixation (14) détachable sans outil, caractérisé en ce que le support (4) avec le corps (2) est fixé sur le corps (2) par le biais d'au moins un raccordement par clips (14), le raccordement par clips (14) présentant un crochet d'encliquetage (16), disposé sur le support (4), qui engrène dans un creux (18) correspondant du corps (2), le creux étant constitué en tant qu'ouverture de passage (18) de sorte que le crochet d'encliquetage (16) peut être facilement extrait par pression hors du creux par un utilisateur.
  2. Insert de centrifugation (1) selon la revendication 1, caractérisé en ce que la fixation détachable est disposée dans la direction d'oscillation (A) de l'insert de centrifugation (1).
  3. Insert de centrifugation (1) selon la revendication 1 ou 2, caractérisé en ce que le crochet d'encliquetage (16) est disposé latéralement (16a) sur le support (4) et s'étend essentiellement verticalement (16c) en relation avec le fond (10).
  4. Insert de centrifugation (1) selon l'une des revendications précédentes, caractérisé en ce que l'insert de centrifugation (1) est constitué de façon arrondie (24, 26) au moins par tronçons dans un plan perpendiculairement à la direction d'oscillation (A), l'élément de retenue (6) étant de préférence constitué de façon arrondie (26) côté fond.
  5. Insert de centrifugation (1) selon l'une des revendications précédentes, caractérisé en ce que, au moins sur le côté du fond (10) éloigné du support (4), il est disposé au moins un élément de rigidification, de préférence sous la forme d'une ailette (22) ou d'une nervure, qui est constitué de façon arrondie en particulier au moins perpendiculairement à la direction d'oscillation (A).
  6. Insert de centrifugation (1) selon la revendication 5, caractérisé en ce que plusieurs éléments de rigidification (22, 22a) sont prévus, de préférence au moins deux éléments de rigidification (22, 22a) étant disposés perpendiculairement entre eux par rapport au fond (10).
  7. Insert de centrifugation (1) selon l'une des revendications précédentes, caractérisé en ce qu'au moins la surface de base (12) du support est constituée de façon élastique au moins partiellement.
  8. Insert de centrifugation (1) selon l'une des revendications précédentes, caractérisé en ce qu'au moins une cavité (30) s'étend sous la surface de base, étant de préférence prévu qu'une structure de soutien (32) est disposée dans la cavité (30) pour soutenir la surface de base (12) par rapport au fond (10).
  9. Insert de centrifugation (1) selon l'une des revendications précédentes, caractérisé en ce que le support (4) est constitué pour l'immobilisation (28) stationnaire d'une ou de plusieurs plaques microtitres, plaques Deepwell, plaques PCR ou plaques de cultures cellulaires.
  10. Support (4) pour des réceptacles d'échantillons en forme de plaques tels que plaques microtitres, plaques Deepwell, plaques PCR et plaques de culture cellulaires, destinés à être disposés dans un insert de centrifugation (1) qui présente un corps (2) avec un fond (10) et au moins un élément de retenue (6) destiné à la fixation sur un rotor (8), le support (4) pouvant être disposé de façon détachable sur le fond (10) de l'insert de centrifugation (1) et présentant une surface de base (12) destinée à recevoir les réceptacles d'échantillons, caractérisé en ce que le support (4) présente les caractéristiques de la revendication 1 liées au support (4) .
  11. Support (4) selon la revendication 10, caractérisé en ce que le support (4) présente en outre les caractéristiques d'une des revendications 2, 3, 7, 8 et 9 liées au support (4).
EP12006215.3A 2012-09-03 2012-09-03 Insert de centrifugation et support à cet effet Active EP2703084B1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP17182672.0A EP3254761B1 (fr) 2012-09-03 2012-09-03 Insert de centrifugation et support á cet effet
PL17182672T PL3254761T3 (pl) 2012-09-03 2012-09-03 Wkładka do wirówki i nośnik dla tej wkładki
EP12006215.3A EP2703084B1 (fr) 2012-09-03 2012-09-03 Insert de centrifugation et support à cet effet

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12006215.3A EP2703084B1 (fr) 2012-09-03 2012-09-03 Insert de centrifugation et support à cet effet

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP17182672.0A Division-Into EP3254761B1 (fr) 2012-09-03 2012-09-03 Insert de centrifugation et support á cet effet
EP17182672.0A Division EP3254761B1 (fr) 2012-09-03 2012-09-03 Insert de centrifugation et support á cet effet

Publications (2)

Publication Number Publication Date
EP2703084A1 EP2703084A1 (fr) 2014-03-05
EP2703084B1 true EP2703084B1 (fr) 2017-12-20

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Application Number Title Priority Date Filing Date
EP17182672.0A Active EP3254761B1 (fr) 2012-09-03 2012-09-03 Insert de centrifugation et support á cet effet
EP12006215.3A Active EP2703084B1 (fr) 2012-09-03 2012-09-03 Insert de centrifugation et support à cet effet

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Application Number Title Priority Date Filing Date
EP17182672.0A Active EP3254761B1 (fr) 2012-09-03 2012-09-03 Insert de centrifugation et support á cet effet

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EP (2) EP3254761B1 (fr)
PL (1) PL3254761T3 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4103325A4 (fr) * 2020-02-15 2024-03-06 Heska Corporation Cartouches d'échantillon

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19953453C2 (de) * 1999-11-05 2003-11-27 Kendro Lab Prod Gmbh Zentrifugeneinsatz für Mikrotiterplatten
DE202009000613U1 (de) * 2009-01-15 2009-03-19 Eppendorf Ag Stapeladapter

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6045760A (en) 1995-12-05 2000-04-04 Hitachi Koki Co., Ltd. Micro-plate adapter
AU2001247971A1 (en) 2000-02-14 2001-08-27 Orchid Biosciences, Inc. Well plate holder
US20040184968A1 (en) 2003-03-21 2004-09-23 Bio-Rad Laboratories, Inc. Adaptor for dye terminator removal apparatus
KR101420094B1 (ko) * 2010-10-27 2014-07-17 (주)바이오니아 다양한 생체시료분석을 위한 전자동실시간정량증폭장비, 다양한 생체시료분석을 위한 자동정제 및 반응준비 장치, 전자동 핵산정제 및 실시간 정량 유전자증폭 방법, 전자동 핵산정제방법, 실시간정량ｐｃｒ을 이용한 병원균의 전자동 생균수검사방법, 정량면역ｐｃｒ을 이용한 전자동 항원농도획득방법 및 타겟항원에 라벨링된 부착용 타겟핵산의 정제방법

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19953453C2 (de) * 1999-11-05 2003-11-27 Kendro Lab Prod Gmbh Zentrifugeneinsatz für Mikrotiterplatten
DE202009000613U1 (de) * 2009-01-15 2009-03-19 Eppendorf Ag Stapeladapter

Also Published As

Publication number Publication date
EP2703084A1 (fr) 2014-03-05
EP3254761A1 (fr) 2017-12-13
EP3254761B1 (fr) 2018-11-14
PL3254761T3 (pl) 2019-05-31

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