EP2675808A4 - Process for pemetrexed disodium - Google Patents

Process for pemetrexed disodium

Info

Publication number
EP2675808A4
EP2675808A4 EP12747282.7A EP12747282A EP2675808A4 EP 2675808 A4 EP2675808 A4 EP 2675808A4 EP 12747282 A EP12747282 A EP 12747282A EP 2675808 A4 EP2675808 A4 EP 2675808A4
Authority
EP
European Patent Office
Prior art keywords
pemetrexed disodium
pemetrexed
disodium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12747282.7A
Other languages
German (de)
French (fr)
Other versions
EP2675808A2 (en
Inventor
Reddy Bandi Parthasaradhi
Reddy Kura Rathnakar
Reddy Dasari Muralidhara
Puranik Ramachandra
Krishna Bandi Vamsi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hetero Research Foundation
Original Assignee
Hetero Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hetero Research Foundation filed Critical Hetero Research Foundation
Publication of EP2675808A2 publication Critical patent/EP2675808A2/en
Publication of EP2675808A4 publication Critical patent/EP2675808A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP12747282.7A 2011-02-15 2012-02-14 Process for pemetrexed disodium Withdrawn EP2675808A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN434CH2011 2011-02-15
PCT/IN2012/000103 WO2012111027A2 (en) 2011-02-15 2012-02-14 Process for pemetrexed disodium

Publications (2)

Publication Number Publication Date
EP2675808A2 EP2675808A2 (en) 2013-12-25
EP2675808A4 true EP2675808A4 (en) 2014-07-09

Family

ID=46672998

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12747282.7A Withdrawn EP2675808A4 (en) 2011-02-15 2012-02-14 Process for pemetrexed disodium

Country Status (2)

Country Link
EP (1) EP2675808A4 (en)
WO (1) WO2012111027A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101578093B1 (en) * 2013-09-05 2015-12-16 주식회사 삼양바이오팜 Improved method for preparing an intermediate for preparing pemetrexed with high purity and method for preparing pemetrexed with high purity by using the intermediate
CN107628947B (en) * 2017-09-14 2020-07-28 浙江工业大学 Preparation method of pemetrexed disodium key intermediate
JPWO2019244965A1 (en) * 2018-06-20 2020-06-25 日本化薬株式会社 Pemetrexed sodium injection solution formulation and method for producing the same
CN110031567A (en) * 2019-05-15 2019-07-19 南京制药厂有限公司 The analysis method of pemetrexed disodium intermediate diethylester
CN111333658A (en) * 2020-05-06 2020-06-26 贵州联科中贝制药科技有限公司 Preparation method of pemetrexed disodium hydrate

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999016742A1 (en) * 1997-09-26 1999-04-08 Eli Lilly And Company Processes and intermediates useful to make antifolates
WO2011019986A2 (en) * 2009-08-13 2011-02-17 Dr. Reddy's Laboratories Ltd. Processes for preparing pemetrexed

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5403843A (en) * 1991-08-12 1995-04-04 Takeda Chemical Industries, Ltd. Pyrrolopyrimidinyalglutaminate derivatives and their use
WO2001014379A2 (en) * 1999-08-23 2001-03-01 Eli Lilly And Company A novel crystalline form of disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid salt and processes therefor
CN101417998B (en) * 2007-10-24 2012-10-24 重庆医药工业研究院有限责任公司 Purification method of pemetrexed salt
CN101591247B (en) * 2008-05-30 2012-09-05 上海希迪制药有限公司 Method for synthesizing 4-(4-carbomethoxyphenyl) butyraldehyde
WO2010030598A2 (en) * 2008-09-11 2010-03-18 Dr. Reddy's Laboratories Limited Pharmaceutical formulations comprising pemetrexed

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999016742A1 (en) * 1997-09-26 1999-04-08 Eli Lilly And Company Processes and intermediates useful to make antifolates
WO2011019986A2 (en) * 2009-08-13 2011-02-17 Dr. Reddy's Laboratories Ltd. Processes for preparing pemetrexed

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BARNETT C J ET AL: "A PRACTICAL SYNTHESIS OF MULTITARGETED ANTIFOLATE LY231514", ORGANIC PROCESS RESEARCH AND DEVELOPMENT, CAMBRIDGE, GB, vol. 3, no. 3, 1 January 1999 (1999-01-01), pages 184 - 188, XP000982091, DOI: 10.1021/OP9802172 *
DOUGLAS P KJELL ET AL: "Determination of the source of N-methyl impurity in the synthesis of pemetrexed disodium heptahydrate", ORGANIC PROCESS RESEARCH AND DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 9, no. 6, 18 November 2005 (2005-11-18), pages 739 - 742, XP002634585, ISSN: 1083-6160, [retrieved on 20051006], DOI: 10.1021/OP0498013 *
EDWARD C. TAYLOR ET AL: "A New and Efficient Synthesis of Pyrrolo 2,3- d |pyrimidine Anticancer Agents: Alimta (LY231514, MTA), Homo-Alimta, TNP-351, and Some Aryl 5-Substituted Pyrrolo 2,3- d |pyrimidines", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 68, no. 26, 1 December 2003 (2003-12-01), pages 9938 - 9947, XP055002811, ISSN: 0022-3263, DOI: 10.1021/jo030248h *

Also Published As

Publication number Publication date
EP2675808A2 (en) 2013-12-25
WO2012111027A3 (en) 2012-10-11
WO2012111027A2 (en) 2012-08-23

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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A4 Supplementary search report drawn up and despatched

Effective date: 20140612

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Ipc: C07D 487/04 20060101AFI20140605BHEP

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Effective date: 20150113