EP2632518B1 - Injection devices - Google Patents
Injection devices Download PDFInfo
- Publication number
- EP2632518B1 EP2632518B1 EP11776826.7A EP11776826A EP2632518B1 EP 2632518 B1 EP2632518 B1 EP 2632518B1 EP 11776826 A EP11776826 A EP 11776826A EP 2632518 B1 EP2632518 B1 EP 2632518B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- cap
- injection device
- housing
- aperture
- shield
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31501—Means for blocking or restricting the movement of the rod or piston
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
- A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/206—With automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
- A61M5/3245—Constructional features thereof, e.g. to improve manipulation or functioning
- A61M2005/3247—Means to impede repositioning of protection sleeve from needle covering to needle uncovering position
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/35—Communication
- A61M2205/3507—Communication with implanted devices, e.g. external control
- A61M2205/3515—Communication with implanted devices, e.g. external control using magnetic means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
- A61M5/3204—Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices
Definitions
- This invention relates to injection devices.
- Known autoinjector devices typically include a trigger button that is pressed to deploy the needle. Although convenient to use, unintentional pressing of the button could result in a person being accidentally injected with a drug that may be harmful to him/her.
- Conventional injection devices also typically include a solid body that does not allow visual inspection of the contents of the syringe.
- some drugs are photosensitive and so it is not desirable for the bodies of injection devices to be fully transparent.
- An example of prior art devices is given in WO2008/029280 .
- Embodiments of the present invention are intended to address at least some of the abovementioned problems.
- this invention provides an injection device including:
- the trigger device may be slidably mounted within the housing and the cap can includes at least one arm that, in the fitted configuration, prevents sliding of the trigger device in an activation direction.
- the trigger device may projects rearwardly from a rear end of the housing.
- the trigger device may be biased against the activation direction.
- the trigger device can be biased by means of at least one sprung member.
- the at least one sprung member can include a cam surface which, in use when sliding in the activation direction, rides over an abutment inside the housing.
- the at least one arm when the cap is in the fitted configuration, can prevent the cam surface of the sprung member from riding over the abutment.
- the injection device may further include a rear collar that fits over a rear portion of the housing and the at least one arm, when the cap in the fitted configuration, may be located inside a channel defined between an inner surface of the collar and an outer surface of the rear portion of the housing, thereby restricting movement of the at least one sprung arm.
- the injection device may further include a shield for the needle and the cap may further include an arrangement that removes the needle shield when, in use, the cap is removed.
- the needle shield may be supported within an interior arrangement of the cap.
- the interior arrangement can include a re-entrant cylindrical portion.
- the arrangement for removing the needle shield can include at least one claw feature that, in use when the cap is removed from the housing, pulls the needle shield away from the syringe.
- the cap may further include:
- a biasing arrangement may bias the shield arrangement to the closed configuration.
- the shield arrangement can include a portion with at least one solid wall slidably mounted within the cap, the solid wall being aligned with the aperture when the shield is in its closed configuration.
- the housing can further include at least one aperture, where the at least one aperture of the cap, when the cap is its fitted configuration, is aligned with the at least one housing aperture.
- the cap can have two diametrically-opposed elongate said apertures.
- the autoinjector comprises an outer housing 10 of cylindrical form in the bore of which is disposed a syringe 12 of known form with a barrel 14, a needle 16 extending from the forward end, and a flange 18 at its rear end.
- a medicament is contained within the syringe and can be expressed through the needle by a piston 20 inside the barrel.
- the syringe is supported and surrounded by moulded plastics shroud/carrier 22 assembly comprising a forward hollow cylindrical portion 24 integrally formed with diametrically opposed springs 26 to either side, and a collar 28 adapted to engage the forward face of the syringe flange.
- a drive mechanism which comprises a first outer spring 36 which acts between the front face of a transverse inner wall 38 at the rear of the housing and a forward flange 40 of a top hat-shaped intermediate member 42.
- An inner, second, spring 44 is received within a cylindrical part of the intermediate member 42 and acts between an inner face of the rear end wall thereof and a circumferential rib 46 on the forward part of a plunger 48.
- the plunger has a resilient hooked arm 50 (see Figures 1, 3(b) ) which latches around the edge of an aperture in the transverse inner wall 38 of the housing.
- a captive axially slideable trigger button 52 Projecting rearwardly from the rear end of the housing is a captive axially slideable trigger button 52 movable against a rearward bias from the position shown in e.g. Figure 3(b) , where a release finger 54 is spaced rearwardly of the hooked arm 50, to a forward portion where the finger 54 cams the hooked arm to release its retention by the wall 38, thereby allowing the springs 36, 44 to drive the plunger 48 forwardly.
- the plunger is shaped and sized so that it can pass into and down the internal bore of the syringe barrel 14, to urge the piston 20 to express a dose.
- a cylindrical recess In the forward end of the plunger is a cylindrical recess in which is located a small powerful magnet 56.
- the trigger button 52 is biased rearwardly by means of two integral forwardly extending sprung arms 58 with cam surfaces 60 which ride over respective abutments 62 inside the rear of the housing. However, initially, forward movement of the trigger button is prevented by means of two rearwardly extending locking arms 64 which extend back from the rear end of a cap 66.
- a rear collar 37 is fitted over the rear portion of the housing 10, out of which the button 52 protrudes rearwardly.
- the locking arms 64 are located inside an annular channel 39 defined between an inner surface of the collar and an outer surface of the rear portion of the housing. In its fitted configuration, the cap covers the whole of the forward end of the housing and has a re-entrant cylindrical portion 68 with claw features 70.
- the claw features 70 slip over the rear end of a needle shield 72 which is secured to the front end of the needle during manufacture.
- the cap 66 fulfils the functions of acting as a safety catch for the trigger button 52, serving as a shield remover.
- Anchored inside the forward end of the housing is a latch 74 formed of pressed steel or other ferro-magnetic material to provide two latch arms 76 which extend forwardly from an anchorage normally to sit in an annular space between the shroud 24 and an inner part of the housing wall.
- the user pulls the cap 66 off forwardly which removes the needle shield 22 from the syringe and arms the device by rendering the trigger button 52 operational.
- the user then offers the injection device up to the injection site and presses the trigger button 52.
- the first spring 36 expands to extend the syringe 20 so that the needle penetrates the flesh.
- the second spring 44 remains substantially fully compressed, with the plunger 48 bearing against the piston 20 within the syringe but not moving it relative to the syringe.
- the clearance fingers 32 on the syringe supporting collar 28 are constrained against outward splaying movement by the grooves 34 and so a gap is preserved between the syringe flange 18 and the flange 40 of the intermediate member 42, as long as the fingers are still in engagement with the constraining grooves.
- the cap may include at least one member other than the arms 64 for blocking/interfering with the sliding motion of the button.
- the fingers 32 exit the constraining grooves 34 at about the same time as forward movement of the syringe is arrested by the compression spring portions 26 bottoming out, the shroud 24 being held against movement by contact with the skin surface.
- the first spring 36 continues to expand to drive the flange 40 of the intermediate member into engagement with the syringe flange 18 thereby contributing to the force required to initiate movement of the piston down the syringe ( Figure 5(b) ). From this position the second spring 44 expands to drive the piston down the barrel of the syringe to express a dose.
- further magnets or ferro-magnet material may be disposed in the front end of the housing around or in front of the syringe in order to provide a magnetic boost effect as the plunger nears the end of its stroke.
- This second embodiment incorporates a magnetic coupling embodiment between the plunger 48 and the syringe designed so that during an initial penetration phase of movement the plunger is coupled magnetically to a thrust collar 80 of ferro-magnetic material that is positioned in contact with the rear face of the syringe flange 18.
- a magnetic coupling embodiment between the plunger 48 and the syringe designed so that during an initial penetration phase of movement the plunger is coupled magnetically to a thrust collar 80 of ferro-magnetic material that is positioned in contact with the rear face of the syringe flange 18.
- the spring force acting on the plunger overcomes the magnetic coupling force and the coupling yields so that the plunger is released to move forward relative to the syringe to move the plunger into contact with and to urge the piston forwardly to expel a dose.
- the plunger moves alongside the ferro-magnetic latching arms 76 and they are attracted inwardly. This is enhanced in the embodiment by provision of two magnets 82 on the forward ends of the latching arms. These magnets are aligned so as to be attached towards and to exert a pull on the magnet 56 in the plunger to provide a magnetically influenced forward boost to the plunger toward the forwardmost end of its stroke.
- the shroud 24 Upon completion of the injection and removal of the device from the site, the shroud 24 extends forwardly as the spring portions 26 reexpand, and as a rearward lip on the shroud passes the magnets, the latching arms move inwards to block retraction movement of the shroud and thereby lock it out.
- the magnets 82 may be housed slideably in through-holes in the housing wall, allowing them also to move inwards with the latching arms as the rearward lip on the shroud passes the magnets, and so provide a visual and tactile confirmation of locking out of the shroud 24.
- the cap 66 includes at least one aperture 91.
- the housing 10 also includes at least one corresponding aperture 91 a and when the cap is fitted on the shield, the sets of apertures are at least partially aligned.
- a light shield 92 is slidably mounted inside the cap 66, over the cylindrical housing 10.
- the light shield may be slidably mounted on another component of the device and may be accessible through the cap.
- the example light shield includes a cylindrical portion with solid walls from which a spring 94 portion extends.
- a pair of diametrically opposed circular buttons 93 with finger grooves are located at the other end of the cylindrical portion and stand proud of its outer surface.
- the cylindrical portion of the light shield covers the apertures, preventing the content of the syringe 20 from being exposed to light. This can be advantageous in the case of photosensitive drugs.
- buttons 93 can be used to push the light shield downwards, which compresses the plastic spring 94 against an abutment 95 on the inner surface of the cap 66. The user can then check the contents of the syringe through the apertures and when he/she releases the button(s), the shield springs back to the position of Figure 9(c) .
- Alternatives to the light shield described above are possible, e.g. a hinged lid on the cap.
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Environmental & Geological Engineering (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Description
- This invention relates to injection devices.
- It is important that the needles of injection devices remain covered when not in use for reasons of safety. Known autoinjector devices typically include a trigger button that is pressed to deploy the needle. Although convenient to use, unintentional pressing of the button could result in a person being accidentally injected with a drug that may be harmful to him/her.
- Conventional injection devices also typically include a solid body that does not allow visual inspection of the contents of the syringe. However, some drugs are photosensitive and so it is not desirable for the bodies of injection devices to be fully transparent. An example of prior art devices is given in
WO2008/029280 . - Embodiments of the present invention are intended to address at least some of the abovementioned problems.
- Accordingly, in one aspect, this invention provides an injection device including:
- an elongate housing;
- a syringe disposed in said housing and having an internal piston to express a dose from a needle at its front end;
- a trigger device for, in use, activating the internal piston, and
- a cap that, in a fitted configuration, fits over at least part of the elongate housing and prevents activation of the trigger device
- and characterised in that the cap (66) includes at least one member that, in the fitted configuration, blocks or interferes with the sliding of the trigger device in an activation direction.
- The trigger device may be slidably mounted within the housing and the cap can includes at least one arm that, in the fitted configuration, prevents sliding of the trigger device in an activation direction. The trigger device may projects rearwardly from a rear end of the housing. The trigger device may be biased against the activation direction. The trigger device can be biased by means of at least one sprung member. The at least one sprung member can include a cam surface which, in use when sliding in the activation direction, rides over an abutment inside the housing. The at least one arm, when the cap is in the fitted configuration, can prevent the cam surface of the sprung member from riding over the abutment. The injection device may further include a rear collar that fits over a rear portion of the housing and the at least one arm, when the cap in the fitted configuration, may be located inside a channel defined between an inner surface of the collar and an outer surface of the rear portion of the housing, thereby restricting movement of the at least one sprung arm.
- The injection device may further include a shield for the needle and the cap may further include an arrangement that removes the needle shield when, in use, the cap is removed. The needle shield may be supported within an interior arrangement of the cap. The interior arrangement can include a re-entrant cylindrical portion. The arrangement for removing the needle shield can include at least one claw feature that, in use when the cap is removed from the housing, pulls the needle shield away from the syringe.
- The cap may further include:
- at least one aperture, that, when the cap is in its fitted configuration is aligned with an aperture in the housing located above a portion of the syringe, and
- a shield arrangement configured to move between a closed configuration that blocks the at least one cap aperture and an open configuration that at least partially exposes the at least one cap aperture.
- A biasing arrangement may bias the shield arrangement to the closed configuration. The shield arrangement can include a portion with at least one solid wall slidably mounted within the cap, the solid wall being aligned with the aperture when the shield is in its closed configuration. The housing can further include at least one aperture, where the at least one aperture of the cap, when the cap is its fitted configuration, is aligned with the at least one housing aperture. The cap can have two diametrically-opposed elongate said apertures.
- Whilst the invention has been described above, it extends to any inventive combination set out above, or in the following description or drawings.
- The invention may be performed in various ways, and two embodiments thereof will now be described by way of example only, reference being made to the accompanying drawings, in which:
-
Figure 1 is an exploded view of the first embodiment of an autoinjector in accordance with this invention; -
Figure 2 is a side section view through the autoinjector ofFigure 1 assembled and prior to use; -
Figures 3(a) and (b) are respective side and top section views of the autoinjector with the cap in place, and removed; -
Figures 4(a) and (b) are respective side and top section views of the autoinjector with the firing button partially depressed immediately prior to the release of the plunger; -
Figures 5(a), (b) and (c) are respective side section views showing the autoinjector with the syringe in its forwardmost position, shortly after breakout of the piston, and at the injection complete stage, respectively; -
Figure 6 is a view of the autoinjector after use, with the shroud extended and locked out by the magnetically enabled latch; -
Figure 7 is a side view through a second embodiment of an autoinjector (without its cap); -
Figure 8 is a shaded side view ofFigure 7 ; -
Figures 9(a) and (b) are respective side and top section views of a third embodiment of the autoinjector with a cap in its fitted configuration; -
Figure 9(c) is a plan view of the second embodiment with the cap in its fitted configuration; -
Figure 10 shows a light shield feature of the second embodiment, and -
Figures 11(a) and (b) are respective side and top section views of the second embodiment with the cap partly removed. - Referring initially to
Figures 1 to 3 , the autoinjector comprises anouter housing 10 of cylindrical form in the bore of which is disposed asyringe 12 of known form with abarrel 14, aneedle 16 extending from the forward end, and aflange 18 at its rear end. A medicament is contained within the syringe and can be expressed through the needle by apiston 20 inside the barrel. The syringe is supported and surrounded by moulded plastics shroud/carrier 22 assembly comprising a forward hollowcylindrical portion 24 integrally formed with diametrically opposedsprings 26 to either side, and acollar 28 adapted to engage the forward face of the syringe flange. Extending rearwardly from the collar are two diametrically opposedclearance fingers 30 withbarbed teeth 32 that engage the intermediate member, as to be described below. In the pre-use position as shown inFigure 3(a) , the barbed fingers are prevented from outward splaying movement by the base of respective diametrically opposedgrooves 34 on the inner surface of the rear part of the housing. In the pre-use position, theshroud portion 24 is telescopically received within the forward end of the housing and co-terminous therewith. - In the rear of the housing is provided a drive mechanism which comprises a first
outer spring 36 which acts between the front face of a transverseinner wall 38 at the rear of the housing and aforward flange 40 of a top hat-shapedintermediate member 42. An inner, second,spring 44 is received within a cylindrical part of theintermediate member 42 and acts between an inner face of the rear end wall thereof and acircumferential rib 46 on the forward part of aplunger 48. At the rear end, the plunger has a resilient hooked arm 50 (seeFigures 1, 3(b) ) which latches around the edge of an aperture in the transverseinner wall 38 of the housing. Projecting rearwardly from the rear end of the housing is a captive axiallyslideable trigger button 52 movable against a rearward bias from the position shown in e.g.Figure 3(b) , where arelease finger 54 is spaced rearwardly of the hookedarm 50, to a forward portion where thefinger 54 cams the hooked arm to release its retention by thewall 38, thereby allowing thesprings plunger 48 forwardly. The plunger is shaped and sized so that it can pass into and down the internal bore of thesyringe barrel 14, to urge thepiston 20 to express a dose. In the forward end of the plunger is a cylindrical recess in which is located a smallpowerful magnet 56. - The
trigger button 52 is biased rearwardly by means of two integral forwardly extending sprungarms 58 withcam surfaces 60 which ride overrespective abutments 62 inside the rear of the housing. However, initially, forward movement of the trigger button is prevented by means of two rearwardly extending lockingarms 64 which extend back from the rear end of acap 66. Arear collar 37 is fitted over the rear portion of thehousing 10, out of which thebutton 52 protrudes rearwardly. When the cap is in its fitted configuration, thelocking arms 64 are located inside anannular channel 39 defined between an inner surface of the collar and an outer surface of the rear portion of the housing. In its fitted configuration, the cap covers the whole of the forward end of the housing and has a re-entrantcylindrical portion 68 with claw features 70. The claw features 70 slip over the rear end of aneedle shield 72 which is secured to the front end of the needle during manufacture. Thus thecap 66 fulfils the functions of acting as a safety catch for thetrigger button 52, serving as a shield remover. Anchored inside the forward end of the housing is alatch 74 formed of pressed steel or other ferro-magnetic material to provide twolatch arms 76 which extend forwardly from an anchorage normally to sit in an annular space between theshroud 24 and an inner part of the housing wall. - In operation, the user pulls the
cap 66 off forwardly which removes theneedle shield 22 from the syringe and arms the device by rendering thetrigger button 52 operational. The user then offers the injection device up to the injection site and presses thetrigger button 52. This releases the hookedarm 50 of theplunger 48 as shown more particularly inFigure 4(b) . Once the plunger is released, thefirst spring 36 expands to extend thesyringe 20 so that the needle penetrates the flesh. During this period (Figure 5(a) ), thesecond spring 44 remains substantially fully compressed, with theplunger 48 bearing against thepiston 20 within the syringe but not moving it relative to the syringe. During the initial phase of penetration, theclearance fingers 32 on thesyringe supporting collar 28 are constrained against outward splaying movement by thegrooves 34 and so a gap is preserved between thesyringe flange 18 and theflange 40 of theintermediate member 42, as long as the fingers are still in engagement with the constraining grooves. - It will be appreciated that many variations of the cap and trigger button blocking mechanisms described above are possible. For instance, the cap may include at least one member other than the
arms 64 for blocking/interfering with the sliding motion of the button. - The
fingers 32 exit the constraininggrooves 34 at about the same time as forward movement of the syringe is arrested by thecompression spring portions 26 bottoming out, theshroud 24 being held against movement by contact with the skin surface. When the syringe is arrested, thefirst spring 36 continues to expand to drive theflange 40 of the intermediate member into engagement with thesyringe flange 18 thereby contributing to the force required to initiate movement of the piston down the syringe (Figure 5(b) ). From this position thesecond spring 44 expands to drive the piston down the barrel of the syringe to express a dose. At the end of its travel, it will be noted that themagnet 56 in the plunger is spaced between the latchingarms 76 of thelatch 74, as shown inFigure 5(c) . When the dose has been expressed, the user pulls the device away from the flesh and so theshroud portion 24 is free to expand under the influence of thecompression spring portions 26. The shroud portion is driven by thesprings 26 forwardly beyond the front tips of the latchingarms 76. Once this happens, the latching arms are free to move inwardly to the latching positions shown inFigure 6 , under the influence of themagnet 20. Theshroud portion 24 is therefore locked out and the device thereby rendered safe. - In other embodiments, not shown, further magnets or ferro-magnet material may be disposed in the front end of the housing around or in front of the syringe in order to provide a magnetic boost effect as the plunger nears the end of its stroke.
- Referring now to
Figures 7 and 8 the second embodiment has many of the same components as the first embodiment and which act in a similar fashion. These components are given the same reference numbers and will not therefore be described in detail again. This second embodiment incorporates a magnetic coupling embodiment between theplunger 48 and the syringe designed so that during an initial penetration phase of movement the plunger is coupled magnetically to athrust collar 80 of ferro-magnetic material that is positioned in contact with the rear face of thesyringe flange 18. Thus theplunger 48 and thesyringe 18 are initially held against relative movement and so move as one during this phase, until the syringe is arrested by reaching its forwardmost position, with the needle inserted into the injection site. Upon arrest of the syringe, the spring force acting on the plunger overcomes the magnetic coupling force and the coupling yields so that the plunger is released to move forward relative to the syringe to move the plunger into contact with and to urge the piston forwardly to expel a dose. As previously, as the plunger moves alongside the ferro-magnetic latching arms 76 and they are attracted inwardly. This is enhanced in the embodiment by provision of twomagnets 82 on the forward ends of the latching arms. These magnets are aligned so as to be attached towards and to exert a pull on themagnet 56 in the plunger to provide a magnetically influenced forward boost to the plunger toward the forwardmost end of its stroke. Upon completion of the injection and removal of the device from the site, theshroud 24 extends forwardly as thespring portions 26 reexpand, and as a rearward lip on the shroud passes the magnets, the latching arms move inwards to block retraction movement of the shroud and thereby lock it out. Themagnets 82 may be housed slideably in through-holes in the housing wall, allowing them also to move inwards with the latching arms as the rearward lip on the shroud passes the magnets, and so provide a visual and tactile confirmation of locking out of theshroud 24. - Referring to
Figures 9(a), (b) and (c) and 11 (b) and (b) , athird embodiment 90 of the autoinjector is shown. Components in common with the earlier embodiments have been given the same reference numerals. In this embodiment, thecap 66 includes at least oneaperture 91. In the example there are two diametrically-opposed elongate apertures with rounded ends, located around midway along the length of the cap, but it will be appreciated that the number, position and shape of the aperture(s) can vary. Thehousing 10 also includes at least one correspondingaperture 91 a and when the cap is fitted on the shield, the sets of apertures are at least partially aligned. - A
light shield 92 is slidably mounted inside thecap 66, over thecylindrical housing 10. In alternative embodiments, the light shield may be slidably mounted on another component of the device and may be accessible through the cap. As can be seen inFigure 10 , the example light shield includes a cylindrical portion with solid walls from which aspring 94 portion extends. A pair of diametrically opposedcircular buttons 93 with finger grooves are located at the other end of the cylindrical portion and stand proud of its outer surface. In the position shown inFigures 9 , the cylindrical portion of the light shield covers the apertures, preventing the content of thesyringe 20 from being exposed to light. This can be advantageous in the case of photosensitive drugs. A user can use one or both of thebuttons 93 to push the light shield downwards, which compresses theplastic spring 94 against an abutment 95 on the inner surface of thecap 66. The user can then check the contents of the syringe through the apertures and when he/she releases the button(s), the shield springs back to the position ofFigure 9(c) . Alternatives to the light shield described above are possible, e.g. a hinged lid on the cap.
Claims (17)
- An injection device including:an elongate housing (10);a syringe (12) disposed in said housing and having an internal piston (20) to express a dose from a needle (16) at its front end;a trigger device (52) for, in use, activating the internal piston, anda cap (66) that, in a fitted configuration, fits over at least part of the elongate housing and prevents activation of the trigger deviceand characterised in that the cap (66) includes at least one member that, in the fitted configuration, blocks or interferes with the sliding of the trigger device in an activation direction.
- An injection device according to claim 1, wherein the trigger device (52) is slidably mounted within the housing (10) and the at least one member comprises at least one arm (64) that, in the fitted configuration, prevents sliding of the trigger device.
- An injection device according to claim 2, wherein the trigger device (52) projects rearwardly from a rear end of the housing (10).
- An injection device according to claim 3, wherein the trigger device (52) is biased against the activation direction.
- An injection device according to claim 4, wherein the trigger device (52) is biased by means of at least one sprung member (58).
- An injection device according to claim 5, wherein the at least one sprung member (58) includes a cam surface (60) which, in use when sliding in the activation direction, rides over an abutment (62) inside the housing (10).
- An injection device according to claim 6, wherein the at least one arm (64), when the cap (66) is in the fitted configuration, prevents the cam surface (60) of the sprung member (58) from riding over the abutment (62).
- An injection device according to claim 7, further including a rear collar (37) that fits over a rear portion of the housing (10) and wherein the at least one arm (64), when the cap (66) in the fitted configuration, is located inside a channel (39) defined between an inner surface of the collar and an outer surface of the rear portion of the housing, thereby restricting movement of the at least one sprung arm (58).
- An injection device according to any one of the preceding claims, further including a shield (72) for the needle (16) and wherein the cap (66) further includes an arrangement (74) that removes the needle shield when, in use, the cap is removed.
- An injection device according to claim 9, wherein the needle shield (72) is supported within an interior arrangement (68) of the cap (66).
- An injection device according to claim 10, wherein the interior arrangement includes a re-entrant cylindrical portion (68).
- An injection device according to claim 10 or 11, wherein the arrangement for removing the needle shield (72) includes at least one claw feature (70) that, in use when the cap (66) is removed from the housing (10), pulls the needle shield away from the syringe (12).
- An injection device according to any one of the preceding claims, wherein the cap (66) further includes:at least one aperture (91), that, when the cap is in its fitted configuration is aligned with an aperture (91 a) in the housing (10) located above a portion of the syringe (12), anda shield arrangement (92) configured to move between a closed configuration that blocks the at least one cap aperture and an open configuration that at least partially exposes the at least one cap aperture.
- An injection device according to claim 13, wherein a biasing arrangement (94) biases the shield arrangement to the closed configuration.
- An injection device according to claim 14, wherein the shield arrangement includes a portion (92) with at least one solid wall slidably mounted within the cap, the solid wall being aligned with the aperture (91) when the shield is in its closed configuration.
- An injection device according to any one of claims 13 to 15, wherein the housing (10) further includes at least one aperture (91 a), where the at least one aperture (91) of the cap (66), when the cap is its fitted configuration, is aligned with the at least one housing aperture.
- An injection device according to any one of claims 13 to 16, wherein the cap (66) has two diametrically-opposed elongate said apertures (91).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1017363.1A GB201017363D0 (en) | 2010-10-14 | 2010-10-14 | Injection devices |
US39489610P | 2010-10-20 | 2010-10-20 | |
PCT/GB2011/051950 WO2012049484A2 (en) | 2010-10-14 | 2011-10-11 | Injection devices |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2632518A2 EP2632518A2 (en) | 2013-09-04 |
EP2632518B1 true EP2632518B1 (en) | 2016-06-22 |
Family
ID=43304569
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
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EP17162134.5A Withdrawn EP3219348A1 (en) | 2010-10-14 | 2011-09-19 | Injection devices |
EP11764253.8A Not-in-force EP2632517B1 (en) | 2010-10-14 | 2011-09-19 | Injection devices |
EP11776826.7A Revoked EP2632518B1 (en) | 2010-10-14 | 2011-10-11 | Injection devices |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
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EP17162134.5A Withdrawn EP3219348A1 (en) | 2010-10-14 | 2011-09-19 | Injection devices |
EP11764253.8A Not-in-force EP2632517B1 (en) | 2010-10-14 | 2011-09-19 | Injection devices |
Country Status (5)
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US (2) | US9814840B2 (en) |
EP (3) | EP3219348A1 (en) |
JP (2) | JP6092779B2 (en) |
GB (1) | GB201017363D0 (en) |
WO (2) | WO2012049468A2 (en) |
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Also Published As
Publication number | Publication date |
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JP6092779B2 (en) | 2017-03-08 |
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WO2012049468A2 (en) | 2012-04-19 |
EP2632517B1 (en) | 2017-05-03 |
US20130281933A1 (en) | 2013-10-24 |
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