EP2581914B1 - Verfahren und Anlage für die Herstellung eines Radioisotops - Google Patents
Verfahren und Anlage für die Herstellung eines Radioisotops Download PDFInfo
- Publication number
- EP2581914B1 EP2581914B1 EP11184551.7A EP11184551A EP2581914B1 EP 2581914 B1 EP2581914 B1 EP 2581914B1 EP 11184551 A EP11184551 A EP 11184551A EP 2581914 B1 EP2581914 B1 EP 2581914B1
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- European Patent Office
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- internal pressure
- pressure
- given
- hermetic cell
- target
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- 238000000034 method Methods 0.000 title claims description 17
- 239000002243 precursor Substances 0.000 claims description 43
- 239000012530 fluid Substances 0.000 claims description 28
- 239000002245 particle Substances 0.000 claims description 20
- 238000001816 cooling Methods 0.000 claims description 19
- 238000009434 installation Methods 0.000 claims description 13
- 238000004519 manufacturing process Methods 0.000 claims description 13
- 230000001678 irradiating effect Effects 0.000 claims description 5
- 230000003247 decreasing effect Effects 0.000 claims 1
- 239000007789 gas Substances 0.000 description 9
- 239000007788 liquid Substances 0.000 description 7
- 238000010926 purge Methods 0.000 description 6
- 230000007423 decrease Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000005641 tunneling Effects 0.000 description 5
- 239000002826 coolant Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 239000011261 inert gas Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 230000002950 deficient Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000013178 mathematical model Methods 0.000 description 1
- 238000009206 nuclear medicine Methods 0.000 description 1
- 238000013021 overheating Methods 0.000 description 1
- 238000002600 positron emission tomography Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 239000012808 vapor phase Substances 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
- G21G1/10—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by bombardment with electrically charged particles
Definitions
- the present invention relates to a method for producing a radioisotope and an installation for carrying out this method.
- positron emission tomography is an imaging technique that requires positron-emitting radioisotopes or molecules labeled with these same radioisotopes.
- the 18 F radioisotope is one of the most commonly used radioisotopes. Other radioisotopes commonly used are: 13 N; 15 O; and 11 C.
- the 18 F radioisotope has a half-life of 109.6 min and can thus be transported to other sites than its production site.
- a device for producing radioisotopes comprises a proton accelerator and a target cooled by a cooling device. This target comprises a cavity sealed by an irradiation window to form a hermetic cell inside which is included a radioisotope precursor in liquid or gaseous form.
- the energy of the proton beam directed on the target is of the order of a few MeV to about twenty MeV.
- Such a beam energy causes a heating of the target and a vaporization of the liquid containing the radioisotope precursor. Since the vapor phase has a lower stopping power, more particles of the irradiation beam pass through the hermetic cell without being absorbed by the radioisotope precursor, which decreases not only the production efficiency of the radioisotope. radioisotopes, but also warms the target further. This well-known phenomenon is commonly called tunneling effect.
- the document JP2009103611 discloses a device for producing radioisotopes comprising a system for pressurizing the hermetic cell capable of maintaining a constant internal pressure inside the hermetic cell.
- the document JP 2009103611 proposes to equip the hermetic cell with a control valve allowing a controlled discharge of radioisotope precursor fluid if the pressure in the hermetic cell exceeds a threshold value.
- This solution has the particular disadvantage of causing the loss of volume of radioisotope precursor fluid contained in the hermetic cell.
- some precursor fluids of radioisotopes can be very expensive, so that it is necessary at all costs to avoid untimely discharges.
- the working pressure in the sealed cell of the target must be substantially less than the discharge pressure.
- a target for the production of radioisotopes When a target for the production of radioisotopes is irradiated daily by a proton beam for several hours, some areas of the target may become weaker over time. The heating of the irradiation cell can thus damage the seals sealing the cavity closed by the irradiation window, causing leaks. Leaks may also appear at the irradiation window.
- the irradiation of the target produces secondary radiation that can damage nearby parts, such as ducts, valves or a pressure sensor fitted to the target, which also causes leaks.
- the aforementioned pressurizing device has the advantage of keeping the radioisotope precursor fluid in a condensed or semi-condensed state, possible leaks in the irradiation cell and / or poor filling of the target of the example to a defective valve, can not be detected in time. Indeed, if the device for monitoring the internal pressure in the hermetic cell records a decrease in this pressure, the pressurizing device will normally inject inert gas into the target to re-increase its internal pressure. It will also be noted that impurities resulting from a washing of the target followed by poor drying may also cause an overpressure, which may be masked by the aforementioned pressurizing device.
- An object of the present invention is, in the production of radioisotopes, to detect in time the problems of leakage or poor filling of a target and to avoid deterioration of the target either by said tunneling effect or by an increase in excessive pressure.
- a method according to the invention comprises, in a manner known per se, an irradiation of a volume of radioisotope precursor fluid contained in a hermetic cell of a target, this using a particle beam of a given current, which is produced by a particle accelerator.
- the target is cooled, and internal pressure is measured in the airtight cell.
- the internal pressure (P) is allowed to freely establish itself in the hermetic cell during the irradiation, without trying to control it by an injection of a pressurizing gas and / or a depressurization valve.
- the irradiation is interrupted or its intensity reduced, when the internal pressure (P) in the hermetic cell comes out of a first tolerance interval, which is defined according to different parameters having an influence on the evolution of the internal pressure in the hermetic cell during irradiation.
- Such parameters include, for a given target and radioisotope precursor fluid, including the degree of filling of the hermetic cell, the cooling power of the target and the beam current (I).
- This lower limit corresponds to an excessively large deviation from an optimum internal pressure determined for a hermetic cell containing a given volume of radioisotope precursor fluid and irradiated by a given beam current.
- the irradiation is interrupted or its intensity is reduced so as to also prevent a rupture of the irradiation window due to an excessive increase of the pressure in the hermetic cell.
- This upper limit can indeed be defined so that it represents a sufficient security with respect to the breaking pressure of the irradiation window.
- this procedure does not require any injection of a pressurizing gas, which would increase the total pressure in the airtight cell, i.e. the nominal pressure for which the target is to be designed, and would also risk hide leaks. It also does not require depressurization by a discharge causing an expensive radioisotope precursor fluid loss.
- the particle accelerator acts normally directly on the particle accelerator.
- This nominal pressure value (Pmax) is supposed to represent the maximum pressure value for which the hermetic cell is guaranteed.
- the upper limit of internal pressure of the first tolerance interval is advantageously at least 20% lower than the nominal pressure value (Pmax) of the hermetic cell. This normally provides sufficient security against rupture of the irradiation window.
- a control device advantageously triggers an alarm when the internal pressure (P) in said hermetic cell exits a given second tolerance interval for said given beam current (I), a given volume of radioisotope precursor fluid and a radiating power. given cooling of said target, said second tolerance interval being included in the first tolerance interval. The operator is thus warned that the evolution of the pressure in the hermetic cell may soon cause an interruption of irradiation, and it may possibly still prevent this automatic interruption.
- the degree of filling of the hermetic cell is advantageously optimized so as to obtain a high radioisotope production yield.
- the radioisotope precursor is advantageously a precursor of 11 C, 13 N, 15 O or 18 F.
- This installation comprises a target with a hermetic cell capable of containing a volume of precursor fluid, this hermetic cell being guaranteed to withstand a nominal pressure (Pmax), a particle accelerator capable of producing and directing an accelerated particle beam. a given current (I) on the target, a system for monitoring the internal pressure of the cell hermetic, and a control device programmed to interrupt the particle beam or reduce its intensity when the internal pressure (P) in the hermetic cell comes out of a first tolerance range determined according to different parameters having an influence on the evolution internal pressure in the hermetic cell during irradiation.
- the control device is advantageously programmed to trigger an alarm when the internal pressure of the hermetic cell is outside a second interval in said first tolerance range.
- the control device may also be advantageously programmed to cause a decrease in the intensity of the beam current when the internal pressure (P) in said airtight cell exceeds an upper limit of internal pressure.
- FIG. Fig. 1 A non-limiting embodiment of a radioisotope production installation 10 according to the present invention is illustrated on the basis of the diagram of FIG. Fig. 1 .
- This installation 10 comprises a target, globally identified by the reference sign 12.
- This target 12 comprises a hermetic cell 14 enclosing a volume of radioisotope precursor fluid. It is equipped, in known manner, with a cooling circuit 16.
- the plant 10 further comprises a particle accelerator 18 capable of producing an accelerated particle beam 20 which is directed at the target 12 to irradiate the radioisotope precursor in the airtight cell 14.
- the beam 20 enters the airtight cell 14 by an irradiation window 22 having a thickness of the order of a few tens of micrometers.
- the maximum internal pressure that the target 12 can withstand depends in particular on the thickness of this irradiation window.
- the nominal pressure (Pmax) of the target 12 is the maximum internal pressure in the hermetic cell 14 guaranteed by the producer of the target. As long as the internal pressure in the airtight cell 14 remains below the nominal pressure (Pmax), the producer of the target ensures that the irradiation window 22 is pressure-resistant.
- This nominal pressure (Pmax) is of course a function of the geometry of the hermetic cell 14.
- the reference sign 24 identifies a schematic representation of a pressure sensor, which measures the internal pressure in the hermetic cell 14. A signal representative of this measured pressure is transmitted, for example through a data bus 26, to a control device 28. On the basis of this pressure signal, the control device 28 monitors the pressure in the hermetic cell 14 in a continuous or quasi-continuous manner.
- the installation 10 advantageously comprises a multi-way valve 30, which makes it possible to communicate the hermetic cell 14 with different auxiliary equipment.
- a first port A of this valve 30 is for example connected to a three-way valve 32, itself connected to a reservoir 34 containing the radioisotope precursor and to a pipetting device 36, such as a syringe.
- a second port B is connected to a first port of the hermetic cell 14 by a conduit 38 for filling and emptying the hermetic cell 14.
- a third port C is connected to a container 40, intended to receive the irradiated product when the irradiation is complete.
- a fourth port D is connected to an overflow vessel 42 for collecting the excess fluid introduced into the airtight cell 14.
- a fifth port E is connected to a second port of the airtight cell 14, via a conduit 44.
- conduit 44 which serves to evacuate the excess fluid introduced into the hermetic cell 14, respectively to the introduction of a purge gas gas in the hermetic cell 14.
- This purge gas is contained in a reservoir 46, connected to a sixth port F.
- the control system 12 controls the various valves 30, 32, the pipetting device 36, the cooling device 16, the flow of the purge gas cylinder 10 and the particle accelerator 18.
- the valve 30 When filling the hermetic cell 14, the valve 30 connects the port A with port B and port D with port E.
- the three-way valve 32 connects reservoir 34 containing the radioisotope precursor with pipetting device 36 which draws a quantity of fluid including the radioisotope precursor.
- the three-way valve 32 then connects the pipetting device 36 to the port A of the valve 30.
- the pipetting device 36 can now inject the fluid containing the radioisotope precursor into the airtight cell 14, any excess liquid being discharged. to the overflow vessel 42.
- valve 30 closes all the ports, and the accelerator 18 produces the beam irradiating the target 12.
- the valve 30 connects the port F with the port E, and the port B with the port C, so that the purge gas is injected into the hermetic cell 14, and the irradiated fluid is removed from the target 12 to be then collected in the irradiated product container 40.
- the internal pressure (P) is freely allowed to establish in the airtight cell 14. This means that no device for adjusting the pressure is required. internal in the airtight cell 14, on the basis of a pressurization system using a pressurizing gas and a depressurization system using a purge valve.
- the internal pressure (P) in the airtight cell 14 is measured by the pressure sensor 24 and monitored by the control device 28.
- the controller 28 interrupts simply irradiating the target 12 or reducing its intensity.
- this first tolerance interval is defined specifically for the current I of the beam 20, the volume V of the radioisotope precursor fluid contained in the hermetic cell 14 and the cooling power of the target 12. (Normally, the cooling power is kept constant.)
- the control system 12 is therefore programmed to interrupt the irradiation of the target 12, when the internal pressure (P) in the sealed cell 14 comes out of a first defined tolerance range. It is also advantageously programmed to trigger a prior alarm, and / or reduce the intensity of irradiation, when the internal pressure (P) in the hermetic cell 14 comes out of a second fixed tolerance range, which is included in the first tolerance interval.
- the beam current was gradually increased by measuring the internal pressure of the target using the pressure sensor 24. These measurements were made until the value of nominal pressure (Pmax) guaranteed for the target 12 for a beam current I of approximately 60 pA. During all the measurements, the coolant flow rate was kept substantially constant, as was the coolant inlet temperature in the target 12.
- FIG. 2 An example of a second tolerance interval is also shown on the Fig. 2 .
- a radioisotope production efficiency curve is plotted against the degree of cell filling which in practice shows a constant yield above a critical degree of filling and a large yield drop below that same degree of filling. critical.
- a degree of filling of the hermetic cell corresponding to this degree of critical filling or a slightly higher degree of filling is established. either experimentally or theoretically the curve of the pressure P as a function of the beam current I for this degree of filling of the hermetic cell.
- radioisotope production facility 32 three way valve 34 tank containing the radioisotope precursor 12 target 14 hermetic cell 36 pipetting device 16 cooling system 38 pipe 40 container for receiving the irradiated product 18 particle accelerator 20 particle beam 42 overflow container 22 irradiation window 24 Pressure sensor 44 pipe 26 data bus 46 tank with purge gas 28 control device 30 multi-way valve
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Particle Accelerators (AREA)
Claims (13)
- Verfahren zur Herstellung eines Radioisotops, das umfasst:eine Bestrahlung eines Radioisotop-Vorläuferfluidvolumens in einer hermetischen Zelle eines Ziels mit Hilfe eines Teilchenstrahls eines gegebenen Stroms, der von einem Teilchenbeschleuniger produziert wird,eine Abkühlung des Ziels undeine Messung des internen Drucks in der hermetischen Zelle,dadurch gekennzeichnet, dasssich der interne Druck (P) in der hermetischen Zelle während der Bestrahlung frei aufbaut unddie Bestrahlung unterbrochen oder ihre Stärke reduziert wird, wenn der interne Druck (P) in der hermetischen Zelle ein in Abhängigkeit von verschiedenen Parametern, die einen Einfluss auf die Entwicklung des internen Drucks in der hermetischen Zelle bei der Bestrahlung haben, bestimmtes erstes Toleranzintervall verlässt, wobei die Parameter für ein Ziel einen bestimmten Teilchenstrahl und ein bestimmtes Radioisotop-Vorläuferfluid, den Füllstand der hermetischen Zelle, die Kühlleistung des Ziels und den Strahlstrom (I) umfassen.
- Verfahren nach Anspruch 1, wobei:eine Kurve P = f(I) bestimmt wird, die den internen Druck (P) der hermetischen Zelle für verschiedene Strahlströme (I) liefert, und zwar für ein gegebenes Radioisotop-Vorläuferfluidvolumen und eine gegebene Kühlleistung des Ziels,wobei das erste Toleranzintervall einen unteren Druckgrenzwert und einen oberen Druckgrenzwert darstellt, die für den gegebenen Strahlstrom (I) auf der Basis der Kurve P = f(I) definiert sind,wobei der untere interne Druckgrenzwert derart definiert ist, dass er kleiner, vorzugsweise zwischen 5 % bis 20 % kleiner, als der von der Kurve P = f(I) für den gegebenen Strahlstrom (I) abgeleitete Druckwert ist, undder obere interne Druckgrenzwert ein Druck ist, der zwischen dem von der Kurve P = f(I) für den gegebenen Strahlstrom abgeleiteten Druckwert und einem nominalen Druckwert (Pmax) der hermetischen Zelle inklusive ist, wobei der nominale Druckwert (Pmax) den maximalen Druckwert darstellt, für den die hermetische Zelle garantiert ist.
- Verfahren nach Anspruch 2, wobei der obere interne Druckgrenzwert des ersten Toleranzintervalls im Verhältnis zum nominalen Druckwert (Pmax) der hermetischen Zelle um mindestens 20 % kleiner ist.
- Verfahren nach Anspruch 2 oder 3, wobei der obere interne Druckgrenzwert des ersten Toleranzintervalls zwischen 5 und 10 bar höher ist als der aus der Kurve P = f(I) für den gegebenen Strahlstrom (I) abgeleitete Druckwert und auf einen Druckwert (P2) begrenzt ist, der kleiner als der nominale Druckwert (Pmax) der hermetischen Zelle ist.
- Verfahren nach einem der vorangehenden Ansprüche, wobei eine Überwachungsvorrichtung einen Alarm auslöst, wenn der interne Druck (P) in der hermetischen Zelle ein zweites Toleranzintervall verlässt, das in Abhängigkeit von verschiedenen Parametern bestimmt wurde, die einen Einfluss auf die Entwicklung des internen Drucks in der hermetischen Zelle bei der Bestrahlung haben, wobei das zweite Toleranzintervall im ersten Toleranzintervall inbegriffen ist.
- Verfahren nach Anspruch 5, wobei:eine Kurve P = f(I) bestimmt wird, die den internen Druck (P) der hermetischen Zelle für verschiedene Strahlströme (I) liefert, und zwar für ein bestimmtes Radioisotop-Vorläuferfluidvolumen und eine bestimmte Kühlleistung des Ziels,wobei das erste Toleranzintervall einen unteren Druckgrenzwert und einen oberen Druckgrenzwert darstellt, die für den gegebenen Strahlstrom (I) auf der Basis der Kurve P = f(I) definiert sind,wobei das zweite Toleranzintervall einen unteren Druckgrenzwert und einen oberen Druckgrenzwert darstellt, die auf der Basis der Kurve P = f(I) definiert sind,wobei der untere interne Druckgrenzwert des zweiten Toleranzintervalls derart bestimmt ist, dass er kleiner, vorzugsweise um mindestens 2 %, als der von der Kurve P = f(I) für den gegebenen Strahlstrom (I) abgeleitete Druckwert ist, wobei er über dem unteren internen Druckgrenzwert des ersten Toleranzintervalls bleibt, undder obere interne Druckgrenzwert des zweiten Toleranzintervalls derart bestimmt ist, dass er größer als der von der Kurve P = f(I) für den gegebenen Strahlstrom (I) abgeleitete Druckwert ist, wobei er unter dem oberen internen Druckgrenzwert des ersten Toleranzintervalls bleibt.
- Verfahren nach einem der vorangehenden Ansprüche, wobei, wenn der interne Druck (P) in der hermetischen Zelle einen oberen internen Druckgrenzwert, der im ersten Toleranzintervall festgelegt ist, überschreitet, der Strahlstrom reduziert wird.
- Verfahren nach einem der vorangehenden Ansprüche, wobei der Füllstand der hermetischen Zelle für einen Bereich betrachteter Strahlströme experimentell optimiert wird.
- Verfahren nach einem der vorangehenden Ansprüche, wobei der Radioisotopvorläufer ein Vorläufer von 11C, 13N, 15O oder 18F ist.
- Anlage zur Umsetzung des Verfahrens nach einem der vorangehenden Ansprüche, die umfasst:ein Ziel mit einer hermetischen Zelle, die imstande ist, ein Vorläuferfluidvolumen zu enthalten, wobei die hermetische Zelle garantiert ist, um einem nominalen Druck (Pmax) zu widerstehen,einen Teilchenbeschleuniger, der imstande ist, einen Strahl beschleunigter Teilchen eines gegebenen Stroms (I) zu produzieren und auf das Ziel zu richten,ein Überwachungssystem des internen Drucks in der hermetischen Zelle,dadurch gekennzeichnet, dass sie eine Überwachungsvorrichtung umfasst, die programmiert ist, um den Teilchenstrahl zu unterbrechen, wenn der interne Druck (P) in der hermetischen Zelle ein erstes, in Abhängigkeit von verschiedenen Parametern, die einen Einfluss auf die Entwicklung des internen Drucks in der hermetischen Zelle bei der Bestrahlung haben, bestimmtes erstes Toleranzintervall verlässt.
- Installation nach Anspruch 10, wobei die Überwachungsvorrichtung programmiert ist, um einen Alarm auszulösen, wenn sich der interne Druck in der hermetischen Zelle außerhalb eines zweiten Intervalls befindet, das im ersten Toleranzintervall inbegriffen ist.
- Installation nach Anspruch 10 oder 11, wobei die Überwachungsvorrichtung programmiert ist, um die Stärke des Strahlstroms zu reduzieren, wenn der interne Druck (P) in der hermetischen Zelle einen oberen internen Druckgrenzwert, der in dem zweiten Intervall inbegriffen ist, überschreitet.
- Installation nach einem der Ansprüche 10 bis 12, wobei die Überwachungsvorrichtung mit einer Kurve P = f(I) programmiert ist, die den internen Druck (P) der hermetischen Zelle für verschiedene Strahlströme (I) bereitstellt, und zwar für ein gegebenes Radioisotop-Vorläuferfluidvolumen und eine gegebene Kühlleistung des Ziels, wobei die Kurve P = f(I) von der Überwachungsvorrichtung verwendet wird, um das erste Toleranzintervall in Abhängigkeit vom Strahlstrom (I) zu bestimmen.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11184551.7A EP2581914B1 (de) | 2011-10-10 | 2011-10-10 | Verfahren und Anlage für die Herstellung eines Radioisotops |
CA2851126A CA2851126C (fr) | 2011-10-10 | 2012-10-10 | Procede et installation pour la production d'un radioisotope |
JP2014535039A JP6301254B2 (ja) | 2011-10-10 | 2012-10-10 | 放射性同位体を生成するための方法及び装置 |
CN201280058343.2A CN104011803A (zh) | 2011-10-10 | 2012-10-10 | 制备放射性同位素的方法和设备 |
US14/350,524 US9941027B2 (en) | 2011-10-10 | 2012-10-10 | Process and installation for producing radioisotopes |
PCT/EP2012/070013 WO2013064342A1 (fr) | 2011-10-10 | 2012-10-10 | Procédé et installation pour la production d'un radioisotope |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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EP11184551.7A EP2581914B1 (de) | 2011-10-10 | 2011-10-10 | Verfahren und Anlage für die Herstellung eines Radioisotops |
Publications (2)
Publication Number | Publication Date |
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EP2581914A1 EP2581914A1 (de) | 2013-04-17 |
EP2581914B1 true EP2581914B1 (de) | 2014-12-31 |
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EP11184551.7A Active EP2581914B1 (de) | 2011-10-10 | 2011-10-10 | Verfahren und Anlage für die Herstellung eines Radioisotops |
Country Status (6)
Country | Link |
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US (1) | US9941027B2 (de) |
EP (1) | EP2581914B1 (de) |
JP (1) | JP6301254B2 (de) |
CN (1) | CN104011803A (de) |
CA (1) | CA2851126C (de) |
WO (1) | WO2013064342A1 (de) |
Families Citing this family (4)
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US10820403B2 (en) * | 2015-01-29 | 2020-10-27 | Framatome Gmbh | Irradiation target for radioisotope production, method for preparing and use of the irradiation target |
NL2016110A (en) * | 2015-03-03 | 2016-09-30 | Asml Netherlands Bv | Radioisotope Production. |
CN106948810B (zh) * | 2017-04-10 | 2020-05-05 | 河南省科学院同位素研究所有限责任公司 | 一种疏水性液态放射性示踪剂的制备方法 |
WO2019088113A1 (ja) * | 2017-10-31 | 2019-05-09 | 国立研究開発法人量子科学技術研究開発機構 | 放射性同位体の製造方法、放射性同位体製造装置 |
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JPS60104300A (ja) * | 1983-11-11 | 1985-06-08 | 株式会社日本製鋼所 | 医療用放射性同位元素製造装置の運転システム |
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JP3333465B2 (ja) * | 1999-03-05 | 2002-10-15 | 住友重機械工業株式会社 | 放射性物質の製造方法及び装置 |
EP1216715A1 (de) * | 2000-12-22 | 2002-06-26 | Ion Beam Applications S.A. | Synthetisierungsvorrichtung von Radiopharmaca |
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EP1412951A2 (de) * | 2001-06-13 | 2004-04-28 | The Uni. Of Alberta, the Uni. of British Columbia, Carleton Uni., Simon Fraser Uni., the Uni. of Victoria, d.b.a. TRIUMF | Apparat und prozedur zur erzeugung von 18f-fluoriden durch ionenstrahlen |
JP2003098295A (ja) * | 2002-06-24 | 2003-04-03 | Sumitomo Heavy Ind Ltd | 放射性物質の製造装置及び放射性物質の製造方法 |
EP1429345A1 (de) * | 2002-12-10 | 2004-06-16 | Ion Beam Applications S.A. | Radioisotopen Herstellungsverfahren und -vorrichtung |
ATE468589T1 (de) * | 2004-09-28 | 2010-06-15 | Soreq Nuclear Res Ct Israel At | Verfahren und system zur herstellung von radioisotopen |
US20070040115A1 (en) * | 2005-08-05 | 2007-02-22 | Publicover Julia G | Method for calibrating particle beam energy |
WO2008070693A1 (en) * | 2006-12-06 | 2008-06-12 | Hammersmith Imanet Limited | Non-aqueous extraction of [18f] fluoride from cyclotron targets |
CN101681689B (zh) * | 2007-06-08 | 2012-07-04 | 住友重机械工业株式会社 | 放射性同位素制造装置及放射性同位素的制造方法 |
JP5179142B2 (ja) | 2007-10-24 | 2013-04-10 | 行政院原子能委員会核能研究所 | ターゲット物質コンベヤシステム |
EP2146555A1 (de) * | 2008-07-18 | 2010-01-20 | Ion Beam Applications S.A. | Zielgerät zur Herstellung von Radioisotopen |
-
2011
- 2011-10-10 EP EP11184551.7A patent/EP2581914B1/de active Active
-
2012
- 2012-10-10 WO PCT/EP2012/070013 patent/WO2013064342A1/fr active Application Filing
- 2012-10-10 CN CN201280058343.2A patent/CN104011803A/zh active Pending
- 2012-10-10 JP JP2014535039A patent/JP6301254B2/ja active Active
- 2012-10-10 CA CA2851126A patent/CA2851126C/fr active Active
- 2012-10-10 US US14/350,524 patent/US9941027B2/en active Active
Also Published As
Publication number | Publication date |
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CA2851126C (fr) | 2019-07-09 |
JP2014529089A (ja) | 2014-10-30 |
JP6301254B2 (ja) | 2018-03-28 |
WO2013064342A1 (fr) | 2013-05-10 |
US9941027B2 (en) | 2018-04-10 |
CA2851126A1 (fr) | 2013-05-10 |
US20140376677A1 (en) | 2014-12-25 |
EP2581914A1 (de) | 2013-04-17 |
CN104011803A (zh) | 2014-08-27 |
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