EP2558859A4 - Microarrays - Google Patents

Microarrays

Info

Publication number: EP2558859A4
Authority: EP; European Patent Office
Prior art keywords: microarrays
Prior art date: 2010-04-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP11769148.5A

Other languages

German (de)

French (fr)

Other versions

EP2558859A1 (en

EP2558859B1 (en

Inventor

Andrew Haynes

Ashton Cyril Partridge

Yinqiu Wu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Digital Sensing Ltd

Original Assignee

Digital Sensing Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-04-15

Filing date

2011-04-15

Publication date

2013-09-11

2010-04-15 Priority claimed from AU2010901595A external-priority patent/AU2010901595A0/en

2011-04-15 Application filed by Digital Sensing Ltd filed Critical Digital Sensing Ltd

2013-02-20 Publication of EP2558859A1 publication Critical patent/EP2558859A1/en

2013-09-11 Publication of EP2558859A4 publication Critical patent/EP2558859A4/en

2017-09-27 Application granted granted Critical

2017-09-27 Publication of EP2558859B1 publication Critical patent/EP2558859B1/en

Status Active legal-status Critical Current

2031-04-15 Anticipated expiration legal-status Critical

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
- B01J2219/00531—Sheets essentially square
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00608—DNA chips
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/0061—The surface being organic
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00614—Delimitation of the attachment areas
- B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00623—Immobilisation or binding
- B01J2219/00626—Covalent
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00632—Introduction of reactive groups to the surface
- B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Urology & Nephrology (AREA)
Cell Biology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Sampling And Sample Adjustment (AREA)

EP11769148.5A 2010-04-15 2011-04-15 Three dimensionsal microarrays Active EP2558859B1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
AU2010901595A AU2010901595A0 (en)		2010-04-15	Three-dimensional microarray
AU2010902365A AU2010902365A0 (en)		2010-05-31	A screening method
PCT/NZ2011/000052 WO2011129710A1 (en)	2010-04-15	2011-04-15	Microarrays

Publications (3)

Publication Number	Publication Date
EP2558859A1 EP2558859A1 (en)	2013-02-20
EP2558859A4 true EP2558859A4 (en)	2013-09-11
EP2558859B1 EP2558859B1 (en)	2017-09-27

Family

ID=44798870

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP11769148.5A Active EP2558859B1 (en)	2010-04-15	2011-04-15	Three dimensionsal microarrays

Country Status (6)

Country	Link
US (2)	US20130109585A1 (en)
EP (1)	EP2558859B1 (en)
CN (1)	CN102971629B (en)
AU (1)	AU2011241208B2 (en)
NZ (1)	NZ603547A (en)
WO (1)	WO2011129710A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN103958174B (en)	2011-10-14	2016-10-26	数码传感有限公司	Array and manufacture method
US20170191912A1 (en)	2016-01-06	2017-07-06	International Business Machines Corporation	Semiconductor manufactured nano-structures for microbe or virus trapping or destruction
WO2018106129A1 (en) *	2016-12-09	2018-06-14	Digital Sensing Limited	Electrochemical sensors and methods of use thereof
KR20200128408A (en)	2018-02-28	2020-11-12	매뉴팩터링 시스템즈 리미티드	Catalysis apparatus and method
CN111208122A (en) *	2020-01-09	2020-05-29	量准（上海）医疗器械有限公司	Plasma colorimetric device for chemical biological assay analysis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20100114238A (en) *	2009-04-15	2010-10-25	임현우	The highly sensitive pre-patterned micro array chip for bio-molecules detection with hydrophobic and hydrophilic surface and fabrication method thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US10157A (en) *		1853-10-25		Charles perley
US6045996A (en) *	1993-10-26	2000-04-04	Affymetrix, Inc.	Hybridization assays on oligonucleotide arrays
US6586193B2 (en) *	1996-04-25	2003-07-01	Genicon Sciences Corporation	Analyte assay using particulate labels
US6489102B2 (en) *	1999-08-05	2002-12-03	Wisconsin Alumni Research Foundation	Biomolecule and/or cellular arrays on metal surfaces and product produced thereby
US7504213B2 (en) *	1999-07-09	2009-03-17	Agilent Technologies, Inc.	Methods and apparatus for preparing arrays comprising features having degenerate biopolymers
WO2001021838A2 (en) *	1999-09-22	2001-03-29	Motorola Inc.	Three-dimensional microarray system for parallel genotyping of single nucleotide polymorphisms
US20040209376A1 (en) *	1999-10-01	2004-10-21	Surromed, Inc.	Assemblies of differentiable segmented particles
WO2001062887A1 (en) *	2000-02-23	2001-08-30	Zyomyx, Inc.	Chips having elevated sample surfaces
KR20040010041A (en) *	2000-05-04	2004-01-31	예일 유니버시티	High density protein arrays for screening of protein activity
US20020182603A1 (en) *	2001-04-20	2002-12-05	Chapman William H.	Uniformly functionalized surfaces for microarrays
US20020187249A1 (en) *	2001-05-08	2002-12-12	Wilhelm Pluster	Process for the production of surface-functionalized supports that serve as starting materials for microarrays used for immobilizing biomolecules
EP1434993B1 (en) *	2001-09-18	2013-04-24	Fibrogen, Inc.	Methods of assaying connective tissue growth factor
AU2003209361A1 (en) *	2002-01-25	2003-09-02	Large Scale Proteomics Corporation	Microarrays produced by cross-sectioning multi-sample plates
AU2003900368A0 (en) *	2003-01-24	2003-02-13	Human Genetic Signatures Pty Ltd	Assay for nucleic acid molecules
DE10309201A1 (en) *	2003-02-25	2004-09-16	Siemens Ag	Sample carrier, for reactor, to take sample oligonucleotides as interactive partners for identification of DNA sequences, has inserts pushed through passage openings to lower electrical contacts
DE10328730B4 (en) *	2003-06-25	2006-08-17	Micronas Gmbh	Method for producing a microarray and device for providing a carrier for a microarray with coating materials
US20090042741A1 (en) *	2004-05-06	2009-02-12	Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University	Microarray of three-dimensional heteropolymer microstructures and method therefor
GB2438440B (en) *	2006-05-26	2008-04-23	Design Led Products Ltd	A composite light guiding device
US8637436B2 (en) *	2006-08-24	2014-01-28	California Institute Of Technology	Integrated semiconductor bioarray
KR100791335B1 (en) *	2006-07-17	2008-01-07	삼성전자주식회사	Microarray and method of fabricating the same
CN101529227B (en) *	2006-08-03	2011-05-25	新加坡国立大学	A microarray system and a process for producing microarrays
WO2008091386A2 (en) *	2006-08-04	2008-07-31	Northwestern University	Biomimetic modular adhesive complex: material, methods and applications therefore
CN101573665A (en) *	2006-10-27	2009-11-04	伊利诺伊大学评议会	Devices and methods for pattern generation by ink lithography

2011
- 2011-04-15 EP EP11769148.5A patent/EP2558859B1/en active Active
- 2011-04-15 NZ NZ603547A patent/NZ603547A/en unknown
- 2011-04-15 WO PCT/NZ2011/000052 patent/WO2011129710A1/en active Application Filing
- 2011-04-15 CN CN201180029536.0A patent/CN102971629B/en active Active
- 2011-04-15 US US13/641,151 patent/US20130109585A1/en not_active Abandoned
- 2011-04-15 AU AU2011241208A patent/AU2011241208B2/en active Active
2018
- 2018-04-30 US US15/967,395 patent/US20180327824A1/en active Pending

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20100114238A (en) *	2009-04-15	2010-10-25	임현우	The highly sensitive pre-patterned micro array chip for bio-molecules detection with hydrophobic and hydrophilic surface and fabrication method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PETERSHANS A ET AL: "TOF-SIMS analysis of structured surfaces biofunctionalized by a one-step coupling of a spacer-linked GRGDS peptide", JOURNAL OF COLLOID AND INTERFACE SCIENCE, ACADEMIC PRESS, NEW YORK, NY, US, vol. 341, no. 1, 1 January 2010 (2010-01-01), pages 30 - 37, XP026987167, ISSN: 0021-9797, [retrieved on 20090916] *
See also references of WO2011129710A1 *

Also Published As

Publication number	Publication date
CN102971629A (en)	2013-03-13
EP2558859A1 (en)	2013-02-20
WO2011129710A1 (en)	2011-10-20
US20130109585A1 (en)	2013-05-02
US20180327824A1 (en)	2018-11-15
CN102971629B (en)	2016-10-12
AU2011241208A1 (en)	2012-11-29
AU2011241208B2 (en)	2017-02-02
NZ603547A (en)	2015-01-30
WO2011129710A4 (en)	2012-01-12
EP2558859B1 (en)	2017-09-27

Legal Events

Date	Code	Title	Description
2013-01-18	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2013-02-20	17P	Request for examination filed	Effective date: 20121114
2013-02-20	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2013-07-24	DAX	Request for extension of the european patent (deleted)
2013-08-02	REG	Reference to a national code	Ref country code: DE Ref legal event code: R079 Ref document number: 602011041941 Country of ref document: DE Free format text: PREVIOUS MAIN CLASS: G01N0033530000 Ipc: C12Q0001680000
2013-09-11	A4	Supplementary search report drawn up and despatched	Effective date: 20130808
2013-09-11	RIC1	Information provided on ipc code assigned before grant	Ipc: C12Q 1/68 20060101AFI20130802BHEP Ipc: G01N 33/53 20060101ALI20130802BHEP Ipc: C12M 1/34 20060101ALI20130802BHEP
2014-02-19	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: DIGITAL SENSING LIMITED
2014-02-19	RIN1	Information on inventor provided before grant (corrected)	Inventor name: PARTRIDGE, ASHTON, CYRIL Inventor name: HAYNES, ANDREW Inventor name: WU, YINQIU
2014-07-02	17Q	First examination report despatched	Effective date: 20140602
2017-02-21	GRAP	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOSNIGR1
2017-03-22	INTG	Intention to grant announced	Effective date: 20170222
2017-05-24	GRAJ	Information related to disapproval of communication of intention to grant by the applicant or resumption of examination proceedings by the epo deleted	Free format text: ORIGINAL CODE: EPIDOSDIGR1
2017-06-28	INTC	Intention to grant announced (deleted)
2017-07-06	GRAP	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOSNIGR1
2017-08-02	INTG	Intention to grant announced	Effective date: 20170707
2017-08-18	GRAS	Grant fee paid	Free format text: ORIGINAL CODE: EPIDOSNIGR3
2017-08-25	GRAA	(expected) grant	Free format text: ORIGINAL CODE: 0009210
2017-09-27	AK	Designated contracting states	Kind code of ref document: B1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2017-09-27	REG	Reference to a national code	Ref country code: GB Ref legal event code: FG4D
2017-09-29	REG	Reference to a national code	Ref country code: CH Ref legal event code: EP
2017-10-15	REG	Reference to a national code	Ref country code: AT Ref legal event code: REF Ref document number: 932004 Country of ref document: AT Kind code of ref document: T Effective date: 20171015
2017-10-18	REG	Reference to a national code	Ref country code: IE Ref legal event code: FG4D
2017-11-09	REG	Reference to a national code	Ref country code: DE Ref legal event code: R096 Ref document number: 602011041941 Country of ref document: DE
2018-01-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: NO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20171227 Ref country code: LT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170927 Ref country code: FI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170927 Ref country code: HR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170927 Ref country code: SE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170927
2018-01-31	REG	Reference to a national code	Ref country code: NL Ref legal event code: MP Effective date: 20170927
2018-02-12	REG	Reference to a national code	Ref country code: LT Ref legal event code: MG4D
2018-02-15	REG	Reference to a national code	Ref country code: AT Ref legal event code: MK05 Ref document number: 932004 Country of ref document: AT Kind code of ref document: T Effective date: 20170927
2018-02-28	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: LV Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170927 Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20171228 Ref country code: BG Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20171227 Ref country code: RS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170927
2018-03-30	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: NL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170927
2018-04-20	REG	Reference to a national code	Ref country code: FR Ref legal event code: PLFP Year of fee payment: 8
2018-04-30	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: CZ Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170927 Ref country code: RO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170927 Ref country code: ES Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170927
2018-05-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: AT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170927 Ref country code: SK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170927 Ref country code: IT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170927 Ref country code: EE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170927 Ref country code: IS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20180127 Ref country code: SM Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170927
2018-06-28	REG	Reference to a national code	Ref country code: DE Ref legal event code: R097 Ref document number: 602011041941 Country of ref document: DE
2018-07-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: DK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170927
2018-08-03	PLBE	No opposition filed within time limit	Free format text: ORIGINAL CODE: 0009261
2018-08-03	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT
2018-08-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: PL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170927
2018-09-05	26N	No opposition filed	Effective date: 20180628
2018-11-30	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: SI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170927 Ref country code: MC Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170927
2018-12-19	REG	Reference to a national code	Ref country code: BE Ref legal event code: MM Effective date: 20180430
2019-01-23	REG	Reference to a national code	Ref country code: IE Ref legal event code: MM4A
2019-01-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20180415
2019-02-28	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: BE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20180430
2019-04-30	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: IE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20180415
2020-01-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: MT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20180415
2020-03-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: TR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170927
2020-05-29	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: HU Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO Effective date: 20110415 Ref country code: PT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170927
2020-06-30	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: CY Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170927 Ref country code: MK Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20170927
2020-07-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: AL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170927
2023-05-31	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: GB Payment date: 20230322 Year of fee payment: 13
2023-07-19	P01	Opt-out of the competence of the unified patent court (upc) registered	Effective date: 20230609
2023-07-26	P02	Opt-out of the competence of the unified patent court (upc) corrected	Effective date: 20230619
2023-07-31	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: FR Payment date: 20230420 Year of fee payment: 13 Ref country code: DE Payment date: 20230331 Year of fee payment: 13 Ref country code: CH Payment date: 20230502 Year of fee payment: 13

Publication	Publication Date	Title
DK3342786T3 (en)	2021-09-27	Anti-dll3-antistof
AP3107A (en)	2015-01-31	5-Alkynyl-pyrimidines
EP2566479A4 (en)	2013-10-23	Azaindazoles
GB201205984D0 (en)	2012-05-16	No details
IL226299A0 (en)	2013-07-31	Immunostimulatiory oligonucleotides
PL2616465T3 (en)	2016-04-29	Triazine-oxadiazoles
EP2640189A4 (en)	2014-03-19	3-deutero-pomalidomide
GB201112400D0 (en)	2011-08-31	No details
DK3466977T3 (en)	2022-04-11	Anti-vla-4-antistoffer
EP2651505A4 (en)	2014-06-11	Electroporation-induced electrosensitization
EP2641891A4 (en)	2014-07-23	Pkc- activator
GB201001760D0 (en)	2010-03-24	Dipenser
EP2558859A4 (en)	2013-09-11	Microarrays
GB201202348D0 (en)	2012-03-28	No details
GB201001546D0 (en)	2010-03-17	Knocktop
GB201001385D0 (en)	2010-03-17	Cable-tidies
GB201105908D0 (en)	2011-05-18	No details
AU4536P (en)	2013-04-30	TB01 Tibouchina urvilleana
AU4937P (en)	2014-10-21	FlatinsulGL Myoporum insulare
AU4932P (en)	2014-10-21	FlatwaxpinkGL Chamelaucium uncinatum
AU4931P (en)	2014-10-21	FlatwaxDarkGL Chamelaucium uncinatum
AU4822P (en)	2014-06-11	FlatwaxwhiteGL Chamelaucium uncinatum
GB201118380D0 (en)	2011-12-07	No Details
GB201202556D0 (en)	2012-03-28	No details
AU2010194V (en)	2010-11-23	CalpenGL Calothamnus quadrifidus