EP2511283A4 - N6-substituierte adenosinderivate, n6-substituierte adeninderivate und ihre verwendung - Google Patents

N6-substituierte adenosinderivate, n6-substituierte adeninderivate und ihre verwendung

Info

Publication number
EP2511283A4
EP2511283A4 EP09851974.7A EP09851974A EP2511283A4 EP 2511283 A4 EP2511283 A4 EP 2511283A4 EP 09851974 A EP09851974 A EP 09851974A EP 2511283 A4 EP2511283 A4 EP 2511283A4
Authority
EP
European Patent Office
Prior art keywords
substituted
derivatives
adenosine
adenine
adenosine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09851974.7A
Other languages
English (en)
French (fr)
Other versions
EP2511283A1 (de
Inventor
Jiangong Shi
Jianjun Zhang
Zhenggang Yue
Min Li
Chenggen Zhu
Ying Zhang
Jiachen Zi
Yafang Wang
Xiaona Fan
Ruiming Xu
Sheng Lin
Yan Li
Yongchun Yang
Li Sheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institute of Materia Medica of CAMS
Original Assignee
Institute of Materia Medica of CAMS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute of Materia Medica of CAMS filed Critical Institute of Materia Medica of CAMS
Publication of EP2511283A1 publication Critical patent/EP2511283A1/de
Publication of EP2511283A4 publication Critical patent/EP2511283A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
EP09851974.7A 2009-12-10 2009-12-10 N6-substituierte adenosinderivate, n6-substituierte adeninderivate und ihre verwendung Withdrawn EP2511283A4 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2009/075478 WO2011069294A1 (zh) 2009-12-10 2009-12-10 N6-取代腺苷衍生物和n6-取代腺嘌呤衍生物及其用途

Publications (2)

Publication Number Publication Date
EP2511283A1 EP2511283A1 (de) 2012-10-17
EP2511283A4 true EP2511283A4 (de) 2013-07-03

Family

ID=44145091

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09851974.7A Withdrawn EP2511283A4 (de) 2009-12-10 2009-12-10 N6-substituierte adenosinderivate, n6-substituierte adeninderivate und ihre verwendung

Country Status (6)

Country Link
US (1) US10174033B2 (de)
EP (1) EP2511283A4 (de)
JP (1) JP2013513551A (de)
CN (1) CN102812033B (de)
CA (1) CA2783859A1 (de)
WO (1) WO2011069294A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ597050A (en) 2009-06-29 2014-02-28 Incyte Corp Pyrimidinones as pi3k inhibitors
US8759359B2 (en) 2009-12-18 2014-06-24 Incyte Corporation Substituted heteroaryl fused derivatives as PI3K inhibitors
EP2558463A1 (de) 2010-04-14 2013-02-20 Incyte Corporation Kondensierte derivate als i3-hemmer
WO2011163195A1 (en) 2010-06-21 2011-12-29 Incyte Corporation Fused pyrrole derivatives as pi3k inhibitors
AR084366A1 (es) 2010-12-20 2013-05-08 Incyte Corp N-(1-(fenil sustituido)etil)-9h-purin-6-aminas como inhibidores de pi3k
US9108984B2 (en) 2011-03-14 2015-08-18 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
WO2012135009A1 (en) 2011-03-25 2012-10-04 Incyte Corporation Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
BR122019020716B1 (pt) 2011-09-02 2021-02-17 Incyte Holdings Corporation heterociclilaminas como inibidores de pi3k e composição farmacêutica que as compreende
US20150038445A1 (en) * 2012-02-11 2015-02-05 Academia Sinica Methods and compositions for treating pain
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
NZ710444A (en) * 2013-02-11 2020-08-28 Univ California Compositions and methods for treating neurodegenerative diseases and cardiomyopathy
CN104173363B (zh) * 2013-05-28 2019-12-13 中国医学科学院药物研究所 一种腺苷化合物在制备防治应激障碍药物中的用途
SG11201603063WA (en) 2013-10-23 2016-05-30 Academia Sinica Compounds for use in prevention and treatment of neurodegenerative diseases and pain
WO2015123365A1 (en) 2014-02-11 2015-08-20 Mitokinin Llc Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease
US10077277B2 (en) 2014-06-11 2018-09-18 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
US20160024135A1 (en) * 2014-07-27 2016-01-28 Zhejiang Subtropical Crops Research Institute Adenosine receptor activation reagent and the uses of thereof
TWI668007B (zh) * 2014-11-11 2019-08-11 中央研究院 用於預防及治療神經退化疾病及疼痛之化合物
TWI650328B (zh) * 2014-11-11 2019-02-11 中央研究院 用於預防及治療神經退化疾病及疼痛之化合物
CZ308881B6 (cs) * 2014-12-09 2021-08-04 Univerzita Palackého v Olomouci 6-aryl-9-glykosylpuriny a jejich použití
MD3262046T2 (ro) 2015-02-27 2021-03-31 Incyte Corp Săruri de inhibitori ai PI3K și procedee pentru prepararea lor
US9732097B2 (en) 2015-05-11 2017-08-15 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
WO2016183063A1 (en) 2015-05-11 2016-11-17 Incyte Corporation Crystalline forms of a pi3k inhibitor
WO2018140734A1 (en) 2017-01-27 2018-08-02 Academia Sinica Compound with analgesic effect for use in prevention and treatment of pain
WO2018237145A1 (en) 2017-06-21 2018-12-27 Mitokinin, Inc. COMPOSITIONS AND METHODS USING THEM FOR THE TREATMENT OF NEURODEGENERATIVE AND MITOCHONDRIAL DISEASE
CN117338801A (zh) * 2023-11-13 2024-01-05 河北医科大学 N6-取代腺苷衍生物或n6-取代嘌呤衍生物在制备减轻围术期神经炎症药品中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004058791A2 (en) * 2002-12-30 2004-07-15 Ustav Experimentalni Botaniky Akademie Ved Ceske Republiky Substitution derivatives of n6-benzyladenosine, methods of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds
WO2005084653A2 (en) * 2004-03-05 2005-09-15 Cambridge Biotechnology Limited Adenosine receptor agonists

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL128629C (de) * 1966-05-07
NL130136C (de) * 1966-10-20
DE1962387C2 (de) * 1969-12-12 1983-08-25 Schering AG, 1000 Berlin und 4709 Bergkamen N↑6↑-(3-Chlorbuten(2)-yl)-adenosin
US4593019A (en) * 1984-10-26 1986-06-03 Warner-Lambert Company N6 -tricyclic adenosines
GB9723590D0 (en) * 1997-11-08 1998-01-07 Glaxo Group Ltd Chemical compounds
US20030008841A1 (en) * 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
US20050187389A1 (en) * 2004-01-13 2005-08-25 Ambit Biosciences Corporation Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
HUE035188T2 (en) 2009-11-13 2018-05-02 Academia Sinica Adenosine A2A receptor and adenzoin transporter double acting compounds for the prevention and treatment of neurodegenerative diseases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004058791A2 (en) * 2002-12-30 2004-07-15 Ustav Experimentalni Botaniky Akademie Ved Ceske Republiky Substitution derivatives of n6-benzyladenosine, methods of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds
WO2005084653A2 (en) * 2004-03-05 2005-09-15 Cambridge Biotechnology Limited Adenosine receptor agonists

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
AFIFY H M N M ET AL: "A NOVEL AND FACILE REACTION TO N6-ALKYLATED ADENOSINE VIA BENZOTRIAZOLE AS A SYNTHETIC AUXILIARY", JOURNAL OF HETEROCYCLIC CHEMISTRY, WILEY-BLACKWELL PUBLISHING, INC, US, vol. 37, no. 2, 1 March 2000 (2000-03-01), pages 339 - 341, XP001147847, ISSN: 0022-152X, DOI: 10.1002/JHET.5570370218 *
BRESSI JC ET AL: "Adenosine analgoues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N6-subsituted adenosine", JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, 12 October 2000 (2000-10-12), pages 4135 - 4150, XP002695882 *
CAPPELACCI L ET AL: "RIBOSE-MODIFIED PURINE NUCLEOSIDES AS RIBONUCLEOTIDE REDUCTASE INHIBITORS. SYNTHESIS, ANTITUMOR ACTIVITY, AND MOLECULAR MODELING OF N6-SUBSTITUTED 3'-C-METHYLADENOSINE", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, 28 June 2008 (2008-06-28), pages 4260 - 4269, XP002695883 *
DE ZWART M ET AL: "A FUNCTIONAL SCREENING OF ADENOSINE ANALOGUES AT THE ADENOSINE A2B RECEPTOR: A SEARCH FOR POTENT AGONISTS", NUCLEOSIDES & NUCLEOTIDES, MARCEL DEKKER INC, vol. 17, no. 6, 1 January 1998 (1998-01-01), pages 969 - 985, XP002108781, ISSN: 0732-8311 *
HA ET AL: "new base-altered adenosine analogues: synthesis and affinity at adenosine A1 and A2 receptors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 7, no. 24, 1 November 1997 (1997-11-01), pages 3085 - 3090 *
KAREL DOLEZAL ET AL: "Preparation, biological activity and endogenous occurrence of N6-benzyladenosines", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 15, no. 11, 1 June 2007 (2007-06-01), pages 3737 - 3747, XP055103745, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2007.03.038 *
LETHAM ET AL: "Cytokinins from Zea Mays", PHYTOCHEMISTRY, vol. 12, 1 January 1973 (1973-01-01), pages 2445 - 2455 *
ROIVAINEN J ET AL: "An enzymatic transglycosylation of purine bases", NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS, vol. 26, 1 January 2007 (2007-01-01), pages 905 - 909, XP002695884 *
See also references of WO2011069294A1 *
WALSH: "Kinetics of nucleophilic substitution on 6-chloropurine ribonucleoside in aqueous solution", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 89, no. 24, 22 November 1967 (1967-11-22), pages 6221 - 6225 *
Z-G GAO ET AL: "N6-Substituted adenosine derivatives: selectivity, efficacy, and species differences at A3 adenosine receptors", 20030101; 20030000, vol. 65, 1 January 2003 (2003-01-01), pages 1675 - 1684, XP002309313 *

Also Published As

Publication number Publication date
US20130045942A1 (en) 2013-02-21
CN102812033B (zh) 2015-11-25
JP2013513551A (ja) 2013-04-22
CA2783859A1 (en) 2011-06-16
US10174033B2 (en) 2019-01-08
EP2511283A1 (de) 2012-10-17
WO2011069294A1 (zh) 2011-06-16
CN102812033A (zh) 2012-12-05

Similar Documents

Publication Publication Date Title
EP2511283A4 (de) N6-substituierte adenosinderivate, n6-substituierte adeninderivate und ihre verwendung
HRP20171398T1 (hr) Novi derivati adenina
HRP20181774T1 (hr) Novi citostatski 7-deazapurinski nukleosidi
HK1203488A1 (en) Pyrimidine substituted purine derivatives
ZA201008829B (en) Nucleoside cyclicphosphates
AP2011005929A0 (en) Substituted nucleoside and nucleotide analogs.
ME02100B (me) Derivati 4-aminopirimidina i njihova primena kao antagonista adenozinskog a2a receptora
HK1167392A1 (en) Adenosine receptor ligands and uses thereof
IL213698A0 (en) Nucleoside phosphoramidates
IL210176A0 (en) Substituted pyrimidone derivatives
AP2011005958A0 (en) Uracyl spirooxetane nucleosides.
GB0706632D0 (en) New purine derivatives
HK1142639A1 (en) Stable recombinant adenosine deaminase
GB0803707D0 (en) Antiviral agent
GB2469104B (en) Dynamic rear wing
ZA201107883B (en) Substituted 6-(2-hydroxybenzylamino)purine derivatives, their use as medicaments and compositions containint these derivatives
IL219341A0 (en) Heterocyclyl substituted arylindenopyrimidines and their use as highly selective adenosine a2a receptor antgonists
EP2426130A4 (de) Purinderivat und antitumormittel damit
AU2012900791A0 (en) 2',3' and 5' Riboside Modified Nucleosides
GB0703715D0 (en) Novel modified nucleotides with antiviral activity

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20120710

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 25/28 20060101ALI20130516BHEP

Ipc: A61P 25/20 20060101ALI20130516BHEP

Ipc: A61K 31/70 20060101ALI20130516BHEP

Ipc: A61P 25/08 20060101ALI20130516BHEP

Ipc: A61P 25/16 20060101ALI20130516BHEP

Ipc: C07D 473/00 20060101ALI20130516BHEP

Ipc: C07H 19/167 20060101AFI20130516BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20130604

17Q First examination report despatched

Effective date: 20160229

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20180703