EP2485055B1 - Specimen preprocessing system - Google Patents
Specimen preprocessing system Download PDFInfo
- Publication number
- EP2485055B1 EP2485055B1 EP10820058.5A EP10820058A EP2485055B1 EP 2485055 B1 EP2485055 B1 EP 2485055B1 EP 10820058 A EP10820058 A EP 10820058A EP 2485055 B1 EP2485055 B1 EP 2485055B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- samples
- sample
- carrier
- order
- preprocessing system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000007781 pre-processing Methods 0.000 title claims description 24
- 238000004458 analytical method Methods 0.000 claims description 21
- 239000000969 carrier Substances 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 11
- 238000005119 centrifugation Methods 0.000 claims description 7
- 239000000523 sample Substances 0.000 description 65
- 230000007423 decrease Effects 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000011143 downstream manufacturing Methods 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 230000000694 effects Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- -1 urine Substances 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/0092—Scheduling
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B11/00—Feeding, charging, or discharging bowls
- B04B11/04—Periodical feeding or discharging; Control arrangements therefor
- B04B2011/046—Loading, unloading, manipulating sample containers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/0092—Scheduling
- G01N2035/0094—Scheduling optimisation; experiment design
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/0092—Scheduling
- G01N35/0095—Scheduling introducing urgent samples with priority, e.g. Short Turn Around Time Samples [STATS]
Definitions
- the present invention relates generally to sample preprocessing systems that automatically preprocess blood, urine, and other biological samples prior to analysis, and more particularly, to a sample preprocessing system equipped with a centrifuge unit for centrifuging samples.
- Sample preprocessing systems are designed so that when supplied with blood, urine, or other biological samples previously taken from patients, the system automatically conducts centrifuging, decapping, dispensing, sorting, conveying, and other processes, upon the samples.
- a scheme of carrying samples in such a sample preprocessing system commonly uses either carriers each loaded with a plurality of samples, or carriers each loaded with one sample container.
- the samples are loaded into the sample preprocessing system by means of the carriers.
- shapes of the sample containers on the same carrier, and the kinds of samples used have needed to be unified, which in turn has required processing with an apparatus represented by those described in Patent Document 1 or 2, as well as an operator's manual intervention.
- a succession of samples different in the type of processing required may reach various processing units. If a group consisting of a plurality of samples includes samples different in the type of processing required, this does not enable collective, simultaneous processing of the samples, even by a unit capable of processing samples collectively as a group. A need arises, therefore, to subgroup the samples and repeat processing a plurality of times.
- the sample preprocessing system decreases in throughput that is more or less affected by a manner of arranging the samples on the trays supplied.
- a centrifuge unit positioned at an upstream process site to process a plurality of samples in a collective manner includes control means that changes transfer order for feeding out centrifuged samples from order for transferring the samples into the centrifuge unit. This change of the transfer order prevents a decrease in throughput of the processing units positioned at downstream process sites.
- the present invention has a beneficial effect in that it prevents the decrease in the throughput of the sample preprocessing system without requiring an apparatus represented by those described in Patent Document 1 or 2, as well as an operator's manual intervention.
- the present invention has another beneficial effect in that it prevents a decrease in throughput of analyzers connected via connection lines.
- Fig. 2 is a schematic diagram that shows a sample preprocessing system according to the embodiment of the present invention, and analyzers connected to the system.
- a tray 206 is loaded with samples and then mounted in a loading unit 205.
- the loading unit 205 transfers the samples from the tray 206 to carriers supplied from a carrier supply unit 204.
- ID reading means reads the sample identification codes assigned to the samples, and carrier identification codes assigned to the carriers.
- which carrier is loaded with which sample is registered in a controller 201.
- the controller 201 uses the registered information to transport each carrier and control samples processing.
- the carrier loaded with samples is carried from the loading unit 205 to a centrifuge unit 207 using a conveyance line 203.
- Fig. 3 is a diagram for assistance in explaining the centrifuge unit 207.
- the centrifuge unit 207 includes a centrifuging mechanism 303, an adapter handling mechanism 301, an adapter retaining unit 302, a sample handling mechanism 304, a centrifugation-queued sample retaining unit 306, and a centrifuged sample retaining unit 307.
- the adapter retaining unit 302 is constructed to accept, by way of example, eight adapters 305, four in a space for adapters queued for centrifugation, and four in a space for centrifuged adapters.
- the centrifuging mechanism 303 is configured to centrifuge a maximum of four adapters at the same time.
- the adapter handling mechanism 301 transfers each centrifugation-queued adapter 305 from the space for centrifugation-queued adapters to the centrifuging mechanism 303.
- the adapter handling mechanism 301 also transfers each centrifuged adapter 305 from the centrifuging mechanism 303 to the space for centrifuged adapters.
- one adapter 305 is constructed so that nine samples, for example, can be set up thereupon.
- the sample handling mechanism 304 undertakes transfer of samples from carriers in the centrifugation-queued sample retaining unit 306 to the adapters 305 on the adapter retaining unit 302, and transfer of samples from the adapters 305 on the adapter retaining unit 302 to carriers in the centrifuged sample retaining unit 307.
- a samples processing sequence in the centrifuge unit 207 is described below.
- a samples-loaded carrier that has been carried to the centrifuge unit 207 is further carried to the centrifugation-queued sample retaining unit 306 by the conveyance line 203.
- the sample handling mechanism 304 extracts the samples from the carrier in the sample retaining unit 306, and then the samples are transferred to the adapters 305 on the adapter retaining unit 302.
- the information that has been stored into the controller 201 in order to indicate which carrier is loaded with which samples is erased upon completion of the transfer.
- a historical record of which carrier has been loaded with which samples, however, is saved without being erased.
- the carrier from which the samples have been extracted is carried to the centrifuged sample retaining unit 307, whereby the carrier can then be loaded with other samples.
- samples that have been carried to the centrifuge unit 207 are likewise transferred to the adapters 305 on the adapter retaining unit 302.
- the transfer of the samples is repeated for a specified time or until four adapters 305 have become full of centrifugation-queued samples.
- each adapter 305 is transferred to the centrifuging mechanism 303, in which, centrifugal separation is started.
- each sample becomes ready for carrier loading at the centrifuged sample retaining unit 307 via the adapter retaining unit 302.
- a carrier in a centrifuged sample retaining unit 307 has been loaded with carrier-loadable samples by a centrifuge unit 207 in the same order as that in which a sample handling mechanism 304 had extracted the samples from the carrier.
- the carrier-loaded samples have been decapped in a decapping unit 208 and then carried to a dispensing unit 209.
- Registered in the controller 201 are analytical item registration information that denotes analysis items which the analyzers 211, 212, and 213 can execute, analyzability attribute information that denotes whether the analysis items can each be executed from one child sample, priority level information on samples, and analysis request information.
- the child sample is a sample that the dispensing unit 209 generates by dispensing a supplied sample. If the analyzability attribute information differs between analytical items, a plurality of child samples are generated.
- the controller 201 also provides a screen menu shown in Fig. 1 .
- This menu is for specifying a method of changing the carrier-loading order.
- the menu can be used to select whether the carrier-loading order is to be changed, and to select a corresponding carrier-loading order changing method in the case where the carrier-loading order is changed.
- FIG. 4 shows an example of creating the information stored into the centrifuge unit 207.
- This information is composed of information that denotes the order 402 in which the sample was transferred to the adapter 305, a logically assigned adapter number 403, a logically assigned sample-in-adapter position number 404, and a sample identification code 405.
- the information is reported to the controller 201 as sample-in-adapter information 401 when centrifugation is started.
- Fig. 5 shows a process flow of steps in which the controller 201 determines the carrier-loading order. The determination is based upon the settings in the loading order setting menu 101 of Fig. 1 and the sample-in-adapter information 401 in Fig. 4 , as well as upon the above-described analysis item registration information, analyzability attribute information, samples carrier-loading order information, and samples analysis request information.
- loading order determination step 501 determines whether a loading order change is present or ineffective.
- loading order determination step 514 relating to all samples is executed in accordance with the order information 402, that is, in the order that the samples were transferred to the adapters 305.
- loading order of an urgent sample is to be preferentially set is determined in urgent-sample loading-order change existence determination step 502, and the determination is followed by loading-order determination step 511 for the urgent sample.
- loading order of the urgent sample only is determined in accordance with the order information 402 denoting the order of transfer to an adapter 305.
- Analyzability attribute information on samples whose carrier loading order has not been determined is viewed and how many analyzability attribute information patterns exist and how many samples corresponding to each pattern exist are compiled in analyzability attribute information compiling step 503. If the carrier loading order of the urgent sample has already been determined, this compiling step is executed only for non-urgent samples. If the carrier loading order of the urgent sample is undetermined, the compiling step is executed for all samples including the urgent sample.
- analyzability attribute information rearranging step 504 is executed to rearrange the obtained analyzability attribute information patterns in descending order of magnitude of the number of samples corresponding to the pattern.
- Analyzability attribute information updating step 505 for samples selection next follows to extract the patterns, one at a time, in order.
- operational states of the analyzers connected via connection lines 210 may be considered during the extraction of each analyzability attribute information pattern.
- step 506 of selecting analyzability attribute information matching samples samples with an analyzability attribute information pattern that matches the extracted pattern are selected.
- samples grouping step 507 to sort out all selected samples into groups for each analyzer to which the sample is to be carried. The sorting is based on analysis item registration information.
- loading order of the samples contained in the group is determined in accordance with the order information 402 denoting the order of transfer to the adapters 305.
- the process returns from all-samples loading-order determination end checking step 509 to analyzability attribute information updating step 505, in which step, the analyzability attribute information pattern to be used for samples selection is then updated into the analyzability attribute information pattern that is next largest in the number of corresponding samples.
- Analyzability attribute information matching samples selection step 506 onward is repeated after that.
- step 510 order of loading from adapters to a carrier is indicated to the centrifuge unit 207 in step 510 of indicating the adapter-to-carrier loading order to the centrifuge unit 207.
- the samples are loaded onto the carrier in the centrifuged sample retaining unit 307 by the centrifuge unit 207 in the order specified from the controller 201.
- the ID reading means reads the sample identification code assigned to the sample, and the carrier identification code assigned to the carrier.
- the order for feeding out the samples from the centrifuge unit 207 upon completion of centrifugation is changed from the order in which the samples have been transferred into the centrifuge unit 207 prior to the centrifugation.
- Throughput of the processing units positioned at downstream process sites can therefore be prevented from decreasing.
- analyzability attribute information compiling step 503 to grouped-samples loading order determination step 508 may be executed only for the urgent samples, to make further changes to transfer order of the urgent samples.
Landscapes
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Description
- The present invention relates generally to sample preprocessing systems that automatically preprocess blood, urine, and other biological samples prior to analysis, and more particularly, to a sample preprocessing system equipped with a centrifuge unit for centrifuging samples.
- Sample preprocessing systems are designed so that when supplied with blood, urine, or other biological samples previously taken from patients, the system automatically conducts centrifuging, decapping, dispensing, sorting, conveying, and other processes, upon the samples.
- A scheme of carrying samples in such a sample preprocessing system commonly uses either carriers each loaded with a plurality of samples, or carriers each loaded with one sample container.
- In the carrying scheme that uses carriers each loaded with a plurality of samples, the samples are loaded into the sample preprocessing system by means of the carriers. In this scheme, shapes of the sample containers on the same carrier, and the kinds of samples used have needed to be unified, which in turn has required processing with an apparatus represented by those described in
Patent Document - On the other hand, in the carrying scheme that uses carriers each loaded with one sample container, upon samples being loaded in a tray-rested condition into the sample preprocessing system, the samples are each transferred from the tray to a carrier in fixed order automatically. This has eliminated the need to unify the shapes of the sample containers and the kinds of samples, because of the carrier being loaded with one sample only.
- In the above scheme, however, a succession of samples different in the type of processing required may reach various processing units. If a group consisting of a plurality of samples includes samples different in the type of processing required, this does not enable collective, simultaneous processing of the samples, even by a unit capable of processing samples collectively as a group. A need arises, therefore, to subgroup the samples and repeat processing a plurality of times.
- As a result, the sample preprocessing system decreases in throughput that is more or less affected by a manner of arranging the samples on the trays supplied.
-
- Patent Document 1:
JP-5-142232-A - Patent Document 2:
JP-2007-40880-A - Patent Document 3:
JP-11-304806-A - Provided is a sample preprocessing system of a carrier conveying scheme, neither requiring an operator's manual intervention nor suffering a decrease in throughput due to a manner of arranging samples on trays supplied. Means for Solving the Problems
- The invention solving the above object is defined by the appended claims.
- Of a plurality of processing units included in the sample preprocessing system, a centrifuge unit positioned at an upstream process site to process a plurality of samples in a collective manner includes control means that changes transfer order for feeding out centrifuged samples from order for transferring the samples into the centrifuge unit. This change of the transfer order prevents a decrease in throughput of the processing units positioned at downstream process sites.
- The present invention has a beneficial effect in that it prevents the decrease in the throughput of the sample preprocessing system without requiring an apparatus represented by those described in
Patent Document - The present invention has another beneficial effect in that it prevents a decrease in throughput of analyzers connected via connection lines.
-
-
Fig. 1 is an exemplary screen menu format for specifying a method of changing carrier-loading order; -
Fig. 2 is a schematic diagram showing a sample preprocessing system and analyzers connected thereto; -
Fig. 3 is a diagram for assistance in explaining a centrifuge unit; -
Fig. 4 shows an example of creating information on the samples mounted on adapters; and -
Fig. 5 shows a process flow for determining the carrier-loading order. - Hereunder, the present invention will be described in detail using an embodiment.
-
Fig. 2 is a schematic diagram that shows a sample preprocessing system according to the embodiment of the present invention, and analyzers connected to the system. Atray 206 is loaded with samples and then mounted in aloading unit 205. Theloading unit 205 transfers the samples from thetray 206 to carriers supplied from acarrier supply unit 204. After the samples have been transferred to the carriers, ID reading means reads the sample identification codes assigned to the samples, and carrier identification codes assigned to the carriers. In addition, which carrier is loaded with which sample is registered in acontroller 201. Thecontroller 201 uses the registered information to transport each carrier and control samples processing. - The carrier loaded with samples is carried from the
loading unit 205 to acentrifuge unit 207 using aconveyance line 203. -
Fig. 3 is a diagram for assistance in explaining thecentrifuge unit 207. Thecentrifuge unit 207 includes acentrifuging mechanism 303, anadapter handling mechanism 301, anadapter retaining unit 302, asample handling mechanism 304, a centrifugation-queuedsample retaining unit 306, and a centrifugedsample retaining unit 307. - Referring to
Fig. 3 , theadapter retaining unit 302 is constructed to accept, by way of example, eightadapters 305, four in a space for adapters queued for centrifugation, and four in a space for centrifuged adapters. Thecentrifuging mechanism 303 is configured to centrifuge a maximum of four adapters at the same time. Theadapter handling mechanism 301 transfers each centrifugation-queuedadapter 305 from the space for centrifugation-queued adapters to thecentrifuging mechanism 303. Theadapter handling mechanism 301 also transfers eachcentrifuged adapter 305 from thecentrifuging mechanism 303 to the space for centrifuged adapters. In addition, oneadapter 305 is constructed so that nine samples, for example, can be set up thereupon. Thesample handling mechanism 304 undertakes transfer of samples from carriers in the centrifugation-queuedsample retaining unit 306 to theadapters 305 on theadapter retaining unit 302, and transfer of samples from theadapters 305 on theadapter retaining unit 302 to carriers in the centrifugedsample retaining unit 307. - Next, a samples processing sequence in the
centrifuge unit 207 is described below. A samples-loaded carrier that has been carried to thecentrifuge unit 207 is further carried to the centrifugation-queuedsample retaining unit 306 by theconveyance line 203. Thesample handling mechanism 304 extracts the samples from the carrier in thesample retaining unit 306, and then the samples are transferred to theadapters 305 on theadapter retaining unit 302. The information that has been stored into thecontroller 201 in order to indicate which carrier is loaded with which samples is erased upon completion of the transfer. A historical record of which carrier has been loaded with which samples, however, is saved without being erased. The carrier from which the samples have been extracted is carried to the centrifugedsample retaining unit 307, whereby the carrier can then be loaded with other samples. - After that, samples that have been carried to the
centrifuge unit 207 are likewise transferred to theadapters 305 on theadapter retaining unit 302. The transfer of the samples is repeated for a specified time or until fouradapters 305 have become full of centrifugation-queued samples. Upon completion of the transfer, eachadapter 305 is transferred to thecentrifuging mechanism 303, in which, centrifugal separation is started. - After centrifugation, each sample becomes ready for carrier loading at the centrifuged
sample retaining unit 307 via theadapter retaining unit 302. - In a conventional system, a carrier in a centrifuged
sample retaining unit 307 has been loaded with carrier-loadable samples by acentrifuge unit 207 in the same order as that in which asample handling mechanism 304 had extracted the samples from the carrier. - The carrier-loaded samples have been decapped in a
decapping unit 208 and then carried to a dispensingunit 209. - In the present invention, however, order of carrier loading with samples is changed. The following describes a carrier-loading order changing sequence.
- Registered in the
controller 201 are analytical item registration information that denotes analysis items which theanalyzers unit 209 generates by dispensing a supplied sample. If the analyzability attribute information differs between analytical items, a plurality of child samples are generated. - The
controller 201 also provides a screen menu shown inFig. 1 . This menu is for specifying a method of changing the carrier-loading order. The menu can be used to select whether the carrier-loading order is to be changed, and to select a corresponding carrier-loading order changing method in the case where the carrier-loading order is changed. - Data that is entered in the menu will be used during carrier-loading order determination based on a process flow of
Fig. 5 . - Each time a sample is transferred to one
adapter 305 on theadapter retaining unit 302, which sample has been transferred to whichadapter 305 is stored in time series into thecentrifuge unit 207.Fig. 4 shows an example of creating the information stored into thecentrifuge unit 207. This information is composed of information that denotes theorder 402 in which the sample was transferred to theadapter 305, a logically assignedadapter number 403, a logically assigned sample-in-adapter position number 404, and asample identification code 405. The information is reported to thecontroller 201 as sample-in-adapter information 401 when centrifugation is started. -
Fig. 5 shows a process flow of steps in which thecontroller 201 determines the carrier-loading order. The determination is based upon the settings in the loadingorder setting menu 101 ofFig. 1 and the sample-in-adapter information 401 inFig. 4 , as well as upon the above-described analysis item registration information, analyzability attribute information, samples carrier-loading order information, and samples analysis request information. - First, presence/absence of a loading order change is determined in loading-order change
existence determination step 501, and if the change is present and ineffective, loadingorder determination step 514 relating to all samples is executed in accordance with theorder information 402, that is, in the order that the samples were transferred to theadapters 305. - If the change is effective, whether loading order of an urgent sample is to be preferentially set is determined in urgent-sample loading-order change
existence determination step 502, and the determination is followed by loading-order determination step 511 for the urgent sample. In urgent-sample loadingorder determination step 511, the loading order of the urgent sample only is determined in accordance with theorder information 402 denoting the order of transfer to anadapter 305. - Analyzability attribute information on samples whose carrier loading order has not been determined is viewed and how many analyzability attribute information patterns exist and how many samples corresponding to each pattern exist are compiled in analyzability attribute
information compiling step 503. If the carrier loading order of the urgent sample has already been determined, this compiling step is executed only for non-urgent samples. If the carrier loading order of the urgent sample is undetermined, the compiling step is executed for all samples including the urgent sample. - Next, analyzability attribute
information rearranging step 504 is executed to rearrange the obtained analyzability attribute information patterns in descending order of magnitude of the number of samples corresponding to the pattern. Analyzability attributeinformation updating step 505 for samples selection next follows to extract the patterns, one at a time, in order. In analyzability attributeinformation updating step 505, operational states of the analyzers connected viaconnection lines 210 may be considered during the extraction of each analyzability attribute information pattern. - In
step 506 of selecting analyzability attribute information matching samples, samples with an analyzability attribute information pattern that matches the extracted pattern are selected. In order to complete the analyses corresponding to the samples analysis request information, the system executessamples grouping step 507 to sort out all selected samples into groups for each analyzer to which the sample is to be carried. The sorting is based on analysis item registration information. - In grouped-samples loading
order determination step 508, loading order of the samples contained in the group is determined in accordance with theorder information 402 denoting the order of transfer to theadapters 305. - If the loading order of all samples is not yet determined, the process returns from all-samples loading-order determination
end checking step 509 to analyzability attributeinformation updating step 505, in which step, the analyzability attribute information pattern to be used for samples selection is then updated into the analyzability attribute information pattern that is next largest in the number of corresponding samples. Analyzability attribute information matchingsamples selection step 506 onward is repeated after that. - If the loading order of all samples is already determined, order of loading from adapters to a carrier is indicated to the
centrifuge unit 207 in step 510 of indicating the adapter-to-carrier loading order to thecentrifuge unit 207. - After this, upon completion of centrifugation, the samples are loaded onto the carrier in the centrifuged
sample retaining unit 307 by thecentrifuge unit 207 in the order specified from thecontroller 201. After the transfer of each sample to the carrier, the ID reading means reads the sample identification code assigned to the sample, and the carrier identification code assigned to the carrier. Thus, which carrier is loaded with which samples are registered in thecontroller 201 once again. - In this way, in the
centrifuge unit 207 positioned at an upstream process site relative to the plurality of processing units included in the sample preprocessing system, the order for feeding out the samples from thecentrifuge unit 207 upon completion of centrifugation is changed from the order in which the samples have been transferred into thecentrifuge unit 207 prior to the centrifugation. Throughput of the processing units positioned at downstream process sites can therefore be prevented from decreasing. - In addition, since child samples that will be conveyed via the same path are continuously created in the
dispensing unit 209, throughput of the analyzers connected via theconnection lines 210 can also be prevented from decreasing. - Although this is not described in the present example, when carrier loading order of urgent samples is determined in urgent-sample loading
order determination step 511 ofFig. 5 , analyzability attributeinformation compiling step 503 to grouped-samples loadingorder determination step 508 may be executed only for the urgent samples, to make further changes to transfer order of the urgent samples. -
- 101 Loading order setting menu
- 102 Loading order change setting button
- 103 Loading order change priority setting button
- 201 Controller
- 202 Communications cable
- 203 Conveyance line
- 204 Carrier supply unit
- 205 Loading unit
- 206 Tray
- 207 Centrifuge unit
- 208 Decapping unit
- 209 Dispensing unit
- 210 Connection line
- 211, 212, 213 Analyzers
- 301 Adapter handling mechanism
- 302 Adapter retaining unit
- 303 Centrifuging mechanism
- 304 Sample handling mechanism
- 305 Adapter
- 306 Centrifugation-queued sample retaining unit
- 307 Centrifuged sample retaining unit
- 401 Sample-in-adapter information
- 402 Order of transfer to adapter
- 403 Adapter number
- 404 Sample-in-adapter position number
- 405 Sample identification code
- 501 Step of determining whether loading order change exists
- 502 Step of determining whether urgent-samples loading order change exists
- 503 Step of compiling analyzability attribute information
- 504 Step of rearranging analyzability attribute information
- 505 Step of updating analyzability attribute information for sample selection
- 506 Step of selecting samples that match in analyzability attribute information
- 507 Step of grouping samples
- 508 Step of determining grouped-samples loading order
- 509, 515 Step of checking whether determination of loading order of all samples is completed
- 510 Step of indicating the adapter-to-carrier loading order to centrifuge unit
- 511 Step of determining urgent-sample loading order
- 512 Step of checking whether determination of loading order of all urgent samples is completed
- 513 Step of determining whether non-urgent samples loading order change exists
- 514 Step of determining all-samples loading order
Claims (7)
- A sample preprocessing system comprising:carriers each loaded with sample containers;a conveyance line (203) for carrying each carrier;a plurality of processing units (204, 205, 207, 208, 209) arranged along the conveyance line, including at least a centrifuge unit (207) for centrifuging the sample containers in a collective manner; anda controller (201) for instructing the processing units to process the samples in addition to instructing the conveyance line to convey the carriers;characterised in that:it (302), and a sample handling mechanism (304) for transferring the sample containers from the carriers to adapters (305) on the adapter retaining unit (302) and from the adapters on the adapter retaining unit (302) to the carriers, and a centrifuging mechanism (303) for centrifuging the adapters, and in thatthe controller (201) is programmed to change the order for feeding out the samples from the centrifuge unit after centrifugation, from the order of the transfer of the samples into the centrifuge unit, by changing the order of loading the carriers with the sample containers by the sample handling mechanism.
- The sample preprocessing system according to claim 1, wherein:
the order of transfer of the samples from the centrifuge unit is changed using information on priority levels of the samples. - The sample preprocessing system according to claim 1, wherein:
the order of transfer of the samples from the centrifuge unit is changed using analysis item registration information that denotes analysis items on which analyzers (211, 212, 213) connected to the sample preprocessing system via connection lines (210) conduct analyses, analyzability attribute information that denotes whether the analysis items are each appropriate for analysis from one specific child sample, and analysis request information on each sample. - The sample preprocessing system according to claim 1, wherein the order of transfer of the samples from the centrifuge unit is changed using:information on priority levels of the samples;analysis request information;analysis item registration information that denotes analysis items on which analyzers (211, 212, 213) connected to the sample preprocessing system via connection lines (210) conduct analyses; andanalyzability attribute information that denotes whether the analysis items are each appropriate for analysis from one specific child sample.
- The sample preprocessing system according to claim 1, further comprising means (101) for setting a method of changing the order of transfer of the samples from the centrifuge unit.
- The sample preprocessing system according to claim 1, wherein:
after a carrier from which samples were unloaded has been loaded with other samples, sample identification codes assigned to the other samples, and a carrier identification code assigned to the carrier are read and which carrier has been loaded with which of said other samples is registered once again. - The sample preprocessing system according to claim 6, wherein:
during transfer of the samples from one carrier to another, a historical record of which carrier has been loaded with the samples is saved.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009225917 | 2009-09-30 | ||
PCT/JP2010/005158 WO2011039932A1 (en) | 2009-09-30 | 2010-08-23 | Specimen preprocessing system |
Publications (3)
Publication Number | Publication Date |
---|---|
EP2485055A1 EP2485055A1 (en) | 2012-08-08 |
EP2485055A4 EP2485055A4 (en) | 2017-07-05 |
EP2485055B1 true EP2485055B1 (en) | 2020-06-24 |
Family
ID=43825787
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10820058.5A Active EP2485055B1 (en) | 2009-09-30 | 2010-08-23 | Specimen preprocessing system |
Country Status (5)
Country | Link |
---|---|
US (1) | US20120177548A1 (en) |
EP (1) | EP2485055B1 (en) |
JP (1) | JP5656852B2 (en) |
CN (1) | CN102472762B (en) |
WO (1) | WO2011039932A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5417351B2 (en) * | 2011-01-26 | 2014-02-12 | 株式会社日立ハイテクノロジーズ | Sample transport system and control method thereof |
BR112014010955A2 (en) * | 2011-11-07 | 2017-06-06 | Beckman Coulter Inc | system and method for processing samples |
DE102012111867B4 (en) * | 2011-12-06 | 2013-11-21 | Hirata Corp. | sorter |
EP2857822B1 (en) | 2012-05-28 | 2019-10-30 | Hitachi High-Technologies Corporation | Specimen processing system and processing method for a centrifuge system |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3035926B2 (en) * | 1989-10-14 | 2000-04-24 | 日立工機株式会社 | Automatic centrifuge |
JP2973133B2 (en) * | 1990-09-19 | 1999-11-08 | 株式会社日立製作所 | Sample sorting device for clinical test |
JP3047571B2 (en) | 1991-11-20 | 2000-05-29 | 株式会社日立製作所 | Clinical test equipment |
JPH0592729U (en) * | 1992-03-17 | 1993-12-17 | 株式会社ニッテク | Blood container transfer device |
JPH0651870U (en) * | 1992-12-21 | 1994-07-15 | 株式会社ニッテク | Blood container sorting instruction device |
JPH09276743A (en) * | 1996-04-15 | 1997-10-28 | Aloka Co Ltd | Rack transfer method in centrifuge |
US6586255B1 (en) * | 1997-07-21 | 2003-07-01 | Quest Diagnostics Incorporated | Automated centrifuge loading device |
JP3441960B2 (en) * | 1998-03-27 | 2003-09-02 | 株式会社日立製作所 | Specimen test pre-processing system and its operation method |
JPH11304806A (en) * | 1998-04-20 | 1999-11-05 | Hitachi Ltd | Automatic pretreatment system for specimen inspection |
JP3484353B2 (en) * | 1998-09-14 | 2004-01-06 | アロカ株式会社 | Centrifuge |
CH698240B1 (en) * | 1998-11-17 | 2009-06-30 | Tecan Trading Ag | A method for weighing sample tubes, feeding and workstation. |
JP2002040034A (en) * | 2000-07-24 | 2002-02-06 | Olympus Optical Co Ltd | Specimen sorting device |
JP2002090374A (en) * | 2000-09-13 | 2002-03-27 | Olympus Optical Co Ltd | Specimen pre-treatment device and specimen carrying method |
JP4422079B2 (en) | 2005-08-04 | 2010-02-24 | 株式会社日立ハイテクノロジーズ | Sample transport system |
-
2010
- 2010-08-23 US US13/388,401 patent/US20120177548A1/en not_active Abandoned
- 2010-08-23 JP JP2011534041A patent/JP5656852B2/en active Active
- 2010-08-23 CN CN201080034442.8A patent/CN102472762B/en active Active
- 2010-08-23 EP EP10820058.5A patent/EP2485055B1/en active Active
- 2010-08-23 WO PCT/JP2010/005158 patent/WO2011039932A1/en active Application Filing
Non-Patent Citations (1)
Title |
---|
None * |
Also Published As
Publication number | Publication date |
---|---|
JP5656852B2 (en) | 2015-01-21 |
EP2485055A1 (en) | 2012-08-08 |
WO2011039932A1 (en) | 2011-04-07 |
CN102472762B (en) | 2015-05-13 |
US20120177548A1 (en) | 2012-07-12 |
CN102472762A (en) | 2012-05-23 |
JPWO2011039932A1 (en) | 2013-02-21 |
EP2485055A4 (en) | 2017-07-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10816564B2 (en) | Sample test automation system | |
US5814276A (en) | Automated blood sample processing system | |
CN102027375B (en) | Process for managing urgent samples in automation installation | |
US20160244269A1 (en) | Sample transfer device and sample processing system | |
JP6307446B2 (en) | Centrifuge system, specimen pretreatment system, and control method | |
EP3594691A1 (en) | Automated analyzer | |
EP2485055B1 (en) | Specimen preprocessing system | |
WO2013180017A1 (en) | Centrifugal separator, processing system provided with centrifugal separator, and method for controlling said system | |
US9483048B2 (en) | Sample transport system and method for controlling the same | |
JPH0833400B2 (en) | Sample operation device | |
JP2002357612A (en) | Sample treatment system | |
JP3618067B2 (en) | Sample sorter | |
JP2000065842A (en) | Medical specimen examination pretreatment automation system and operation thereof | |
EP3502709A1 (en) | Automated sample inspection system and method for controlling same | |
CN112345776B (en) | Sample analysis system, device and sample testing method | |
US20240183872A1 (en) | Diagnostic instruments having sorting capability and sorting methods thereof | |
CN112345744B (en) | Pipeline system and test method thereof | |
JP2000046839A (en) | Specimen treatment system | |
EP4372384A1 (en) | Method for optimizing laboratory system | |
CN112345778B (en) | Cascade sample analysis system, device and quality control project out-of-control processing method | |
CN117120842A (en) | Diagnostic instrument with classification capability and classification method thereof | |
CN111108395A (en) | Specimen processing system | |
CN117795346A (en) | Automatic analysis device and control method thereof | |
JPH0264462A (en) | Biochemical automatic analytical system |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20120329 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR |
|
DAX | Request for extension of the european patent (deleted) | ||
RA4 | Supplementary search report drawn up and despatched (corrected) |
Effective date: 20170607 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: G01N 35/02 20060101AFI20170531BHEP Ipc: G01N 35/00 20060101ALI20170531BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |
|
17Q | First examination report despatched |
Effective date: 20191009 |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: GRANT OF PATENT IS INTENDED |
|
INTG | Intention to grant announced |
Effective date: 20200114 |
|
GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE PATENT HAS BEEN GRANTED |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: HITACHI HIGH-TECH CORPORATION |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: FG4D |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: EP |
|
REG | Reference to a national code |
Ref country code: AT Ref legal event code: REF Ref document number: 1284406 Country of ref document: AT Kind code of ref document: T Effective date: 20200715 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R096 Ref document number: 602010064746 Country of ref document: DE |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200624 Ref country code: FI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200624 Ref country code: NO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200924 Ref country code: SE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200624 Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200925 |
|
REG | Reference to a national code |
Ref country code: LT Ref legal event code: MG4D |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LV Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200624 Ref country code: HR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200624 Ref country code: BG Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200924 |
|
REG | Reference to a national code |
Ref country code: NL Ref legal event code: MP Effective date: 20200624 |
|
REG | Reference to a national code |
Ref country code: AT Ref legal event code: MK05 Ref document number: 1284406 Country of ref document: AT Kind code of ref document: T Effective date: 20200624 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: NL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200624 Ref country code: AL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200624 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: CZ Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200624 Ref country code: ES Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200624 Ref country code: PT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20201026 Ref country code: EE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200624 Ref country code: SM Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200624 Ref country code: RO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200624 Ref country code: IT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200624 Ref country code: AT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200624 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: PL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200624 Ref country code: SK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200624 Ref country code: IS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20201024 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R097 Ref document number: 602010064746 Country of ref document: DE |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MC Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200624 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PL |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20200831 Ref country code: DK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200624 Ref country code: CH Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20200831 Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20200823 |
|
PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
GBPC | Gb: european patent ceased through non-payment of renewal fee |
Effective date: 20200924 |
|
REG | Reference to a national code |
Ref country code: BE Ref legal event code: MM Effective date: 20200831 |
|
26N | No opposition filed |
Effective date: 20210325 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20200823 Ref country code: GB Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20200924 Ref country code: SI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200624 Ref country code: BE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20200831 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: TR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200624 Ref country code: MT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200624 Ref country code: CY Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200624 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20200624 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: FR Payment date: 20230703 Year of fee payment: 14 Ref country code: DE Payment date: 20230627 Year of fee payment: 14 |